Expert review of respiratory medicine最新文献_第10页

Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population. CYP2B6的基因多态性可能与中国汉族人群的肺癌风险有关。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2024-01-04 DOI: 10.1080/17476348.2024.2302199

Xiaoya Ma, Xufeng Zang, Leteng Yang, Wenqian Zhou, Yujie Li, Jie Wei, Jinping Guo, Junhui Han, Jing Liang, Tianbo Jin

{"title":"Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population.","authors":"Xiaoya Ma, Xufeng Zang, Leteng Yang, Wenqian Zhou, Yujie Li, Jie Wei, Jinping Guo, Junhui Han, Jing Liang, Tianbo Jin","doi":"10.1080/17476348.2024.2302199","DOIUrl":"10.1080/17476348.2024.2302199","url":null,"abstract":"Background: Our study aimed to elucidate the association between single nucleotide polymorphisms (SNPs) in CYP2B6 gene and susceptibility to lung cancer (LC).Methods: Five SNPs in CYP2B6 were genotyped in Chinese Han population (507 cases and 505 controls) utilizing Agena MassARRAY. The relationship between these SNPs and LC susceptibility was assessed using odds ratios, 95% confidence intervals, and χ2 tests. Additionally, multifactor dimensionality reduction was employed to analyze SNP-SNP interactions. Bioinformatics methods were applied to investigate the function of these SNPs.Results: We found that rs2099361 was associated with an increased susceptibility to LC in the codominant model (OR = 1.31, p = 0.045). Stratification analysis revealed the allele G at rs4803418 and the allele T at rs4803420 of CYP2B6 (BMI >24 kg/m2) were significantly linked to decreased susceptibility of LC. Conversely, the allele C at rs12979270 (BMI >24 kg/m2) showed increased susceptibility to LC. Moreover, a robust redundant relationship between rs12979270 and rs4803420 was identified in the study. According to the VannoPortal database, we found that rs4803420, rs12979270 and rs2099361 may modulate the binding affinity of LMNB1, SP1 and HDAC2, respectively.Conclusions: Our results suggest that SNPs in the CYP2B6 gene play crucial roles in LC susceptibility.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1297-1305"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-existence of OSA and respiratory diseases and the influence of gender. OSA 与呼吸系统疾病并存以及性别的影响。

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2024-02-06 DOI: 10.1080/17476348.2024.2304065

Sophia Schiza, Esther I Schwarz, Maria R Bonsignore, Walter T McNicholas, Athanasia Pataka, Izolde Bouloukaki

{"title":"Co-existence of OSA and respiratory diseases and the influence of gender.","authors":"Sophia Schiza, Esther I Schwarz, Maria R Bonsignore, Walter T McNicholas, Athanasia Pataka, Izolde Bouloukaki","doi":"10.1080/17476348.2024.2304065","DOIUrl":"10.1080/17476348.2024.2304065","url":null,"abstract":"Introduction: Sleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), is commonly associated with respiratory diseases, such as COPD, asthma and interstitial lung disease.Areas covered: This narrative review aims to comprehensively synthesize the existing information on SDB in respiratory diseases, investigate the role of gender in this association, and highlight the importance of OSA management in improving sleep, quality of life, and disease prognosis in these specific patient populations.Expert opinion: Research indicates a synergistic link between OSA and chronic respiratory diseases, which leads to greater morbidity and mortality compared to each disorder alone. Given the lack of an optimal OSA screening tool for these patients, a comprehensive patient approach and overnight diagnostic sleep study are imperative. Despite the limited evidence available, it seems that gender has an impact on the prevalence, severity, and susceptibility of this coexistence. Recognizing the role of gender in the coexistence of OSA and other respiratory diseases can enhance everyday medical practice and enable clinicians to adopt a more personalized approach toward optimal screening and diagnosis of these patients.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1221-1235"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stratification of patients with KRAS-mutated advanced non-small cell lung cancer: improving prognostics. KRAS-突变晚期非小细胞肺癌癌症患者的分层：改善预后。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-10-27 DOI: 10.1080/17476348.2023.2265810

Yuda Zhang, Fanxu Zeng, Shixuan Peng, Yangqian Chen, Wenjuan Jiang, Zhan Wang, Li Deng, Zhe Huang, Haoyue Qin, Huan Yan, Xing Zhang, Lin Zhang, Nong Yang, Qian Gong, Liang Zeng, Yongchang Zhang

{"title":"Stratification of patients with KRAS-mutated advanced non-small cell lung cancer: improving prognostics.","authors":"Yuda Zhang, Fanxu Zeng, Shixuan Peng, Yangqian Chen, Wenjuan Jiang, Zhan Wang, Li Deng, Zhe Huang, Haoyue Qin, Huan Yan, Xing Zhang, Lin Zhang, Nong Yang, Qian Gong, Liang Zeng, Yongchang Zhang","doi":"10.1080/17476348.2023.2265810","DOIUrl":"10.1080/17476348.2023.2265810","url":null,"abstract":"Introduction: KRAS is the most frequently mutated oncogene in cancer and encodes a key signaling protein in tumors. Due to its high affinity for GTP and the lack of a large binding pocket that allosteric inhibitors can occupy, KRAS has long been considered 'non-druggable.' Finding effective treatment measures for patients with KRAS mutations is our top priority.Areas covered: In this article, we will provide an overview of the KRAS pathway and review the current state of therapeutic strategies for targeting oncogenic KRAS, as well as their potential to improve outcomes in patients with KRAS-mutant malignancies. We will also discuss the development of these strategies and gave an outlook on prospects.Expert opinion: KRAS mutations have posed a significant challenge in the treatment of advanced non-small cell lung cancer (NSCLC) over the past few decades. However, the emergence of immunotherapy and KRAS inhibitors, such as Sotorasib (AMG 510) and Adagrasib (MRTX849), has marked a new era in cancer therapy. As more research and clinical trials continue, we anticipate the development of more effective treatment strategies and better options for lung cancer patients.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"743-751"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism. 中心性肺栓塞患者肺梗死的临床预测因素和预后。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-10-27 DOI: 10.1080/17476348.2023.2263359

Jose Manuel Martinez Manzano, Kevin Bryan Lo, Omar Cantu-Martinez, Long Nguyen, Brenda Chiang, Simone A Jarrett, Sahana Tito, Alexander Prendergast, Maria A Planchart Ferretto, Willy Roque, Ammaar Wattoo, Zurab Azmaiparashvili, Sadia Benzaquen

{"title":"Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism.","authors":"Jose Manuel Martinez Manzano, Kevin Bryan Lo, Omar Cantu-Martinez, Long Nguyen, Brenda Chiang, Simone A Jarrett, Sahana Tito, Alexander Prendergast, Maria A Planchart Ferretto, Willy Roque, Ammaar Wattoo, Zurab Azmaiparashvili, Sadia Benzaquen","doi":"10.1080/17476348.2023.2263359","DOIUrl":"10.1080/17476348.2023.2263359","url":null,"abstract":"Background: Given the heterogeneity of predisposing factors associated with pulmonary infarction (PI) and the lack of clinically relevant outcomes among patients with acute pulmonary embolism (PE) complicated by PI, further investigation is required.Methods: Retrospective study of patients with central PE in an 11-year period. Data were stratified according to the diagnosis of PI. Multivariable logistic regression analysis was used to analyze factors associated with PI development and determine if PI was associated with severe hypoxemic respiratory failure and mechanical ventilation use.Results: Of 645 patients with central PE, 24% (n = 156) had PI. After adjusting for demographics, comorbidities, and clinical features on admission, only age (OR 0.98, CI 0.96-0.99; p = 0.008) was independently associated with PI. Regarding outcomes, 35% (n = 55) had severe hypoxemic respiratory failure, and 19% (n = 29) required mechanical ventilation. After adjusting for demographics, PE severity, and right ventricular dysfunction, PI was independently associated with severe hypoxemic respiratory failure (OR 1.78; CI 1.18-2.69, p = 0.005) and mechanical ventilation (OR 1.92; CI 1.14-3.22, p = 0.013).Conclusions: Aging is a protective factor against PI. In acute central PE, subjects with PI had higher odds of developing severe hypoxemic respiratory failure and requiring mechanical ventilation.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"815-821"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spirometry in atrial fibrillation: what's the catch? 心房颤动的肺活量测定：有什么问题？

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-11-24 DOI: 10.1080/17476348.2023.2279236

Anne E Ioannides, Upasana Tayal, Jennifer K Quint

{"title":"Spirometry in atrial fibrillation: what's the catch?","authors":"Anne E Ioannides, Upasana Tayal, Jennifer K Quint","doi":"10.1080/17476348.2023.2279236","DOIUrl":"10.1080/17476348.2023.2279236","url":null,"abstract":"Introduction: People with COPD rarely have COPD alone, and the commonest co-morbidities occurring with COPD are cardiovascular. Whilst multiple studies have explored the association between major cardiovascular events and COPD, less attention has been paid to arrhythmias, specifically atrial fibrillation (AF). AF and COPD frequently occur together, posing challenges in diagnosis and management. In this review, we describe the relationship between AF and COPD epidemiologically and physiologically, demonstrating the role of spirometry as a diagnostic and disease management tool.Areas covered: We provide epidemiological evidence that COPD and AF are independent risk factors for one another, that either disease is highly prevalent amongst people with the other, and that they have shared risk factors; all of which contribute to adverse prognostic. We elucidated common pathophysiological mechanisms implicated in AF-COPD. We ultimately present the epidemiological and physiological evidence with a view to highlight specific areas where we feel spirometry is of value in the management of AF-COPD.Expert opinion: AF and COPD commonly co-occur, there is often diagnostic delay, increased risk of reduced cardioversion success, and missed opportunity to intervene to reduce stroke risk. Greater awareness and timelier diagnosis and guideline directed management may improve outcomes for people with both diseases.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"937-950"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of radiation in oligometastases and oligoprogression in metastatic non-small cell lung cancer: consensus and controversy. 放射在转移性非小细胞肺癌寡转移和寡进展中的作用:共识和争议。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-12-26 DOI: 10.1080/17476348.2023.2284362

Abhishek Kumar, Joseph K Salama

{"title":"Role of radiation in oligometastases and oligoprogression in metastatic non-small cell lung cancer: consensus and controversy.","authors":"Abhishek Kumar, Joseph K Salama","doi":"10.1080/17476348.2023.2284362","DOIUrl":"10.1080/17476348.2023.2284362","url":null,"abstract":"Introduction: The oligometastatic state in non-small cell lung cancer (NSCLC) has recently become well-established. However, the specific definition of oligometastases remains unclear. Several smaller randomized studies have investigated the safety and efficacy of radiation as metastasis-directed therapy (MDT) in oligometastatic NSCLC, which have led the way to larger studies currently accruing patients globally.Areas covered: This review covers the definitions of 'oligometastases' and explains why the oligometastatic state is becoming increasingly relevant in metastatic NSCLC. This includes the rationale for MDT in oligometastatic NSCLC, specifically reviewing stereotactic body radiation therapy (SBRT) as a treatment strategy. This review details many randomized trials that support radiation as MDT and introduces trials that are currently accruing patients. Finally, it explores some of the controversies that warrant further investigation.Expert opinion: Radiation treatment, specifically SBRT, has been shown to be safe, convenient, and cost-effective as MDT. As systemic therapy, including targeted agents and immunotherapy, continues to improve, the precise role(s) and timing of radiation therapy may evolve. However, radiation therapy as MDT will continue to be an integral part of treatment in patients with oligometastatic NSCLC.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1033-1040"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92158101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of short-term air pollution exposure on symptoms development in the course of idiopathic pulmonary fibrosis. 特发性肺纤维化过程中短期空气污染暴露对症状发展的影响。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-12-26 DOI: 10.1080/17476348.2023.2281992

Konstantina Dimakopoulou, Ioannis Tomos, Effrosyni D Manali, Spyros A Papiris, Anna Karakatsani

{"title":"Effects of short-term air pollution exposure on symptoms development in the course of idiopathic pulmonary fibrosis.","authors":"Konstantina Dimakopoulou, Ioannis Tomos, Effrosyni D Manali, Spyros A Papiris, Anna Karakatsani","doi":"10.1080/17476348.2023.2281992","DOIUrl":"10.1080/17476348.2023.2281992","url":null,"abstract":"Background: Lately a potential detrimental effect of air pollution to idiopathic pulmonary fibrosis emerged. We aimed to assess the effects of short-term air pollution exposure to the clinical course of IPF.Research design and methods: IPF patients were followed intensively for four nonconsecutive study periods between 13 July 2020 and 5 September 2021. Short-term exposure to O3, NO2 and PM10 concentrations was estimated using spatio-temporal land use regression models. Associations among symptoms, lung function, oxygen saturation, and short-term personal air pollutant exposure were assessed through multiple mixed effects logistic regression models.Results: Data for up to 24 IPF patients (mean age: 72.2 ± 7.6 years) were analyzed. We detected positive significant associations between cough and a 10 μg/m3 increase in same day mean level of NO2 (OR = 1.59, 95%CI: 1.00-2.53), PM10 (OR = 2.42, 95%CI: 1.54-3.79), and O3 (OR = 1.63, 95%CI: 1.14-2.32). A 10 μg/m3 increase in same day mean level of NO2 was also associated with the risk of appearance of wheezing (OR = 3.01, 95%CI: 1.00-9.04), while exposure to O3 was associated with common cold (OR = 6.30, 95%CI: 3.59-11.07). No significant associations were detected between short-term exposure to air pollutants and forced vital capacity or saturation of oxygen.Conclusions: Short-term exposure to increased concentrations of air pollutants is an independent risk factor for IPF symptoms' aggravation.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1069-1078"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential COVID-19 preventive behaviors among Asian subgroups in the United States. 美国亚裔亚群的COVID-19预防行为差异

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-12-26 DOI: 10.1080/17476348.2023.2289527

YuJing Wu, Ahan Shi, Laite Chen, Dejun Su

{"title":"Differential COVID-19 preventive behaviors among Asian subgroups in the United States.","authors":"YuJing Wu, Ahan Shi, Laite Chen, Dejun Su","doi":"10.1080/17476348.2023.2289527","DOIUrl":"10.1080/17476348.2023.2289527","url":null,"abstract":"Background: Given the observed within-Asian disparity in COVID-19 incidence, we aimed to explore the differential preventive behaviors among Asian subgroups in the United States.Methods: Based on data from the Asian subsample (N = 982) of the 2020 Health, Ethnicity, and Pandemic survey, we estimated the weighted proportion of noncompliance with Centers for Disease Control and Prevention (CDC) guidelines on preventive behaviors and COVID-19 testing by Asian subgroups (Asian Indian, Chinese, Filipino, Japanese, Korean, Vietnamese, Other Asian). We examined these subgroup differences after adjusting for demographic factors and state-level clustering.Results: Filipinos demonstrated the lowest rate of noncompliance for mask-wearing, social distancing, and handwashing. As compared with the Filipinos, our logistic models showed that the Chinese and the 'other Asians' subgroup had significantly higher risk of noncompliance with mask-wearing, while the Japanese, the Vietnamese, and other Asians were significantly more likely to report noncompliance with social distancing.Conclusions: The significant variation of preventive behavior across Asian subgroups signals the necessity of data disaggregation when it comes to understanding the health behavior of Asian Americans, which is critical for future pandemic preparedness. The excess behavioral risk among certain Asian subgroups (especially those 'other Asians') warrants further investigation and interventions about the driving forces behind these disparities.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1049-1059"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene signatures in U-BIOPRED severe asthma for molecular phenotyping and precision medicine: time for clinical use. U-BIOPRED重症哮喘的基因标记用于分子表型和精准医学:临床应用的时机。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-12-26 DOI: 10.1080/17476348.2023.2278606

Nazanin Kermani, Ali Versi, Aurore Gay, Jelmer Vlasma, Akshaya Keerthi Saikumar Jayalatha, Gerard H Koppelman, Martijn Nawijn, Alen Faiz, Maarten van den Berge, Ian M Adcock, Kian Fan Chung

{"title":"Gene signatures in U-BIOPRED severe asthma for molecular phenotyping and precision medicine: time for clinical use.","authors":"Nazanin Kermani, Ali Versi, Aurore Gay, Jelmer Vlasma, Akshaya Keerthi Saikumar Jayalatha, Gerard H Koppelman, Martijn Nawijn, Alen Faiz, Maarten van den Berge, Ian M Adcock, Kian Fan Chung","doi":"10.1080/17476348.2023.2278606","DOIUrl":"10.1080/17476348.2023.2278606","url":null,"abstract":"Introduction: The use and generation of gene signatures have been established as a method to define molecular endotypes in complex diseases such as severe asthma. Bioinformatic approaches have now been applied to large omics datasets to define the various co-existing inflammatory and cellular functional pathways driving or characterizing a particular molecular endotype.Areas covered: Molecular phenotypes and endotypes of Type 2 inflammatory pathways and also of non-Type 2 inflammatory pathways, such as IL-6 trans-signaling, IL-17 activation, and IL-22 activation, have been defined in the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes dataset. There has also been the identification of the role of mast cell activation and of macrophage dysfunction in various phenotypes of severe asthma.Expert opinion: Phenotyping on the basis of clinical treatable traits is not sufficient for understanding of mechanisms driving the disease in severe asthma. It is time to consider whether certain patients with severe asthma, such as those non-responsive to current therapies, including Type 2 biologics, would be better served using an approach of molecular endotyping using gene signatures for management purposes rather than the current sole reliance on blood eosinophil counts or exhaled nitric oxide measurements.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"965-971"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential clinical value of pairing procalcitonin and lung ultrasonography to guide antibiotic therapy in patients with community-acquired pneumonia: a narrative review. 降钙素原与肺部超声配对指导社区获得性肺炎患者抗生素治疗的潜在临床价值：叙述性综述。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-11-24 DOI: 10.1080/17476348.2023.2254232

Cécile Bessat, Noémie Boillat-Blanco, Werner C Albrich

{"title":"The potential clinical value of pairing procalcitonin and lung ultrasonography to guide antibiotic therapy in patients with community-acquired pneumonia: a narrative review.","authors":"Cécile Bessat, Noémie Boillat-Blanco, Werner C Albrich","doi":"10.1080/17476348.2023.2254232","DOIUrl":"10.1080/17476348.2023.2254232","url":null,"abstract":"Introduction: Lower respiratory tract infections (LRTIs) are among the most frequent infections and are prone to inappropriate antibiotic treatments. This results from a limited accuracy of diagnostic tools in identifying bacterial pneumonia. Lung ultrasound (LUS) has excellent sensitivity and specificity in diagnosing pneumonia. Additionally, elevated procalcitonin (PCT) levels correlate with an increased likelihood of bacterial infection. LUS and PCT appear to be complementary in identifying patients with bacterial pneumonia who are likely to benefit from antibiotics.Areas covered: This narrative review aims to summarize the current evidence for LUS to diagnose pneumonia, for PCT to guide antibiotic therapy and the clinical value of pairing both tools.Expert opinion: LUS has excellent diagnostic accuracy for pneumonia in different settings, regardless of the examiner's experience. PCT guidance safely reduces antibiotic prescription in LRTIs. The combination of both tools has demonstrated an enhanced accuracy in the diagnosis of pneumonia, including CAP in the ED and VAP in the ICU, but randomized controlled studies need to validate the clinical impact of a combined approach.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"919-927"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41180061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0