Journal of gastrointestinal and liver diseases : JGLD最新文献

{"title":"The Role of Sex Hormones and Sex Hormone-binding Globulin in Functional Gatrointestinal Disorders: A Bidirectional Two-sample Mendelian Randomization Study.","authors":"Zhengyang Fan, Changming Shao, Zhifu Kou, Feng Xie, Hongyu Wang, Shuai Zheng, Bo Wen, Zheng Chen, Binfang Zeng","doi":"10.15403/jgld-5642","DOIUrl":"https://doi.org/10.15403/jgld-5642","url":null,"abstract":"<p><strong>Background and aims: </strong>Sex hormones and sex hormone-binding globulin (SHBG) have been confirmed to involve in the pathophysiology of functional gastrointestinal disorders (FGIDs), including irritable bowel syndrome (IBS) and functional dyspepsia (FD). However, causal associations have not yet been investigated. Utilizing data from Genome-wide association studies, we conducted bidirectional two-sample mendelian randomization (MR) analyses to assess the causal relationships between sex hormones, SHBG and FGIDs.</p><p><strong>Methods: </strong>Data for sex hormones including testosterone and estradiol, and SHBG were collected from the UK Biobank and FinnGen study. Relevant single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs). Inverse variance weighted (IVW) analysis were performed to assess the causal relationships., supplemented with MR-Egger, weighted median, and weighted mode approaches. Additionally, we used Cochran's Q test to evaluate the heterogeneity of genetic variants and implemented leave-one-out analysis to assess the impact of individual SNPs on the causal estimates. Several sensitivity analyses were conducted to assess the robustness of the results.</p><p><strong>Results: </strong>Significant negative causal relationship was found between genetically predicted testosterone and the risk of IBS (OR=0.90, 95%CI: 0.83-0.97; p=0.007). SHBG demonstrated an inverse correlation with the risk of IBS (OR=0.82, 95%CI: 0.68-0.98; p=0.035) and FD (OR=0.83, 95%CI: 0.69-0.99; p=0.048). However, no statistically significant association was found between testosterone and FD, while estradiol also showed no causal association with FGIDs.</p><p><strong>Conclusions: </strong>Our study revealed a negative causal relationship between testosterone and IBS risk, and SHBG appears to be inversely associated with FD. This provided new ideas for the prevention and control of IBS, and future research is warranted to elucidate the underlying mechanisms driving these associations and their potential clinical implications.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"474-481"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Role of Brain Fog, Fatigue, and Psychological Distress on Quality of Life in Individuals Living with Inflammatory Bowel Disease: A Cross-sectional Study.","authors":"Simon R Knowles, Matthew Dickinson","doi":"10.15403/jgld-5759","DOIUrl":"https://doi.org/10.15403/jgld-5759","url":null,"abstract":"<p><strong>Background and aims: </strong>Despite reports of brain fog in patients with inflammatory bowel disease (IBD), empirical research into this phenomenon has been lacking. This study aimed to validate a brain fog scale and explore the relationships between IBD symptom activity, brain fog, fatigue, psychological distress, and quality of life (QoL).</p><p><strong>Method: </strong>A cross-sectional online study.</p><p><strong>Results: </strong>Of the 170 adults with IBD (mean age 38.75 years, 85.9% female, 62.35% Crohn's disease), 94.10% percent reported experiencing brain fog, with the majority (53.75%) experiencing brain fog at least 2 times a week, with each episode lasting around 2 hours. A confirmatory factor analysis supported the first hypothesis, demonstrating validity and stability of the brain fog scale in an IBD sample. Correlation analyses supported the second hypothesis, revealing positive relationships between IBD symptom activity and brain fog, fatigue and psychological distress, and a negative relationship between IBD symptom activity and QoL. A structural equation model with excellent fit (CMIN/df=1.84, p=0.137, TLI=0.98, CFI=0.99, SRMR=0.03, and RMSEA=0.07), provided support for the third hypothesis in that the relationship between IBD symptom activity and QoL was fully mediated by brain fog, fatigue, and psychological distress.</p><p><strong>Conclusions: </strong>This is the first study to explore the lived experience of brain fog and to validate the brain fog scale in an IBD sample. The study provides evidence that like fatigue, brain fog is not only common in IBD cohorts but is also frequent and adversely impacts psychological distress and QoL.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"488-495"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rectal Submucosal Squamous Cell Carcinoma Metastasis Case Mimicking a 4th Layer Lesion in EUS.","authors":"Hasan Eruzun, Hatice Ölger Uzuner, Kasım Demir","doi":"10.15403/jgld-5837","DOIUrl":"https://doi.org/10.15403/jgld-5837","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"454"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Biopsy-proven Nonalcoholic Fatty Liver Disease with Obesity and Apolipoproteins.","authors":"Ömer Kurt, Kadir Ozturk, Hakan Demirci, Ahmet Tas, Yıldırım Karslioglu, Turker Turker, Cafer Ozdemir, Taner Ozgurtas, Ahmet Uygun","doi":"10.15403/jgld-5550","DOIUrl":"https://doi.org/10.15403/jgld-5550","url":null,"abstract":"<p><strong>Background and aims: </strong>Insulin resistance is considered the most important key mechanism in the development of nonalcoholic fatty liver disease (NAFLD). Some studies have reported that hyperinsulinemia decreases the hepatic secretion of apolipoprotein (Apo) B. Chronic hyperinsulinemia in NAFLD may be responsible for the accumulation of triglycerides in hepatocytes. We aimed to investigate whether apolipoproteins are related to histological findings in patients with biopsy-proven NAFLD. We also aimed to evaluate the effects of obesity on apolipoproteins and the pathogenesis of NAFLD.</p><p><strong>Methods: </strong>In this cross-sectional study, 91 patients with biopsy-proven NAFLD were included. The control group consisted of 39 healthy subjects who had no history of liver disease or alcohol consumption and were matched for age, gender and smoking. Apoliprotein A1 and Apo B were measured via an immunoturbidimetric method with commercially available OSR6142 Apo A1 and OSR6143 Apo B immunoassay kits on an Olympus AU2700 analyzer.</p><p><strong>Results: </strong>Age, gender, and smoking distribution were similar among nonalcoholic steatohepatitis patients, simple steatosis patients, and controls. The differences in the mean Apo A1 and Apo B levels and the Apo B/A1 ratio among non-alcoholic steatosis, simple steatosis, and control subjects did not reach statistical significance. In addition, patients with obese NAFLD had higher steatosis scores than patients with nonobese NAFLD (p<0.05).</p><p><strong>Conclusions: </strong>Apo A1 and B levels and the B/A1 ratio were not associated with histopathological findings in patients with NAFLD. Fibrosis and ApoB1/A were found to be independent risk factors for metabolic associated fatty liver disease. In addition, obesity increases the grade of hepatic steatosis but does not cause lobular inflammation, ballooning or fibrosis.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"510-516"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Atypical Case of Menetrier's Disease with Antral-Duodenal Extension.","authors":"Diana Elena Țanțu, Anca-Mirela Dimitriu, Gabriel Becheanu, Mircea Diculescu, Cristian Gheorghe","doi":"10.15403/jgld-5823","DOIUrl":"https://doi.org/10.15403/jgld-5823","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"450"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the Role of Measuring Urinary Gluten Immunogenic Peptides in Clinical Practice in Patients with Coeliac Disease?","authors":"Suneil A Raju, Katerina E Ingham, Olivia Green, Calvin M Johnson, Mohamed G Shiha, Nicoletta Nandi, Nick Trott, Hugo A Penny, Marios Hadjivassiliou, Graeme Wild, David S Sanders","doi":"10.15403/jgld-5659","DOIUrl":"https://doi.org/10.15403/jgld-5659","url":null,"abstract":"<p><strong>Background and aims: </strong>In coeliac disease, the clinical role of the urinary gluten immunogenic peptide is unclear. It has been suggested it can be a non-invasive marker of villous atrophy. Therefore, we present the largest cross-sectional clinical data in patients with coeliac disease to establish the diagnostic accuracy of the urinary gluten immunogenic peptide in identifying villous atrophy.</p><p><strong>Methods: </strong>Patients providing urinary gluten immunogenic peptide were identified between September 2018 and August 2023 at the National Health Service (NHS) England National Centre for Non-Responsive and Refractory CD. In our retrospective study, the results of the urinary gluten immunogenic peptide test collected within 7 days, self-reported adherence to a gluten free diet reported within 3 months, serology collected within 7 days (immunoglobulin A - tissue transglutaminase and endomysial antibody) and histology at the time of endoscopy were compared in individuals with coeliac disease who were either asymptomatic and undergoing remission biopsies (group 1), non-responsive coeliac disease (group 2) and refractory coeliac disease on immunosuppressive therapy (group 3). Associations between dichotomous variables were calculated using chi-squared test.</p><p><strong>Results: </strong>In group 1 the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting villous atrophy were 42.9%, 83.3.%, 64.3% and 67.6% respectively. In group 2 the sensitivity, specificity, PPV and NPV for detecting villous atrophy were 36.2%, 79.0%, 39.5% and 76.6% respectively. In group 3 the sensitivity, specificity, PPV and NPV for detecting villous atrophy were 56.3%, 70.6%, 73.0% and 53.3%. More patients on immunosuppression had a positive urinary gluten immunogenic peptide than those not on immunosuppression (43.3% vs 24.1%, p<0.001).</p><p><strong>Conclusions: </strong>The urinary gluten immunogenic peptide does not have a role in identifying villous atrophy. Therefore, to assess for villous atrophy an upper gastrointestinal endoscopy is still required.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"482-487"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron and Copper Liver Concentrations in Wilson Disease.","authors":"Patrick Lloyd Day, Ria Fyffe-Freil, Patrick Vanderboom, Grant Spears, Kirk Wangensteen, Joshua Bornhorst, Sara Hassan, Paul J Jannetto","doi":"10.15403/jgld-5662","DOIUrl":"10.15403/jgld-5662","url":null,"abstract":"<p><strong>Background and aims: </strong>Wilson disease (WD) results in the defective incorporation of copper into ceruloplasmin as well as decreased biliary copper excretion. Secondary iron overload has also been associated with WD; however, the prevalence is currently unknown. This study aims to determine the prevalence of potential secondary iron overload in patients suspected to have WD. The secondary aim was to determine whether common laboratory tests were associated with liver copper concentrations or the need for liver transplantation in a subset of patients with confirmed WD.</p><p><strong>Methods: </strong>Using our institution's laboratory information system, 197 patients with liver copper concentrations > 250 mcg/g were identified who also had a concurrent liver iron concentration available. Correlations between copper, iron, and hepatic iron index were performed by log-transforming the data and then using the Pearson method. Furthermore, in a subpopulation of ten patients clinically confirmed to have WD, various laboratory test values were evaluated to determine associations with liver copper concentration or liver transplantation.</p><p><strong>Results: </strong>There was no significant association between copper and iron liver tissue concentrations (p=0.84). However, 13 (8%) patients aged 13 or older had a hepatic iron index >1.0 which may indicate secondary iron overload. Furthermore, in clinically confirmed WD patients, hemoglobin and hematocrit were inversely associated with liver copper concentrations (p=0.036).</p><p><strong>Conclusions: </strong>Iron overload can be detected in liver tissues with elevated copper concentrations characteristic of WD Furthermore, in WD, low hemoglobin and hematocrit values were associated with elevated liver copper concentration. Clinicians should consider the possibility of secondary iron overload and/or anemia in patients with WD.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"517-523"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Landscape of Helicobacter pylori-related Gastric Carcinogenesis.","authors":"Paulo Pimentel de Assumpção, Robert M Genta, Maria Constanza Camargo, Jessica Manoelli Costa da Silva, Manuel Ricardo Amieva, Massimo Rugge","doi":"10.15403/jgld-5959","DOIUrl":"https://doi.org/10.15403/jgld-5959","url":null,"abstract":"<p><p>The relationship between Helicobacter pylori (H. pylori) and humans remains a complex enigma. While other factors contribute to gastric cancer (GC), their impact pales in comparison to the central role of H. pylori. Various cofactors, such as dietary carcinogens and Epstein-Barr virus infection, can lead to GC independently of H. pylori. However, it is likely the combination of mechanisms, especially those driven by H. pylori, that represents the primary force behind GC development. Identifying individuals at high risk of developing H. pylori-related GC or detecting the disease in its earliest stages remains a significant challenge. To address this, we aim to refine the existing gastric carcinogenic model by incorporating molecular data, oncological concepts common to many cancers, and data from innovative experimental approaches. This updated model, applicable to both intestinal and diffuse GC, builds on Pelayo Correa's carcinogenesis pathway while expanding our understanding of H. pylori's role in gastric carcinogenesis. It not only emphasizes the direct cellular effects of H. pylori virulence factors but also integrates underrecognized carcinogenic mechanisms, including the interactions between H. pylori and stem cells, providing a more comprehensive view of H. pylori's contribution. By acknowledging additional molecular drivers in GC and recognizing H. pylori's potential involvement in these processes, this model could offer more precise interpretations of GC development and open new avenues for clinical interventions.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"524-534"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Nomenclature in Fatty Liver Disease: The Need for \"MetVir\" in Metabolic and Viral Overlap.","authors":"Abdulrahman Ismaiel, Stefan-Lucian Popa, Dan L Dumitrascu","doi":"10.15403/jgld-6041","DOIUrl":"https://doi.org/10.15403/jgld-6041","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"441-443"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Gastric cystic polyp mimicking early gastric cancer.","authors":"Ling Xiao, Fei-Fan Chen, Jun-Chao Wu","doi":"10.15403/jgld-5799","DOIUrl":"https://doi.org/10.15403/jgld-5799","url":null,"abstract":"<p><p>In this study, we present a case of a 51-year-old man with a gastric lesion initially suspected to be early gastric cancer but was ultimately diagnosed as a Gastric cystic polyp (GCP). The patient underwent diagnostic endoscopic submucosal dissection (ESD) based on the lesion's appearance and characteristics. Detailed pathological and immunohistochemical analysis confirmed the diagnosis of GCP. A follow-up revealed no recurrence six months post-treatment.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"449"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}