Journal of gastrointestinal and liver diseases : JGLD最新文献

{"title":"Pancreatic Enzyme Replacement Therapy: Not Only in Chronic Pancreatitis.","authors":"Mario Capasso, Ludovica Venezia, Filippo Antonini, Luca Barresi, Germana De Nucci, Marco Valvano","doi":"10.15403/jgld-6287","DOIUrl":"https://doi.org/10.15403/jgld-6287","url":null,"abstract":"<p><p>The therapeutic application of Pancrelipase spans several key gastroenterological conditions, ranging from chronic pancreatitis to genetic disorders such as cystic fibrosis. Consequently, pancreatic enzyme replacement therapy (PERT) is applicable in a variety of clinical settings, managing pancreatic insufficiency. Beyond chronic pancreatitis, PERT has also shown effectiveness in addressing malabsorption associated with pancreatic surgery, gastrointestinal malignancies, and various dysmetabolic conditions. This review aims to provide a comprehensive overview of the therapeutic applications of PERT and its clinical role in managing both surgical and non-surgical conditions, beyond chronic pancreatitis. PERT has proven crucial in improving patient outcomes, addressing gastrointestinal symptoms, and supporting long-term health in patients with pancreatic insufficiency. While more research, particularly from randomized controlled trials, is required to optimize dosing strategies and establish standardized PERT protocols, clinicians should consider tailoring PERT to individual patient needs based on the available evidence across various clinical scenarios.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 3","pages":"390-399"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective endoscopic diagnosis for neoplastic or non-neoplastic reddish depressed lesions after H. pylori eradication.","authors":"Tomomitsu Tahara, Takuya Shijimaya, Tsubasa Shimogama, Noriyuki Horiguchi, Hyuga Yamada, Kohei Funasaka, Tomoyuki Shibata, Makoto Naganuma, Naoki Ohmiya","doi":"10.15403/jgld-6374","DOIUrl":"https://doi.org/10.15403/jgld-6374","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 3","pages":"407-408"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Full-Thickness Resection of a Flat Elevated Lesion Invading the Appendiceal Stump.","authors":"Fabio De Vincentis, Alessandro Mussetto","doi":"10.15403/jgld-6133","DOIUrl":"https://doi.org/10.15403/jgld-6133","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 3","pages":"286"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold Snare Resection of a Small Distal Esophageal Fibroepithelial Polyp.","authors":"Vincent Zimmer","doi":"10.15403/jgld-6267","DOIUrl":"https://doi.org/10.15403/jgld-6267","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 3","pages":"283"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When rapid weight loss backfires: hepatic encephalopathy from GLP-1 RA in MASH cirrhosis.","authors":"Lisa-Maria Lunardon, Annalisa Berzigotti, Susana Rodrigues","doi":"10.15403/jgld-6191","DOIUrl":"https://doi.org/10.15403/jgld-6191","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 3","pages":"408-409"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton Pump Inhibitor Challenge to Confirm Diagnosis of Atrophic Gastritis of the Stomach: A Proposal.","authors":"Francesco Di Mario, Marilisa Franceschi, Kryssia Isabel Rodriguez-Castro, Maria Piera Panozzo, Michele Russo, Antonio Ferronato, Alessandra Violi, Lorella Franzoni, Antonio Tursi, Giovanni Brandimarte, Pellegrino Crafa","doi":"10.15403/jgld-6212","DOIUrl":"10.15403/jgld-6212","url":null,"abstract":"<p><strong>Background and aims: </strong>Chronic atrophic gastritis (CAG) is a known precancerous condition that can lead to the development of gastric cancer (GC). Low serum pepsinogen (PG) I levels have been proposed as a non-invasive marker for chronic atrophic gastritis of the stomach body, but the adequate upper cut-off for diagnosis remains controversial, as values ranging from 30 to 50 mcg/L are currently considered as a \"grey zone\". We aimed to identify patients with chronic atrophic gastritis (CAG) of the stomach body amongst subjects with PG-I levels ranging between 30 and 50 mcg/L by means of a proton pump inhibitor (PPI) challenge.</p><p><strong>Methods: </strong>We selected 102 patients with baseline PG-I <60 mcg/L in whom upper gastrointestinal endoscopy with protocol biopsies staged according to OLGA system had been performed. Subsequently, all patients underwent a PPI challenge (consisting of PG-I testing after taking Esomeprazole 40 mg daily for 1 week). This population was divided into 5 groups according to PG-I levels: group A (PG-I< 30 mcg/L); group B (PG-I: 31-35 mcg/L); group C (PG-I: 36-40 mcg/L); group D (PG-I: 41-50 mcg/L); group E (PG-I: 51-60 mcg/L). By using the ROC curve, a cut-off of 30% increase from baseline PG-I was chosen.</p><p><strong>Results: </strong>A statistically significant relationship between PG-I levels and OLGA staging was found, being 100% in the group of PG-I < 30mcg/L. Based on the value of the cut-off of 30% (calculated by ROC curve) corresponding to the delta increase between PG-I baseline value and after a one-week full dose of PPI, the positive predictive value was 95%, the negative predictive value 86%, the sensitivity 83% and the specificity 96%.</p><p><strong>Conclusions: </strong>The use of the PPI challenge allows to identify subjects with CAG showing pepsinogen I values ranging between 30 and 50 mcg/L.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":" ","pages":"287-294"},"PeriodicalIF":2.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Endometriosis, A Challenge for Gastroenterologists: A Narrative Review.","authors":"Adelina Nicoleta Galica, Reitano Galica, Dan Lucian Dumitrascu","doi":"10.15403/jgld-6456","DOIUrl":"10.15403/jgld-6456","url":null,"abstract":"<p><p>Endometriosis is a medical condition where endometrial tissue and glands are found outside the uterine cavity: on ovaries, pelvic peritoneum, rectovaginal septum, bladder, bowel and more. The ectopic tissue is estrogen dependent and cause inflammation and immune response and is responsible for chronic pain, infertility and disability of these patients. Without a specific biomarker and with a wide range of symptoms, the diagnosis is often overlooked or delayed. Abdominal and pelvic pain together with dysmenorrhea, dyspareunia, irregular bleeding, and cyclic alteration of intestinal habits are a challenging combination of symptoms that characterise endometriosis. One of the less recognized yet significant causes of abdominal pain is intestinal endometriosis. Gastroenterologists and gynecologists must solve the intricate puzzle of gynecological, gastrointestinal and nonspecific symptoms that are present in patients with intestinal endometriosis; further managements should be decided by a multidisciplinary team. This review aims to present the pathogenic mechanisms, diagnostic challenges and treatment while highlighting the importance of recognizing intestinal endometriosis as a potential differential diagnosis in patients with gastrointestinal symptoms.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":" ","pages":"381-389"},"PeriodicalIF":2.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Single Nucleotide Polymorphisms with Infection Susceptibility in Patients with Severe Alcoholic Hepatitis.","authors":"Adelina Horhat, Camelia Alexandra Coada, Mina Dana Ignat, Petra Fischer, Bogdan Procopet, Horia Stefanescu, Zeno Sparchez","doi":"10.15403/jgld-6214","DOIUrl":"10.15403/jgld-6214","url":null,"abstract":"<p><strong>Background and aims: </strong>Severe alcoholic hepatitis is characterized by an increased risk of infections. Polymorphisms in immune response-related genes may influence susceptibility to infections in alcoholic hepatitis. This study aimed to investigate the association between two clusters of differentiation 14's (CD14) single nucleotide polymorphisms (SNPs), rs2569190 and rs5744455, and the occurrence of infections in severe alcoholic hepatitis, the response to corticotherapy and the mortality rates at one and three months.</p><p><strong>Methods: </strong>Patients with severe alcoholic hepatitis were genotyped for CD14 - rs2569190 and rs5744455 SNPs. Genotype and allele frequencies were compared between patients who presented infections and those who did not.</p><p><strong>Results: </strong>A total of 97 patients with biopsy proven sAH were included in the study, out of which 47 (48.4 %) had an associated infection. rs5744455 SNP was significantly associated with the presence of infection. Patients carrying the rs5744455T variant allele had a lower incidence of infections compared to those with the wild-type allele (32% vs 68%; p=0.002). In contrast, the rs2569190 SNP revealed no significant differences, either in the single genotype analysis (p=0.608) or under a dominant model (p=0.318). Community-acquired infections were primarily urinary tract infections (21.65%), followed by pulmonary infections (4.12%), with Escherichia coli responsible for 41.67% of cases. Healthcare-associated infections were more varied, including urinary tract (7.22%), respiratory (6.19%), digestive (7.21%), cutaneous (3.09%), and blood infections (5.15%). Klebsiella pneumoniae was the most prevalent strain, accounting for 16.67% of these infections.</p><p><strong>Conclusions: </strong>Our findings highlight a potential protective role of the CD14 rs5744455T variant allele against infections in sAH, suggesting that genetic variability may influence infection susceptibility in this population.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":" ","pages":"331-338"},"PeriodicalIF":2.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Randomised Study of a 14 day Clarithromycin Triple Regimen and a 14 Day Bismuth based Quadruple Regimen for Helicobacter Pylori Eradication.","authors":"Bojan Tepes, Milan Stefanovič, Dejan Urlep, Katja Tepes","doi":"10.15403/jgld-6238","DOIUrl":"10.15403/jgld-6238","url":null,"abstract":"<p><strong>Background and aims: </strong>Helicobacter pylori (H. pylori) is a grade I carcinogen, responsible for the development of 89% of non-cardia gastric cancers. All infected patients have an indication for treatment. The ideal first line therapy has not been defined yet. The objective of this study was to evaluate the effectiveness and safety of 14 day bismuth based quadriple and 14 day triple regimens in treatment naive H. pylori infected patients.</p><p><strong>Methods: </strong>Computer based random allocation of patients was used to assign to either a 14 day triple regimen (group 1, esomeprazole 40 mg BID, amoxicillin 1000 mg BID and clarythromycin 500 mg BID ) or a 14 day bismuth based quadruple regimen (group 2, esomeprazole 40 mg BID, amoxicillin 500 mg QID, metronidazole 400 mg QID and bismuth oxide 120 mg QID).</p><p><strong>Results: </strong>Altogether 201 patients were included, 101 to group 1 and 100 to group 2. Average age of patients were 75 years of age ( ± 18 years). Twenty five patients were lost to follow up (12.4%), 176 were available for analysis ( 91 patients from group 1 and 85 from group 2). Eradication rate was 94.5% in the first group and 97,6% in the second group (NS). Side effects were reported in 22.8% in the first treatment group and in 24% in the second treatment group (NS). The majority of side effects were mild and did not resulted in any discontinuation of treatment.</p><p><strong>Conclusions: </strong>Clarithromycin based triple regimen can still be the first line H. pylori regimen in Slovenia. Bismuth based quadruple regimen is to be used in future H. pylori screen and treat programs as the methodology of primary gastric cancer prevention.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":" ","pages":"304-308"},"PeriodicalIF":2.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Vascular Disorder Causing Gastrointestinal Bleeding: Blue Rubber Bleb Nevus Syndrome.","authors":"Jahnvi Dhar, Jimil Shah, Suvradeep Mitra, Saroj Kant Sinha, Jayanta Samanta","doi":"10.15403/jgld-6121","DOIUrl":"https://doi.org/10.15403/jgld-6121","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"156"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}