Frontiers in oral health最新文献

{"title":"Case Report: Digitally driven tooth autotransplantation using surgical templates and three-dimensional printed donor tooth replica.","authors":"Iuliana Babiuc, Marius Ștefan Diaconeasa, Viorel Ștefan Perieanu, Mădălina Adriana Malița, Irina Adriana Beuran, Mihai Burlibașa","doi":"10.3389/froh.2025.1537468","DOIUrl":"10.3389/froh.2025.1537468","url":null,"abstract":"<p><p>Tooth autotransplantation is a procedure involving the surgical repositioning of a tooth or dental germ from one site in the mouth to another within the same individual. A successful procedure requires a donor tooth with healthy cementum and periodontium, gentle surgical maneuvers, a well-fitted neoalveolus, and a short extraalveolar time of the donor tooth. Digital technology increases the accuracy and predictability of the tooth autotransplantation procedure. Surgical templates generate a more precise neoalveolus, with good stability of the donor tooth, and decrease the surgical time. Using a donor tooth replica ensures an optimal morphology of the new alveolus, thus reducing the injury of the root and the extraoral time of the donor tooth. This case report presents the tooth autotransplantation technique, that was employed to reposition a maxillary premolar with two fused roots on a mandibular recipient site. Digital planning, two surgical guides (one for each root), and a 3D printed tooth replica were used to ensure good accuracy, prognosis, and reduced treatment time. The procedure is conservative and offers considerable advantages to the patient, such as retaining natural teeth and proprioception.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1537468"},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral care medications for the prevention and treatment of ventilator-associated pneumonia in intensive care unit.","authors":"Hua Huang, Xiaomin Yu, Chenxi Huang, Jumei Zeng, Yuqing Li","doi":"10.3389/froh.2025.1566355","DOIUrl":"10.3389/froh.2025.1566355","url":null,"abstract":"<p><p>This study aims to ameliorate the management of VAP in clinical practice and deliver more precise care in the ICU. Study selection using the appropriate critical appraisal tools was undertaken by three authors. This review provides an overview of empirical antibiotics, chlorhexidine, and povidone-iodine, which are currently commonly used in critical care. It also discusses oral medications and preparations that may be used to prevent and treat ICU ventilator-associated pneumonia, including new antibiotics, hydrogen peroxide solutions, sodium bicarbonate, octenidine, and oral herbal medicines. It also discusses ongoing research and potential applications, such as the antimicrobial effects of these agents in ICU oral hygiene. Pharmaceuticals and formulations used in oral hygiene are effective or have huge application potential in the prevention and treatment of VAP, but further research is needed to standardize oral health assessment and care practices to develop evidence-based personalized oral hygiene for critically ill patients.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1566355"},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combined cyclosporin and azithromycin treatment on human mononuclear cells under lipopolysaccharide challenge.","authors":"Norah Alotaibi, Aminah Alesawy, Marwa Alalshaikh, Faisal E Aljofi, Nada Aldossary, Nada Alzahrani, Omar Omar, Marwa Madi","doi":"10.3389/froh.2025.1544821","DOIUrl":"10.3389/froh.2025.1544821","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the combined effects of azithromycin and varying concentrations of cyclosporin on peripheral blood mononuclear cells (PBMCs) under lipopolysaccharide (LPS) stimulation.</p><p><strong>Materials and methods: </strong>PBMCs were isolated from four healthy donors and treated with cyclosporin at concentrations of (50, 200, and 1,000 ng/ml) either alone or in combination with azithromycin (0.4 µg/ml), with and without 100 ng ml LPS derived from Porphyromonas gingivalis. Total cell count, cell viability, and lactate dehydrogenase (LDH) activity were assessed at day 1 and 3. While the inflammatory mediators, including IL-6, IL-1β, IL-18, and IgA levels were assessed by ELISA at day 3. Statistical analysis included two-way ANOVA to analyze the effects of the drugs and the presence of LPS (the two independent variables), followed by Tukey's HSD <i>post-hoc</i> test. Multiple linear regression models evaluating treatment effects, LPS exposure, and time points, with assessment of two-way interactions. Models were adjusted for relevant covariates and verified for statistical assumptions, with significance set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>Lower cyclosporin concentrations (50 and 200 ng/ml) combined with azithromycin maintained higher cell counts and showed reduced cytotoxicity compared to 1,000 ng/ml under LPS exposure. The 200 ng/ml cyclosporin-azithromycin combination demonstrated optimal results, reducing IL-6 and IL-1β levels while maintaining cell viability. Higher concentrations elevated IgA levels, particularly with LPS stimulation, suggesting enhanced immune response modulation.</p><p><strong>Conclusion: </strong>The combination of azithromycin with moderate cyclosporin concentrations (200 ng/ml) provides optimal immunomodulatory effects while maintaining cell viability. Higher cyclosporin doses (1,000 ng/ml) showed increased cytotoxicity despite enhanced immunomodulation.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1544821"},"PeriodicalIF":3.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating design thinking into dental education.","authors":"Supachai Chuenjitwongsa, Lisa R Amir, Abbas Jessani, Lakshman P Samaranayake, Thanaphum Osathanon","doi":"10.3389/froh.2025.1547335","DOIUrl":"10.3389/froh.2025.1547335","url":null,"abstract":"<p><p>Design thinking is a human-centred, iterative process that aims to develop innovative solutions tailored to user needs. This article examines the groundwork and incorporation of design thinking in healthcare and medical education, highlighting its potential benefits in dental education, including enhancements in learner-centred approaches, faculty development, interprofessional collaboration, and person-centred care. Design thinking methods foster learner engagement, aligning with cognitive and constructivist learning theories. Active engagement and discourse among learners create meaningful learning experiences, benefiting from a \"learning by doing\" approach. Further, design thinking processes ensure critical thinking and collaborative learning, supporting active engagement with prior knowledge and constructive feedback skills. Thus, applying design thinking in dental education could deepen learners' understanding with improved problem-solving skills, ultimately leading to effective learning outcomes.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1547335"},"PeriodicalIF":3.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Impact of cerebrovascular stroke on inflammatory periodontal indices: a systematic review with meta-analysis and trial sequential analysis of case-control studies.","authors":"Mario Dioguardi, Maria Eleonora Bizzoca, Stefania Cantore, Giorgia Apollonia Caloro, Gennaro Musella, Filiberto Mastrangelo, Lorenzo Lo Muzio, Andrea Ballini","doi":"10.3389/froh.2025.1580261","DOIUrl":"https://doi.org/10.3389/froh.2025.1580261","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/froh.2024.1473744.].</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1580261"},"PeriodicalIF":3.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet oral health needs and barriers to dental services among socially marginalized youth: a scoping review.","authors":"Pranav Vaishampayan, Jaskaran Singh Beniwal, Piotr Wilk, Sarah McLean, Abbas Jessani","doi":"10.3389/froh.2025.1521753","DOIUrl":"10.3389/froh.2025.1521753","url":null,"abstract":"<p><strong>Objectives: </strong>Barriers limiting access to oral health significantly impact dental service utilization among socially marginalized youth, often resulting in unmet needs and poor oral health outcomes. Identifying and understanding these barriers is critical to inform the development of strategies to enhance oral healthcare access for this vulnerable population. This review examines the barriers restricting access to oral healthcare and unmet dental needs among socially marginalized youth worldwide, offering insight to guide the development of targeted interventions.</p><p><strong>Methods: </strong>A comprehensive search was performed across electronic databases, including Embase, MEDLINE (Ovid), Scopus, and the Cochrane Library. Two independent reviewers screened all primary studies, irrespective of publication year, to identify relevant research on barriers to care and unmet oral health needs among socially marginalized youth. Primary studies addressing barriers to oral healthcare access and unmet needs were included, with no restrictions on publication date. Studies published in languages other than English were excluded. Any discrepancies identified during the screening process were resolved through consensus. The CLARITY tool was utilized to evaluate the risk of bias in the included studies.</p><p><strong>Results: </strong>Of the 484 studies identified, six quantitative and one qualitative study met the inclusion criteria. The review identified multiple barriers such as financial constraints, structural impediments, and psychological factors that inhibit access to dental care facilities among socially marginalized youth. Three studies were conducted in the United States, two in Australia, and one each in the United Kingdom and Kenya. Among the identified barriers, four studies reported financial constraints and structural and logistical challenges, respectively while one study reported psychological barriers to dental care. A high prevalence of unmet needs such as dental caries and periodontal diseases, was observed within this demographic. The unmet dental needs identified in the included studies encompassed dental caries (<i>n</i> = 3), missing teeth (<i>n</i> = 2), periodontal diseases (<i>n</i> = 1), tooth pain (<i>n</i> = 1), and dental infections (<i>n</i> = 1). However, small sample sizes and lacking in robust study design limit the findings' generalizability, emphasizing the need for more diverse studies on oral health outcomes in socially marginalized youth.</p><p><strong>Conclusion: </strong>This scoping review identified critical research gaps in regards to access to oral health and dental service utilization among socially marginalized youth. Oral health initiatives are warranted to reduce oral health inequalities among socially marginalized youth.</p><p><strong>Systematic review registration: </strong>https://doi.org/10.17605/OSF.IO/T82D3.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1521753"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel digital workflow to fabricate anterior repositioning splint with fully masticatory function based on virtual dental patient for anterior disc displacement with reduction: a case report.","authors":"Weicai Liu, Xinhuan Zhao, Jiefei Shen, Ran Wei","doi":"10.3389/froh.2025.1534571","DOIUrl":"10.3389/froh.2025.1534571","url":null,"abstract":"<p><strong>Introduction: </strong>Temporomandibular disorders (TMDs) refer to a range of conditions caused by anatomical and functional abnormalities of the temporomandibular joints. Anterior disc displacement with reduction (ADDwR) is one of the most common TMDs, characterized by symptoms such as jaw pain and audible clicking during jaw movements.</p><p><strong>Case report: </strong>A 38-year-old female was admitted to our hospital in April 2023 with a chief complaint of joint snapping and jaw pain persisting for nearly a decade. After a comprehensive examination, she was diagnosed with ADDwR of bilateral temporomandibular joints. The patient then underwent functional anterior repositioning splint (FARS) therapy, which continued until July 2023, resulting in complete symptom remission. She is currently undergoing additional orthodontic treatment.</p><p><strong>Conclusion: </strong>Anterior repositioning splint (ARS) therapy used to be considered one of the most effective therapies for ADDwR. However, concerns have emerged regarding its dependence on clinicians' subjective experience, potential inaccuracies in ARS design, and impact on patients' masticatory function. This case has improved the traditional ARS therapy with the establishment of a novel digital workflow to fabricate ARS with a fully masticatory function based on the virtual dental patient (VDP) for ADDwR. The FARS workflow ensured predictability and visualization of treatment effect through digital simulation, enhanced the personalization and precision of FARS design via VDP, and preserved the patient's masticatory function through the tailored design of occlusal surface morphology.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1534571"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ion release dynamics of bioactive resin cement under variable pH conditions.","authors":"Venkata Suresh Venkataiah, Jogikalmat Krithikadatta, Kavalipurapu Venkata Teja, Deepak Mehta, Mukesh Doble","doi":"10.3389/froh.2025.1564838","DOIUrl":"10.3389/froh.2025.1564838","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the ion release behaviour of bioactive resin cements is essential for evaluating their potential in restorative dentistry. Sustained ion release, especially at cariogenic pH levels, can enhance remineralization and prolong the longevity of dental restorations. This study investigates the influence of pH on the ion release profiles of a bioactive resin cement before and after recharging.</p><p><strong>Methods: </strong>Disk-shaped specimens (<i>n</i> = 15) of bioactive resin cement were prepared and exposed to three different pH conditions (4.5, 5.5, and 6.5) to simulate normal and cariogenic environments. Calcium ion release was quantified using atomic spectrophotometry, while fluoride and phosphate ions were analyzed using quantitative spectrophotometry. After an initial 30-day depletion phase, recharging was performed using casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF) paste.</p><p><strong>Results: </strong>In the pre-recharging phase (Stage 1), calcium ion release was more pronounced at acidic pH (4.5-5.5), particularly in the first five days. Fluoride and phosphate ions also demonstrated higher release at pH 4.5 and 5.5 compared to pH 6.5. Post-recharging (Stage 2) exhibited similar trends, emphasizing the role of regular recharge in sustaining ion availability. The absence of an initial burst release, commonly seen in other bioactive materials, suggests a distinct ion release mechanism in these resin cements.</p><p><strong>Conclusion: </strong>The findings highlight the pH-dependent release characteristics of bioactive resin cements and reinforce the importance of recharging for maintaining their therapeutic potential. The unique release kinetics observed may offer advantages in long-term remineralization strategies for dental restorations.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1564838"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox and oral health among children in Africa.","authors":"Moréniké Oluwátóyìn Foláyan, Adeyinka Ganiyat Ishola, Ahmed Bhayat, Maha El Tantawi, Nadia Adjoa Sam-Agudu, Nicaise Ndembi","doi":"10.3389/froh.2025.1539833","DOIUrl":"10.3389/froh.2025.1539833","url":null,"abstract":"<p><p>Much like it has historically, recent mpox outbreaks in Africa have significantly affected children and highlight major public health challenges, including oral healthcare in pandemic responses. The global 2022 outbreak saw an unprecedented number of mpox cases outside Africa, however children were a minority, constituting less than 2%, with the vast majority of cases reported among adult men who have sex with men. However, African countries continue to report high proportions of pediatric mpox cases, particularly Clade 1 in Burundi, the DRC, and the Congo, and Clade 2 in Nigeria. Oral manifestations of mpox such as ulcers and lesions on the lips and tongue are common and can precede skin rash, making early diagnosis challenging, especially in low-resource settings. Misdiagnosis is also a risk due to the similarity of mpox oral lesions to common pediatric exanthems and enanthems. Oral and other manifestations so mpox among affected children in Africa may be worsened due to delayed treatment and increased morbidity from high rates of malnutrition and immunosuppression, including due to HIV. This paper explores the implications of mpox on the oral health of children in Africa, emphasizing the need for improved surveillance, early detection, and the integration of the mpox response into existing child health programs. Child-focused clinical and public health research, healthcare worker training, and accessible, child-friendly diagnostic tools will be crucial for mitigating the impact of mpox on this vulnerable population.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1539833"},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and the diagnosis of oral cavity cancer and oral potentially malignant disorders from clinical photographs: a narrative review.","authors":"Payam Mirfendereski, Grace Y Li, Alexander T Pearson, Alexander Ross Kerr","doi":"10.3389/froh.2025.1569567","DOIUrl":"10.3389/froh.2025.1569567","url":null,"abstract":"<p><p>Oral cavity cancer is associated with high morbidity and mortality, particularly with advanced stage diagnosis. Oral cavity cancer, typically squamous cell carcinoma (OSCC), is often preceded by oral potentially malignant disorders (OPMDs), which comprise eleven disorders with variable risks for malignant transformation. While OPMDs are clinical diagnoses, conventional oral exam followed by biopsy and histopathological analysis is the gold standard for diagnosis of OSCC. There is vast heterogeneity in the clinical presentation of OPMDs, with possible visual similarities to early-stage OSCC or even to various benign oral mucosal abnormalities. The diagnostic challenge of OSCC/OPMDs is compounded in the non-specialist or primary care setting. There has been significant research interest in technology to assist in the diagnosis of OSCC/OPMDs. Artificial intelligence (AI), which enables machine performance of human tasks, has already shown promise in several domains of medical diagnostics. Computer vision, the field of AI dedicated to the analysis of visual data, has over the past decade been applied to clinical photographs for the diagnosis of OSCC/OPMDs. Various methodological concerns and limitations may be encountered in the literature on OSCC/OPMD image analysis. This narrative review delineates the current landscape of AI clinical photograph analysis in the diagnosis of OSCC/OPMDs and navigates the limitations, methodological issues, and clinical workflow implications of this field, providing context for future research considerations.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1569567"},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}