Research progress in early states of chronic obstructive pulmonary disease: a narrative review on PRISm, pre-COPD, young COPD and mild COPD.

IF 2.7

Expert review of respiratory medicine Pub Date : 2025-07-09 DOI:10.1080/17476348.2025.2526775

Yuepeng Li, Xiaolong Tang, Rui Zhang, Yi Lei, Denian Wang, Zhoufeng Wang, Weimin Li

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Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) represents a significant global health burden. This review addresses the critical need for early identification and intervention by investigating the current research landscape in the early stages of the disease.

Areas covered: This review synthesizes the literature on the definitions, epidemiology, diagnostic approaches, prognosis, and management strategies for early COPD states, including preserved ratio impaired spirometry (PRISm), pre-COPD, young COPD, and mild COPD. A comprehensive literature search was conducted in PubMed and Web of Science up to October 2024.

Expert opinion: Experts believe that while conceptualizing early COPD offers transformative potential, progress is hampered by ambiguous diagnostic criteria and limitations in biomarkers. Future efforts should prioritize precision prevention through deep phenotyping and technological integration, acknowledging the risk of disparities.

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慢性阻塞性肺疾病早期状态的研究进展：PRISm、前期COPD、青年COPD和轻度COPD的叙述性综述

慢性阻塞性肺疾病（COPD）是一个重大的全球健康负担。本综述通过调查目前在疾病早期阶段的研究情况，解决了早期识别和干预的迫切需要。涵盖领域：本综述综合了关于早期COPD状态的定义、流行病学、诊断方法、预后和管理策略的文献，包括保存比例受损肺活量测定法（PRISm）、COPD前期、年轻型COPD和轻度COPD。在PubMed和Web of Science进行了全面的文献检索，截止到2024年10月。专家意见：专家认为，虽然概念化早期COPD具有变革性潜力，但由于诊断标准不明确和生物标志物的局限性，进展受到阻碍。未来的工作应优先考虑通过深度表型和技术整合进行精准预防，并承认存在差异的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Expert review of respiratory medicine

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