International journal of laboratory hematology最新文献_第6页

Evaluation of the immature platelet fraction as a predictive marker of bone marrow regeneration after hematopoietic stem cell transplantation. 评估作为造血干细胞移植后骨髓再生预测标志的未成熟血小板部分。

International journal of laboratory hematology Pub Date : 2024-09-04 DOI: 10.1111/ijlh.14358

Kélian Steibel, Magalie Joris, Valentin Clichet, Amandine Charbonnier, Judith Desoutter, Jean-Pierre Marolleau, Loïc Garçon, Thomas Boyer

{"title":"Evaluation of the immature platelet fraction as a predictive marker of bone marrow regeneration after hematopoietic stem cell transplantation.","authors":"Kélian Steibel, Magalie Joris, Valentin Clichet, Amandine Charbonnier, Judith Desoutter, Jean-Pierre Marolleau, Loïc Garçon, Thomas Boyer","doi":"10.1111/ijlh.14358","DOIUrl":"https://doi.org/10.1111/ijlh.14358","url":null,"abstract":"Introduction: Hematopoietic stem cell transplantation (HCST) is a widely used therapy in the management of hematological malignancies, leading to cytopenias that require transient transfusions. Platelet recovery (PR) following HSCT is assessed by monitoring platelet count (PC). Immature platelet fraction (IPF) is a research parameter offered by Sysmex® on XN series analyzers, enabling rapid diagnostic orientation in the event of thrombocytopenia. It has also been described as a predictive factor for PR after chemotherapy or HSCT, and thresholds have been proposed.Methods: The objective of this study was to assess the predictive capability of IPF for PR in a prospective cohort of patients undergoing HSCT and to evaluate its utility in guiding platelet transfusion decision.Results: An optimized A-IPF (absolute number of IPF) threshold of 2.5 × 109/L was predictive of a PC greater than 50 × 109/L at day 30 with a sensitivity of 78.9%, specificity of 78.6%, positive predictive value (PPV) of 83.3% and negative predictive value (NPV) of 73.3%. We were able to distinguish patients recovering PC before day 15 with an earlier %IPF peak, greater IPF recovery kinetics and faster neutrophil recovery.Conclusion: A-IPF shows promise as a predictor of PR following HSCT. A multicenter study could help confirm both A-IPF and %IPF (IPF) clinical utility before it is made available to clinicians.","PeriodicalId":94050,"journal":{"name":"International journal of laboratory hematology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence-Based Platelet Count, Blood Smear and Pre-Analytics Are Decisive in a Case of Fibrin Strand Interference Masking Severe Thrombocytopenia in an ITP Patient. 基于荧光的血小板计数、血涂片和预分析在一例因纤维蛋白束干扰而掩盖严重血小板减少的 ITP 患者中起决定性作用。

International journal of laboratory hematology Pub Date : 2024-09-03 DOI: 10.1111/ijlh.14367

Marnix Mylemans, Nancy Boeckx, Ann Janssens, Mercedeh Tajdar, Christine Van Laer

引用次数: 0

Delta Immature Platelet Fraction Is Associated With Mortality in Bacteremia Patients. 德尔塔不成熟血小板比例与菌血症患者的死亡率有关。

International journal of laboratory hematology Pub Date : 2024-09-02 DOI: 10.1111/ijlh.14365

Pei-Chun Shih, Yi-Hua Wang, Shey-Ying Chen, Min Tseng, Cheng-An Hsu, Ming-Yan Yang, Hsin-Yao Wang, Jia-Arng Lee

{"title":"Delta Immature Platelet Fraction Is Associated With Mortality in Bacteremia Patients.","authors":"Pei-Chun Shih, Yi-Hua Wang, Shey-Ying Chen, Min Tseng, Cheng-An Hsu, Ming-Yan Yang, Hsin-Yao Wang, Jia-Arng Lee","doi":"10.1111/ijlh.14365","DOIUrl":"https://doi.org/10.1111/ijlh.14365","url":null,"abstract":"Objectives: Immature platelet fraction (IPF) for differentiating bacteremia has been explored, whereas its prognostic correlation remains uncertain. This study aims to confirm the predictive capability of IPF for bacteremia and investigate its association with prognosis.Methods: Patients with complete blood count (CBC) on the blood culture day (D1) and the preceding day (D0) were retrospectively recruited and categorized into bacteremia and nonbacteremia groups. Immature platelet (IP) analysis, alongside CBC, was conducted. Delta IPF, defined by the absolute values of D1 minus D0 results was calculated. The ability to distinguish bacteremia from nonbacteremia patients, and the correlation with mortality were analyzed.Results: From February to December 2020, a total of 150 patients were enrolled, with 75 having bacteremia. The specificity for delta IPF ≥3.4% to predict bacteremia was 97.3% (95% confidence interval [CI]: 90.7-99.7). When delta IPF ≥3.4% combined with procalcitonin ≥0.5 (ng/mL), the sensitivity was 90.5% (95% CI: 69.6%-98.8%). Within the bacteremia group, delta IPF and the proportion of patients with delta IPF ≥1.5% were significantly higher in nonsurvival, while delta platelet levels did not. Furthermore, delta IPF ≥1.5% was independently associated with 30-day mortality (adjusted odds ratio: 3.88, 95% CI: 1.2%-11.4%; p = 0.020). The 30-day survival curve demonstrated a significant difference between patients with delta IPF ≥1.5% and those without (p < 0.001).Conclusions: Delta IPF correlates with mortality in bacteremia patients. Our findings suggest IPF not only helps detect bacteremia but also predicts prognosis in the early stage.","PeriodicalId":94050,"journal":{"name":"International journal of laboratory hematology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishing reference intervals for extended red blood cell parameters with the Mindray BC-6800Plus hematology analyzer in a Chinese population. 在中国人群中使用明德 BC-6800Plus 血液分析仪建立扩展红细胞参数参考区间。

International journal of laboratory hematology Pub Date : 2024-08-23 DOI: 10.1111/ijlh.14361

Yanping Luo, Shuaiyan Wang, Zhuocheng Chen, Shan Lin, Sanping Guo, Hongmei Mo

引用次数: 0

Myeloid sarcoma of the breast with synchronous early T-cell precursor acute lymphoblastic leukemia: A rare presentation. 乳腺髓样肉瘤伴同步早期T细胞前体急性淋巴细胞白血病：罕见病例。

International journal of laboratory hematology Pub Date : 2024-08-19 DOI: 10.1111/ijlh.14360

Subhajit Hajra, Kavya Ur, Zahed Ali Qamer, Karthik Kumar, Priyavadhana Balasubramanian, Gaurav Dhingra, Neha Singh, Nilotpal Chowdhury

引用次数: 0

A rare case of bone marrow infiltration by Langerhans cell with bilobed and folded lobulated nuclei. 一个罕见的朗格汉斯细胞骨髓浸润病例，其细胞核呈双叶和折叠分叶状。

International journal of laboratory hematology Pub Date : 2024-08-14 DOI: 10.1111/ijlh.14362

Jinshuang Bo, Shuai Wang, Shenghai Gao, Xiaowen Xin

引用次数: 0

Mature plasmacytoid dendritic cell proliferation associated with acute myeloid leukemia. 与急性髓性白血病相关的成熟浆细胞树突状细胞增殖。

International journal of laboratory hematology Pub Date : 2024-08-10 DOI: 10.1111/ijlh.14356

J Maes, H Devos, B Cauwelier, P De Paepe, J Emmerechts

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Anaplastic large cell lymphoma with ATIC::ALK in leukemic phase and associated with hemophagocytic lymphohistiocytosis. 白血病期患有 ATIC::ALK 并伴有嗜血细胞淋巴组织细胞增多症的无性大细胞淋巴瘤。

International journal of laboratory hematology Pub Date : 2024-08-07 DOI: 10.1111/ijlh.14355

Shuyu E, Guilin Tang, Shaoying Li, Ellen Schlette, Sa A Wang, Jie Xu

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Transient neutrophil morphological abnormalities in a post-chemotherapy patient receiving G-CSF. 化疗后接受 G-CSF 治疗的患者出现短暂的中性粒细胞形态异常。

International journal of laboratory hematology Pub Date : 2024-07-29 DOI: 10.1111/ijlh.14352

Yangyang Tan, Xinjian Cai

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A diagnostic pitfall due to lymphoplasmacytic morphology in plasma cell leukemia. 浆细胞白血病淋巴浆细胞形态导致的诊断误区。

International journal of laboratory hematology Pub Date : 2024-07-07 DOI: 10.1111/ijlh.14339

Shuhei Kurosawa, Takako Yokota, Yusuke Takada, Yoko Tateishi, Hiroyuki Hayashi, Tomonori Nakazato

引用次数: 0