Expert review of respiratory medicine最新文献

Clesrovimab, a monoclonal antibody for the prevention of respiratory syncytial virus disease in infants: a drug profile. 用于预防婴儿呼吸道合胞病毒疾病的单克隆抗体Clesrovimab：药物概况

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-03 DOI: 10.1080/17476348.2026.2729505

Margarethe Wiedenmann, Ziyaad Dangor, Shabir A Madhi

{"title":"Clesrovimab, a monoclonal antibody for the prevention of respiratory syncytial virus disease in infants: a drug profile.","authors":"Margarethe Wiedenmann, Ziyaad Dangor, Shabir A Madhi","doi":"10.1080/17476348.2026.2729505","DOIUrl":"https://doi.org/10.1080/17476348.2026.2729505","url":null,"abstract":"Introduction: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection (LRTI) in young children. In children < 5 years old, it causes an estimated 33 million LRTI episodes and over 100,000 deaths annually, two-thirds of which occur in infants. The licensure of new long-acting monoclonal antibodies and a maternal RSV vaccine offer opportunities for reducing RSV related infant morbidity and mortality.Areas covered: This drug profile reviews clesrovimab (Enflonsia, Merck & Co. Inc. Rahway, NJ U.S.A.), an extended half-life human IgG1κ monoclonal antibody, targeting the highly conserved antigenic site IV of the RSV fusion protein. We synthesize evidence from phase 1 to phase 3 clinical trials, pharmacokinetic and pharmacodynamic data, regulatory approvals and resistance profiling, drawing on peer-reviewed literature and regulatory sources available until May 2026.Expert opinion: Clesrovimab offers a single, fixed-dose, weight-independent injection per RSV season, with demonstrated safety and efficacy against medically attended RSV disease and hospitalization in infants. Its epitope target is distinct from that of nirsevimab (site Ø) and no cross resistance between the two antibodies has been observed in vitro. Equitable global access to monoclonal antibodies, particularly for low- and middle-income countries, remains critical to reduce the global RSV burden.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upper lobe predominance of fibrocavitary mycobacterial lung disease: physiological, biochemical, and biomechanical mechanisms. 纤维空洞分枝杆菌肺病的上肺叶优势：生理、生化和生物力学机制。

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-02 DOI: 10.1080/17476348.2026.2727166

Edward D Chan, Béla Suki

引用次数: 0

The effect of flooding on respiratory health in children and adults. 洪水对儿童和成人呼吸系统健康的影响。

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-02 DOI: 10.1080/17476348.2026.2726581

Erol A Gaillard

{"title":"The effect of flooding on respiratory health in children and adults.","authors":"Erol A Gaillard","doi":"10.1080/17476348.2026.2726581","DOIUrl":"10.1080/17476348.2026.2726581","url":null,"abstract":"Introduction: The occurrence of severe storms and floods has steadily increased over the last decades world-wide because of climate change and global warming. Flooding events have important effects on respiratory health especially in vulnerable populations. Some health effects are immediate, such as respiratory infections, asthma attacks and chronic obstructive pulmonary disease exacerbations. An important immediate risk arises for patients with technology dependent respiratory conditions if power supplies fail. Post-flood, indoor damp and mold develop in flooded homes creating a high risk of developing chronic respiratory disease in residents.Areas covered: This review summarizes what is known about the immediate and the medium- to long-term effects of flooding on respiratory health. The negative health effects of prolonged living in a damp and moldy home are discussed.Expert opinion: Climate change and global warming appear to be progressing at a more rapid pace than previously predicted and this will increase the number and the severity of global storm and flood events. Floods pose a substantial risk to patients with chronic respiratory disease and health systems world-wide need to be more aware and prepare to manage the immediate and the long-term needs of increasing numbers of patients affected by natural disasters.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-13"},"PeriodicalIF":2.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of physical rehabilitation interventions on pulmonary hypertension: an overview of systematic reviews of randomized controlled trials. 物理康复干预对肺动脉高压的影响：随机对照试验的系统综述。

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-01 Epub Date: 2026-05-18 DOI: 10.1080/17476348.2026.2675630

Natália Lopes Cardoso, Ilsa Priscila Santos, Luciana Mendes, Rodrigo Torres-Castro, Jordi Vilaró, Elena Gimeno-Santos, Isabel Blanco, Guilherme Fregonezi, Vanessa Resqueti

{"title":"Effects of physical rehabilitation interventions on pulmonary hypertension: an overview of systematic reviews of randomized controlled trials.","authors":"Natália Lopes Cardoso, Ilsa Priscila Santos, Luciana Mendes, Rodrigo Torres-Castro, Jordi Vilaró, Elena Gimeno-Santos, Isabel Blanco, Guilherme Fregonezi, Vanessa Resqueti","doi":"10.1080/17476348.2026.2675630","DOIUrl":"10.1080/17476348.2026.2675630","url":null,"abstract":"Introduction: Pulmonary hypertension (PH) is characterized by exertional dyspnea and reduced exercise capacity. This study aims to synthesize current evidence to guide more effective exercise-based interventions.Methods: This overview included systematic reviews (SRs) of randomized controlled trials in adults with PH that performed an exercise intervention as exercise training (ET), inspiratory muscle training (IMT) or combined training (CT). The main outcome was exercise capacity measured (e.g. six-minute walk test (6MWT) or cardiopulmonary exercise test (CPET). The searches were conducted in seven databases. Two independent reviewers conducted the analysis, with a third resolving disagreements. Methodological quality and certainty of evidence were assessed using AMSTAR-2 and GRADE, along with overlap analysis.Results: A total of 14 SRs were included, categorized into ET, IMT, and CT. All three interventions demonstrated improvements in functional capacity, with increases in 6MWT distance of >48.5 m (ET), 39.1 m (IMT), and 49.5 m (CT). VO2peak improved in ET and CT groups by >2.07 and >3.0 mL/kg/min, respectively. Only one study performed IMT, with gains. Overall, methodological quality was rated as critically low, with significant overlap across studies.Conclusion: These findings suggest a clinically significant benefit of exercise-based interventions, with a slight superiority of CT.Protocol registration: http://www.crd.york.ac.uk/prospero identifier is CRD42025643615.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1097-1107"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individualized TB care for drug-susceptible pulmonary tuberculosis: clinical alternatives when HRZE is contraindicated or not tolerated. 药物敏感肺结核的个体化结核病治疗：HRZE禁忌或不耐受时的临床选择

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-01 Epub Date: 2026-05-31 DOI: 10.1080/17476348.2026.2682314

Lucia Allavena, Jessica Mencarini, Giovanni Fumagalli, Antonio Di Biagio, Silvia Nozza, Andrea Calcagno, Maurizio Ferrarese, Marialuisa Valente, Stefania Cerri, Filippo Bartalesi, Luigi Ruffo Codecasa, Niccolò Riccardi

{"title":"Individualized TB care for drug-susceptible pulmonary tuberculosis: clinical alternatives when HRZE is contraindicated or not tolerated.","authors":"Lucia Allavena, Jessica Mencarini, Giovanni Fumagalli, Antonio Di Biagio, Silvia Nozza, Andrea Calcagno, Maurizio Ferrarese, Marialuisa Valente, Stefania Cerri, Filippo Bartalesi, Luigi Ruffo Codecasa, Niccolò Riccardi","doi":"10.1080/17476348.2026.2682314","DOIUrl":"10.1080/17476348.2026.2682314","url":null,"abstract":"Introduction: While the standard HRZE regimen is the cornerstone of drug-susceptible tuberculosis (DS-TB) treatment, its success is frequently undermined by treatment-limiting adverse drug reactions (ADRs) and complex drug-drug interactions (DDIs). In clinical practice, managing those situations remains a critical challenge often overlooked by guidelines. Effective toxicity management is essential to prevent treatment interruption, loss-to-follow up, relapse, and escalating healthcare costs.Areas covered: We provided a clinical framework for identifying and mitigating toxicities associated with HRZE regimen. Reviewing current literature and international guidelines, we analyzed different ADRs, provided safety profiles and management strategies for each HRZE drug. The discussion includes structured protocols for sequential drug re-challenge, management of high-risk populations, and DDIs. Furthermore, we evaluate evidence-based alternative regimens for cases where the standard of care is untenable.Expert opinion: DS-TB therapy must evolve from rigid protocols toward a precision medicine framework prioritizing patient safety alongside efficacy. We advocate for a 'shorter is better, less is more' approach, emphasizing regimen simplification and better-tolerated agents. Clinical success often depends on proactive communication between clinicians and patients, as well as individualized therapeutic adjustments, rather than on novel compounds alone. Bridging the gap between standardized guidelines and nuanced clinical judgment is vital for optimizing real-world outcomes.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1045-1054"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial/ethnic disparities in environmental respiratory allergies among cancer patients: national health interview survey analysis. 癌症患者环境呼吸过敏的种族差异：全国健康访谈调查分析。

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-01 Epub Date: 2026-05-06 DOI: 10.1080/17476348.2026.2670015

Lohuwa Mamudu, Yazmin Acosta, Erasmus Tetteh-Bator, Danny H Kim, Phillip Gedalanga, Bo Young Park, Mubarak Osman, Sampson E Akwafuo, Mohammad Masum, Paul H Atandoh

{"title":"Racial/ethnic disparities in environmental respiratory allergies among cancer patients: national health interview survey analysis.","authors":"Lohuwa Mamudu, Yazmin Acosta, Erasmus Tetteh-Bator, Danny H Kim, Phillip Gedalanga, Bo Young Park, Mubarak Osman, Sampson E Akwafuo, Mohammad Masum, Paul H Atandoh","doi":"10.1080/17476348.2026.2670015","DOIUrl":"10.1080/17476348.2026.2670015","url":null,"abstract":"Background: Environmental respiratory allergies (ERA) can worsen the quality of life of cancer patients. This study examined the prevalence, association, and racial/ethnic disparities in ERA diagnosis among cancer patients in the United States.Methods: We analyzed a retrospective cross-sectional dataset from the National Health Interview Survey (2021) involving weighted samples of 1,879 U.S. adults aged ≥18 years. Bivariate and multivariable analyses were conducted, adjusting for covariates.Results: The prevalence rate of ERA among cancer patients was 55.5%, with a significant difference among race/ethnicity. Non-Hispanic other/Multiracial had the highest prevalence of ERA (83.1%), followed by non-Hispanic Asians (68.2%), and non-Hispanic Black/African American (65.2%). Non-Hispanic Other/Multiracial cancer patients had significantly higher odds of ERA compared to non-Hispanic Whites in sociodemographic, socioeconomic, and fully adjusted models, respectively. Similarly, Non-Hispanic Blacks/African Americans had increased odds of ERA compared to non-Hispanic Whites (AOR = 1.58, 95% CI = 1.00-2.56) after adjusting for education and health insurance. Additionally, race/ethnic minority cancer patients were 1.22 times more likely to be at risk of ERA than their non-Hispanic White counterparts.Conclusion: This study demonstrates that racial/ethnic disparities exist in ERA diagnosis among cancer patients. Therefore, targeted interventions aimed at addressing these disparities can help improve the quality of life for cancer patients.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1109-1117"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of acute chest syndrome in children with sickle cell disease: impact of vaccination and respiratory panels. 镰状细胞病儿童急性胸综合征的治疗：疫苗接种和呼吸系统检查的影响

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-01 DOI: 10.1080/17476348.2026.2725915

Yaoping Zhang, Susannah F Vanderpool, Margaret R Hammerschlag

{"title":"Management of acute chest syndrome in children with sickle cell disease: impact of vaccination and respiratory panels.","authors":"Yaoping Zhang, Susannah F Vanderpool, Margaret R Hammerschlag","doi":"10.1080/17476348.2026.2725915","DOIUrl":"https://doi.org/10.1080/17476348.2026.2725915","url":null,"abstract":"Introduction: Acute chest syndrome (ACS) is a common sickle cell disease (SCD) complication. Infectious pathogens are the most common causes of ACS followed by pulmonary infarction and fat embolism. Infectious pathogens responsible for ACS include viruses, atypical bacteria (Mycoplasma pneumoniae and Chlamydia pneumoniae), and bacteria.Areas covered: The introduction of conjugate pneumococcal and Hemophilus influenzae b vaccines and implementation of penicillin prophylaxis has significantly reduced, but not eliminated the risk of bacterial infections in this population. However, pneumococcal infections still occur but may further decline with the introduction of expanded conjugate vaccines such as PCV20. The introduction of multiplexed PCR respiratory panels in 2014 has enabled more accurate diagnosis of the infectious pathogens responsible for ACS in children with SCD. Recent studies using these panels have found that the majority of cases of ACS were associated with viral infections. M. pneumoniae and C. pneumoniae infections were uncommon.Expert opinion: We suggest that empiric antibiotics in children with SCD presenting with ACS be limited to ceftriaxone. Azithromycin should only be used if the respiratory pathogen panel is positive for M. pneumoniae or C. pneumoniae, as azithromycin will remain in the system for over 7-days even if discontinued after one dose.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme temperature and airway dehydration: current understanding and integrative insights into respiratory vulnerability. 极端温度和气道脱水：目前对呼吸易感性的理解和综合见解。

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-01 Epub Date: 2026-05-19 DOI: 10.1080/17476348.2026.2674958

Yu-Syuan Shih, Chia-Li Han, Yueh Lun Lee, Feng-Ming Yang, Yuan-Hung Wang, Shu-Chuan Ho, Kang-Yun Lee, Kian Fan Chung, Kin-Fai Ho, Kai-Jen Chuang, Jer-Hwa Chang, Hsiao-Chi Chuang

{"title":"Extreme temperature and airway dehydration: current understanding and integrative insights into respiratory vulnerability.","authors":"Yu-Syuan Shih, Chia-Li Han, Yueh Lun Lee, Feng-Ming Yang, Yuan-Hung Wang, Shu-Chuan Ho, Kang-Yun Lee, Kian Fan Chung, Kin-Fai Ho, Kai-Jen Chuang, Jer-Hwa Chang, Hsiao-Chi Chuang","doi":"10.1080/17476348.2026.2674958","DOIUrl":"10.1080/17476348.2026.2674958","url":null,"abstract":"Introduction: Climate change has significantly increased the frequency and intensity of extreme temperature events, posing growing threats to respiratory health. Among the underlying mechanisms, airway dehydration is a critical yet underrecognized pathway that disrupts the airway surface liquid (ASL), which is essential for mucociliary clearance, epithelial integrity, and immune defense.Areas covered: This article examines evidence linking airway dehydration to respiratory disease during temperature extremes. We discuss how hot, dry air and cold, low-humidity conditions disrupt airway hydration balance, leading to impaired mucociliary clearance and increased susceptibility to infection and inflammation. The review summarizes the impacts of airway dehydration on vulnerable populations, including individuals with pre-existing respiratory conditions (asthma, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and cystic fibrosis), children, older adults, outdoor workers, and socioeconomically disadvantaged groups.Expert opinion: Airway dehydration represents a unifying mechanism linking climate extremes to respiratory vulnerability but remains underrepresented in clinical practice and public health strategies. We advocate for greater recognition of airway hydration in disease prevention, development of practical measurement tools, and targeted interventions for at-risk populations. Emphasizing airway dehydration as a key mediator offers opportunities to improve clinical management and develop effective climate adaptation strategies for respiratory health protection.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1055-1066"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in clinical and radiographic features of nontuberculous mycobacterial pulmonary disease in a Chinese population. 中国人群非结核性分枝杆菌肺病临床和影像学特征的性别差异

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-01 Epub Date: 2026-05-21 DOI: 10.1080/17476348.2026.2675633

LiHua Wu, JingXuan Xu, JunKai Qiao, ChunLong Fu, DongPing Hu, XinLing Pan, Li Hong, GongQiang Wu

{"title":"Sex differences in clinical and radiographic features of nontuberculous mycobacterial pulmonary disease in a Chinese population.","authors":"LiHua Wu, JingXuan Xu, JunKai Qiao, ChunLong Fu, DongPing Hu, XinLing Pan, Li Hong, GongQiang Wu","doi":"10.1080/17476348.2026.2675633","DOIUrl":"10.1080/17476348.2026.2675633","url":null,"abstract":"Background: Sex-related differences in nontuberculous mycobacterial pulmonary disease (NTM-PD) may influence both clinical presentation and radiographic phenotypes; however, evidence from Chinese populations remains limited.Research design and methods: This retrospective study included 218 patients with NTM-PD in China. Patients were stratified by sex. Clinical characteristics, comorbidities, laboratory parameters, and high-resolution computed tomography findings were compared. Logistic regression analyses were performed to evaluate the association between sex and specific radiographic manifestations.Results: Females had lower body mass index and higher rates of bronchiectasis and gastroesophageal reflux disease. The nodular bronchiectatic phenotype predominated in females (85.85%), with middle lobe/lingula involvement (71.70%). Female sex was independently associated with tree‑in‑bud opacities (p = 0.031). Males had higher rates of smoking, previous tuberculosis, and chronic obstructive pulmonary disease (COPD), and more fibrocavitary disease (25.00%), but cavitation was linked to smoking, tuberculosis, and COPD rather than sex (p = 0.118).Conclusions: Significant sex differences exist in the clinical and radiographic phenotypes of Chinese patients with NTM-PD. Limitations include the single-center retrospective design, relatively small sample size, lack of long-term follow-up data, and absence of sex hormone and environmental exposure assessments.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1119-1126"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of climate, air pollution, and urbanization on chronic respiratory infections. 气候、空气污染和城市化对慢性呼吸道感染的影响。

IF 2.7

Expert review of respiratory medicine Pub Date : 2026-09-01 Epub Date: 2026-05-25 DOI: 10.1080/17476348.2026.2675617

Paola Faverio, Veronica Capuano, Giovanni Franco, Antonio Morgante, Erika Panetta, Umberto Zanini, Enrico Cesare Maggioni, Paolo Pozzi, Lorenzo Del Castello, Stefano Aliberti, Fabrizio Luppi

{"title":"Impact of climate, air pollution, and urbanization on chronic respiratory infections.","authors":"Paola Faverio, Veronica Capuano, Giovanni Franco, Antonio Morgante, Erika Panetta, Umberto Zanini, Enrico Cesare Maggioni, Paolo Pozzi, Lorenzo Del Castello, Stefano Aliberti, Fabrizio Luppi","doi":"10.1080/17476348.2026.2675617","DOIUrl":"10.1080/17476348.2026.2675617","url":null,"abstract":"Introduction: chronic respiratory infections represent a significant source of global morbidity and mortality, especially among individuals with structural lung diseases or compromised defenses. Emerging evidence highlights the role of environmental factors, such as climate change, air pollution, and urbanization, in the epidemiology and progression of these infections.Areas covered: This review synthesizes current research on the interactions between climate conditions, pollution, and urbanization in bronchiectasis, cystic fibrosis, nontuberculous mycobacterial (NTM) pulmonary disease, and chronic pulmonary aspergillosis. A search of relevant medical literature in the English language was conducted in Medline/PubMed, EMBASE and Scopus up to January 2026.Increases in temperature, fluctuations in humidity, extreme weather events (e.g. heatwaves, floods, and cold spells), and elevated concentrations of particulate matter contribute to both pathogen proliferation and increased host susceptibility, which impact the severity and incidence of chronic respiratory infections, particularly those caused by environmental pathogens such as non-tuberculous mycobacteria and Aspergillus spp. respiratory infections. Higher urban density and changes in microbial ecosystems further enhance transmission and chronicity.Expert opinion: Understanding the complex interactions between environmental stressors and respiratory health and incorporating environmental risk assessment into clinical practice and public health policy is crucial for reducing disease burden in the context of accelerating climate change.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1083-1095"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0