Expert review of respiratory medicine最新文献

Advancements and challenges in the management of pneumonia in elderly patients with COPD. 慢性阻塞性肺病老年患者肺炎管理的进展与挑战。

Expert review of respiratory medicine Pub Date : 2024-11-06 DOI: 10.1080/17476348.2024.2422961

Sebastian Ocrospoma, Antonio Anzueto, Marcos I Restrepo

引用次数: 0

Recent advances in the use of liquid biopsy for the diagnosis and treatment of lung cancer. 利用液体活检诊断和治疗肺癌的最新进展。

Expert review of respiratory medicine Pub Date : 2024-11-03 DOI: 10.1080/17476348.2024.2423824

Valerio Gristina, Gianluca Russo, Tancredi Didier Bazan Russo, Giulia Busuito, Giuliana Iannì, Pasquale Pisapia, Claudia Scimone, Lucia Palumbo, Lorena Incorvaia, Giuseppe Badalamenti, Antonio Galvano, Viviana Bazan, Antonio Russo, Giancarlo Troncone, Umberto Malapelle, Francesco Pepe

{"title":"Recent advances in the use of liquid biopsy for the diagnosis and treatment of lung cancer.","authors":"Valerio Gristina, Gianluca Russo, Tancredi Didier Bazan Russo, Giulia Busuito, Giuliana Iannì, Pasquale Pisapia, Claudia Scimone, Lucia Palumbo, Lorena Incorvaia, Giuseppe Badalamenti, Antonio Galvano, Viviana Bazan, Antonio Russo, Giancarlo Troncone, Umberto Malapelle, Francesco Pepe","doi":"10.1080/17476348.2024.2423824","DOIUrl":"https://doi.org/10.1080/17476348.2024.2423824","url":null,"abstract":"Introduction: In the era of precision medicine, liquid biopsy rapidly emerges as an integrative diagnostic tool to successfully stratify solid tumor patients in accordance with molecular fingerprinting. As the matter of fact, a plethora of analytes may be isolated from liquid biosources supporting the potential application of liquid biopsy in several clinical scenarios. Despite this promising role, liquid biopsy is drastically affected by low abundance of analytes in biological matrix requiring highly sensitive technologies, trained personnel, and optimized diagnostic procedures to successfully administrate this revolutionary diagnostic tool in clinical practice.Areas covered: This review aims to investigate the recent advancements in technical approaches available to manage liquid biopsy samples, particularly focusing on their application in LC diagnosis and treatment.Expert opinion: The rapidly evolving scenario of liquid biopsy-based approaches is revolutionizing clinical administration of lung cancer patients. Of note, the integration of genomic, epigenomic, and transcriptomic markers lays the basis for 'comprehensive' molecular fingerprinting of lung cancer patients. Here, the next-generation technologies are fundamental in molecular profiling in diagnostic routine biofluids.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compatibility of the global lung function 2012 spirometry reference values in children, adolescents and young adults: a systematic review. 2012 年儿童、青少年和年轻成人肺功能参考值的兼容性：系统回顾。

Expert review of respiratory medicine Pub Date : 2024-11-03 DOI: 10.1080/17476348.2024.2421849

Bruna Weber Santos, Janaina Cristina Scalco, Paloma Lopes Francisco Parazzi, Camila Isabel Santos Schivinski

{"title":"Compatibility of the global lung function 2012 spirometry reference values in children, adolescents and young adults: a systematic review.","authors":"Bruna Weber Santos, Janaina Cristina Scalco, Paloma Lopes Francisco Parazzi, Camila Isabel Santos Schivinski","doi":"10.1080/17476348.2024.2421849","DOIUrl":"10.1080/17476348.2024.2421849","url":null,"abstract":"Introduction: The Global Lung Function Initiative (GLI 2012) has published multiethnic spirometry reference values. To identify studies that evaluated the compatibility (applicability, validity, representativeness, agreement and/or adequacy) of the reference equations proposed by the GLI 2012 for spirometry tests in different populations.Methods: Systematic searches were carried out on the PubMed, LILACS (Latin American and Caribbean Health Sciences Literature), Scopus, Web of Science and Google Scholar databases. Cross-sectional observational studies published between 2012 and 2013 onwards that evaluated the compatibility of the GLI 2012 in children, adolescents and young adults (3-20 years old) were included. The references were manually searched and the Joanna Briggs Institute Critical Appraisal Checklist for Cross-Sectional Analytical Studies was applied to assess the methodological quality of the studies included.Results: All of the 5632 studies identified were classified as low risk of bias, but only 21 were deemed eligible for inclusion. Of these, 8 reported satisfactory GLI 2012 compatibility for their populations (Argentina, Spain, Columbia, Djibouti, Norway, Poland, Jordan and Zimbabwe), 5 cautious applicability, and the remaining 8 considered the equation unsatisfactory, since it over or underestimated spirometric parameters.Conclusion: The GLI 2012 equations are not applicable to all populations and must be tested before being adopted.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the future of inhaled antibiotics for bronchiectasis? 吸入式抗生素治疗支气管扩张症的前景如何？

Expert review of respiratory medicine Pub Date : 2024-11-03 DOI: 10.1080/17476348.2024.2423825

Emma D Johnson, James D Chalmers

引用次数: 0

Effects of cystic fibrosis transmembrane conductance regulator potentiators on clinical outcomes of chronic obstructive pulmonary disease: a systematic review and meta-analysis. 囊性纤维化跨膜传导调节剂增效剂对慢性阻塞性肺病临床疗效的影响：系统综述和荟萃分析。

Expert review of respiratory medicine Pub Date : 2024-10-29 DOI: 10.1080/17476348.2024.2421843

Xi Yan, Quzhen Deqing, Feng Yu, Tao Wang, Dan Xu, Fuqiang Wen, Jun Chen

{"title":"Effects of cystic fibrosis transmembrane conductance regulator potentiators on clinical outcomes of chronic obstructive pulmonary disease: a systematic review and meta-analysis.","authors":"Xi Yan, Quzhen Deqing, Feng Yu, Tao Wang, Dan Xu, Fuqiang Wen, Jun Chen","doi":"10.1080/17476348.2024.2421843","DOIUrl":"10.1080/17476348.2024.2421843","url":null,"abstract":"Introduction: Excessive mucus secretion is pivotal in chronic obstructive pulmonary disease (COPD) pathophysiology, particularly in chronic bronchitis phenotypes. Cystic fibrosis transmembrane conductance regulator (CFTR) has been implicated in COPD-related hypersecretion with acquired dysfunction, and emerged as a therapeutic target. However, the clinical efficacy of CFTR-potentiators in COPD remains controversial.Methods: We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal (CSTJ), and Wanfang Database to retrieve eligible studies published before 28 May 2024.Results: A total of 1172 COPD patients were included, meta-analysis showed that CFTR-potentiators significantly increased forced expiratory volume in 1 s (FEV1) and decreased sweat chloride and fibrinogen levels, with moderate-to-high quality evidence. However, no significant effects were observed on the percentage of detected FEV1 to predicted FEV1 (FEV1% predicted), forced vital capacity (FVC), COPD assessment test (CAT) score, St. George's Respiratory Questionnaire (SGRQ) score, or acute exacerbation times, with low-to-moderate quality evidence.Conclusion: Our meta-analysis demonstrated CFTR-potentiators' potential efficacy in increasing FEV1, decreasing sweat chloride and fibrinogen levels, despite limited impacts on FEV1% predicted, FVC, CAT score, SGRQ score, and acute exacerbations, underscoring the necessity for future research to evaluate its effects on mucus hypersecretion, acute exacerbations, hospitalizations, and mortality in COPD management. Review registration PROSPERO Identifier: CRD42024538708.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary endoscopy - central to an interventional pulmonology program. 肺内窥镜检查--介入肺病学项目的核心。

Expert review of respiratory medicine Pub Date : 2024-10-28 DOI: 10.1080/17476348.2024.2413561

Sally Griffiths, Lucy Power, David Breen

{"title":"Pulmonary endoscopy - central to an interventional pulmonology program.","authors":"Sally Griffiths, Lucy Power, David Breen","doi":"10.1080/17476348.2024.2413561","DOIUrl":"10.1080/17476348.2024.2413561","url":null,"abstract":"Introduction: Pulmonary endoscopy occupies a central role in Interventional Pulmonology and is frequently the mainstay of diagnosis of respiratory disease, in particular lung malignancy. Older techniques such as rigid bronchoscopy maintain an important role in central airway obstruction. Renewed interest in the peripheral pulmonary nodule is driving major advances in technologies to increase the diagnostic accuracy and advance new potential endoscopic therapeutic options.Areas covered: This paper describes the role of pulmonary endoscopy, in particular ultrasound in the diagnosis and staging of lung malignancy. We will explore the recent expansion of ultrasound to include endoscopic ultrasound - bronchoscopy (EUS-B) and combined ultrasound (CUS) techniques. We will discuss in detail the advances in the workup of the peripheral pulmonary nodule.We performed a non-systematic, narrative review of the literature to summarize the evidence regarding the indications, diagnostic yield, and safety of current bronchoscopic sampling techniques.Expert opinion: EBUS/EUS-B has revolutionized the diagnosis and staging of thoracic malignancy resulting in more accurate assessment of the mediastinum compared to mediastinoscopy alone, thus reducing the rate of futile thoracotomies. Although major advances in the assessment of the peripheral pulmonary nodule have been made, the role of endoscopy in this area requires further clarification and investigation.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary tuberculosis in non-HIV adults: an evergreen old-fashioned disease in high-income countries. A narrative review. 非艾滋病毒成人肺结核：高收入国家的常青老病。叙述性综述。

Expert review of respiratory medicine Pub Date : 2024-10-28 DOI: 10.1080/17476348.2024.2418932

Marco Guerrieri, Elena Bargagli, Lucia Cassai, Sara Gangi, Michele Genovese, Magda Viani, Andrea S Melani

{"title":"Pulmonary tuberculosis in non-HIV adults: an evergreen old-fashioned disease in high-income countries. A narrative review.","authors":"Marco Guerrieri, Elena Bargagli, Lucia Cassai, Sara Gangi, Michele Genovese, Magda Viani, Andrea S Melani","doi":"10.1080/17476348.2024.2418932","DOIUrl":"10.1080/17476348.2024.2418932","url":null,"abstract":"Introduction: Tuberculosis (TB), an infective air-borne disease with worldwide non-homogeneous distribution, remains a top cause of morbidity and mortality. TB control is linked to early diagnosis and proper treatment of contagious TB cases and infected subjects at high risk of developing TB.Areas covered: A narrative review of pulmonary TB in non-HIV adults with reference to high-income countries. Modern medicine offers several advancements in diagnostics and therapeutics of TB, but they often remain to be extensively implemented in real life. In high-income countries TB is now relatively uncommon, but it remains a health and socio-economic burden that should not be underestimated.Expert opinion: Pulmonologists should maintain expertise toward TB for several reasons. First, the lung is the most common and the infectious moiety of TB. Second, TB remains a global issue due to common travels of western people and migrations from areas with high incidence of TB. Third, as TB has heterogenous clinics, its prompt diagnosis may be difficult. Fourth, TB is a curable disease, but its management is complex and predisposes to poor adherence with failures/relapses and selection of drug-resistant strains.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchomotor tone imbalance evokes airway hyperresponsiveness. 支气管运动张力失衡会引起气道高反应性。

Expert review of respiratory medicine Pub Date : 2024-10-23 DOI: 10.1080/17476348.2024.2419543

Joseph A Jude, Reynold A Panettieri

{"title":"Bronchomotor tone imbalance evokes airway hyperresponsiveness.","authors":"Joseph A Jude, Reynold A Panettieri","doi":"10.1080/17476348.2024.2419543","DOIUrl":"10.1080/17476348.2024.2419543","url":null,"abstract":"Introduction: Obstructive airway diseases asthma and COPD represent a significant healthcare burden. Airway hyperresponsiveness (AHR), a salient feature of these two diseases, remains the main therapeutic target. Airway smooth muscle (ASM) cell is pivotal for bronchomotor tone and development of AHR in airway diseases. The contractile and relaxation processes in ASM cells maintain a homeostatic bronchomotor tone. It is critical to understand the molecular mechanisms that disrupt the homeostasis to identify novel therapeutic strategies for AHR.Areas covered: Based on review of literature and published findings from our laboratory, we describe intrinsic and extrinsic factors - disease phenotype, toxicants, inflammatory/remodeling mediators- that amplify excitation-contraction (E-C) coupling and ASM shortening and or diminish relaxation to alter bronchomotor homeostasis. We posit that an understanding of the ASM mechanisms involved in bronchomotor tone imbalance will provide platforms to develop novel therapeutic approaches to treat AHR in asthma and COPD.Expert opinion: Contractile and relaxation processes in ASM cell are modulated by intrinsic and extrinsic factors to elicit bronchomotor tone imbalance. Innovative experimental approaches will serve as essential tools for elucidating the imbalance mechanisms and to identify novel therapeutic targets for AHR.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary rehabilitation guidelines for COPD; where do we go from here? 慢性阻塞性肺疾病肺康复指南；我们该何去何从？

Expert review of respiratory medicine Pub Date : 2024-10-18 DOI: 10.1080/17476348.2024.2418512

Michele Vitacca, Mara Paneroni

引用次数: 0

Pulmonary rehabilitation and family/friend caregivers: the hidden reciprocal relationship improving outcomes in chronic respiratory diseases. 肺康复与家人/朋友照顾者：改善慢性呼吸系统疾病治疗效果的隐性互惠关系。

Expert review of respiratory medicine Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.1080/17476348.2024.2407812

Alda Marques

{"title":"Pulmonary rehabilitation and family/friend caregivers: the hidden reciprocal relationship improving outcomes in chronic respiratory diseases.","authors":"Alda Marques","doi":"10.1080/17476348.2024.2407812","DOIUrl":"10.1080/17476348.2024.2407812","url":null,"abstract":"Introduction: The experiences and needs of living with chronic respiratory diseases (CRD) can be overwhelming. Individuals often rely on informal care for daily assistance and having a family/friend caregiver has been associated with better health outcomes. Nevertheless, family/friend caregivers frequently feel alone and unsupported. Pulmonary rehabilitation (PR) leads to multidimensional benefits across CRD and individuals have suggested improvements for PR. Family/friend caregivers highly support PR in practical and psychosocial ways and have identified this intervention as an opportunity to be supported. This reciprocal relationship between PR and the family/friend caregivers has been scarcely explored and its importance for the management of CRD is poorly understood.Areas covered: This perspective synthesizes the experiences and needs of living with CRD from the perspective of people with CRD and their family/friend caregivers; and proposes a vision of a reciprocal/symbiotic relationship, through PR, for optimizing care for people with CRD and their caregivers.Expert opinion: A deeper understanding/recognition of the extensiveness and somewhat overlap of the experiences and unmet needs of individuals with CRD and their family/friend caregivers; and of the reciprocal/symbiotic relationship between PR and the family/friend caregivers might be important to optimizing management and, ultimately, individuals and caregivers' outcomes in CRD.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0