Journal of gastrointestinal and liver diseases : JGLD最新文献_第4页

Endoscopic ultrasound-guided drainage with lumen-apposing metal stents: a colorful spectrum of solutions. 内窥镜超声引导引流与腔内金属支架：彩色光谱的解决方案。

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-5983

Filippo Antonini

引用次数: 0

Utility, Performance and Safety of Single Balloon Enteroscopy in Patients with Hereditary Polyposis Syndromes. 遗传性息肉综合征患者单气囊肠镜检查的效用、性能和安全性。

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-5977

Giuseppe Losurdo, Raffaella Rima, Antonella Castiglione Minischetti, Salvatore Rizzi, Andrea Iannone, Francesca Celiberto, Enzo Ierardi, Alfredo Di Leo, Michele Barone, Mariabeatrice Principi

{"title":"Utility, Performance and Safety of Single Balloon Enteroscopy in Patients with Hereditary Polyposis Syndromes.","authors":"Giuseppe Losurdo, Raffaella Rima, Antonella Castiglione Minischetti, Salvatore Rizzi, Andrea Iannone, Francesca Celiberto, Enzo Ierardi, Alfredo Di Leo, Michele Barone, Mariabeatrice Principi","doi":"10.15403/jgld-5977","DOIUrl":"https://doi.org/10.15403/jgld-5977","url":null,"abstract":"Background and aims: Patients with hereditary polyposis syndromes are at high risk of developing small bowel polyps. We aimed to investigate the effectiveness of single balloon enteroscopy (SBE) in detecting and removing such polyps and to compare its diagnostic yield to videocapsule endoscopy (VCE).Methods: We retrospectively recruited patients undergoing SBE and VCE in our center for familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome (PJS), Cowden syndrome (CS) and juvenile polyposis syndrome (JPS). K Cohen concordance index and sensitivity, specificity, positive/negative predictive value (PPV-NPV) and odds ratio (OR) were calculated.Results: We recruited 17 patients (9 females, 8 males, age range 29-82), undergoing 35 SBE procedures (7 JPS, 2 LS, 7 PJS, 4 CS, 15 FAP). Small bowel polyps were found in 19 cases (54%), in 6 JPS, 4 PJS, 2 CS and 7 FAP, with size ranging 3 mm-3 cm. The risk of small bowel polyps was not linked to the presence of gastric (OR=1.12, p=1), nor duodenal polyps (OR=0.89, p=1). Compared to VCE, the k index was 0.33±0.16, with sensitivity 79%, specificity 53%, PPV=68%, NPV=67%. Agreement was higher for polyps >1 cm (k=0.53) than for small ones (k =0.35). Thirteen polypectomy sessions were performed in polyps >1 cm, removing median 3 polyps/session (range 1-6). We observed only one early bleeding, treated with clips, and two cases of post-procedural abdominal pain.Conclusions: Small bowel polyps may be commonly found in the polyposis syndrome. Concordance VCE-SBE is only fair. Polypectomy may be easily performed during SBE, with a low complication rate.","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"174-180"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of endoscopic ultrasound-guided fine needle aspiration biopsy complicated with acute pancreatitis and acute appendicitis. 超声内镜引导下细针穿刺活检合并急性胰腺炎、急性阑尾炎1例。

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-5948

Szymon Barczak

引用次数: 0

Duodenal Lipoma Presenting with Life-threatening Upper Gastrointestinal Hemorrhage Treated with Endoscopic Mucosal Resection. 十二指肠脂肪瘤并发危及生命的上消化道出血，内镜下粘膜切除术治疗。

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-6115

Thomas Skinner, Michele Yi Fu, Robert Sean O'Neill, Bong Sik Matthew Kim

引用次数: 0

Exploring the Impact of Constipation on Mental Health and Non-Motor Symptoms in Parkinson's Disease Patients: A Clinical and Mendelian Randomization Approach. 探索便秘对帕金森病患者心理健康和非运动症状的影响：临床和孟德尔随机化方法

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-6136

Xiaomei Zhang, Jianhua Sun, Jie Jiang, Yin Huang, Qunjuan Wang, Zongbo Zhao, Juping Chen, Dongmei Gu, Jing Guo

{"title":"Exploring the Impact of Constipation on Mental Health and Non-Motor Symptoms in Parkinson's Disease Patients: A Clinical and Mendelian Randomization Approach.","authors":"Xiaomei Zhang, Jianhua Sun, Jie Jiang, Yin Huang, Qunjuan Wang, Zongbo Zhao, Juping Chen, Dongmei Gu, Jing Guo","doi":"10.15403/jgld-6136","DOIUrl":"10.15403/jgld-6136","url":null,"abstract":"Background and aims: Parkinson's disease (PD) patients frequently experience constipation and non-motor symptoms, significantly affecting their quality of life. Although constipation is common, its causal relationship with mental health issues, such as anxiety and depression, remains underexplored. This study aims to investigate the association between constipation severity, non-motor symptoms, and mental health outcomes in PD patients.Methods: A total of 97 PD patients from three hospitals in Changshu City were included in this study. Clinical data were collected using assessment tools, including the Non-Motor Symptoms Scale, Patient Assessment of Constipation Quality of Life questionnaire, Hamilton Depression Rating Scale , and Hamilton Anxiety Rating Scale. Mendelian randomization analysis was applied to examine the causal relationships between constipation severity, non-motor symptoms, and mental health outcomes.Results: A moderate correlation was found between constipation severity and non-motor symptoms, especially in elderly and female patients. However, no significant causal association was identified between constipation and mental health issues such as anxiety, depression, or sleep disorders.Conclusions: The study underscores the importance of managing constipation in PD patients to improve their non-motor symptoms and quality of life. Despite the observed correlation with non-motor symptoms, further studies are needed to clarify the role of constipation in mental health issues in PD.","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"181-198"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress and Perspectives in Overlapping Primary Biliary Cholangitis and Autoimmune Hepatitis: A Comprehensive Review. 原发性胆道胆管炎与自身免疫性肝炎重叠研究进展及展望

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-6138

Xiaowen Qin, Zhenjing Jin

{"title":"Progress and Perspectives in Overlapping Primary Biliary Cholangitis and Autoimmune Hepatitis: A Comprehensive Review.","authors":"Xiaowen Qin, Zhenjing Jin","doi":"10.15403/jgld-6138","DOIUrl":"https://doi.org/10.15403/jgld-6138","url":null,"abstract":"Overlapping primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) represents a distinctive autoimmune phenotype characterized by concurrent cholestatic and hepatocellular damage, culminating in a more aggressive disease course if not recognized. This review synthesizes the existing evidence concerning epidemiology, pathophysiology, and diagnostic criteria, with particular emphasis on histopathology, serological markers, and established scoring systems, including the Paris criteria and the International Autoimmune Hepatitis Group (IAIHG) scoring scheme. We highlight the clinical relevance of combined therapies, typically comprising ursodeoxycholic acid and immunosuppressants, in effectively controlling both components of the disorder and halting fibrosis progression. Additionally, we discuss emerging data regarding second-line agents such as obeticholic acid and innovative immunomodulatory approaches aimed at refining patient outcomes. Special attention is dedicated to pediatric and pregnant populations, in whom disease manifestation and therapeutic responses may differ. Ongoing evaluations of noninvasive biomarkers and imaging modalities, including transient elastography, promise improved monitoring and individualized management strategies. Notably, relevant outcome measures, including quality of life and the burden of pruritus, are paramount for comprehensive patient care. Collectively, these advances hold promise for improved long-term patient survival by enabling more precise diagnostic pathways, targeted therapeutic regimens, and closer surveillance.","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"241-249"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Unseen: Building a Neurogastroenterology Unit - Current Challenges in Clinical Practice. 揭开看不见的：建立一个神经胃肠病学单位-目前在临床实践中的挑战。

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-6126

Vasile Drug, Oana Cristina Petrea, Oana Barboi, Teodora Surdea Blaga, Anca Dimitriu, Ion Bancila, Liliana David, Diana Floria, Anca Trifan, Carol Stanciu, Radu Tutuian, Dan L Dumitrascu

{"title":"Unveiling the Unseen: Building a Neurogastroenterology Unit - Current Challenges in Clinical Practice.","authors":"Vasile Drug, Oana Cristina Petrea, Oana Barboi, Teodora Surdea Blaga, Anca Dimitriu, Ion Bancila, Liliana David, Diana Floria, Anca Trifan, Carol Stanciu, Radu Tutuian, Dan L Dumitrascu","doi":"10.15403/jgld-6126","DOIUrl":"https://doi.org/10.15403/jgld-6126","url":null,"abstract":"Neurogastroenterology disorders, also known as \"Disorders of Gut-Brain Interaction\" are gastrointestinal disorders that comprise a wide range of symptoms such as dysphagia, chest pain, heartburn, abdominal pain, nausea and vomiting, bloating, constipation, diarrhea or stool discharge. Scarcity of recognition, knowledge and training leading to the underdiagnosis of these conditions is associated with increased referrals to gastroenterologists or emergency room visits, along with a dramatic rise in healthcare costs and impaired quality of life. Despite advances in endoscopy and radiology, motility and pH impedance procedures remain the cornerstone of an accurate \"Disorders of Gut-Brain Interaction\" diagnosis, but these procedures need to be performed by well-trained personnel in a dedicated motility unit, with high-performance equipment. The primary motility procedures include high-resolution esophageal manometry and pH monitoring for esophageal function, high-resolution anorectal manometry and balloon expulsion tests for anorectal function, as well as hydrogen/methane breath tests for identifying dysbiosis and food intolerances. The purpose of this article is to highlight the importance of establishing a Neurogastroenterology and Motility Unit, and to provide an up-to-date overview on the main issues encountered when setting up a motility laboratory in the community or academic practice, including considerations for personnel training, equipment, and commonly performed motility procedures and their clinical usefulness.","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"250-255"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wilkie's syndrome - a rare cause of gastrointestinal obstruction. 威尔基综合症，一种罕见的肠梗阻。

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-6079

Ângela Pinto Domingues Almeida, Ricardo Araújo, Eugénia Cancela, Américo Silva

引用次数: 0

A rare case of small intestine ulcers, bleeding, obstruction, and perforation caused by amyloidosis. 由淀粉样变引起的小肠溃疡、出血、梗阻及穿孔的罕见病例。

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-5970

Yanhong Gao, Ran Wang, Jie Mao, Cheng Zhang, Xingshun Qi

引用次数: 0

Lichenoid Esophagitis: A Clinicopathological Comparison with Lymphocytic and Eosinophilic Esophagitis. 苔藓样食管炎：淋巴细胞性和嗜酸性粒细胞性食管炎的临床病理比较。

Journal of gastrointestinal and liver diseases : JGLD Pub Date : 2025-06-28 DOI: 10.15403/jgld-6048

Salima Haque, S Maral K Mohammadi, Anuradha Singhal, Amnon Sonnenberg, Robert Maximilian Genta, Massimo Rugge

{"title":"Lichenoid Esophagitis: A Clinicopathological Comparison with Lymphocytic and Eosinophilic Esophagitis.","authors":"Salima Haque, S Maral K Mohammadi, Anuradha Singhal, Amnon Sonnenberg, Robert Maximilian Genta, Massimo Rugge","doi":"10.15403/jgld-6048","DOIUrl":"https://doi.org/10.15403/jgld-6048","url":null,"abstract":"Background and aims: Lichenoid esophagitis (LichE) is rarely encountered by gastrointestinal endoscopists. Using a large nationwide database of clinicopathological records, the demographic and clinical characteristics of patients with LichE were compared to patients with lymphocytic esophagitis (LyE) and eosinophilic esophagitis (EoE).Methods: In a case-control study, cases with a diagnosis of LichE, LyE, or EoE were compared to a control population of all patients without these 3 conditions. In addition to histopathology, patients' demographics, clinical presentation, and gastrointestinal comorbidities were considered. Statistical significance was assessed using odds ratios (OR) and 95% confidence intervals (95%CI).Results: Among 967,773 unique patients with esophageal biopsies, LichE was found in 511 (0.05%), LyE in 1,786 (0.18%), EoE in 56,474 (5.84%), and none of these 3 diagnoses in a control population of 909,002 patients. LichE patients were significantly older, and EoE patients were significantly younger than the control population (p<0.0001). LichE and LyE significantly prevailed in females (OR=1.69; 95%CI: 1.40-2.04 and 1.34; 1.22-1.47, respectively). EoE was significantly less common in females (OR=0.49; 95%CI: 0.48-0.49). All 3 types of esophagitis were significantly less common among Hispanics, with their respective ORs of 0.70 (95%CI: 0.50-0.98), 0.83 (95%CI: 0.70-0.98), and 0.55 (95%CI: 0.53-0.57). EoE was also less common in persons of East and South Asian ancestry, with respective ORs of 0.52 (95%CI: 0.47-0.56) and 0.66 (95%CI: 0.56-0.76).Conclusions: Increasing clinical awareness of LichE may enhance its clinico-pathological recognition, clarify its natural history, and ultimately lead to more effective clinical management.","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"157-162"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0