Expert review of respiratory medicine最新文献_第2页

Pulmonary rehabilitation guidelines for COPD; where do we go from here? 慢性阻塞性肺疾病肺康复指南；我们该何去何从？

Expert review of respiratory medicine Pub Date : 2024-11-01 Epub Date: 2024-10-18 DOI: 10.1080/17476348.2024.2418512

Michele Vitacca, Mara Paneroni

引用次数: 0

Pulmonary tuberculosis in non-HIV adults: an evergreen old-fashioned disease in high-income countries. A narrative review. 非艾滋病毒成人肺结核：高收入国家的常青老病。叙述性综述。

Expert review of respiratory medicine Pub Date : 2024-11-01 Epub Date: 2024-10-28 DOI: 10.1080/17476348.2024.2418932

Marco Guerrieri, Elena Bargagli, Lucia Cassai, Sara Gangi, Michele Genovese, Magda Viani, Andrea S Melani

{"title":"Pulmonary tuberculosis in non-HIV adults: an evergreen old-fashioned disease in high-income countries. A narrative review.","authors":"Marco Guerrieri, Elena Bargagli, Lucia Cassai, Sara Gangi, Michele Genovese, Magda Viani, Andrea S Melani","doi":"10.1080/17476348.2024.2418932","DOIUrl":"10.1080/17476348.2024.2418932","url":null,"abstract":"Introduction: Tuberculosis (TB), an infective air-borne disease with worldwide non-homogeneous distribution, remains a top cause of morbidity and mortality. TB control is linked to early diagnosis and proper treatment of contagious TB cases and infected subjects at high risk of developing TB.Areas covered: A narrative review of pulmonary TB in non-HIV adults with reference to high-income countries. Modern medicine offers several advancements in diagnostics and therapeutics of TB, but they often remain to be extensively implemented in real life. In high-income countries TB is now relatively uncommon, but it remains a health and socio-economic burden that should not be underestimated.Expert opinion: Pulmonologists should maintain expertise toward TB for several reasons. First, the lung is the most common and the infectious moiety of TB. Second, TB remains a global issue due to common travels of western people and migrations from areas with high incidence of TB. Third, as TB has heterogenous clinics, its prompt diagnosis may be difficult. Fourth, TB is a curable disease, but its management is complex and predisposes to poor adherence with failures/relapses and selection of drug-resistant strains.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"861-872"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of cystic fibrosis transmembrane conductance regulator potentiators on clinical outcomes of chronic obstructive pulmonary disease: a systematic review and meta-analysis. 囊性纤维化跨膜传导调节剂增效剂对慢性阻塞性肺病临床疗效的影响：系统综述和荟萃分析。

Expert review of respiratory medicine Pub Date : 2024-11-01 Epub Date: 2024-10-29 DOI: 10.1080/17476348.2024.2421843

Xi Yan, Quzhen Deqing, Feng Yu, Tao Wang, Dan Xu, Fuqiang Wen, Jun Chen

{"title":"Effects of cystic fibrosis transmembrane conductance regulator potentiators on clinical outcomes of chronic obstructive pulmonary disease: a systematic review and meta-analysis.","authors":"Xi Yan, Quzhen Deqing, Feng Yu, Tao Wang, Dan Xu, Fuqiang Wen, Jun Chen","doi":"10.1080/17476348.2024.2421843","DOIUrl":"10.1080/17476348.2024.2421843","url":null,"abstract":"Introduction: Excessive mucus secretion is pivotal in chronic obstructive pulmonary disease (COPD) pathophysiology, particularly in chronic bronchitis phenotypes. Cystic fibrosis transmembrane conductance regulator (CFTR) has been implicated in COPD-related hypersecretion with acquired dysfunction, and emerged as a therapeutic target. However, the clinical efficacy of CFTR-potentiators in COPD remains controversial.Methods: We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal (CSTJ), and Wanfang Database to retrieve eligible studies published before 28 May 2024.Results: A total of 1172 COPD patients were included, meta-analysis showed that CFTR-potentiators significantly increased forced expiratory volume in 1 s (FEV1) and decreased sweat chloride and fibrinogen levels, with moderate-to-high quality evidence. However, no significant effects were observed on the percentage of detected FEV1 to predicted FEV1 (FEV1% predicted), forced vital capacity (FVC), COPD assessment test (CAT) score, St. George's Respiratory Questionnaire (SGRQ) score, or acute exacerbation times, with low-to-moderate quality evidence.Conclusion: Our meta-analysis demonstrated CFTR-potentiators' potential efficacy in increasing FEV1, decreasing sweat chloride and fibrinogen levels, despite limited impacts on FEV1% predicted, FVC, CAT score, SGRQ score, and acute exacerbations, underscoring the necessity for future research to evaluate its effects on mucus hypersecretion, acute exacerbations, hospitalizations, and mortality in COPD management. Review registration PROSPERO Identifier: CRD42024538708.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"893-902"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compatibility of the global lung function 2012 spirometry reference values in children, adolescents and young adults: a systematic review. 2012 年儿童、青少年和年轻成人肺功能参考值的兼容性：系统回顾。

Expert review of respiratory medicine Pub Date : 2024-11-01 Epub Date: 2024-11-03 DOI: 10.1080/17476348.2024.2421849

Bruna Weber Santos, Janaina Cristina Scalco, Paloma Lopes Francisco Parazzi, Camila Isabel Santos Schivinski

{"title":"Compatibility of the global lung function 2012 spirometry reference values in children, adolescents and young adults: a systematic review.","authors":"Bruna Weber Santos, Janaina Cristina Scalco, Paloma Lopes Francisco Parazzi, Camila Isabel Santos Schivinski","doi":"10.1080/17476348.2024.2421849","DOIUrl":"10.1080/17476348.2024.2421849","url":null,"abstract":"Introduction: The Global Lung Function Initiative (GLI 2012) has published multiethnic spirometry reference values. To identify studies that evaluated the compatibility (applicability, validity, representativeness, agreement and/or adequacy) of the reference equations proposed by the GLI 2012 for spirometry tests in different populations.Methods: Systematic searches were carried out on the PubMed, LILACS (Latin American and Caribbean Health Sciences Literature), Scopus, Web of Science and Google Scholar databases. Cross-sectional observational studies published between 2012 and 2013 onwards that evaluated the compatibility of the GLI 2012 in children, adolescents and young adults (3-20 years old) were included. The references were manually searched and the Joanna Briggs Institute Critical Appraisal Checklist for Cross-Sectional Analytical Studies was applied to assess the methodological quality of the studies included.Results: All of the 5632 studies identified were classified as low risk of bias, but only 21 were deemed eligible for inclusion. Of these, 8 reported satisfactory GLI 2012 compatibility for their populations (Argentina, Spain, Columbia, Djibouti, Norway, Poland, Jordan and Zimbabwe), 5 cautious applicability, and the remaining 8 considered the equation unsatisfactory, since it over or underestimated spirometric parameters.Conclusion: The GLI 2012 equations are not applicable to all populations and must be tested before being adopted.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"883-892"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchomotor tone imbalance evokes airway hyperresponsiveness. 支气管运动张力失衡会引起气道高反应性。

Expert review of respiratory medicine Pub Date : 2024-11-01 Epub Date: 2024-10-23 DOI: 10.1080/17476348.2024.2419543

Joseph A Jude, Reynold A Panettieri

{"title":"Bronchomotor tone imbalance evokes airway hyperresponsiveness.","authors":"Joseph A Jude, Reynold A Panettieri","doi":"10.1080/17476348.2024.2419543","DOIUrl":"10.1080/17476348.2024.2419543","url":null,"abstract":"Introduction: Obstructive airway diseases asthma and COPD represent a significant healthcare burden. Airway hyperresponsiveness (AHR), a salient feature of these two diseases, remains the main therapeutic target. Airway smooth muscle (ASM) cell is pivotal for bronchomotor tone and development of AHR in airway diseases. The contractile and relaxation processes in ASM cells maintain a homeostatic bronchomotor tone. It is critical to understand the molecular mechanisms that disrupt the homeostasis to identify novel therapeutic strategies for AHR.Areas covered: Based on review of literature and published findings from our laboratory, we describe intrinsic and extrinsic factors - disease phenotype, toxicants, inflammatory/remodeling mediators- that amplify excitation-contraction (E-C) coupling and ASM shortening and or diminish relaxation to alter bronchomotor homeostasis. We posit that an understanding of the ASM mechanisms involved in bronchomotor tone imbalance will provide platforms to develop novel therapeutic approaches to treat AHR in asthma and COPD.Expert opinion: Contractile and relaxation processes in ASM cell are modulated by intrinsic and extrinsic factors to elicit bronchomotor tone imbalance. Innovative experimental approaches will serve as essential tools for elucidating the imbalance mechanisms and to identify novel therapeutic targets for AHR.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"835-841"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary rehabilitation and family/friend caregivers: the hidden reciprocal relationship improving outcomes in chronic respiratory diseases. 肺康复与家人/朋友照顾者：改善慢性呼吸系统疾病治疗效果的隐性互惠关系。

Expert review of respiratory medicine Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.1080/17476348.2024.2407812

Alda Marques

{"title":"Pulmonary rehabilitation and family/friend caregivers: the hidden reciprocal relationship improving outcomes in chronic respiratory diseases.","authors":"Alda Marques","doi":"10.1080/17476348.2024.2407812","DOIUrl":"10.1080/17476348.2024.2407812","url":null,"abstract":"Introduction: The experiences and needs of living with chronic respiratory diseases (CRD) can be overwhelming. Individuals often rely on informal care for daily assistance and having a family/friend caregiver has been associated with better health outcomes. Nevertheless, family/friend caregivers frequently feel alone and unsupported. Pulmonary rehabilitation (PR) leads to multidimensional benefits across CRD and individuals have suggested improvements for PR. Family/friend caregivers highly support PR in practical and psychosocial ways and have identified this intervention as an opportunity to be supported. This reciprocal relationship between PR and the family/friend caregivers has been scarcely explored and its importance for the management of CRD is poorly understood.Areas covered: This perspective synthesizes the experiences and needs of living with CRD from the perspective of people with CRD and their family/friend caregivers; and proposes a vision of a reciprocal/symbiotic relationship, through PR, for optimizing care for people with CRD and their caregivers.Expert opinion: A deeper understanding/recognition of the extensiveness and somewhat overlap of the experiences and unmet needs of individuals with CRD and their family/friend caregivers; and of the reciprocal/symbiotic relationship between PR and the family/friend caregivers might be important to optimizing management and, ultimately, individuals and caregivers' outcomes in CRD.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"745-757"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The unique metabolic and lipid profiles of patients with severe COVID-19 compared to severe community-acquired pneumonia: a potential prognostic and therapeutic target. 与重症社区获得性肺炎相比，重症 COVID-19 患者具有独特的代谢和血脂特征：潜在的预后和治疗目标。

Expert review of respiratory medicine Pub Date : 2024-10-01 Epub Date: 2024-09-29 DOI: 10.1080/17476348.2024.2409264

Elsa D Ibáñez-Prada, Jose L Guerrero, Ingrid G Bustos, Lizeth León, Yuli V Fuentes, Mary Santamaría-Torres, Juan M Restrepo-Martínez, Cristian C Serrano-Mayorga, Lina Mendez, Salome Gomez-Duque, Carlos A Santacruz, Andrew Conway-Morris, Ignacio Martín-Loeches, Norberto Gonzalez-Juarbe, Mónica P Cala, Luis Felipe Reyes

{"title":"The unique metabolic and lipid profiles of patients with severe COVID-19 compared to severe community-acquired pneumonia: a potential prognostic and therapeutic target.","authors":"Elsa D Ibáñez-Prada, Jose L Guerrero, Ingrid G Bustos, Lizeth León, Yuli V Fuentes, Mary Santamaría-Torres, Juan M Restrepo-Martínez, Cristian C Serrano-Mayorga, Lina Mendez, Salome Gomez-Duque, Carlos A Santacruz, Andrew Conway-Morris, Ignacio Martín-Loeches, Norberto Gonzalez-Juarbe, Mónica P Cala, Luis Felipe Reyes","doi":"10.1080/17476348.2024.2409264","DOIUrl":"10.1080/17476348.2024.2409264","url":null,"abstract":"Background: Compare the changes and differences in metabolome and lipidome profiles among severe COVID-19 and CAP patients with ARF to identify biomarkers that could be used for personalized diagnosis, prognosis, and treatment.Research design and methods: Plasma samples were taken at hospital admission (baseline) and on the 5th day of hospitalization (follow-up) and examined by RP-LC-QTOF-MS and HILIC-LC-QTOF-MS.Results: 127 patients, 17 with CAP and 110 with COVID-19, were included. The analysis revealed 87 altered metabolites, suggesting changes in the metabolism of arachidonic acid, glycerolipids, glycerophospholipids, linoleic acid, pyruvate, glycolysis, among others. Most of these metabolites are involved in inflammatory, hypoxic, and thrombotic processes. At baseline, the greatest differences were found in phosphatidylcholine (PC) 31:4 (p < 0.001), phosphoserine (PS) 34:3 (p < 0.001), and phosphatidylcholine (PC) 36:5 (p < 0.001), all of which were notably decreased in COVID-19 patients. At follow-up, the most dysregulated metabolites were monomethyl-phosphatidylethanolamine (PE-Nme) 40:5 (p < 0.001) and phosphatidylcholine (PC) 38:4 (p < 0.001).Conclusions: Metabolic and lipidic alterations suggest inhibition of innate anti-inflammatory and anti-thrombotic mechanisms in COVID-19 patients, which might lead to increased viral proliferation, uncontrolled inflammation, and thrombi formation. Results provide novel targets for predictive biomarkers against CAP and COVID-19.Trial registration: Not applicable.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"815-829"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

It is high time to discard a cut-off of 0.70 in the diagnosis of COPD. 在诊断慢性阻塞性肺病时，现在应该摒弃 0.70 的临界值。

Expert review of respiratory medicine Pub Date : 2024-09-01 Epub Date: 2024-08-27 DOI: 10.1080/17476348.2024.2397480

Joon Young Choi, Chin Kook Rhee

引用次数: 0

Apolipoprotein E in patients with undiagnosed pleural effusion: a prospective diagnostic test accuracy study. 未确诊胸腔积液患者体内的载脂蛋白 E：一项前瞻性诊断测试准确性研究。

Expert review of respiratory medicine Pub Date : 2024-09-01 Epub Date: 2024-08-18 DOI: 10.1080/17476348.2024.2391943

Dan-Ni Yang, Cheng Yan, Li Yan, Yan Niu, Jian-Xun Wen, Ling Hai, Wen-Hui Gao, Ying-Jun Wang, Ya-Fei Wang, Qianghua Zhou, Wen-Qi Zheng, Zhi-De Hu

{"title":"Apolipoprotein E in patients with undiagnosed pleural effusion: a prospective diagnostic test accuracy study.","authors":"Dan-Ni Yang, Cheng Yan, Li Yan, Yan Niu, Jian-Xun Wen, Ling Hai, Wen-Hui Gao, Ying-Jun Wang, Ya-Fei Wang, Qianghua Zhou, Wen-Qi Zheng, Zhi-De Hu","doi":"10.1080/17476348.2024.2391943","DOIUrl":"10.1080/17476348.2024.2391943","url":null,"abstract":"Introduction: Pleural effusion is common in clinical practice, and its differential diagnosis remains challenging for clinicians. This study investigates the diagnostic value of apolipoprotein E (apoE) in patients with undetermined pleural effusion.Methods: This prospective, double-blind study enrolled 152 patients with undiagnosed pleural effusion. Their pleural fluid apoE levels were measured, and a receiver operating characteristics (ROC) curve was used to evaluate the diagnostic accuracy of apoE. Decision curve analysis (DCA) was used to assess apoE's net benefit. Subgroup analyses were performed to investigate the effect of age on the diagnostic accuracy of apoE.Results: Among the included participants, 23 had heart failure (HF). HF patients had the lowest apoE level among pleural effusion patients. The area under the curve (AUC) of apoE for HF was 0.79 (95% CI: 0.69-0.89). At the threshold of 40 mg/L, the sensitivity and specificity of apoE were 0.96 (95% CI: 0.87-1.00) and 0.33 (95% CI: 0.25-0.42), respectively. The decision curve for apoE was above reference lines. The AUC of apoE decreased in older patients.Conclusion: Pleural fluid apoE has moderate diagnostic value for HF and has net benefits in patients with undiagnosed pleural effusion. The diagnostic accuracy of apoE decreases with age.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"735-741"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The continuing need for dornase alfa for extracellular airway DNA hydrolysis in the era of CFTR modulators. 在 CFTR 调节剂时代，细胞外气道 DNA 水解仍需 dornase alfa。

Expert review of respiratory medicine Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1080/17476348.2024.2394694

Erica A Roesch, Abdelkader Rahmaoui, Robert A Lazarus, Michael W Konstan

{"title":"The continuing need for dornase alfa for extracellular airway DNA hydrolysis in the era of CFTR modulators.","authors":"Erica A Roesch, Abdelkader Rahmaoui, Robert A Lazarus, Michael W Konstan","doi":"10.1080/17476348.2024.2394694","DOIUrl":"10.1080/17476348.2024.2394694","url":null,"abstract":"Introduction: The availability of cystic fibrosis transmembrane conductance regulator (CFTR) modulators opens the possibility of discontinuing some chronic pulmonary therapies to decrease cystic fibrosis (CF) treatment burden. However, CFTR modulators may not adequately address neutrophilic inflammation, which contributes to a self-perpetual cycle of viscous CF sputum, airway obstruction, inflammation, and lung function decline.Areas covered: This review discusses the emerging role of neutrophil extracellular traps in CF and its role in CF sputum viscosity, airway obstruction, and inflammation, based on a literature search of PubMed (1990-present). We summarize clinical trials and real-world studies that support the efficacy of dornase alfa (Pulmozyme) in improving lung function and reducing pulmonary exacerbation in people with CF (PwCF), and we discuss the potential role of dornase alfa in reducing airway inflammation. We also examine the findings of short-term trials evaluating the discontinuation of mucoactive therapy in PwCF receiving CFTR modulators.Expert opinion: Long-term studies are needed to assess the impact of discontinuing mucoactive therapy in PwCF who are clinically stable while receiving CFTR modulatory therapy. Treatment decisions should take into account the severity of underlying lung disease. People with advanced CF will likely require ongoing mucoactive therapy.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"677-691"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0