Expert review of respiratory medicine最新文献_第7页

Improving access to non-pharmacological treatment for chronic respiratory disease: what? Why? How? 改善慢性呼吸系统疾病非药物治疗的可及性：是什么、为什么、怎么做？

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2025-01-06 DOI: 10.1080/17476348.2024.2444335

Yet H Khor, Narelle S Cox

引用次数: 0

An update on multiple breath washout in children with cystic fibrosis. 囊性纤维化儿童多次呼吸冲洗的最新进展。

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-12-22 DOI: 10.1080/17476348.2024.2445683

Natalia S Escobar, Felix Ratjen

{"title":"An update on multiple breath washout in children with cystic fibrosis.","authors":"Natalia S Escobar, Felix Ratjen","doi":"10.1080/17476348.2024.2445683","DOIUrl":"10.1080/17476348.2024.2445683","url":null,"abstract":"Introduction: Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane regulator (CFTR) gene, leading to progressive lung disease and systemic complications. Lung disease remains the primary cause of morbidity and mortality, making early detection of lung function decline crucial. The Lung Clearance Index (LCI), derived from the multiple breath washout (MBW) test, has emerged as a sensitive measure for identifying early airway disease.Areas covered: This review examines the technical aspects and clinical relevance of LCI, its advantages over traditional lung function tests, and its application in CF clinical trials. A focused literature review highlights LCI's utility in evaluating treatment efficacy and its potential integration into routine CF care.Expert opinion: LCI is more sensitive than spirometry for detecting early lung function decline and is predominantly used in pediatric settings. Its use is expanding in adult CF populations as advances in treatment allow adults to maintain stable lung function. In clinical trials, LCI is widely recognized as an outcome measure. While implemented into clinical care in many centers in Europe, this is not yet the case in North America. Faster testing protocols and point-of-care interpretation tools will support LCI's integration into routine CF monitoring.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1061-1071"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring exhaled nitric oxide in COPD: from theoretical consideration to practical views. 测量慢性阻塞性肺病患者呼出的一氧化氮：从理论思考到实践观点。

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1080/17476348.2024.2433537

Marieann Högman, Hà Pham-Ngoc, Bô Nguyen-Duy, Jens Ellingsen, Thông Hua-Huy, Dinh Van Nguyen, Anh Tuan Dinh-Xuan

{"title":"Measuring exhaled nitric oxide in COPD: from theoretical consideration to practical views.","authors":"Marieann Högman, Hà Pham-Ngoc, Bô Nguyen-Duy, Jens Ellingsen, Thông Hua-Huy, Dinh Van Nguyen, Anh Tuan Dinh-Xuan","doi":"10.1080/17476348.2024.2433537","DOIUrl":"10.1080/17476348.2024.2433537","url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease (COPD) is traditionally perceived as Th1-inflammation, but some patients have Th2-inflammation. A high fraction of exhaled nitric oxide (FENO) is seen in asthma with Th2-inflammation, justifying FENO as a point-of-care biomarker. The use of FENO in COPD is much less frequent. We aimed to review the evidence in favor of FENO measurement in COPD and discuss its potential usefulness in clinical settings.Areas covered: This review covers nitric oxide production in the airways and FENO measurements in COPD patients during stable conditions and acute exacerbation. It discusses why COPD patients may have both low and high FENO levels and the potential clinical utility of FENO.Expert opinion: There is good evidence that FENO increases with an exacerbation irrespective of the initial low or high baseline value. However, there is insufficient evidence to establish a fixed cutoff value for elevated FENO in COPD today. Instead, a personal baseline FENO level should be established when the patient is in a stable phase of the disease, which will subsequently set high and low FENO levels in a personalized manner. In the future, home monitoring of FENO could help identify exacerbations early, allowing proper action to be taken.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1013-1024"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preschool wheeze and asthma endotypes- implications for future therapy. 学龄前喘息和哮喘内源性-对未来治疗的意义。

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-12-13 DOI: 10.1080/17476348.2024.2440468

Kushalinii Hillson, Sejal Saglani, Adnan Custovic

{"title":"Preschool wheeze and asthma endotypes- implications for future therapy.","authors":"Kushalinii Hillson, Sejal Saglani, Adnan Custovic","doi":"10.1080/17476348.2024.2440468","DOIUrl":"10.1080/17476348.2024.2440468","url":null,"abstract":"Introduction: Preschool wheeze and school-aged asthma present a large healthcare burden. Both conditions are now recognized to be heterogeneous, with similar symptom presentation but likely different underlying lung pathology.Areas covered: Current treatment options for preschool wheeze are constrained by extrapolations from the management of school-aged children with asthma. While most cases of asthma at school age are caused by classical atopic, eosinophilic, Type-2 driven asthma, only a quarter of preschool children with wheeze fall into this category. Targeting treatment to specific underlying mechanisms resulting in preschool wheeze may alter the progression to school age asthma. Novel biologics have revolutionized the management of severe, treatment-resistant school age asthma, but a limited evidence base limits their use in young children. There are several potential future non-steroid-based treatment options in development, of which bacterial lysates show the most promise.Expert opinion: Effective treatment of preschool wheeze may preserve lung function into later life, which may alter the progression trajectory toward school age asthma. Endotype-driven management will enable more effective treatment of both preschool wheeze and school age asthma.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1025-1039"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing asthma care in low-to-middle income countries through multisectoral collaboration: recommendation report of the first Philippine Asthma Assembly. 通过多部门合作优化中低收入国家的哮喘护理：第一届菲律宾哮喘大会的建议报告。

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-12-10 DOI: 10.1080/17476348.2024.2389948

Lenora Fernandez, Helen K Reddel, Dina Diaz, Camilo Roa, Ricardo Zotomayor, Josephine Ramos, Gregorio Ocampo, Maria Victoria Cruz, Rommel Punongbayan

{"title":"Optimizing asthma care in low-to-middle income countries through multisectoral collaboration: recommendation report of the first Philippine Asthma Assembly.","authors":"Lenora Fernandez, Helen K Reddel, Dina Diaz, Camilo Roa, Ricardo Zotomayor, Josephine Ramos, Gregorio Ocampo, Maria Victoria Cruz, Rommel Punongbayan","doi":"10.1080/17476348.2024.2389948","DOIUrl":"10.1080/17476348.2024.2389948","url":null,"abstract":"Introduction: Asthma is one of the most common noncommunicable diseases, raising serious concerns about asthma-related deaths globally. Studies have reported safety concerns with short-acting beta-agonists (SABAs) monotherapy. SABA overuse contributes significantly to the healthcare burden in the Philippines. Despite Global Asthma Network's years-long advocacy for equal access to essential medicines at affordable cost, the uptake of international healthcare policies is limited in most low- and middle-income countries, including the Philippines.Areas covered: We reviewed synthesis of targeted nonsystematic literature searches on prevalence of asthma and asthma-related mortality, SABA overreliance and its adverse events, alternatives to SABA, patient referral, and multidisciplinary team (MDT) approach for asthma management. We describe regional challenges and recommendations for improving asthma care through continued multisectoral collaboration.Expert opinion: Use of medications like inhaled corticosteroid-formoterol combinations may aid in reducing adverse events including severe exacerbations, hospitalizations, complications from oral corticosteroid use, and long-term treatment costs. Raising patient awareness about preventive measures, proper inhaler techniques, and medication adherence can mitigate burden of uncontrolled asthma. Improving access to asthma medications alongside developing treatment algorithms and referral pathways (including MDT) for primary care physicians will pave the way for optimal asthma care in LMICs, including the Philippines.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"947-962"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the future of inhaled antibiotics for bronchiectasis? 吸入式抗生素治疗支气管扩张症的前景如何？

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-11-03 DOI: 10.1080/17476348.2024.2423825

Emma D Johnson, James D Chalmers

引用次数: 0

What's next in digital technology for the management of pediatric asthma? 儿科哮喘管理数字技术的下一步是什么？

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-12-17 DOI: 10.1080/17476348.2024.2442663

Giuliana Ferrante

引用次数: 0

Diaphragm pacing compared with mechanical ventilation in patients with chronic respiratory failure caused by diaphragmatic dysfunction: a systematic review and meta-analysis. 膈肌起搏与机械通气在膈肌功能障碍引起的慢性呼吸衰竭患者中的比较：一项系统回顾和荟萃分析。

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1080/17476348.2024.2421846

Maria Lucia Arango-Cortes, Luis Fernando Giraldo-Cadavid, Manuel Latorre Quintana, Jose David Forero-Cubides, Jesus Gonzalez-Bermejo

{"title":"Diaphragm pacing compared with mechanical ventilation in patients with chronic respiratory failure caused by diaphragmatic dysfunction: a systematic review and meta-analysis.","authors":"Maria Lucia Arango-Cortes, Luis Fernando Giraldo-Cadavid, Manuel Latorre Quintana, Jose David Forero-Cubides, Jesus Gonzalez-Bermejo","doi":"10.1080/17476348.2024.2421846","DOIUrl":"10.1080/17476348.2024.2421846","url":null,"abstract":"Background: The effectiveness of diaphragmatic electrical stimulation (DES) compared to mechanical ventilation (MV) in improving clinical outcomes such as quality-of-life (QOL) and hospital stay remains inconsistent.Methods: We conducted a systematic review and meta-analysis by searching PubMed, Scopus, Google Scholar, LILACS, and IEEE Xplore. We included comparative studies (randomized controlled trials and observational studies) of DES administered via the phrenic nerve or intramuscular electrodes, compared with MV in adults with diaphragmatic paralysis or paresis. Two authors independently extracted data and assessed bias, with discrepancies resolved by a senior author. Results were pooled using the inverse variance method.Results: Out of 1,290 articles, nine were included in the systematic review, totaling 852 subjects. In spinal cord injury (SCI), one study reported lower mortality with DES, while three found no difference compared to MV. In these patients, DES was associated with shorter hospital stay, similar QOL, and heterogeneous results on respiratory infections. In amyotrophic lateral sclerosis (ALS), DES was associated with higher mortality and similar QOL compared to MV. Most SCI studies had a serious risk of bias.Conclusion: DES shows potential in reducing hospital stay and respiratory infections in SCI but is associated with higher mortality in ALS.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1101-1111"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary endoscopy - central to an interventional pulmonology program. 肺内窥镜检查--介入肺病学项目的核心。

Expert review of respiratory medicine Pub Date : 2024-11-01 Epub Date: 2024-10-28 DOI: 10.1080/17476348.2024.2413561

Sally Griffiths, Lucy Power, David Breen

{"title":"Pulmonary endoscopy - central to an interventional pulmonology program.","authors":"Sally Griffiths, Lucy Power, David Breen","doi":"10.1080/17476348.2024.2413561","DOIUrl":"10.1080/17476348.2024.2413561","url":null,"abstract":"Introduction: Pulmonary endoscopy occupies a central role in Interventional Pulmonology and is frequently the mainstay of diagnosis of respiratory disease, in particular lung malignancy. Older techniques such as rigid bronchoscopy maintain an important role in central airway obstruction. Renewed interest in the peripheral pulmonary nodule is driving major advances in technologies to increase the diagnostic accuracy and advance new potential endoscopic therapeutic options.Areas covered: This paper describes the role of pulmonary endoscopy, in particular ultrasound in the diagnosis and staging of lung malignancy. We will explore the recent expansion of ultrasound to include endoscopic ultrasound - bronchoscopy (EUS-B) and combined ultrasound (CUS) techniques. We will discuss in detail the advances in the workup of the peripheral pulmonary nodule.We performed a non-systematic, narrative review of the literature to summarize the evidence regarding the indications, diagnostic yield, and safety of current bronchoscopic sampling techniques.Expert opinion: EBUS/EUS-B has revolutionized the diagnosis and staging of thoracic malignancy resulting in more accurate assessment of the mediastinum compared to mediastinoscopy alone, thus reducing the rate of futile thoracotomies. Although major advances in the assessment of the peripheral pulmonary nodule have been made, the role of endoscopy in this area requires further clarification and investigation.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"843-860"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary rehabilitation guidelines for COPD; where do we go from here? 慢性阻塞性肺疾病肺康复指南；我们该何去何从？

Expert review of respiratory medicine Pub Date : 2024-11-01 Epub Date: 2024-10-18 DOI: 10.1080/17476348.2024.2418512

Michele Vitacca, Mara Paneroni

引用次数: 0