Expert review of respiratory medicine最新文献

Prevalence and characteristics of respiratory and cardiovascular sequelae in post-COVID-19 syndromes: a scoping review. covid -19综合征后呼吸和心血管后遗症的患病率和特征：一项范围综述

Expert review of respiratory medicine Pub Date : 2025-06-04 DOI: 10.1080/17476348.2025.2515992

Nathália Leite Barbosa, Thaianne Rangel Agra Oliveira, Larissa Domingos Nóbrega, Thaíly Ticiane Fernandes Araújo, Sarah Rayanne Santos Bezerra, Giovanna Miller Oliveira, Rebeca Monteiro Do Nascimento, Patrícia Angélica Miranda Silva Nogueira, Alecsandra Ferreira Tomaz, Ana Tereza Do Nascimento Sales Figueiredo Fernandes

{"title":"Prevalence and characteristics of respiratory and cardiovascular sequelae in post-COVID-19 syndromes: a scoping review.","authors":"Nathália Leite Barbosa, Thaianne Rangel Agra Oliveira, Larissa Domingos Nóbrega, Thaíly Ticiane Fernandes Araújo, Sarah Rayanne Santos Bezerra, Giovanna Miller Oliveira, Rebeca Monteiro Do Nascimento, Patrícia Angélica Miranda Silva Nogueira, Alecsandra Ferreira Tomaz, Ana Tereza Do Nascimento Sales Figueiredo Fernandes","doi":"10.1080/17476348.2025.2515992","DOIUrl":"https://doi.org/10.1080/17476348.2025.2515992","url":null,"abstract":"Introduction: Post acute and Long COVID-19 are a public health issue, marked by persistent respiratory and cardiovascular symptoms such as dyspnea and palpitations. These complications often extend beyond the acute phase, affecting even individuals with mild or moderate COVID-19. This article reviews the clinical impact of long COVID-19 and emphasizes the need for a multidisciplinary approach to management.Areas covered: A comprehensive literature search was conducted through PubMed, Medline, CINAHL, SciELO, and LILACS to identify studies published up to 28 October 2024, reporting on respiratory and cardiovascular sequelae in long COVID-19. This review examines the prevalence and characteristics of persistent symptoms such as dyspnea, cough, and palpitations, as well as the associated risk factors and assessment methods.Expert opinion: Long COVID-19 represents a significant healthcare challenge, underscoring the need for standardized protocols for diagnosis and treatment. A multidisciplinary approach is crucial to address the diverse symptoms of affected patients. Future research should focus on understanding the underlying pathophysiology, and developing targeted therapeutic strategies to improve patient outcomes.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incretins for management of obesity and obstructive sleep apnea. 肠促胰岛素治疗肥胖和阻塞性睡眠呼吸暂停。

Expert review of respiratory medicine Pub Date : 2025-06-03 DOI: 10.1080/17476348.2025.2513516

Xinxin Hu, Brendon John Yee, Craig Phillips, Julia Chapman, Ronald Grunstein

{"title":"Incretins for management of obesity and obstructive sleep apnea.","authors":"Xinxin Hu, Brendon John Yee, Craig Phillips, Julia Chapman, Ronald Grunstein","doi":"10.1080/17476348.2025.2513516","DOIUrl":"10.1080/17476348.2025.2513516","url":null,"abstract":"Introduction: Recent trials have demonstrated the efficacy of incretin-based pharmacotherapy in obstructive sleep apnea (OSA) in obese patients. In addition to improving sleep indices, these agents also led to sustained weight loss and improvements in cardiometabolic profile. Given cardiovascular mortality remains the most common cause of death among patients with OSA, these agents represent a potential paradigm shift toward more holist management approach toward patients with OSA.Areas covered: This article provides an overview of OSA pathophysiology, in particular, its overlapping risk factors with obesity. The physiology of the incretin axis is covered with reference to molecular targets of current therapies. Key trials in the use of incretins for diabetes and OSA are presented with critical discussion of knowledge gaps and scope for future research. The article focuses on newer incretin agents which appear to have dual activity against obesity and its cardiometabolic complications. Comparisons between incretin-based agents and current treatment modalities are explored including identification of knowledge gaps and future directions for research.Expert opinion: Incretin-based pharmacotherapy has the potential to transform the therapeutic landscape for OSA through their dual action on sleep-disordered breathing and obesity-related complications. Scope for future research remains to optimize patient selection, drug delivery, dosing, and equitable access and identify future molecular targets for OSA.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of lung injury and matrix metalloproteinase activation in ARDS could improve diagnostic and therapeutic strategies? 早期发现急性呼吸窘迫综合征患者的肺损伤和基质金属蛋白酶激活是否有助于改善诊断和治疗策略？

Expert review of respiratory medicine Pub Date : 2025-06-03 DOI: 10.1080/17476348.2025.2515993

Sang-Geon Cho, Sun-Joo Jang, Paul Heerdt, Stephanie L Thorn, Albert J Sinusas

引用次数: 0

What's new in the management of pulmonary complications in allogeneic stem cell transplantation? 同种异体干细胞移植中肺部并发症的处理有什么新进展？

Expert review of respiratory medicine Pub Date : 2025-06-02 DOI: 10.1080/17476348.2025.2513519

Louise Bondeelle, Guang-Shing Cheng, Anne Bergeron

{"title":"What's new in the management of pulmonary complications in allogeneic stem cell transplantation?","authors":"Louise Bondeelle, Guang-Shing Cheng, Anne Bergeron","doi":"10.1080/17476348.2025.2513519","DOIUrl":"10.1080/17476348.2025.2513519","url":null,"abstract":"Introduction: As survival increases after allogeneic hematopoietic stem cell transplantation (allo-HCT), several organ complications have emerged, including those involving the lung, which require a multidisciplinary management approach. The constant evolution of allo-HCT procedures, advances in diagnostic tools for infections and pulmonary disease, as well as new treatment approaches, require frequent updating of knowledge in this field.Areas covered: We review the multiple infectious and noninfectious lung complications that occur both early and late after allo-HCT. This includes an updated description of these complications, risk factors, diagnostic approach and outcome. A literature search was performed using PubMed-indexed journals.Expert opinion: The diagnosis of pulmonary complications after allo-HCT remains challenging, further complicated by the frequent association of co-infections and/or links between infection and noninfectious complications. The development of metagenomic next-generation sequencing (mNGS) should enhance the diagnostic yield of bronchoalveolar lavage, but its clinical relevance remains to be evaluated. A better understanding of the pathophysiology of the lung chronic graft-versus-host disease (GVHD) and improved phenotyping are essential for advancing its diagnostic and therapeutic management. This requires a revision of diagnostic criteria and the identification of new biomarkers of early disease.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and future outlook in clinical trials for treating systemic sclerosis-interstitial lung disease. 系统性硬化症-间质性肺疾病临床研究进展及展望

Expert review of respiratory medicine Pub Date : 2025-06-01 Epub Date: 2025-04-08 DOI: 10.1080/17476348.2025.2490729

Marzieh Jamali, Rocio Bautista Sanchez, Prachi Agarwal, Dinesh Khanna

{"title":"Advances and future outlook in clinical trials for treating systemic sclerosis-interstitial lung disease.","authors":"Marzieh Jamali, Rocio Bautista Sanchez, Prachi Agarwal, Dinesh Khanna","doi":"10.1080/17476348.2025.2490729","DOIUrl":"10.1080/17476348.2025.2490729","url":null,"abstract":"Introduction: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is a common complication of systemic sclerosis (SSc), contributing significantly to morbidity and mortality. We aim to bridge knowledge gaps, inform clinical practice, and identify future research directions in this rapidly evolving field.Areas covered: This review provides a comprehensive analysis of the current understanding and emerging advances in the diagnosis, risk stratification, and treatment of SSc-ILD. High-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) remain cornerstones of diagnosis, but limitations in sensitivity underscore the need for biomarkers such as Chemokine (C-C motif) Ligand 18 (CCL18), Krebs von den Lungen-6 (KL-6), Interleukin-6 (IL-6), and C-reactive protein (CRP) to enhance prognostic precision and treatment personalization. Therapeutic strategies emphasize immunosuppressants alongside antifibrotic agents. Emerging combination therapies and advanced modalities, including hematopoietic stem cell transplantation and chimeric antigen receptor T-cell therapy, show promise in refractory cases. Ongoing clinical trials exploring innovative targets highlight the evolving therapeutic landscape. The review emphasizes challenges in clinical trial design, advocating for adaptive and platform trial methodologies to address disease heterogeneity and enhance treatment sensitivity.Expert opinion: Advances in biomarkers, composite indices, and personalized therapeutic approaches are key to overcoming existing limitations and improving outcomes for patients with SSc-ILD.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"521-533"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approaches to reduce the risk of severe asthma in children with preschool wheeze. 降低学龄前喘息儿童严重哮喘风险的方法。

Expert review of respiratory medicine Pub Date : 2025-06-01 Epub Date: 2025-04-12 DOI: 10.1080/17476348.2025.2491722

Andrew Bush, Bianca Schaub

{"title":"Approaches to reduce the risk of severe asthma in children with preschool wheeze.","authors":"Andrew Bush, Bianca Schaub","doi":"10.1080/17476348.2025.2491722","DOIUrl":"10.1080/17476348.2025.2491722","url":null,"abstract":"Introduction: Asthma is a common, serious condition. We can treat the symptoms of mild-moderate disease, but severe asthma is life-threatening despite treatment. We cannot cure asthma and have no specific preventive strategies.Areas covered: We performed a PubMed search using the terms 'Severe asthma' and 'Prevention' and 'Preschool wheeze' limited to children, humans and English language over the previous five years. We searched the bibliographies of relevant references and also our personal archives. We cover transgenerational, antenatal and early life factors which increase the risk of pre-school wheeze; the factors promoting or protecting the pre-school wheezer from developing school age asthma; and the factors leading to one of the three types of severe asthma defined by WHO (untreated, difficult to treat, and treatment resistant).Expert opinion: Currently we have no pharmacological preventive strategies. Risk can be reduced by public health measures such as reduction in smoking and environmental pollution, and there are tantalizing hints from comparison of farming to other environments that exploring how environmental modulation may lead to more specific, personalized strategies. The effects of the new RSV prevention strategies are awaited. We need a better understanding of the pathways driving disease progression, and biomarkers of risk.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"535-550"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis and prediction of the burden of COPD in original BRICS countries from 1990 to 2050. 1990 年至 2050 年金砖五国原住民慢性阻塞性肺病负担分析与预测。

Expert review of respiratory medicine Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.1080/17476348.2025.2488961

Daidi Gui, Long Zhang, Chuting Wang, Wenjing Zou, Linxin Liu, Jinfeng He, Xinman Qian, Rui Ding

{"title":"Analysis and prediction of the burden of COPD in original BRICS countries from 1990 to 2050.","authors":"Daidi Gui, Long Zhang, Chuting Wang, Wenjing Zou, Linxin Liu, Jinfeng He, Xinman Qian, Rui Ding","doi":"10.1080/17476348.2025.2488961","DOIUrl":"10.1080/17476348.2025.2488961","url":null,"abstract":"Background: The Original BRICS countries (Brazil, Russia, India, China, and South Africa) face similar challenges of a significant increase in the burden of chronic obstructive pulmonary disease (COPD).Research design and methods: This analysis, based on data from the 2021 Global Burden of Disease (GBD 2021), examined trends in the incidence, mortality, and disability-adjusted life years (DALYs) rates of COPD in Original BRICS countries from 1990 to 2021. Linear regression was used to estimate the annual percentage change (EAPC) of age-standardized rates (ASR), and Bayesian age-period-cohort (BAPC) model was used to predict the COPD burden in 2050.Results: The disease burden increased with age in 2021, particularly after 45 years old, with significant gender disparities. From 1990 to 2021, the EAPC for age-standardized incidence, mortality, and DALYs rates decreased, with China experiencing the sharpest decline. The COPD burden is predicted to be alleviated across Original BRICS countries in 2050, although men will still be more affected than women.Conclusion: Despite the substantial improvements, the burden of COPD remains substantial in Original BRICS countries. In 2050, COPD is expected to more pronouncedly affect middle-aged and elderly populations, as well as people exposed to tobacco and environmental pollution.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"619-628"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming pulmonary health care: the role of artificial intelligence in diagnosis and treatment. 转型肺部卫生保健：人工智能在诊断和治疗中的作用。

Expert review of respiratory medicine Pub Date : 2025-06-01 Epub Date: 2025-04-15 DOI: 10.1080/17476348.2025.2491723

Farzat Farha, Sageer Abass, Saba Khan, Javed Ali, Bushra Parveen, Sayeed Ahmad, Rabea Parveen

{"title":"Transforming pulmonary health care: the role of artificial intelligence in diagnosis and treatment.","authors":"Farzat Farha, Sageer Abass, Saba Khan, Javed Ali, Bushra Parveen, Sayeed Ahmad, Rabea Parveen","doi":"10.1080/17476348.2025.2491723","DOIUrl":"10.1080/17476348.2025.2491723","url":null,"abstract":"Introduction: Respiratory diseases like pneumonia, asthma, and COPD are major global health concerns, significantly impacting morbidity and mortality rates worldwide.Areas covered: A selective search on PubMed, Google Scholar, and ScienceDirect (up to 2024) focused on AI in diagnosing and treating respiratory conditions like asthma, pneumonia, and COPD. Studies were chosen for their relevance to prediction models, AI-driven diagnostics, and personalized treatments. This narrative review highlights technological advancements, clinical applications, and challenges in integrating AI into standard practice, with emphasis on predictive tools, deep learning for imaging, and patient outcomes.Expert opinion: Despite these advancements, significant challenges remain in fully integrating AI into pulmonary health care. The need for large, diverse datasets to train AI models is critical, and concerns around data privacy, algorithmic transparency, and potential biases must be carefully managed. Regulatory frameworks also need to evolve to address the unique challenges posed by AI in health care. However, with continued research and collaboration between technology developers, clinicians, and policymakers, AI has the potential to revolutionize pulmonary health care, ultimately leading to more effective, efficient, and personalized care for patients.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"575-595"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Willingness to engage in self-care impacts clinical outcomes at discharge in hospitalized pneumonia patients: a descriptive study. 参与自我护理的意愿影响住院肺炎患者出院时的临床结果：一项描述性研究。

Expert review of respiratory medicine Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1080/17476348.2025.2489735

María Granados-Santiago, Geraldine Valenza-Peña, Ana Belén Gámiz-Molina, Julia Raya-Benítez, Alejandro Heredia-Ciuró, Laura López-López, Marie Carmen Valenza

{"title":"Willingness to engage in self-care impacts clinical outcomes at discharge in hospitalized pneumonia patients: a descriptive study.","authors":"María Granados-Santiago, Geraldine Valenza-Peña, Ana Belén Gámiz-Molina, Julia Raya-Benítez, Alejandro Heredia-Ciuró, Laura López-López, Marie Carmen Valenza","doi":"10.1080/17476348.2025.2489735","DOIUrl":"10.1080/17476348.2025.2489735","url":null,"abstract":"Background: The objective of this study was to evaluate the association between willingness to engage in self-care and clinical outcomes in patients hospitalized with community-acquired pneumonia (CAP).Methods: An observational study in patients hospitalized with CAP was conducted. Patients were divided into two groups according to the willingness to engage in self-care, which was assessed with the Patient Activation Measure (PAM). Participants with scores ≤47.0 points were included in the unwillingness to engage in self-care group, and patients with PAM score >47 points were included in the willingness to engage in self-care group. Main variables were assessed at hospital discharge and included clinical symptoms (cough, dyspnea, pain, and fatigue), physical status, activity levels, psychological inflexibility and restrictions in daily life activities and social participation.Results: A total of 66 patients were included in the study (34 among the patients unwilling to engage and 32 among the patients willing to engage). Significant differences were found in clinical symptoms, psychological inflexibility, and restrictions in daily life activities and social participation in favor of patients' willingness to engage in self-care at hospital discharge.Conclusions: Patients with CAP willing to engage in self-care showed improvements in clinical symptoms, psychological flexibility, and fewer limitations in daily activities and social participation at discharge.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"629-634"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can humidified high flow reverse mucus plugging? 加湿高流量能逆转粘液堵塞吗？

Expert review of respiratory medicine Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI: 10.1080/17476348.2025.2490715

Claudia Crimi, Santi Nolasco

引用次数: 0