Journal of nuclear medicine : official publication, Society of Nuclear Medicine最新文献

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Functional Renal Assessment via Dynamic LAFOV 18F-FDG PET/CT in a Patient with Recurrent Extranodal Marginal-Zone Lymphoma. 动态LAFOV 18F-FDG PET/CT对复发性结外边缘区淋巴瘤患者肾功能的评估
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.126.272086
Jonathan Kuten, Bradley J Beattie, Stephanie Chahwan, Heiko Schöder
{"title":"Functional Renal Assessment via Dynamic LAFOV <sup>18</sup>F-FDG PET/CT in a Patient with Recurrent Extranodal Marginal-Zone Lymphoma.","authors":"Jonathan Kuten, Bradley J Beattie, Stephanie Chahwan, Heiko Schöder","doi":"10.2967/jnumed.126.272086","DOIUrl":"10.2967/jnumed.126.272086","url":null,"abstract":"<p><p>We report the case of a 72-y-old man with recurrent extranodal marginal-zone B-cell lymphoma who underwent dynamic long-axial-field-of-view <sup>18</sup>F-FDG PET/CT. In addition to detecting extensive recurrent disease, a review of a maximum-intensity-projection cine derived from the dynamic acquisition demonstrated delayed uptake and excretion from the left kidney, consistent with impaired function. This incidental functional renal assessment supplemented standard anatomic imaging and influenced treatment management. This case highlights the emerging capability of dynamic long-axial-field-of-view <sup>18</sup>F-FDG PET/CT to provide renal functional information in oncologic imaging.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1481-1483"},"PeriodicalIF":9.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging Modality and Outcomes of Metastasis-Directed Therapy in Oligometastatic Castration-Resistant Prostate Cancer: An Updated Analysis of the PRECISE-MDT Cohort. 低转移性去势抵抗性前列腺癌转移导向治疗的成像方式和结果:precision - mdt队列的最新分析。
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.125.271680
Matteo Bauckneht, Liliana Belgioia, Domenico Albano, Luca Triggiani, Flavia Linguanti, Luca Urso, Rosario Mazzola, Alessio Rizzo, Elisa D'Angelo, Francesco Dondi, Eneida Mataj, Gloria Pedersoli, Elisabetta Maria Abenavoli, Luca Vaggelli, Beatrice Detti, Naima Ortolan, Antonio Malorgio, Alessia Guarneri, Federico Garrou, Jacopo Passoni, Matilde Fiorini, Serena Grimaldi, Pietro Ghedini, Giuseppe Carlo Iorio, Antonella Iudicello, Guido Rovera, Giuseppe Fornarini, Elisa Zanardi, Diego Bongiovanni, Michela Marcenaro, Alessandra Agosti, Giorgia Timon, Matteo Salgarello, Manuela Racca, Mirco Bartolomei, Stefano Panareo, Umberto Ricardi, Francesco Bertagna, Filippo Alongi, Salvina Barra, Silvia Morbelli, Francesco Lanfranchi, Gianmario Sambuceti
{"title":"Imaging Modality and Outcomes of Metastasis-Directed Therapy in Oligometastatic Castration-Resistant Prostate Cancer: An Updated Analysis of the PRECISE-MDT Cohort.","authors":"Matteo Bauckneht, Liliana Belgioia, Domenico Albano, Luca Triggiani, Flavia Linguanti, Luca Urso, Rosario Mazzola, Alessio Rizzo, Elisa D'Angelo, Francesco Dondi, Eneida Mataj, Gloria Pedersoli, Elisabetta Maria Abenavoli, Luca Vaggelli, Beatrice Detti, Naima Ortolan, Antonio Malorgio, Alessia Guarneri, Federico Garrou, Jacopo Passoni, Matilde Fiorini, Serena Grimaldi, Pietro Ghedini, Giuseppe Carlo Iorio, Antonella Iudicello, Guido Rovera, Giuseppe Fornarini, Elisa Zanardi, Diego Bongiovanni, Michela Marcenaro, Alessandra Agosti, Giorgia Timon, Matteo Salgarello, Manuela Racca, Mirco Bartolomei, Stefano Panareo, Umberto Ricardi, Francesco Bertagna, Filippo Alongi, Salvina Barra, Silvia Morbelli, Francesco Lanfranchi, Gianmario Sambuceti","doi":"10.2967/jnumed.125.271680","DOIUrl":"10.2967/jnumed.125.271680","url":null,"abstract":"<p><p>It is unclear whether the imaging modality used to guide metastasis-directed therapy (MDT) influences outcomes in oligometastatic castration-resistant prostate cancer (omCRPC). <b>Methods:</b> We performed an updated analysis of the PRECISE-MDT cohort, adding 27 patients to the original cohort. MDT guided by prostate-specific membrane antigen (PSMA) PET/CT, choline PET/CT, and conventional imaging was compared in 102 patients with omCRPC. The primary outcomes were biochemical recurrence-free survival and overall survival after adjustment for inverse probability of treatment weighting. <b>Results:</b> MDT was guided by conventional imaging in 20 (19.6%) patients, choline PET/CT in 56 (54.9%) patients, and PSMA PET/CT in 26 (25.5%) patients. PSMA PET/CT guidance yielded longer biochemical recurrence-free survival than did choline PET/CT (median not reached [NR] vs. 11.7 mo, <i>P</i> = 0.031) and conventional imaging (NR vs. 7.1 mo, <i>P</i> = 0.002). Overall survival favored PSMA PET/CT versus conventional imaging (NR vs. 46.0 mo, <i>P</i> = 0.036). <b>Conclusion:</b> PSMA PET/CT guidance was associated with improved clinical outcome, supporting its therapeutic relevance for MDT planning in omCRPC.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1409-1412"},"PeriodicalIF":9.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sub-0.5-mm Resolution PET Versus Autoradiography: Comparison of mGluR1 Concentrations in Mouse Brain. 低于0.5 mm分辨率PET与放射自显像:小鼠脑内mGluR1浓度的比较。
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.125.271600
Han Gyu Kang, Hideaki Tashima, Hidekatsu Wakizaka, Takeharu Minamihisamatsu, Tomoteru Yamasaki, Masayuki Fujinaga, Ming-Rong Zhang, Makoto Higuchi, Taiga Yamaya
{"title":"Sub-0.5-mm Resolution PET Versus Autoradiography: Comparison of mGluR1 Concentrations in Mouse Brain.","authors":"Han Gyu Kang, Hideaki Tashima, Hidekatsu Wakizaka, Takeharu Minamihisamatsu, Tomoteru Yamasaki, Masayuki Fujinaga, Ming-Rong Zhang, Makoto Higuchi, Taiga Yamaya","doi":"10.2967/jnumed.125.271600","DOIUrl":"10.2967/jnumed.125.271600","url":null,"abstract":"<p><p>For mouse brain PET imaging with high quantification accuracy, ultrahigh resolution is essential. Metabotropic glutamate receptors are important molecular targets, linked to various neurologic diseases. Here, we report the comparison of in vivo mouse brain images obtained with sub-0.5-mm resolution PET and those obtained with autoradiography using 4-<sup>18</sup>F-fluoro-<i>N</i>-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-<i>N</i>-methylbenzamide (<sup>18</sup>F-FITM) that binds to metabotropic glutamate receptor subtype 1. <b>Methods:</b> We recently developed a sub-0.5-mm resolution PET scanner having an axial coverage of 23.4 mm and an inner diameter of 48 mm. The PET scanner comprises 32 depth-of-interaction detectors, each of which has staggered 3-layer lutetium-yttrium-orthosilicate crystal arrays with a pitch of 0.8 mm. A resolution phantom was used to evaluate the imaging performance of the PET scanner. Dynamic PET imaging was performed to evaluate the concentration changes of <sup>18</sup>F-FITM at various mouse brain regions. In vivo metabotropic glutamate receptor imaging of a mouse brain was performed using <sup>18</sup>F-FITM and the PET scanner. Subsequently, autoradiography images of the same mouse brain were obtained using <sup>18</sup>F-FITM. <b>Results:</b> The 0.45-mm rod structure was resolved with the PET scanner. Time-activity curves of various mouse brain regions were obtained. The sub-0.5-mm resolution PET visualized <sup>18</sup>F-FITM uptake in the mouse brain with high correlation to the autoradiography images. <b>Conclusion:</b> The sub-0.5-mm resolution PET opens up new opportunities for translational neuroscience research using mice models.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1503-1509"},"PeriodicalIF":9.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MIRD Pamphlet No. 34, Part 2: Benchmarking of MIRDct Software for CT Organ Dose Estimation. MIRD小册子第34号,第2部分:用于CT器官剂量估计的MIRDct软件的基准。
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.125.271501
Gunjan Kayal, Juan Camilo Ocampo Ramos, Laura E Dinwiddie, Jared M Baggett, Robert J Dawson, Harry Marquis, Stefan K Wehmeier, Oleksandra Ivashchenko, Lukas M Carter, Wesley E Bolch, Adam L Kesner
{"title":"MIRD Pamphlet No. 34, Part 2: Benchmarking of MIRDct Software for CT Organ Dose Estimation.","authors":"Gunjan Kayal, Juan Camilo Ocampo Ramos, Laura E Dinwiddie, Jared M Baggett, Robert J Dawson, Harry Marquis, Stefan K Wehmeier, Oleksandra Ivashchenko, Lukas M Carter, Wesley E Bolch, Adam L Kesner","doi":"10.2967/jnumed.125.271501","DOIUrl":"10.2967/jnumed.125.271501","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Accurate estimation of organ and effective doses in CT imaging is essential for risk assessment, protocol optimization, and personalized care in diagnostic radiology and nuclear medicine. We systematically benchmarked MIRDct, a freely available mesh phantom-based CT dose calculation software, against established reference software (National Cancer Institute Dosimetry System for Computed Tomography [NCICT] and VirtualDose [Virtual Phantoms]) by evaluating agreement between organ-absorbed doses and effective doses across representative scanners, phantoms, and protocols. &lt;b&gt;Methods:&lt;/b&gt; Organ absorbed and effective doses were calculated for adult and pediatric phantoms for whole-body (WB) and regional (head, chest, abdomen-pelvis [AP]) CT examinations. MIRDct uses mesh-based International Commission on Radiologic Protection (ICRP) reference phantoms with anatomically realistic organ surfaces, whereas NCICT and VirtualDose use voxel-based ICRP 110 and hybrid Rensselaer Polytechnic Institute/University of Florida phantom models, respectively. For each software, volumetric CT dose index (CTDIvol) values were obtained from the software interface using matched acquisition parameters; in MIRDct, these values were derived from scanner console-reported outputs for the corresponding protocol settings. Organ absorbed doses, dose coefficients, and effective doses were computed across 44 matched scanner-phantom-protocol configurations. Inter-software differences were summarized using medians and interquartile ranges. For regional protocols, organ-absorbed doses were stratified by irradiation category (in-field, partial-in-field, out-of-field), to assess field-dependent variability. &lt;b&gt;Results:&lt;/b&gt; CTDIvol​ values reported by the 3 software tools showed close agreement across matched protocol configurations, with median inter-software differences not exceeding 7%. For in-field organs, dose coefficients from NCICT and VirtualDose generally agreed with MIRDct values within ±25% across adult and pediatric head, chest, AP, and WB protocols, indicating good agreement in the primary beam region. Larger relative deviations occurred for partial-in-field and out-of-field organs, where doses were scatter-dominated; however, absolute organ doses were less than 2 mGy, limiting clinical relevance. Effective dose estimates showed similar concordance: differences were below 25% for all VirtualDose comparisons except head scans and for WB protocols, whereas adult chest and AP protocols differed by up to 40% relative to NCICT. These differences were associated with variations in phantom anatomy and fixed, pre-tabulated CTDIvol reference values in NCICT and VirtualDose, compared with protocol-specific, console-reported CTDIvol inputs in MIRDct. &lt;b&gt;Conclusion:&lt;/b&gt; MIRDct provides organ- and effective-dose estimates that are broadly consistent with established CT dosimetry tools, with agreement typically within ±25% for in-field organs and within a few milligray for absolute ","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1491-1502"},"PeriodicalIF":9.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total-Body Dynamic PET/CT Imaging of Proton-Induced Activity and Biologic Washout After Proton Therapy. 质子治疗后质子诱导活性和生物洗脱的全身动态PET/CT成像。
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.126.272338
Hongmei Tang, Shuang Song, Fei Liu, Jiahui Xu, Yang Wu, Renchao Zheng, Zhaoting Cheng, Shengle Wang, Yuankai Zhu, Zhiping Xiao, Fan Zhu, Hairong Zheng, Zhen Tao, Xianglin Yuan, Xiaohua Zhu
{"title":"Total-Body Dynamic PET/CT Imaging of Proton-Induced Activity and Biologic Washout After Proton Therapy.","authors":"Hongmei Tang, Shuang Song, Fei Liu, Jiahui Xu, Yang Wu, Renchao Zheng, Zhaoting Cheng, Shengle Wang, Yuankai Zhu, Zhiping Xiao, Fan Zhu, Hairong Zheng, Zhen Tao, Xianglin Yuan, Xiaohua Zhu","doi":"10.2967/jnumed.126.272338","DOIUrl":"10.2967/jnumed.126.272338","url":null,"abstract":"<p><p>Off-line PET imaging after proton therapy is limited by transport delay and by the sensitivity and short axial field of view of conventional scanners, which hinder imaging at ultralow activity and characterization of whole-body biologic washout. We evaluated whether a near-room total-body PET/CT system could enable clinically practical imaging of proton-induced activity after treatment and its whole-body biologic washout. <b>Methods:</b> We conducted a series of phantom studies to evaluate the performance of total-body PET at ultralow activity with Monte Carlo (MC)-simulated activity distributions as references. Nineteen patients with solid tumors underwent off-line total-body dynamic PET/CT imaging shortly after proton therapy. Spatial correlation between PET and MC results was quantified using the Dice similarity coefficient (DSC) and normalized cross-correlation (NCC). Dynamic images were reconstructed, and time-activity curves were extracted from volumes of interest to analyze the dynamic behavior of proton-induced activity. <b>Results:</b> In phantom experiments, PET images showed close spatial correspondence to MC reference distributions under ultralow activity. In patients, the agreement between PET and MC was higher for relatively stationary targets, with a mean DSC/NCC of 0.81 ± 0.09/0.81 ± 0.09 for the brain and 0.81 ± 0.05/0.83 ± 0.08 for the breast. Dynamic total-body PET images revealed biologic washout and whole-body redistribution of isotope activity within and beyond the gross tumor volumes, showing enrichment within the cardiac blood pool, major blood vessels, and blood-rich organs, such as the spleen and liver. <b>Conclusion:</b> Near-room total-body PET/CT enabled interpretable imaging under ultralow activity after treatment. Dynamic total-body imaging additionally captured whole-body biologic washout of proton-induced activity through blood circulation, providing a foundation for future washout modeling and methodologic development for in vivo treatment assessment.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1484-1490"},"PeriodicalIF":9.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAIX and CD70 Theranostics in Clear Cell Renal Cell Carcinoma: Navigating the Promise and Perils. CAIX和CD70在透明细胞肾细胞癌的治疗:导航的希望和危险。
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.126.272707
Weijun Wei, Irene Burger, Jin Zhang, Ken Herrmann, Brian M Shuch
{"title":"CAIX and CD70 Theranostics in Clear Cell Renal Cell Carcinoma: Navigating the Promise and Perils.","authors":"Weijun Wei, Irene Burger, Jin Zhang, Ken Herrmann, Brian M Shuch","doi":"10.2967/jnumed.126.272707","DOIUrl":"https://doi.org/10.2967/jnumed.126.272707","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":"67 9","pages":"1431-1433"},"PeriodicalIF":9.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of 18F-PSMA PET/MRI in Prostate Cancer Recurrence After Prostatectomy. 18F-PSMA PET/MRI在前列腺切除术后前列腺癌复发中的作用
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.126.272126
Alexandra Paule, Soizic Masson, Johan Rose Dite Modestine, Norelyakin Kara, David Taieb, Emeline Colomba, Guillaume Crespel, Philippe D'Abadie, Karim Fard
{"title":"Role of <sup>18</sup>F-PSMA PET/MRI in Prostate Cancer Recurrence After Prostatectomy.","authors":"Alexandra Paule, Soizic Masson, Johan Rose Dite Modestine, Norelyakin Kara, David Taieb, Emeline Colomba, Guillaume Crespel, Philippe D'Abadie, Karim Fard","doi":"10.2967/jnumed.126.272126","DOIUrl":"10.2967/jnumed.126.272126","url":null,"abstract":"<p><p><sup>18</sup>F-PSMA PET/CT and pelvic MRI are useful for assessing biochemical recurrence of prostate cancer after prostatectomy. We evaluated the role of <sup>18</sup>F-PSMA PET/MRI in a 1-stop-shop protocol combining a single injection of <sup>18</sup>F-PSMA, followed by pelvic PET/multiparametric MRI (mpMRI) and whole-body PET/CT acquisitions for the detection of recurrent disease. <b>Methods:</b> We evaluated 106 consecutive patients referred to our institute for biochemical recurrence after prostatectomy using a 1-stop-shop protocol comprising whole-body <sup>18</sup>F-PSMA PET/CT and pelvic <sup>18</sup>F-PSMA PET/mpMRI. Each imaging modality was reviewed in a blinded manner by 2 independent, experienced readers. <sup>18</sup>F-PSMA PET/MRI, with positivity on either MRI or PSMA PET, served as the reference standard. <b>Results:</b> <sup>18</sup>F-PSMA PET/MRI detected more local recurrences (<i>n</i> = 52, 49.06%) compared with <sup>18</sup>F-PSMA PET/CT (<i>n</i> = 42, 39.62%) and mpMRI (<i>n</i> = 46, 43.00%). Discordant cases accounted for 18 patients (17%): 10% were positive only on MRI and 7% only on PSMA PET. Compared with <sup>18</sup>F-PSMA PET/MRI, both mpMRI and <sup>18</sup>F-PSMA PET demonstrated similar performance, with sensitivities of 88.5% and 78.8% and specificities of 100% and 98.1%, respectively. <b>Conclusion:</b> <sup>18</sup>F-PSMA PET/MRI outperformed PET/CT and mpMRI in the detection of local recurrences of prostate cancer.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1385-1391"},"PeriodicalIF":9.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCa Detection in PI-RADS 4 and 5 Lesions: Comparison of [68Ga]Ga-PSMA-11 PET/CT-Guided Robot-Assisted Biopsy Versus mpMRI Cognitive-Fusion TRUS-Guided Prostate Biopsy. 前列腺癌在PI-RADS 4和5病变中的检测:[68Ga]Ga-PSMA-11 PET/ ct引导的机器人辅助活检与mpMRI认知融合trus引导的前列腺活检的比较
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.126.272036
Rajender Kumar, Aravindh Ram, Santosh Kumar, Harmandeep Singh, Nandita Kakkar, Ujjwal Gorsi, Anupam Lal, Bhagwant Rai Mittal, Shrawan Kumar Singh
{"title":"PCa Detection in PI-RADS 4 and 5 Lesions: Comparison of [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT-Guided Robot-Assisted Biopsy Versus mpMRI Cognitive-Fusion TRUS-Guided Prostate Biopsy.","authors":"Rajender Kumar, Aravindh Ram, Santosh Kumar, Harmandeep Singh, Nandita Kakkar, Ujjwal Gorsi, Anupam Lal, Bhagwant Rai Mittal, Shrawan Kumar Singh","doi":"10.2967/jnumed.126.272036","DOIUrl":"10.2967/jnumed.126.272036","url":null,"abstract":"<p><p>Lesions with a Prostate Imaging-Reporting and Data System (PI-RADS) score of 4 or greater on multiparametric MRI (mpMRI) indicate a high likelihood of prostate cancer (PCa), and guidelines recommend a targeted biopsy. We aimed to compare the diagnostic performance of robotic arm-assisted [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT-guided prostate biopsy (PGPB) with mpMRI-directed cognitive-fusion transrectal ultrasound-guided biopsy (MCFB) in biopsy-naïve men with clinical findings suggestive of PCa. <b>Methods:</b> This prospective, single-center, randomized clinical trial (NCT05137561) enrolled biopsy-naïve men age 50-90 y with elevated levels of prostate-specific antigen (≥4 ng/mL) and abnormal digital rectal examination findings. All participants underwent mpMRI, and those with a PI-RADS score of 4 or greater were randomized into 2 arms. In arm 1, participants underwent PGPB for a [<sup>68</sup>Ga]Ga-PSMA-avid lesion, and participants in arm 2 underwent MCFB. Participants in arm 1 with PET-negative findings subsequently underwent MCFB, and participants with negative biopsy results underwent PET and PGPB. The primary outcome was the detection of PCa. Secondary outcomes included complication rates and participant-reported pain. <b>Result:</b> Of the 267 participants enrolled, 81.3% (217) had lesions with a PI-RADS score of 4 or greater and were randomized to either PGPB (<i>n</i> = 112) or MCFB (<i>n</i> = 105). PCa was detected in 97.1% of participants (101/104) in arm 1 and 81.0% (85/105) in arm 2 (<i>P</i> < 0.05). PGPB showed higher diagnostic accuracy for PI-RADS 5 lesions (100% vs. 95.1%, <i>P</i> = 0.09). Major complications were observed in arm 2 only (<i>n</i> = 5). Arm 1 had significantly fewer complications (10.8% vs. 51.4%, <i>P</i> < 0.01), a lower median visual analog scale score for pain (3 vs. 5), and shorter procedure times. The core positivity rate was higher in arm 1 (60% ± 20%), despite obtaining fewer cores. <b>Conclusion:</b> [<sup>68</sup>Ga]Ga-PSMA-11 PGPB demonstrated higher diagnostic performance, fewer complications, and better tolerability compared with MCFB. This approach enables integrated diagnosis and staging, offering a promising alternative for efficient, safe, and accurate evaluation of prostate cancer.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"1401-1408"},"PeriodicalIF":9.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[68Ga]Ga-DOTA-5G PET/CT Detects Brain and Bone Metastases in a Patient with Metastatic Pancreatic Cancer. [68Ga]Ga-DOTA-5G PET/CT检测转移性胰腺癌脑骨转移
IF 9.1
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2026-09-02 DOI: 10.2967/jnumed.126.272419
Cameron C Foster, Tanushree Ganguly, Sven H Hausner, Edward Kim, Ebaa Al-Obeidi, Julie L Sutcliffe
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引用次数: 0
The Equivalents Are Coming! FDA Approval Pathways for Nuclear Medicine. 等价物来了!核医学的FDA批准途径。
IF 9.1
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引用次数: 0
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