Journal of gastrointestinal and liver diseases : JGLD最新文献

{"title":"A Rare Vascular Disorder Causing Gastrointestinal Bleeding: Blue Rubber Bleb Nevus Syndrome.","authors":"Jahnvi Dhar, Jimil Shah, Suvradeep Mitra, Saroj Kant Sinha, Jayanta Samanta","doi":"10.15403/jgld-6121","DOIUrl":"https://doi.org/10.15403/jgld-6121","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"156"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided drainage with lumen-apposing metal stents: a colorful spectrum of solutions.","authors":"Filippo Antonini","doi":"10.15403/jgld-5983","DOIUrl":"https://doi.org/10.15403/jgld-5983","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"261-262"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility, Performance and Safety of Single Balloon Enteroscopy in Patients with Hereditary Polyposis Syndromes.","authors":"Giuseppe Losurdo, Raffaella Rima, Antonella Castiglione Minischetti, Salvatore Rizzi, Andrea Iannone, Francesca Celiberto, Enzo Ierardi, Alfredo Di Leo, Michele Barone, Mariabeatrice Principi","doi":"10.15403/jgld-5977","DOIUrl":"https://doi.org/10.15403/jgld-5977","url":null,"abstract":"<p><strong>Background and aims: </strong>Patients with hereditary polyposis syndromes are at high risk of developing small bowel polyps. We aimed to investigate the effectiveness of single balloon enteroscopy (SBE) in detecting and removing such polyps and to compare its diagnostic yield to videocapsule endoscopy (VCE).</p><p><strong>Methods: </strong>We retrospectively recruited patients undergoing SBE and VCE in our center for familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome (PJS), Cowden syndrome (CS) and juvenile polyposis syndrome (JPS). K Cohen concordance index and sensitivity, specificity, positive/negative predictive value (PPV-NPV) and odds ratio (OR) were calculated.</p><p><strong>Results: </strong>We recruited 17 patients (9 females, 8 males, age range 29-82), undergoing 35 SBE procedures (7 JPS, 2 LS, 7 PJS, 4 CS, 15 FAP). Small bowel polyps were found in 19 cases (54%), in 6 JPS, 4 PJS, 2 CS and 7 FAP, with size ranging 3 mm-3 cm. The risk of small bowel polyps was not linked to the presence of gastric (OR=1.12, p=1), nor duodenal polyps (OR=0.89, p=1). Compared to VCE, the k index was 0.33±0.16, with sensitivity 79%, specificity 53%, PPV=68%, NPV=67%. Agreement was higher for polyps >1 cm (k=0.53) than for small ones (k =0.35). Thirteen polypectomy sessions were performed in polyps >1 cm, removing median 3 polyps/session (range 1-6). We observed only one early bleeding, treated with clips, and two cases of post-procedural abdominal pain.</p><p><strong>Conclusions: </strong>Small bowel polyps may be commonly found in the polyposis syndrome. Concordance VCE-SBE is only fair. Polypectomy may be easily performed during SBE, with a low complication rate.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"174-180"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of endoscopic ultrasound-guided fine needle aspiration biopsy complicated with acute pancreatitis and acute appendicitis.","authors":"Szymon Barczak","doi":"10.15403/jgld-5948","DOIUrl":"https://doi.org/10.15403/jgld-5948","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"262-263"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duodenal Lipoma Presenting with Life-threatening Upper Gastrointestinal Hemorrhage Treated with Endoscopic Mucosal Resection.","authors":"Thomas Skinner, Michele Yi Fu, Robert Sean O'Neill, Bong Sik Matthew Kim","doi":"10.15403/jgld-6115","DOIUrl":"https://doi.org/10.15403/jgld-6115","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"155"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress and Perspectives in Overlapping Primary Biliary Cholangitis and Autoimmune Hepatitis: A Comprehensive Review.","authors":"Xiaowen Qin, Zhenjing Jin","doi":"10.15403/jgld-6138","DOIUrl":"https://doi.org/10.15403/jgld-6138","url":null,"abstract":"<p><p>Overlapping primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) represents a distinctive autoimmune phenotype characterized by concurrent cholestatic and hepatocellular damage, culminating in a more aggressive disease course if not recognized. This review synthesizes the existing evidence concerning epidemiology, pathophysiology, and diagnostic criteria, with particular emphasis on histopathology, serological markers, and established scoring systems, including the Paris criteria and the International Autoimmune Hepatitis Group (IAIHG) scoring scheme. We highlight the clinical relevance of combined therapies, typically comprising ursodeoxycholic acid and immunosuppressants, in effectively controlling both components of the disorder and halting fibrosis progression. Additionally, we discuss emerging data regarding second-line agents such as obeticholic acid and innovative immunomodulatory approaches aimed at refining patient outcomes. Special attention is dedicated to pediatric and pregnant populations, in whom disease manifestation and therapeutic responses may differ. Ongoing evaluations of noninvasive biomarkers and imaging modalities, including transient elastography, promise improved monitoring and individualized management strategies. Notably, relevant outcome measures, including quality of life and the burden of pruritus, are paramount for comprehensive patient care. Collectively, these advances hold promise for improved long-term patient survival by enabling more precise diagnostic pathways, targeted therapeutic regimens, and closer surveillance.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"241-249"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Unseen: Building a Neurogastroenterology Unit - Current Challenges in Clinical Practice.","authors":"Vasile Drug, Oana Cristina Petrea, Oana Barboi, Teodora Surdea Blaga, Anca Dimitriu, Ion Bancila, Liliana David, Diana Floria, Anca Trifan, Carol Stanciu, Radu Tutuian, Dan L Dumitrascu","doi":"10.15403/jgld-6126","DOIUrl":"https://doi.org/10.15403/jgld-6126","url":null,"abstract":"<p><p>Neurogastroenterology disorders, also known as \"Disorders of Gut-Brain Interaction\" are gastrointestinal disorders that comprise a wide range of symptoms such as dysphagia, chest pain, heartburn, abdominal pain, nausea and vomiting, bloating, constipation, diarrhea or stool discharge. Scarcity of recognition, knowledge and training leading to the underdiagnosis of these conditions is associated with increased referrals to gastroenterologists or emergency room visits, along with a dramatic rise in healthcare costs and impaired quality of life. Despite advances in endoscopy and radiology, motility and pH impedance procedures remain the cornerstone of an accurate \"Disorders of Gut-Brain Interaction\" diagnosis, but these procedures need to be performed by well-trained personnel in a dedicated motility unit, with high-performance equipment. The primary motility procedures include high-resolution esophageal manometry and pH monitoring for esophageal function, high-resolution anorectal manometry and balloon expulsion tests for anorectal function, as well as hydrogen/methane breath tests for identifying dysbiosis and food intolerances. The purpose of this article is to highlight the importance of establishing a Neurogastroenterology and Motility Unit, and to provide an up-to-date overview on the main issues encountered when setting up a motility laboratory in the community or academic practice, including considerations for personnel training, equipment, and commonly performed motility procedures and their clinical usefulness.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"250-255"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wilkie's syndrome - a rare cause of gastrointestinal obstruction.","authors":"Ângela Pinto Domingues Almeida, Ricardo Araújo, Eugénia Cancela, Américo Silva","doi":"10.15403/jgld-6079","DOIUrl":"https://doi.org/10.15403/jgld-6079","url":null,"abstract":"","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"260-261"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impact of Constipation on Mental Health and Non-Motor Symptoms in Parkinson's Disease Patients: A Clinical and Mendelian Randomization Approach.","authors":"Xiaomei Zhang, Jianhua Sun, Jie Jiang, Yin Huang, Qunjuan Wang, Zongbo Zhao, Juping Chen, Dongmei Gu, Jing Guo","doi":"10.15403/jgld-6136","DOIUrl":"10.15403/jgld-6136","url":null,"abstract":"<p><strong>Background and aims: </strong>Parkinson's disease (PD) patients frequently experience constipation and non-motor symptoms, significantly affecting their quality of life. Although constipation is common, its causal relationship with mental health issues, such as anxiety and depression, remains underexplored. This study aims to investigate the association between constipation severity, non-motor symptoms, and mental health outcomes in PD patients.</p><p><strong>Methods: </strong>A total of 97 PD patients from three hospitals in Changshu City were included in this study. Clinical data were collected using assessment tools, including the Non-Motor Symptoms Scale, Patient Assessment of Constipation Quality of Life questionnaire, Hamilton Depression Rating Scale , and Hamilton Anxiety Rating Scale. Mendelian randomization analysis was applied to examine the causal relationships between constipation severity, non-motor symptoms, and mental health outcomes.</p><p><strong>Results: </strong>A moderate correlation was found between constipation severity and non-motor symptoms, especially in elderly and female patients. However, no significant causal association was identified between constipation and mental health issues such as anxiety, depression, or sleep disorders.</p><p><strong>Conclusions: </strong>The study underscores the importance of managing constipation in PD patients to improve their non-motor symptoms and quality of life. Despite the observed correlation with non-motor symptoms, further studies are needed to clarify the role of constipation in mental health issues in PD.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"181-198"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Easy-to-use Non-invasive Scores in the Assessment of Hepatocellular Carcinoma Prognosis - Data from the Romanian Hepatocellular Carcinoma Registry.","authors":"Dana Crișan, Bogdan Procopeț, Rareș Crăciun, Horia Ștefănescu, Liana Gheorghe, Ioan Sporea, Larisa Daniela Săndulescu, Anca Trifan, Zeno Spârchez, Mirela Dănilă, Ion Rogoveanu, Răzvan Cerban, Camelia Cojocariu, Roxana Șirli, Cristiana Marinela Urhut, Călin Burciu, Lidia Ciobanu, Mihai Rătan, Tudor Cosma, Nadim Al-Hajjar, Mircea Grigorescu","doi":"10.15403/jgld-6114","DOIUrl":"10.15403/jgld-6114","url":null,"abstract":"<p><strong>Background and aims: </strong>Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer-related mortality, a figure that is on the rise. The shared hallmark of different etiologies, progression, and HCC survival is chronic inflammation, making it a significant field of interest for prognostic and therapeutic strategies. We aimed to evaluate the prognostic accuracy of several inflammation-based scores in HCC.</p><p><strong>Methods: </strong>A consecutive series of patients at their first HCC diagnosis were enrolled during a 5-year timespan in a prospectively maintained multicentric database. Demographic, clinical, biological, and imagistic data were collected. Representative inflammation-based prognostic scores, including the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII), prognostic nutritional index (PNI), albumin-to-bilirubin index (ALBI), platelet-albumin-bilirubin-index (PALBI), AST-to-lymphocyte ratio (ALRI), AST/ALT, AST-to-platelet ratio (APRI) were assessed for prediction of overall survival (OS) in a scenario-based setting, using Kaplan-Meier curves, univariate and multivariate analyses.</p><p><strong>Results: </strong>A total of 467 patients from five tertiary-care hospitals were enrolled in this study. The median age was 64.94 years, and the most frequent etiology of the liver disease was hepatitis C (50%). During a median of 14.85 (35) months of follow-up, the cumulative mortality was 84.8%. In the univariate analysis, PNI (HR=2.414; p=0.021), ALBI grade (HR=2.023; p<0.001), and PALBI grade (HR=2.022; p<0.001) demonstrated the highest prognostic accuracies for OS in HCC, regardless of the clinical scenario. Moreover, PLR (HR=1.635; p=0.002), ALRI (HR=1.555; p<0.001), NLR (HR=1.461; p=0.007), AST/ALT (HR=1.420; p=0.012), and APRI (HR=1.356; p=0.009) were also significant prognostic factors for OS. The multivariate analysis showed that only ALBI grade (HR=1.974; p<0.001), SII (HR=1.487; p=0.009), and PLR (HR=1.647; p=0.014) were independently associated with OS.</p><p><strong>Conclusions: </strong>Inflammation-based scores allow for an accurate prediction of survival in HCC. Their ability to predict the response to treatment and complications merits further investigation.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 2","pages":"205-213"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}