Journal of gastrointestinal and liver diseases : JGLD最新文献

{"title":"Abscess-like Evolution of Non-occlusive Caecum Ischemia.","authors":"Francesco Michele Ronza, Teresa Letizia Di Gennaro, Vittorio Patanè, Stefania Tamburrini","doi":"10.15403/jgld-6056","DOIUrl":"https://doi.org/10.15403/jgld-6056","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombophlebitis of the Umbilical Vein: A Rare Complication of Acute Pancreatitis.","authors":"Megan Ml Engels, Aart Spilt, Johan P Kuijvenhoven","doi":"10.15403/jgld-5988","DOIUrl":"https://doi.org/10.15403/jgld-5988","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnifying Narrow-band Imaging with Endoscopic Ultrasound for the Diagnosis of Synchronous Triple Primary Tumors of the Esophagus.","authors":"Feifan Chen, Zhihan Wu, Kai Deng, Mingguang Zhang, Jinlin Yang","doi":"10.15403/jgld-5893","DOIUrl":"https://doi.org/10.15403/jgld-5893","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Clinical Assessment of Prognosis of Chronic Pancreatitis.","authors":"Petr Dite, David Solil, Marie Precechtelova, Martina Bojkova, Magdalena Uvirova, Jiri Dolina, Bohuslav Kianička","doi":"10.15403/jgld-6198","DOIUrl":"https://doi.org/10.15403/jgld-6198","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mucosal Protection in the Treatment of Erosive Reflux Esophagitis: Mechanisms for Restoring Epithelial Permeability. A Randomized Clinical Trial.","authors":"Dmitry S Bordin, Maria A Livzan, Sergei I Mozgovoi, Olga V Gaus, Irina V Lapteva","doi":"10.15403/jgld-5859","DOIUrl":"10.15403/jgld-5859","url":null,"abstract":"<p><strong>Background and aims: </strong>Gastroesophageal reflux disease (GERD) is widespread in the population and is characterized by the risk of developing Barrett's esophagus and associated adenocarcinoma. Key factors in the progression of the disease are not only the frequency and duration of reflux episodes, but also the resistance of the esophageal mucosa to aggressive reflux molecules. Assessment of the state of tight junction proteins, the rate of their recovery under the influence of various treatment regimens is an urgent task for choosing optimal approaches to curing patients with GERD. The purpose of the study was to evaluate the efficacy and safety of the combination therapy with a proton pump inhibitor (PPI) and a topical mucosal protective agent (MPA) to relieve GERD symptoms and achieve a complete remission of reflux esophagitis faster.</p><p><strong>Methods: </strong>60 patients (38 men and 22 women with an average age 41.5 years) with GERD duration of 5 years, took part in an open randomized prospective clinical study. Participants were randomized in a 1:1 ratio to be divided into the main group taking MPA and PPI and a comparison group taking a PPI only. The duration of therapy was 4 weeks. Before the treatment onset and after the end of treatment, the occurrence and severity of GERD symptoms were assessed, an endoscopic examination was performed and biopsy specimens were taken from the edge of the erosive area and the area of unchanged esophageal mucosa. The severity of histological signs of esophagitis, the expression of tight junction proteins and the proliferation marker Ki-67 were assessed.</p><p><strong>Results: </strong>A more effective relief of GERD symptoms was documented when using combination therapy PPIs and MPAs. A more pronounced reduction in macroscopic changes was found in patients with erosive esophagitis taking PPIs and MPAs. The use of MPAs in addition to PPIs made it possible to achieve the primary and secondary endpoints more often, which suggested a high efficiency of the drug in combination with PPIs in the treatment of erosive esophagitis.</p><p><strong>Conclusions: </strong>An individualized approach based on the combination therapy of PPIs and MPAs can improve the effectiveness of treatment in achieving clinical, endoscopic and, more importantly, histological remission in a patient with erosive GERD.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"455-462"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Clips Marking for Transcatheter Arterial Embolization in Refractory Peptic Ulcer Bleeding Patients: A Cohort Study.","authors":"Yuqiang Liu, Xiaocun Xing, Xiaoze Wang, Xuefeng Luo, Jinlin Yang, Xue Xiao","doi":"10.15403/jgld-5820","DOIUrl":"https://doi.org/10.15403/jgld-5820","url":null,"abstract":"<p><strong>Background and aims: </strong>Transcatheter arterial embolization (TAE) is recommended for refractory peptic ulcer bleeding. There are 46% of patients showed no detectable contrast extravasation during TAE. Endoscopic clip in bleeding lesion is visible and could be used as a marker in TAE. We aimed to learn whether endoscopic clips marking would ameliorate the prognosis.</p><p><strong>Methods: </strong>We retrospectively collected data of patents who received TAE because of refractory peptic ulcer bleeding, between 1 January 2016 to 31 December 2022. 188 patients were included and divided into two groups according to clips visibility in angiography. Baseline data about age, gender, bleeding severity, comorbidities, history of antiplatelet or anticoagulation drugs and endoscopic findings were balanced with the inverse probability of treatment weighting method.</p><p><strong>Results: </strong>There were 59 patients without clips received TAE, and 129 with clips. The in-hospital rebleeding rate after TAE was much higher in patients without clip than with clips (45.8% vs 33.3%). Cox regression analysis indicated that endoscopic clips marking decreased the rebleeding (aHR=0.492, 95%CI: 0.242-1.001, p=0.050). Also, in patient with clips, the empirical TAE rate was higher (64.3% vs 11.9%, p<0.001). No difference in in-hospital all-cause mortality was found (without clips vs with clips 11.9% vs 12.4%). The hospital stay length and embolized vessels types showed no differences between the two groups.</p><p><strong>Conclusions: </strong>In refractory peptic ulcer bleeding patients, endoscopic clips marking decreased the in-hospital rebleeding rate after TAE, but did not affect the mortality.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"468-473"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost, Cost-effectiveness and Survival Impact Assessment for A Better Management of Colorectal Cancer Patients: A Single Centre Comprehensive Analysis.","authors":"Adrian Ionut Gana, Cecilia Bica, Cristina Alexandra Ciocan, Elena Ofelia Moșteanu, Teodora Atena Pop, Ioana Berindan-Neagoe, Ioan Cătălin Vlad, Patriciu Andrei Achimaș-Cadariu","doi":"10.15403/jgld-5796","DOIUrl":"10.15403/jgld-5796","url":null,"abstract":"<p><strong>Background and aims: </strong>The world healthcare systems are currently challenged by the accumulating burden of colorectal cancer (CRC), and cancer registries represent an important segment for prevention and developing management plans, being useful in providing data regarding incidence, mortality, survival, exposure to carcinogens, lifestyle. Retrospective data from CRC patients in Romania was used to assess survival impact, costs, and cost-effectiveness considering three crucial aspects: pharmacology, chemo-/radio-therapy, and hospitalization for care and management of these patients.</p><p><strong>Methods: </strong>423 CRC patients from the Institutional Cancer Registry of the Prof. Dr. Ion Chiricuta Institute of Oncology in Cluj-Napoca, Romania were included in the cost analysis. For the assessment of cost efficiency of the primary treatment strategy, we collected data regarding direct medical costs associated with surgery, radiotherapy and medication, as well as the afferent day or continuous hospitalization, for each patient. For the cost-effectiveness analysis we used the method of estimation of incremental cost-effectiveness ratio.</p><p><strong>Results: </strong>No compelling differences regarding survival time were observed in different therapeutic options per CRC stage. Substantial differences in cost effectiveness among therapeutic options in the same stage of several thousand Euros in stages I-III, while for stage IV, the ICER was more than 100,000 Euros per life saved.</p><p><strong>Conclusions: </strong>Systematic evaluation of costs, cost-effectiveness, and survival impact, helps healthcare systems can make informed decisions to improve the management of colorectal cancer patients, optimizing outcomes while minimizing financial burden.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":" ","pages":"496-502"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Extremely Rare Case of Colonic Leiomyoma Disguised as Pedunculated Colonic Polyp.","authors":"Nguyen Pham, Elise Y Nguyen, Noam Jacob","doi":"10.15403/jgld-5805","DOIUrl":"https://doi.org/10.15403/jgld-5805","url":null,"abstract":"<p><p>Colonic leiomyoma is extremely rare and is endoscopically indistinguishable from gastrointestinal stromal tumor. We present a case of colonic leiomyoma disguised as a pedunculated colonic polyp in a 62-year-old male who underwent surveillance colonoscopy.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"453"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Weight Loss Diets in Inflammatory Bowel Disease Patients: What Physicians Should Know.","authors":"Cristiano Pagnini, Riccardo Urgesi, Maria Carla Di Paolo, Fernando De Angelis, Stefano Fonte, Eugenio Pandinelli, Gianfranco Fanello, Lorella Pallotta, Giuseppe Villotti, Maria Giovanna Graziani","doi":"10.15403/jgld-5671","DOIUrl":"https://doi.org/10.15403/jgld-5671","url":null,"abstract":"<p><p>Nutritional approach has been intensely investigated in inflammatory bowel disease (IBD) patients, but, despite many sparse reports, at present, there is not a universally accepted specific diet. In fact, nutritional requirements and, therefore, the ideal diet, may vary according to disease type, extension and activity. Among nutritional related issue in IBD, obesity has become a relevant one. In fact, obesity and IBD are both increasing in prevalence in last decades, and more and more IBD patients are overweight or obese. These two conditions present common metabolic pathways, leading to dysbiosis and mucosal barrier dysfunction, but the real clinical relationship and the potential reciprocal relative influences are not clear. In order to control weight, many IBD patients follow different weight loss diets, often without any specialized medical advice. Among those, low carb, intermittent fasting, paleolithic, and low-fat diets are some of the most popular, and plant based and Mediterranean diet, even though they are not just strictly weight loss diets, are followed by many IBD patients even for weight control. All the diets mentioned above have been effectively associated with weight loss, reduction in waist circumference and body mass index. However, there are still conflicting data regarding safety in IBD patients and potential experimental and clinical anti-inflammatory effect. In the present review, we described potential relations between obesity and IBD, and we analysed available evidence on efficacy and safety of weight loss diets in IBD patients, in order to provide a practical guide to physicians.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"542-551"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childlessness in Patients with Inflammatory Bowel Disease - Data from the Prospective Multi-center Swiss IBD Cohort Study.","authors":"Munazza Marium, Muhammad Maaz, Aashish Kumar","doi":"10.15403/jgld-5830","DOIUrl":"10.15403/jgld-5830","url":null,"abstract":"<p><p>This study investigates childlessness and infertility in individuals diagnosed with inflammatory bowel disease (IBD). Notably, the research reveals intriguing patterns related to gender and specific IBD subtypes. Among female patients with Crohn's disease (CD), a higher childlessness rate is observed compared to the general Swiss population. This finding prompts questions about CD's impact on reproductive health, including factors such as disease severity and treatment regimens. Conversely, women with ulcerative colitis (UC) exhibit a stable childlessness rate similar to the general population. UC, as a distinct IBD subtype, may have varying effects on fertility, influenced by disease location and duration. Healthcare providers should address reproductive concerns in IBD patients, emphasizing fertility counseling and tailored management strategies. Future research should explore medication effects on fertility outcomes, and longitudinal studies can enhance our understanding of this evolving landscape. In summary, recognizing the unique challenges faced by IBD patients allows clinicians to provide holistic care that integrates disease control and family planning, necessitating collaboration among specialists and patients.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"33 4","pages":"573-574"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}