Expert review of respiratory medicine最新文献_第9页

The ageing of Cystic Fibrosis patients with new modulators: current gaps and challenges. 囊性纤维化患者的老龄化与新调节剂：当前的差距与挑战。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2024-02-12 DOI: 10.1080/17476348.2024.2311109

Almudena Felipe Montiel, Antonio Álvarez Fernández, Letizia Traversi, Eva Polverino

引用次数: 0

Pulmonary embolism: a practical approach to update risk stratification and treatment decisions based on the guidelines. 肺栓塞：根据指南更新风险分层和治疗决策的实用方法。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2023-12-26 DOI: 10.1080/17476348.2023.2298826

María Barca-Hernando, Luis Jara-Palomares

{"title":"Pulmonary embolism: a practical approach to update risk stratification and treatment decisions based on the guidelines.","authors":"María Barca-Hernando, Luis Jara-Palomares","doi":"10.1080/17476348.2023.2298826","DOIUrl":"10.1080/17476348.2023.2298826","url":null,"abstract":"Introduction: Pulmonary embolism (PE) is a prevalent condition with a substantial morbi-mortality worldwide. Proper risk stratification of PE is essential for identifying the most suitable therapeutic strategy and the optimal care setting for the patient. This process entails evaluating various factors, including symptoms, comorbidities, and right heart dysfunction.Areas covered: This review assesses the tools and methods utilized to identify and stratify individuals based on the probability of developing deterioration or death related to PE. Current guidelines divide PE into three groups: high-risk (previously termed massive) PE, intermediate-risk (sub-massive) PE, and low-risk PE. Various risk scores, such as the simplified pulmonary embolism severity index (sPESI), Bova score, and the FAST score (incorporating Heart-Fatty Acid binding protein [H-ABP], Syncope, Tachycardia), aid in identifying patients at higher risk. Additionally, the Hestia score is instrumental in pinpointing low-risk patients.Expert opinion: Presently, there is a dearth of high-quality frameworks for the optimal management and treatment of PE patients at risk of hemodynamic collapse. A consortium of experts is in the process of formulating a new conceptual model for risk stratification, taking into account a comprehensive array of variables and outcomes to facilitate more individualized management of acute PE.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and management of cough in interstitial lung disease. 间质性肺病咳嗽的机理和治疗。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2023-12-30 DOI: 10.1080/17476348.2023.2299751

Ameer Z Rasheed, Mark L Metersky, Fatima Ghazal

{"title":"Mechanisms and management of cough in interstitial lung disease.","authors":"Ameer Z Rasheed, Mark L Metersky, Fatima Ghazal","doi":"10.1080/17476348.2023.2299751","DOIUrl":"10.1080/17476348.2023.2299751","url":null,"abstract":"Introduction: Many patients with interstitial lung diseases (ILDs), especially fibrotic ILDs, experience chronic cough. It negatively impacts both physical and psychological well-being. Effective treatment options are limited.Areas covered: The pathophysiology of chronic cough in IPF is complex and involves multiple mechanisms, including mechanical distortion of airways, parenchyma, and nerve fibers. The pathophysiology of cough in other fibrosing ILDs is poorly understood and involves various pathways. The purpose of this review is to highlight mechanisms of chronic cough and to present therapeutic evidence for its management in the most commonly occurring diffuse fibrosing lung diseases including idiopathic pulmonary fibrosis (IPF), connective tissue disease-related interstitial lung disease (CTD-ILD), sarcoidosis-related ILD (Sc-ILD), chronic hypersensitivity pneumonitis-related ILD (CHP-ILD), and post-COVID-19-related interstitial lung disease (PC-ILD).Expert opinion: This review guides the management of chronic cough in fibrosing ILDs. In this era of precision medicine, chronic cough management should be individualized in each interstitial lung disease.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139076419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of air pollution on asthma: clinical outcomes, current epidemiology, and health disparities. 空气污染对哮喘的影响：临床结果、当前流行病学和健康差异。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2024-01-25 DOI: 10.1080/17476348.2024.2307545

Ryan J Fiter, Lila J Murphy, Michelle N Gong, Krystal L Cleven

{"title":"The impact of air pollution on asthma: clinical outcomes, current epidemiology, and health disparities.","authors":"Ryan J Fiter, Lila J Murphy, Michelle N Gong, Krystal L Cleven","doi":"10.1080/17476348.2024.2307545","DOIUrl":"10.1080/17476348.2024.2307545","url":null,"abstract":"Introduction: Air pollution has been shown to have a significant impact on morbidity and mortality of respiratory illnesses including asthma.Areas covered: Outdoor air pollution consists of a mixture of individual pollutants including vehicle traffic and industrial pollution. Studies have implicated an array of individual components of air pollution, with PM2.5, NO2, SO2, and ozone being the most classically described, and newer literature implicating other pollutants such as black carbon and volatile organic compounds. Epidemiological and cohort studies have described incidence and prevalence of pollution-related asthma and investigated both acute and chronic air pollution exposure as they relate to asthma outcomes. There is an increasing body of literature tying disparities in pollution exposure to clinical outcomes. In this narrative review, we assessed the published research investigating the association of pollution with asthma outcomes, focusing on the adult population and health care disparities.Expert opinion: Pollution has multiple deleterious effects on respiratory health but there is a lack of data on individualized pollution monitoring, making it difficult to establish a temporal relationship between exposure and symptoms, thereby limiting our understanding of safe exposure levels. Future research should focus on more personalized monitoring and treatment plans for mitigating exposure.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interventional bronchoscopy in pediatric pulmonary tuberculosis. 小儿肺结核的介入性支气管镜检查。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2023-12-28 DOI: 10.1080/17476348.2023.2299336

Pierre Goussard, Ernst Eber, Shyam Venkatakrishna, Lisa Frigati, Leonore Greybe, Jacques Janson, Pawel Schubert, Savvas Andronikou

{"title":"Interventional bronchoscopy in pediatric pulmonary tuberculosis.","authors":"Pierre Goussard, Ernst Eber, Shyam Venkatakrishna, Lisa Frigati, Leonore Greybe, Jacques Janson, Pawel Schubert, Savvas Andronikou","doi":"10.1080/17476348.2023.2299336","DOIUrl":"10.1080/17476348.2023.2299336","url":null,"abstract":"Introduction: Lymphobronchial tuberculosis (TB) is common in children with primary TB and enlarged lymph nodes can cause airway compression of the large airways. If not treated correctly, airway compression can result in persistent and permanent parenchymal pathology, as well as irreversible lung destruction. Bronchoscopy was originally used to collect diagnostic samples; however, its role has evolved, and it is now used as an interventional tool in the diagnosis and management of complicated airway disease. Endoscopic treatment guidelines for children with TB are scarce.Areas covered: The role of interventional bronchoscopy in the diagnosis and management of complicated pulmonary TB will be discussed. This review will provide practical insights into how and when to perform interventional procedures in children with complicated TB for both diagnostic and therapeutic purposes. This discussion incorporates current scientific evidence and refers to adult literature, as some of the interventions have only been done in adults but may have a role in children. Limitations and future perspectives will be examined.Expert opinion: Pediatric pulmonary TB lends itself to endoscopic interventions as it is a disease with a good outcome if treated correctly. However, interventions must be limited to safeguard the parenchyma and prevent permanent damage.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138886817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of indoor environment on children's pulmonary health. 室内环境对儿童肺部健康的影响。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2024-01-31 DOI: 10.1080/17476348.2024.2307561

Jared Murphy, Ramiyya Tharumakunarajah, Karl A Holden, Charlotte King, Alice R Lee, Katie Rose, Daniel B Hawcutt, Ian P Sinha

{"title":"Impact of indoor environment on children's pulmonary health.","authors":"Jared Murphy, Ramiyya Tharumakunarajah, Karl A Holden, Charlotte King, Alice R Lee, Katie Rose, Daniel B Hawcutt, Ian P Sinha","doi":"10.1080/17476348.2024.2307561","DOIUrl":"10.1080/17476348.2024.2307561","url":null,"abstract":"Introduction: A child's living environment has a significant impact on their respiratory health, with exposure to poor indoor air quality (IAQ) contributing to potentially lifelong respiratory morbidity. These effects occur throughout childhood, from the antenatal period through to adolescence. Children are particularly susceptible to the effects of environmental insults, and children living in socioeconomic deprivation globally are more likely to breathe air both indoors and outdoors, which poses an acute and long-term risk to their health. Adult respiratory health is, at least in part, determined by exposures and respiratory system development in childhood, starting in utero.Areas covered: This narrative review will discuss, from a global perspective, what contributes to poor IAQ in the child's home and school environment and the impact that indoor air pollution exposure has on respiratory health throughout the different stages of childhood.Expert opinion: All children have the right to a living and educational environment without the threat of pollution affecting their health. Action is needed at multiple levels to address this pressing issue to improve lifelong respiratory health. Such action should incorporate a child's rights-based approach, empowering children, and their families, to have access to clean air to breathe in their living environment.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population. CYP2B6的基因多态性可能与中国汉族人群的肺癌风险有关。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2024-01-04 DOI: 10.1080/17476348.2024.2302199

Xiaoya Ma, Xufeng Zang, Leteng Yang, Wenqian Zhou, Yujie Li, Jie Wei, Jinping Guo, Junhui Han, Jing Liang, Tianbo Jin

{"title":"Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population.","authors":"Xiaoya Ma, Xufeng Zang, Leteng Yang, Wenqian Zhou, Yujie Li, Jie Wei, Jinping Guo, Junhui Han, Jing Liang, Tianbo Jin","doi":"10.1080/17476348.2024.2302199","DOIUrl":"10.1080/17476348.2024.2302199","url":null,"abstract":"Background: Our study aimed to elucidate the association between single nucleotide polymorphisms (SNPs) in CYP2B6 gene and susceptibility to lung cancer (LC).Methods: Five SNPs in CYP2B6 were genotyped in Chinese Han population (507 cases and 505 controls) utilizing Agena MassARRAY. The relationship between these SNPs and LC susceptibility was assessed using odds ratios, 95% confidence intervals, and χ2 tests. Additionally, multifactor dimensionality reduction was employed to analyze SNP-SNP interactions. Bioinformatics methods were applied to investigate the function of these SNPs.Results: We found that rs2099361 was associated with an increased susceptibility to LC in the codominant model (OR = 1.31, p = 0.045). Stratification analysis revealed the allele G at rs4803418 and the allele T at rs4803420 of CYP2B6 (BMI >24 kg/m2) were significantly linked to decreased susceptibility of LC. Conversely, the allele C at rs12979270 (BMI >24 kg/m2) showed increased susceptibility to LC. Moreover, a robust redundant relationship between rs12979270 and rs4803420 was identified in the study. According to the VannoPortal database, we found that rs4803420, rs12979270 and rs2099361 may modulate the binding affinity of LMNB1, SP1 and HDAC2, respectively.Conclusions: Our results suggest that SNPs in the CYP2B6 gene play crucial roles in LC susceptibility.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-existence of OSA and respiratory diseases and the influence of gender. OSA 与呼吸系统疾病并存以及性别的影响。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2024-02-06 DOI: 10.1080/17476348.2024.2304065

Sophia Schiza, Esther I Schwarz, Maria R Bonsignore, Walter T McNicholas, Athanasia Pataka, Izolde Bouloukaki

{"title":"Co-existence of OSA and respiratory diseases and the influence of gender.","authors":"Sophia Schiza, Esther I Schwarz, Maria R Bonsignore, Walter T McNicholas, Athanasia Pataka, Izolde Bouloukaki","doi":"10.1080/17476348.2024.2304065","DOIUrl":"10.1080/17476348.2024.2304065","url":null,"abstract":"Introduction: Sleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), is commonly associated with respiratory diseases, such as COPD, asthma and interstitial lung disease.Areas covered: This narrative review aims to comprehensively synthesize the existing information on SDB in respiratory diseases, investigate the role of gender in this association, and highlight the importance of OSA management in improving sleep, quality of life, and disease prognosis in these specific patient populations.Expert opinion: Research indicates a synergistic link between OSA and chronic respiratory diseases, which leads to greater morbidity and mortality compared to each disorder alone. Given the lack of an optimal OSA screening tool for these patients, a comprehensive patient approach and overnight diagnostic sleep study are imperative. Despite the limited evidence available, it seems that gender has an impact on the prevalence, severity, and susceptibility of this coexistence. Recognizing the role of gender in the coexistence of OSA and other respiratory diseases can enhance everyday medical practice and enable clinicians to adopt a more personalized approach toward optimal screening and diagnosis of these patients.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stratification of patients with KRAS-mutated advanced non-small cell lung cancer: improving prognostics. KRAS-突变晚期非小细胞肺癌癌症患者的分层：改善预后。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-10-27 DOI: 10.1080/17476348.2023.2265810

Yuda Zhang, Fanxu Zeng, Shixuan Peng, Yangqian Chen, Wenjuan Jiang, Zhan Wang, Li Deng, Zhe Huang, Haoyue Qin, Huan Yan, Xing Zhang, Lin Zhang, Nong Yang, Qian Gong, Liang Zeng, Yongchang Zhang

{"title":"Stratification of patients with KRAS-mutated advanced non-small cell lung cancer: improving prognostics.","authors":"Yuda Zhang, Fanxu Zeng, Shixuan Peng, Yangqian Chen, Wenjuan Jiang, Zhan Wang, Li Deng, Zhe Huang, Haoyue Qin, Huan Yan, Xing Zhang, Lin Zhang, Nong Yang, Qian Gong, Liang Zeng, Yongchang Zhang","doi":"10.1080/17476348.2023.2265810","DOIUrl":"10.1080/17476348.2023.2265810","url":null,"abstract":"Introduction: KRAS is the most frequently mutated oncogene in cancer and encodes a key signaling protein in tumors. Due to its high affinity for GTP and the lack of a large binding pocket that allosteric inhibitors can occupy, KRAS has long been considered 'non-druggable.' Finding effective treatment measures for patients with KRAS mutations is our top priority.Areas covered: In this article, we will provide an overview of the KRAS pathway and review the current state of therapeutic strategies for targeting oncogenic KRAS, as well as their potential to improve outcomes in patients with KRAS-mutant malignancies. We will also discuss the development of these strategies and gave an outlook on prospects.Expert opinion: KRAS mutations have posed a significant challenge in the treatment of advanced non-small cell lung cancer (NSCLC) over the past few decades. However, the emergence of immunotherapy and KRAS inhibitors, such as Sotorasib (AMG 510) and Adagrasib (MRTX849), has marked a new era in cancer therapy. As more research and clinical trials continue, we anticipate the development of more effective treatment strategies and better options for lung cancer patients.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism. 中心性肺栓塞患者肺梗死的临床预测因素和预后。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-10-27 DOI: 10.1080/17476348.2023.2263359

Jose Manuel Martinez Manzano, Kevin Bryan Lo, Omar Cantu-Martinez, Long Nguyen, Brenda Chiang, Simone A Jarrett, Sahana Tito, Alexander Prendergast, Maria A Planchart Ferretto, Willy Roque, Ammaar Wattoo, Zurab Azmaiparashvili, Sadia Benzaquen

{"title":"Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism.","authors":"Jose Manuel Martinez Manzano, Kevin Bryan Lo, Omar Cantu-Martinez, Long Nguyen, Brenda Chiang, Simone A Jarrett, Sahana Tito, Alexander Prendergast, Maria A Planchart Ferretto, Willy Roque, Ammaar Wattoo, Zurab Azmaiparashvili, Sadia Benzaquen","doi":"10.1080/17476348.2023.2263359","DOIUrl":"10.1080/17476348.2023.2263359","url":null,"abstract":"Background: Given the heterogeneity of predisposing factors associated with pulmonary infarction (PI) and the lack of clinically relevant outcomes among patients with acute pulmonary embolism (PE) complicated by PI, further investigation is required.Methods: Retrospective study of patients with central PE in an 11-year period. Data were stratified according to the diagnosis of PI. Multivariable logistic regression analysis was used to analyze factors associated with PI development and determine if PI was associated with severe hypoxemic respiratory failure and mechanical ventilation use.Results: Of 645 patients with central PE, 24% (n = 156) had PI. After adjusting for demographics, comorbidities, and clinical features on admission, only age (OR 0.98, CI 0.96-0.99; p = 0.008) was independently associated with PI. Regarding outcomes, 35% (n = 55) had severe hypoxemic respiratory failure, and 19% (n = 29) required mechanical ventilation. After adjusting for demographics, PE severity, and right ventricular dysfunction, PI was independently associated with severe hypoxemic respiratory failure (OR 1.78; CI 1.18-2.69, p = 0.005) and mechanical ventilation (OR 1.92; CI 1.14-3.22, p = 0.013).Conclusions: Aging is a protective factor against PI. In acute central PE, subjects with PI had higher odds of developing severe hypoxemic respiratory failure and requiring mechanical ventilation.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0