Expert review of respiratory medicine最新文献_第5页

Multifaceted pulmonary manifestations of amyloidosis: state-of-the-art update. 淀粉样变的多面肺部表现：最新进展。

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1080/17476348.2025.2457374

Antonios Charokopos, Misbah Baqir, Anja C Roden, Jay H Ryu, Teng Moua

{"title":"Multifaceted pulmonary manifestations of amyloidosis: state-of-the-art update.","authors":"Antonios Charokopos, Misbah Baqir, Anja C Roden, Jay H Ryu, Teng Moua","doi":"10.1080/17476348.2025.2457374","DOIUrl":"10.1080/17476348.2025.2457374","url":null,"abstract":"Introduction: Amyloidosis, a polymeric deposition disease classified according to protein subtype, may have varied pulmonary manifestations. Its anatomic-radiologic phenotypes include nodular, cystic, alveolar-septal, and tracheobronchial forms. Clinical presentation may range from asymptomatic parenchymal nodules to respiratory failure from diffuse parenchymal infiltration or diaphragmatic deposition.Areas covered: In this review, we systematically describe the molecular subtypes of amyloidosis and their clinical and radiologic findings in the lungs as well as key extrapulmonary organ systems. We detail novel treatment approaches to systemic amyloidosis. We also discuss prognostic elements for each subtype. We identify key clinical scenarios where reaching a precise diagnosis can be complicated, and we offer insights on the varied presentations of pulmonary amyloidosis.Expert opinion: Pulmonary amyloidosis is often difficult to diagnose as it may mimic other conditions, including fibrotic interstitial lung diseases and neoplasms, or can co-exist with certain connective tissue diseases. Despite some early artificial intelligence screening tools, improved familiarity among clinicians can aid in the more accurate and timely diagnosis of this multidimensional clinical entity. We additionally believe that multidisciplinary clinical pathwaysto diagnose and/or treat pulmonary amyloidosis have the potential to improve awareness, decrease diagnostic delay, and further elucidate knowledge on this multifaceted disease.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"107-120"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the potential of lung transplantation for situs inversus. 揭示逆位肺移植的潜力。

Expert review of respiratory medicine Pub Date : 2025-01-01 Epub Date: 2024-12-26 DOI: 10.1080/17476348.2024.2447513

Yudai Miyashita, Taisuke Kaiho, Chitaru Kurihara

{"title":"Unveiling the potential of lung transplantation for situs inversus.","authors":"Yudai Miyashita, Taisuke Kaiho, Chitaru Kurihara","doi":"10.1080/17476348.2024.2447513","DOIUrl":"10.1080/17476348.2024.2447513","url":null,"abstract":"Introduction: Situs inversus is a rare congenital condition where the organs in the chest and abdomen are reversed, thus complicating surgeries such as lung transplantation. Kartagener syndrome (KS), associated with situs inversus, includes chronic sinusitis and bronchiectasis, which can progress to end-stage lung disease requiring transplantation. This review discusses the unique surgical considerations, technical challenges, and outcomes of lung transplantation in patients with situs inversus, particularly KS.Areas covered: The review highlights anatomical and physiological challenges in lung transplantation due to reversed organ positioning, requiring customized surgical approaches and intraoperative modifications. Preoperative imaging, anesthesia adjustments, and tailored surgical techniques are crucial for successful transplantation. Postoperative care focuses on managing complications such as primary graft dysfunction, infections, and anastomotic issues. Literature on survival rates, chronic lung allograft dysfunction, and quality of life is analyzed, indicating outcomes comparable to other lung transplant recipients.Expert opinion: Despite significant challenges, lung transplantation in patients with situs inversus and KS is feasible with outcomes similar to traditional cases. Advances in imaging, surgical planning, and minimally invasive techniques offer promise for improved outcomes. Ongoing research, collaboration, and ethical considerations are essential to optimizing care and expand treatment possibilities for this high-risk patient population.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"43-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions between epithelial mesenchymal plasticity, barrier dysfunction and innate immune pathways shape the genesis of allergic airway disease. 上皮间充质可塑性、屏障功能障碍和先天免疫途径之间的相互作用形成了过敏性气道疾病的发生。

Expert review of respiratory medicine Pub Date : 2025-01-01 Epub Date: 2025-01-06 DOI: 10.1080/17476348.2024.2449079

Allan R Brasier

{"title":"Interactions between epithelial mesenchymal plasticity, barrier dysfunction and innate immune pathways shape the genesis of allergic airway disease.","authors":"Allan R Brasier","doi":"10.1080/17476348.2024.2449079","DOIUrl":"10.1080/17476348.2024.2449079","url":null,"abstract":"Introduction: In genetically predisposed individuals, exposure to aeroallergens and infections from RNA viruses shape epithelial barrier function, leading to Allergic Asthma (AA). Here, activated pattern recognition receptors (PRRs) in lower airway sentinel cells signal epithelial injury-repair pathways leading to cell-state changes [epithelial mesenchymal plasticity (EMP)], barrier disruption and sensitization.Areas covered: 1. Characteristics of sentinel epithelial cells of the bronchoalveolar junction, 2. The effect of aeroallergens on epithelial PRRs, 3. Role of tight junctions (TJs) in barrier function and how aeroallergens disrupt their function, 4. Induction of mucosal TGF autocrine loops activating type-2 innate lymphoid cells (ICL2s) leading to Th2 polarization, 5. How respiratory syncytial virus (RSV) directs goblet cell hyperplasia, and 6. Coupling of endoplasmic reticulum (ER) stress to metabolic adaptations and effects on basal lamina remodeling.Expert opinion: When aeroallergens or viral infections activate innate immunity in sentinel cells of the bronchoalveolar junction, normal barrier function is disrupted, promoting chronic inflammation and Th2 responses. An improved mechanistic understanding of how activated PRRs induce EMP couples with TJ disruption, metabolic reprogramming and ECM deposition provides new biologically validated targets to restore barrier function, reduce sensitization, and remodeling in AA.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"29-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current perspectives on the rehabilitation of COPD patients with comorbidities. COPD合并合并症患者的康复治疗现状

Expert review of respiratory medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1080/17476348.2025.2452441

Audrey Borghi-Silva, Patrícia Faria Camargo, Flávia Cristina Rossi Caruso, Cássia da Luz Goulart, Renata Trimer, Aldair Darlan Santos-Araújo, Izadora Moraes Dourado, Andrea Lúcia Gonçalves da Silva

{"title":"Current perspectives on the rehabilitation of COPD patients with comorbidities.","authors":"Audrey Borghi-Silva, Patrícia Faria Camargo, Flávia Cristina Rossi Caruso, Cássia da Luz Goulart, Renata Trimer, Aldair Darlan Santos-Araújo, Izadora Moraes Dourado, Andrea Lúcia Gonçalves da Silva","doi":"10.1080/17476348.2025.2452441","DOIUrl":"10.1080/17476348.2025.2452441","url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease (COPD) is frequently accompanied by a variety of comorbidities, complicating management and rehabilitation efforts. Understanding this interplay is crucial for optimizing patient outcomes.Areas covered: This review, based on the MEDLINE, Embase and Cochrane Library databases, summarizes the main research on the rehabilitation of patients with COPD, with an emphasis on relevant comorbidities, such as cardiovascular diseases, pulmonary hypertension, lung cancer, metabolic, musculoskeletal, and gastrointestinal disorders. anxiety/depression and cognitive disorders. The study highlights the importance of pre-participation assessments, ongoing monitoring and personalized rehabilitation programs. A review includes a comprehensive literature search to assess the scientific evidence on these interventions and their impact.Expert opinion: The integration of cardiorespiratory rehabilitation program is essential for improving physical capacity and quality of life in COPD patients with comorbidities. While existing studies highlight positive outcomes, challenges such as interdisciplinary collaboration and access to rehabilitation services remain. Future strategies must prioritize personalized and integrated approaches programs combining pharmacological optimization and a close monitoring during cardiopulmonary rehabilitation to significantly reduce hospital readmissions and mortality, even in patients with complex multimorbidities. Continued research is necessary to refine rehabilitation protocols and better understand the complexities of managing COPD alongside cardiac conditions.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"11-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addressing the need for better management of pleural infections in low- to middle-income countries. 解决中低收入国家更好地管理胸膜感染的需要。

Expert review of respiratory medicine Pub Date : 2025-01-01 Epub Date: 2025-01-14 DOI: 10.1080/17476348.2025.2453117

Jane A Shaw, Coenraad F N Koegelenberg

引用次数: 0

Respiratory manifestations of sickle cell disease in children: a comprehensive review for the pediatrician. 儿童镰状细胞病的呼吸表现：儿科医生的综合综述。

Expert review of respiratory medicine Pub Date : 2025-01-01 Epub Date: 2025-01-20 DOI: 10.1080/17476348.2025.2451960

Lisa Grigoli, Maria Marocchi, Laura Venditto, Michele Piazza, Laura Tenero, Giorgio Piacentini, Marco Zaffanello, Giuliana Ferrante

{"title":"Respiratory manifestations of sickle cell disease in children: a comprehensive review for the pediatrician.","authors":"Lisa Grigoli, Maria Marocchi, Laura Venditto, Michele Piazza, Laura Tenero, Giorgio Piacentini, Marco Zaffanello, Giuliana Ferrante","doi":"10.1080/17476348.2025.2451960","DOIUrl":"10.1080/17476348.2025.2451960","url":null,"abstract":"Introduction: Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by the production of sickle hemoglobin, leading to red blood cells sickling and hemolysis in hypoxic conditions. The resulting acute and chronic endothelial inflammation leads to chronic organ damage. Respiratory manifestations in SCD usually start from childhood and represent the leading causes of morbidity and mortality. Nevertheless, they are generally poorly addressed or recognized later in life, often contributing to a more severe course and complications.Areas covered: This narrative review aims to outline the significant acute and chronic respiratory manifestations in children with SCD, focusing on prevention and clinical management. Compelling issues that need to be addressed in the future are also discussed. We searched the PubMed database for original papers written in English. Age restrictions were set for children (birth to 18 years). No limitations were set for the date and study country.Expert opinion: Early detection and treatment of respiratory manifestations in SCD should be central to follow-up with patients affected by SCD. Nonetheless, studies are lacking, especially in pediatric age, and there is still no consensus on their management. Further research is strongly needed to accomplish universally accepted guidelines to guarantee patients the best care possible.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"55-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving sustained remission in severe asthma: goals, challenges, issues and opportunities. 实现严重哮喘的持续缓解：目标、挑战、问题和机遇。

Expert review of respiratory medicine Pub Date : 2025-01-01 Epub Date: 2025-01-05 DOI: 10.1080/17476348.2024.2449080

Alessandro Vatrella, Angelantonio Maglio

引用次数: 0

Radon exposure as an occupational risk factor for lung cancer in conventional workplaces. An overview. 氡暴露作为传统工作场所肺癌的职业风险因素。概述。

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-12-22 DOI: 10.1080/17476348.2024.2444363

Lucía Martin-Gisbert, Guadalupe García, Ana Teijeiro, Alberto Ruano-Ravina

{"title":"Radon exposure as an occupational risk factor for lung cancer in conventional workplaces. An overview.","authors":"Lucía Martin-Gisbert, Guadalupe García, Ana Teijeiro, Alberto Ruano-Ravina","doi":"10.1080/17476348.2024.2444363","DOIUrl":"10.1080/17476348.2024.2444363","url":null,"abstract":"Introduction: Radon gas has been a declared human carcinogen for more than 30 years and has been causally associated with lung cancer. Studies have shown a linear relationship between residential radon exposure and lung cancer risk.Areas covered: Initially, this risk was subjected to cohorts of underground miners and then in case-control studies in the general population.While the evidence on residential radon exposure and lung cancer risk is extensive, there is little evidence on occupational radon exposure in conventional workplaces. Studies estimating radon-attributed mortality and prevalence also consider only residential radon exposure.Expert opinion: As individuals are also exposed to radon in the workplace, further studies should incorporate an integrated assessment of radon exposure, including both residential and occupational exposure.The European Council Directive established specifications for occupational exposure to radon, indicating the reference level and making it mandatory to measure radon in the workplace. EU countries have adopted national legislation incorporating this framework, some relatively recently. These regulations create an unprecedented situation for previously and currently exposed workers. It is important that the legislation on the determination of radon concentrations in the workplace is rigorously enforced and introduced in countries where this is not yet the case.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1041-1046"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing protective ventilation in adults with acute brain injury-challenging misconceptions and prioritizing neuromonitoring. 优化急性脑损伤成人的保护性通气——挑战误解，优先进行神经监测。

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-12-10 DOI: 10.1080/17476348.2024.2438088

Robin L Goossen, Marcus J Schultz, David M P van Meenen, Janneke Horn, Patricia R Rocco, Chiara Robba

引用次数: 0

Inhaled immunosuppressants after lung transplantation -real potential to enhance patient outcomes. 肺移植术后吸入免疫抑制剂--提高患者疗效的真正潜力。

Expert review of respiratory medicine Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1080/17476348.2024.2434152

Gregory I Snell, Samantha L Ennis, Bronwyn J Levvey

引用次数: 0