Expert review of respiratory medicine最新文献

Scoping review of the literature supporting the exclusion of pulmonary embolism without radiation in children. 对支持排除儿童无放疗肺栓塞的文献进行范围综述。

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-22 DOI: 10.1080/17476348.2025.2576336

Jeffrey A Kline, Angela M Ellison, Nathan Kuppermann

{"title":"Scoping review of the literature supporting the exclusion of pulmonary embolism without radiation in children.","authors":"Jeffrey A Kline, Angela M Ellison, Nathan Kuppermann","doi":"10.1080/17476348.2025.2576336","DOIUrl":"10.1080/17476348.2025.2576336","url":null,"abstract":"Introduction: Traditional dogma suggests that acute pulmonary embolism (PE) occurs rarely in children <18 years. However, in the emergency department (ED) setting, the frequency of PE diagnosis in children with signs or symptoms that raise suspicion for PE is unknown. This uncertainty is fueled by the lack of prospective studies of PE exclusion and diagnosis in children. Children occasionally die unexpectedly from an acute PE that was missed during the initial evaluation by a physician. However, over-testing also carries risks.Areas covered: This review addresses the risks of over-testing and radiation exposure, and the use of clinical criteria to assess the pretest probability of PE to decide when to test for this condition in children. We discuss what is known about the theoretical test threshold and the unstructured and structured pretest probability of PE assessment in children. Additionally, we review the theory behind the D-dimer assay and the current literature that has reported the diagnostic accuracy of the D-dimer for PE in children.Expert opinion: We propose a hypothetical clinical algorithm that incorporates the use of a prediction rule that relies upon both unstructured and structured pretest probability assessments, coupled with the D-dimer to safely rule out the diagnosis of PE in children without the use of radiation.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of and risk factors for bronchiectasis in inflammatory bowel disease: a chest CT-based case-control study. 炎症性肠病中支气管扩张的患病率和危险因素：一项基于胸部ct的病例对照研究

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-21 DOI: 10.1080/17476348.2025.2576337

Jiaqi Ren, Lina Sun, Meijiao Li, Xun Liu, Shigang Ding, Yongchang Sun

{"title":"The prevalence of and risk factors for bronchiectasis in inflammatory bowel disease: a chest CT-based case-control study.","authors":"Jiaqi Ren, Lina Sun, Meijiao Li, Xun Liu, Shigang Ding, Yongchang Sun","doi":"10.1080/17476348.2025.2576337","DOIUrl":"10.1080/17476348.2025.2576337","url":null,"abstract":"Background: To identify the prevalence, clinical and imaging characteristics, and the risk factors for bronchiectasis in IBD.Research design and methods: We retrospectively enrolled IBD patients from 1 January 2020 to 1 July 2022. Chest HRCT was evaluated for the presence and severity of bronchiectasis. The clinical characteristics were compared between the IBD patients with and without bronchiectasis.Results: Among the 429 IBD patients, 34.5% showed bronchiectasis on chest HRCT. Four main imaging characteristics of bronchiectasis showed in IBD patients: multiple lobe involvement: 72.3% (107/148) of the patients had ≥2 lobes involved; Central predominance (>50%) in distribution; Mostly cylindrical bronchiectasis (>90%); Mild severity in most cases with Smith score <4 and Bhalla score of one point. Multi-factor logistic regression analysis showed that age of IBD onset ≥35 years (OR = 2.05, 95%CI 1.26-3.32), history of immunosuppressant therapy (OR = 3.93, 95%CI 2.12-7.27), ESR > 20 mm/h (OR = 2.01, 95%CI 1.21-3.33) and positive ASCA (OR = 1.37, 95% CI 1.06-1.77) were independently associated with the presence of bronchiectasis in IBD.Conclusions: More than 1/3 IBD patients in our cohort presented bronchiectasis on chest HRCT, with almost no respiratory symptoms and the mild degree of bronchiectasis, which is easily overlooked. IBD patients may need routine chest HRCT scanning for bronchiectasis.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into sinonasal disease in patients with primary ciliary dyskinesia. 原发性纤毛运动障碍患者鼻窦疾病的认识。

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-20 DOI: 10.1080/17476348.2025.2577483

Ela Erdem Eralp, Bulent Karadag

{"title":"Insights into sinonasal disease in patients with primary ciliary dyskinesia.","authors":"Ela Erdem Eralp, Bulent Karadag","doi":"10.1080/17476348.2025.2577483","DOIUrl":"10.1080/17476348.2025.2577483","url":null,"abstract":"Introduction: Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by impaired motile ciliary function, resulting in defective mucociliary clearance and chronic sinopulmonary disease. Although lower airway manifestations are well known, sinonasal disease is often underrecognized or undertreated outside specialist centers, particularly in adults and in settings without routine Ear-Nose-Throat evaluation.Areas covered: Despite its clinical burden, standardized diagnostic and therapeutic protocols for sinonasal disease in PCD are limited. This review synthesizes current knowledge on the pathophysiology, clinical presentation, diagnostic approaches, and management strategies for sinonasal involvement in PCD based on recent publications. Additionally, the review highlights the burden of disease and its impact on quality of life, role of genotype-phenotype correlations, and the emerging need for disease-specific outcome measures.Expert opinion: Despite growing evidence, diagnosis and management remain inconsistent due to a lack of standardized tools and guidelines. Multidisciplinary care and implementation of validated outcome measures are essential to optimize clinical follow-up and improve quality of life in this population. Future advances in imaging, microbiome profiling, and personalized interventions are needed. Furthermore, defining a standardized criteria for sinonasal exacerbations and integrating upper airway outcomes into clinical studies will be critical for advancing both research and patient care.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.7,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COPD and the burden of multimorbidity: navigating the complexity. 慢性阻塞性肺病和多重疾病的负担：在复杂性中导航。

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-07 DOI: 10.1080/17476348.2025.2569126

Maria Kallieri, Georgios Hillas, Konstantinos Bartziokas, Stelios Loukides, Dimitrios Toumpanakis

{"title":"COPD and the burden of multimorbidity: navigating the complexity.","authors":"Maria Kallieri, Georgios Hillas, Konstantinos Bartziokas, Stelios Loukides, Dimitrios Toumpanakis","doi":"10.1080/17476348.2025.2569126","DOIUrl":"https://doi.org/10.1080/17476348.2025.2569126","url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease (COPD) is a chronic condition that affects millions of people worldwide. The majority of patients with COPD have multiple coexisting chronic diseases, such as cardiovascular diseases, osteoporosis, lung cancer, and metabolic syndrome, a phenomenon that is known as multimorbidity. The coexistence of these diseases with COPD complicates diagnosis, treatment, and prognosis.Areas covered: This review explores the underlining mechanisms that connect COPD and multimorbidity, such as shared risk factors and pathophysiological pathways. It also highlights the challenges in managing multimorbid patients and emphasizes the fact that the complexity of comorbidities may require a multidisciplinary approach in COPD management.Expert opinion: Managing COPD in the context of multimorbidity requires a multidisciplinary approach. This approach should combine pharmacological and non-pharmacological treatments for COPD, adhere to evidence-based guidelines for managing comorbidities, and target modifiable shared risk factors to improve overall patient outcomes.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-16"},"PeriodicalIF":2.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in type 2-high asthma therapy: what remains missing? 2型高哮喘治疗的进展：还缺少什么？

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-07 DOI: 10.1080/17476348.2025.2569844

Ahmad Z Al Meslamani, Anan S Jarab, Abdullah Elrefae

{"title":"Advances in type 2-high asthma therapy: what remains missing?","authors":"Ahmad Z Al Meslamani, Anan S Jarab, Abdullah Elrefae","doi":"10.1080/17476348.2025.2569844","DOIUrl":"10.1080/17476348.2025.2569844","url":null,"abstract":"Introduction: Type 2-high asthma (T2HA) accounts for most severe asthma morbidity and is driven by eosinophilic, IgE- and alarmin-mediated inflammation. Although five biologics are licensed, many patients remain symptomatic, corticosteroid-dependent or financially excluded.Areas covered: PubMed, Embase, Web of Science, Scopus, Cochrane Library, EconLit, ClinicalTrials.gov and WHO-ICTRP were searched (1 January 2005 - 30 June 2025). Evidence from randomized trials, economic evaluations and translational studies on biologics, small-molecule drugs, cell-based and microbiome-directed interventions was synthesized across four domains: late-stage attrition, ultra-long-acting biologic limitations, slow small-molecule progress, and cost - access barriers. Durability, pediatric data and OCS-sparing potential were also examined.Expert opinion: Phenotype-guided biologics have replaced corticosteroid escalation after two decades of research; nevertheless, plateaus in effectiveness, uncertain long-term safety profiles, and exorbitant costs persist. Future progress will depend on value-based pricing that facilitates global adoption, adaptive biomarker-anchored clinical trials, rational combination or bispecific therapeutics, and rigorous post-marketing surveillance of cell-based and microbiome-directed therapies. Delivering sustainable, equitable management of T2HA necessitates the coordination of scientific, regulatory, and economic mechanisms rather than focusing on increasingly narrow cytokine targets.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-14"},"PeriodicalIF":2.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimorbidity in the modulator era: challenges of managing an ageing cystic fibrosis population. 调节剂时代的多病：管理老龄化囊性纤维化人群的挑战。

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-05 DOI: 10.1080/17476348.2025.2568244

Alex Chan, Freddy Frost, Dilip Nazareth

{"title":"Multimorbidity in the modulator era: challenges of managing an ageing cystic fibrosis population.","authors":"Alex Chan, Freddy Frost, Dilip Nazareth","doi":"10.1080/17476348.2025.2568244","DOIUrl":"10.1080/17476348.2025.2568244","url":null,"abstract":"Introduction: Cystic Fibrosis (CF) is an autosomal recessive disorder caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, leading to defective chloride ion transport and multisystem disease. The introduction of CFTR modulators, particularly elexacaftor/tezacaftor/ivacaftor (ETI), has significantly improved life expectancy and quality of life for people with CF (pwCF). As survival increases, an aging CF population faces different new challenges.Areas covered: This review aims to highlight emerging challenges and comorbidities in an aging CF population to ensure sustained benefits from recent therapeutic advancements. The review includes the discussion of the changes in lung function, nutrition, cardiometabolic diseases, malignancy risk and psychosocial health. A structured literature search was conducted using PubMed, focusing on articles published between 2000 and 2025, including recent clinical trials and international guidelines. National registry data has also been reviewed.Expert opinion: With CFTR modulators progress rapidly, the future focus should shift to refining and optimizing CF care. Standard practice should involve a multidisciplinary, proactive and preventative strategy to manage co-morbidities, ensuring the ultimate goal moving from simply extending pwCF's life to ensuring a high quality of life throughout their lifespan.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of artificial intelligence for the detection of obstructive sleep apnea based on clinical and demographic data: a systematic review. 基于临床和人口统计数据的人工智能在阻塞性睡眠呼吸暂停检测中的应用：系统综述。

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-05 DOI: 10.1080/17476348.2025.2567046

Manuel Casal-Guisande, Mar Mosteiro-Añón, María Torres-Durán, Alberto Comesaña-Campos, Alberto Fernández-Villar

{"title":"Application of artificial intelligence for the detection of obstructive sleep apnea based on clinical and demographic data: a systematic review.","authors":"Manuel Casal-Guisande, Mar Mosteiro-Añón, María Torres-Durán, Alberto Comesaña-Campos, Alberto Fernández-Villar","doi":"10.1080/17476348.2025.2567046","DOIUrl":"10.1080/17476348.2025.2567046","url":null,"abstract":"Introduction: Artificial intelligence (AI) has shown promise in enhancing the detection and stratification of obstructive sleep apnea (OSA) using clinical and demographic data. This systematic review assessed the effectiveness of AI models, methodological quality, and future research needs.Methods: Following PRISMA guidelines, a systematic search of PubMed (2014-2024) identified studies applying AI to detect or stratify OSA using clinical/demographic data, validated against polysomnography or cardiorespiratory polygraphy, and reporting performance metrics such as the area under the curve (AUC). Studies primarily based on wearable devices were excluded. Methodological quality and risk of bias were evaluated using the PROBAST tool.Results: Of 447 records, 26 met inclusion criteria. Common algorithms included decision trees, support vector machines, and neural networks, frequently using variables such as age, BMI, neck circumference, and comorbidities. AUC values ranged from 0.62 to 0.93, with most exceeding 0.80. Research output increased substantially between 2021 and 2024. Methodological heterogeneity and limited external validation hindered comparability. Exclusion of incomplete cases was a recurrent issue.Conclusions: AI models show potential for improving OSA detection, but methodological limitations restrict generalizability. Future studies should prioritize external validation, diverse populations, and adherence to standardized reporting frameworks to enable clinical translation.Protocol registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251025868 identifier is CRD420251025868.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-18"},"PeriodicalIF":2.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High burden of severe and very severe undernutrition among adults with tuberculosis: findings from a state wide operational research in Chhattisgarh, India. 成人结核病患者严重和极严重营养不良的高负担：来自印度恰蒂斯加尔邦一项全国性业务研究的结果。

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-05 DOI: 10.1080/17476348.2025.2569845

Vishnu Gupta, Chetanya Malik, Kalpita Shringarpure, Himanshu A Gupte, Hemant D Shewade, Khemraj Sonwani, Vikash Ranjan Keshri

{"title":"High burden of severe and very severe undernutrition among adults with tuberculosis: findings from a state wide operational research in Chhattisgarh, India.","authors":"Vishnu Gupta, Chetanya Malik, Kalpita Shringarpure, Himanshu A Gupte, Hemant D Shewade, Khemraj Sonwani, Vikash Ranjan Keshri","doi":"10.1080/17476348.2025.2569845","DOIUrl":"10.1080/17476348.2025.2569845","url":null,"abstract":"Background: Undernutrition drives the TB epidemic in India with 4-5 times higher mortality among adults with severe/very severe undernutrition. We assessed proportion of severe/very severe undernutrition among adults with TB and timeliness in receiving monetary support for nutrition (Direct benefit transfer-DBT) and food baskets.Research design and methods: This analytical cross-sectional study conducted in Chhattisgarh, tribal Indian state, utilized program data of adults with TB notified in public facilities under the National TB Elimination Program from April-June 2024. Body Mass Index (BMI) was categorized for nutritional status and equity in distribution of DBT and foodbaskets was evaluated using frequency, proportions, and Chi-square for trend.Results: Of 6568 adults with TB, BMI was calculated for 6397 (97%). Proportion of severe and very severe undernutrition was 22% and 13% respectively. First DBT instalment was received by 81%, with 29% receiving it within two months; 21% received foodbaskets, with similar coverage across all undernutrition categories (p > 0.05), reflecting inequity.Conclusions: There is a high burden of severe/very severe undernutrition among TB patients. Similar DBT and food basket coverage among those with severe/very severe undernutrition and other TB patients indicates inequity in distribution. Undernutrition-basedindicators and linkage of DBT and food baskets should be prioritized.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-7"},"PeriodicalIF":2.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do we know about respiratory syncytial virus in Türkiye? 我们知道呼吸道合胞病毒在<s:1>基耶病毒？

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-04 DOI: 10.1080/17476348.2025.2569125

Dilşah Başkol Elik, Gökhan Vatansever, Selin Ece Taşbakan, Serdal Ateş, Hüsnü Pullukçu, Meltem Taşbakan, İftihar Köksal

{"title":"Do we know about respiratory syncytial virus in Türkiye?","authors":"Dilşah Başkol Elik, Gökhan Vatansever, Selin Ece Taşbakan, Serdal Ateş, Hüsnü Pullukçu, Meltem Taşbakan, İftihar Köksal","doi":"10.1080/17476348.2025.2569125","DOIUrl":"10.1080/17476348.2025.2569125","url":null,"abstract":"Background: Respiratory Syncytial Virus (RSV) is a major cause of severe respiratory illness in infants, older adults, and immunocompromised individuals. However, data on physicians' knowledge and attitudes toward RSV and its prevention in Türkiye are limited. The aim of this study was to evaluate the knowledge and attitudes of physicians in Türkiye about RSV.Research design and methods: A cross-sectional online survey was conducted among physicians in Türkiye between October and November 2024.Results: A total of 1270 physicians (median age: 35; 62.44% female) participated, 30.5% of whom specialized in Infectious Diseases (ID). While 43.54% correctly identified RSV symptoms, only 15.9% recognized high-risk groups, and 49.7% were familiar with associated clinical conditions. ID specialists had significantly greater knowledge of symptoms (p = 0.015) and complications (p < 0.001) compared to other physicians. Overall, 51.57% perceived the national RSV burden as high. However, only 40.31% were aware of prevention tools. Although 51.88% knew about FDA-approved RSV vaccines, just 21.54% knew they were not yet available in Türkiye. Among vaccine-aware participants, most would recommend it to elderly (85.28%), while fewer supported maternal vaccination (58.87%).Conclusions: These findings reveal that despite higher knowledge among ID physicians, overall awareness of RSV and its prevention is inadequate.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impairment of neural mechanosensitivity in the Long COVID haulers. COVID - 19长途运输车辆神经力学敏感性损伤。

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-10-02 DOI: 10.1080/17476348.2025.2568243

Andrés Calvache-Mateo, Alberto Rodríguez-López, Alba Navas-Otero, Javier Martín Núñez, Alejandro Heredia-Ciuró, Laura López-López, Marie Carmen Valenza

{"title":"Impairment of neural mechanosensitivity in the Long COVID haulers.","authors":"Andrés Calvache-Mateo, Alberto Rodríguez-López, Alba Navas-Otero, Javier Martín Núñez, Alejandro Heredia-Ciuró, Laura López-López, Marie Carmen Valenza","doi":"10.1080/17476348.2025.2568243","DOIUrl":"10.1080/17476348.2025.2568243","url":null,"abstract":"Background: The aim of this study was to evaluate and characterize the alteration in mechanosensitivity in Long COVID haulers as well as its impact on patients' functionality and quality of life.Research design and methods: In this study there were two groups: a group of Long COVID haulers and a group of healthy controls matched for age and sex. The mechanosensitivity clinical profile and peripheral nerve mechanosensitivity were evaluated. The mechanosensitivity clinical profile included the functionality and quality of life (World Health Organization Disability Assessment Schedule 2.0, Patient-Reported Outcomes Measurement Information System, EuroQol-5 Dimensions) and neural mechanosensitivity (Leeds Assessment of Neuropathic Symptoms and Signs). The peripheral nerve mechanosensitivity included neurodynamic tests (median, radial, ulnar, slump test and straight leg raise).Results: A total of 64 patients were included in the study (Long COVID haulers group n = 33, healthy controls group n = 31). Long COVID haulers group obtained significantly worse results in functionality (p < 0.001), quality of life (p < 0.001), neural mechanosensitivity (p < 0.001) and peripheral nerve mechanosensitivity (p < 0.001).Conclusions: Long COVID haulers have significant alterations in neural mechanosensitivity, contributing to a greater degree of functional impairment and poorer quality of life.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-7"},"PeriodicalIF":2.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0