Expert review of respiratory medicine最新文献_第4页

An update on spinal cord injury and diaphragm neuromotor control. 脊髓损伤和膈神经运动控制的最新进展。

Expert review of respiratory medicine Pub Date : 2025-07-01 Epub Date: 2025-04-22 DOI: 10.1080/17476348.2025.2495165

Obaid U Khurram, Gary C Sieck

{"title":"An update on spinal cord injury and diaphragm neuromotor control.","authors":"Obaid U Khurram, Gary C Sieck","doi":"10.1080/17476348.2025.2495165","DOIUrl":"10.1080/17476348.2025.2495165","url":null,"abstract":"Introduction: Understanding neuromotor control of the diaphragm muscle (DIAm) is the foundation for developing therapeutic approaches for functional recovery of ventilatory and non-ventilatory behaviors. Although the DIAm is the primary inspiratory pump, it plays a vital role in a wide variety of higher-force behaviors including airway clearance activities. After spinal cord injury (SCI), higher-force behaviors experience the greatest deficits. A classification scheme for SCI that incorporates this information would be clinically valuable.Areas covered: We begin by presenting foundational information about DIAm motor units. In addition, we introduce a classification scheme of SCI based on the impact it has on neural circuitry involved in breathing and other functions of the DIAm. Finally, we consider various promising therapeutic options available to improve DIAm motor function. Relevant literature was identified by searching PubMed and Google Scholar without specific limits on the dates.Expert opinion: Classification of SCI based on its impact on the neural circuitry involved in DIAm motor behaviors is an important part of developing effective therapeutics. An approach that considers the specific type of SCI and leverages a combination of interventions will likely yield the best outcomes for restoring both ventilatory and non-ventilatory functions.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"679-695"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: 'Roles of vitamins and nutrition in obstructive sleep apnea'. 致编辑的信：“维生素和营养在阻塞性睡眠呼吸暂停中的作用”。

Expert review of respiratory medicine Pub Date : 2025-07-01 Epub Date: 2025-04-26 DOI: 10.1080/17476348.2025.2499145

Dalmacito A Cordero

引用次数: 0

Interventional strategies to unload the right ventricle: a systematic review. 卸载右心室的介入策略：系统回顾。

Expert review of respiratory medicine Pub Date : 2025-07-01 Epub Date: 2025-05-15 DOI: 10.1080/17476348.2025.2495164

Leila Alajbegovic, Irene M Lang

{"title":"Interventional strategies to unload the right ventricle: a systematic review.","authors":"Leila Alajbegovic, Irene M Lang","doi":"10.1080/17476348.2025.2495164","DOIUrl":"10.1080/17476348.2025.2495164","url":null,"abstract":"Introduction: The function of the right ventricle (RV) is dependent on preload, end-systolic elastance (afterload), and intrinsic RV contractility. RV dysfunction comprises dilatation and hypertrophy, leading to RV failure and commonly death despite advances in medical treatments. This systematic review summarizes current and future interventional treatments to mechanically unload the RV. First, this review focuses on targeting pulmonary vascular afterload by addressing 1. Catheter-directed treatment for acute pulmonary embolism, 2. Balloon Pulmonary Angioplasty for chronic thromboembolic pulmonary hypertension, and 3. Pulmonary Artery Denervation for pulmonary hypertension. Second, mechanical support systems for enhancing RV contractility and interventions targeting tricuspid regurgitation as a cause of RV failure are discussed.Methods: On 2nd December 2024, a systematic search for publications between 2022 and 2025 was performed, using MEDLINE, EMBASE, Cochrane, and SCOPUS. The primary outcome was an improvement in hemodynamic measurements. Secondary outcomes included in-hospital mortality and complications. Meta-analyses, randomized controlled trials and for newer devices, observational studies and case series were included.Results: Of 32,852 screened studies, 80 were included. All treatments demonstrated various degrees of RV unloading.Conclusion: Novel treatments directed at mechanical RV unloading may improve survival, but further research is needed to examine long-term effects.Prospero registration: CRD42024616310.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"741-757"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic pleuroparenchymal fibroelastosis: diagnosis and management. 特发性胸膜实质纤维弹性病的诊断和治疗。

Expert review of respiratory medicine Pub Date : 2025-07-01 Epub Date: 2025-05-05 DOI: 10.1080/17476348.2025.2499651

Hiroshi Ishii, Yoshiaki Kinoshita, Naoki Hamada, Masaki Fujita, Hisako Kushima

{"title":"Idiopathic pleuroparenchymal fibroelastosis: diagnosis and management.","authors":"Hiroshi Ishii, Yoshiaki Kinoshita, Naoki Hamada, Masaki Fujita, Hisako Kushima","doi":"10.1080/17476348.2025.2499651","DOIUrl":"10.1080/17476348.2025.2499651","url":null,"abstract":"Introduction: Idiopathic pleuroparenchymal fibroelastosis (iPPFE) is a rare progressive interstitial lung disease characterized by upper-lobe fibrosis, severe restrictive impairment, and poor prognosis. Unlike idiopathic pulmonary fibrosis, in which acute exacerbations, chronic respiratory failure, and lung cancer are the major causes of death, iPPFE primarily leads to progressive respiratory failure, often complicated by malnutrition and recurrent pneumothorax. Despite growing recognition, its pathogenesis remains unclear and no effective treatments exist.Areas covered: This review summarizes the epidemiological, clinical, radiological, and pathological features of iPPFE, as well as diagnostic and prognostic advancements. Key prognostic factors include weight loss, reduced forced vital capacity, hypercapnia, and lower-lobe interstitial pneumonia. Serum biomarkers (e.g. latent transforming growth factor-beta binding protein-4) are being explored for early detection and prognostic purposes. Although antifibrotic agents show limited efficacy, supportive care - pulmonary rehabilitation, nutritional management, and pneumothorax prevention - remains essential. Research on the fibroelastotic pathways may inform the development of future therapies.Expert opinion: IPPFE remains a challenging disease. Therefore, early diagnosis and comprehensive management of this condition are crucial. Future research should refine prognostic models and explore novel therapeutic approaches for treating fibroelastosis. Lung transplantation may be an option for select patients. Further studies are required to optimize these outcomes.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"697-708"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of management strategies for pediatric obstructive sleep apnea following adenotonsillectomy. 儿童腺扁桃体切除术后阻塞性睡眠呼吸暂停的治疗策略综述。

Expert review of respiratory medicine Pub Date : 2025-07-01 Epub Date: 2025-05-11 DOI: 10.1080/17476348.2025.2500630

Saudamini J Lele, Neila Louise Kline, Alyssa Claire Chapel, Felicity Lenes-Voit, Ron B Mitchell

{"title":"An overview of management strategies for pediatric obstructive sleep apnea following adenotonsillectomy.","authors":"Saudamini J Lele, Neila Louise Kline, Alyssa Claire Chapel, Felicity Lenes-Voit, Ron B Mitchell","doi":"10.1080/17476348.2025.2500630","DOIUrl":"10.1080/17476348.2025.2500630","url":null,"abstract":"Introduction: Persistent obstructive sleep apnea (OSA) following adenotonsillectomy is a frequently encountered challenge for clinicians including pediatricians, neurologists, otolaryngologists and sleep specialists, and if untreated poses severe health risks to children.Areas covered: This article evaluates the etiology and pathophysiology of persistent pediatric OSA. It also discusses the conditions that predispose some children to persistent OSA following adenotonsillectomy and reviews the different diagnostic modalities and various options for management of persistent pediatric OSA. A PubMed search was performed using the following terms in various combinations: persistent obstructive sleep apnea, pediatric obstructive sleep apnea, positive airway pressure, hypoglossal nerve stimulator, myofunctional therapy, nasal surgery, CPAP tolerance, obesity, Down syndrome, montelukast, frenulectomy, bariatric surgery, drug induced sleep endoscopy, cine MRI.Expert opinion: Persistent OSA following adenotonsillectomy is commonly seen in children. Understanding the anatomic and physiologic mechanisms at play is important to formulate specific management strategies. It is important to have a higher degree of suspicion for persistent OSA after an adenotonsillectomy in children with neurological comorbidities and obesity.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"721-731"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on oscillometry in asthma. 哮喘振荡测量的最新进展。

Expert review of respiratory medicine Pub Date : 2025-07-01 DOI: 10.1080/17476348.2025.2526774

Francesco Menzella, Rory Chan, Carlo Lombardi, Alvise Berti, Marcello Cottini

{"title":"An update on oscillometry in asthma.","authors":"Francesco Menzella, Rory Chan, Carlo Lombardi, Alvise Berti, Marcello Cottini","doi":"10.1080/17476348.2025.2526774","DOIUrl":"10.1080/17476348.2025.2526774","url":null,"abstract":"Introduction: Notwithstanding considerable progress in asthma management, a significant proportion of patients continue to demonstrate suboptimal control. Research has identified small airways dysfunction (SAD) as a critical site for airflow limitation and an independent risk factor of exacerbations, with airway oscillometry (AO) playing a pivotal role in this field.Areas covered: Spirometry is widely accepted as the gold standard for evaluating respiratory function. However, it is primarily sensitive to large airway obstruction… AO has emerged as a valuable tool for quantifying SAD, and recent studies have established strong correlations between AO, advanced imaging techniques and type 2 biomarkers. We conducted a review of the English-language literature from the beginning of the databases reviewed through June 2025.Expert opinion: In recent years, a substantial body of literature has emerged, leading to a resurgence of interest in the role of AO in asthma management. It is recommended that AO be utilized as a primary diagnostic tool for the early detection of SAD, even when spirometric values are within normal limits. The identification of patients with asthma in accordance with the criteria of defined severe SAD-oscillometry signifies the culmination of the evolution of AO from a research tool to a clinical tool.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in exhaled breath condensate markers for severe asthma management: a systematic review. 呼气冷凝水标记物在严重哮喘管理中的进展：系统综述。

Expert review of respiratory medicine Pub Date : 2025-06-30 DOI: 10.1080/17476348.2025.2522743

Claudia Gagliani, Paul Brinkman, Marco Del Riccio, Alida Benfante, Shahriyar Shahbazi Khamas, Anke-H Maitland-van der Zee, Stefania Principe, Nicola Scichilone

{"title":"Advances in exhaled breath condensate markers for severe asthma management: a systematic review.","authors":"Claudia Gagliani, Paul Brinkman, Marco Del Riccio, Alida Benfante, Shahriyar Shahbazi Khamas, Anke-H Maitland-van der Zee, Stefania Principe, Nicola Scichilone","doi":"10.1080/17476348.2025.2522743","DOIUrl":"10.1080/17476348.2025.2522743","url":null,"abstract":"Background: Severe asthma is a chronic respiratory disease posing challenges for clinicians and patients, increasing health-care costs and patients' poor quality of life. Advances in precision medicine have introduced novel approaches to managing severe asthma, including breathomics, a promising field using exhaled breath analysis to identify disease biomarkers. Among these techniques, exhaled breath condensate (EBC) analysis has emerged as a potential noninvasive tool for monitoring airway inflammation and disease progression.Methods: A systematic literature review was conducted to identify EBC biomarkers for monitoring severe asthma, searching across PubMed, Cochrane, Google Scholar, MEDLINE, ISRCTN, EMBASE and Web of Science.Results: Twenty-three studies were included in the review. Key markers identified were 8-isoprostane, hydrogen peroxide (H₂O₂), nitric oxide (NO), and eicosanoids. Among these, 8-isoprostane was the most widely studied biomarker in severe asthma, while H₂O₂ seems to be most closely linked to assessing asthma control.Conclusions: To the best of our knowledge, this is the first systematic review focusing on EBC biomarkers in severe asthma. Breath analysis represents a promising noninvasive approach to evaluate airway inflammation, identify early signs of poorly controlled asthma and monitor treatment response. Further research is needed to validate these biomarkers for clinical application.Protocol registration: uk/prospero with identifier CRD42023406669 https://www.crd.york.ac.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of fixed-dose tiotropium/olodaterol combined therapy on exercise-related outcome measures in individuals with chronic obstructive pulmonary disease: a systematic review and meta-analysis. 固定剂量噻托溴铵/奥替特罗联合治疗对慢性阻塞性肺疾病患者运动相关结局指标的影响：一项系统综述和荟萃分析

Expert review of respiratory medicine Pub Date : 2025-06-25 DOI: 10.1080/17476348.2025.2522754

Sanaa A Alsubheen, Myanca Rodrigues, Kristian Thorlund

{"title":"Effect of fixed-dose tiotropium/olodaterol combined therapy on exercise-related outcome measures in individuals with chronic obstructive pulmonary disease: a systematic review and meta-analysis.","authors":"Sanaa A Alsubheen, Myanca Rodrigues, Kristian Thorlund","doi":"10.1080/17476348.2025.2522754","DOIUrl":"10.1080/17476348.2025.2522754","url":null,"abstract":"Introduction/objectives: This systematic review aimed to summarize the evidence on the effect of the fixed-dose combination of tiotropium/olodaterol (Tio/Olo 5/5 μg FDC) on exercise-related outcome measures.Methods: We included randomized clinical trials (RCTs) from four databases that investigated the effectiveness of Tio/Olo 5/5 μg FDC on exercise tolerance, breathlessness, lung function, and physical activity from inception to October 2024.Results: Findings from eight RCTs indicated that Tio/Olo 5/5 μg FDC was superior to Tio 5 μg or placebo for the following outcomes: exercise tolerance [Tio 5 μg: 3 RCTs, mean difference (MD) = 16.6 m, 95% CI: 5.2-28.1, p < 0.001], exercise endurance time [Placebo: 2 RCTs, SMD = 0.29, 95% CI: 0.19-0.39, p = p < 0.001], inspiratory capacity [Tio 5 μg: 3 RCTs, MD = 0.13 L, 95% CI: 0.07-0.19, p < 0.001], and forced expiratory volume in 1 second (FEV1) [Tio 5 μg: 4 RCTs, MD = 0.12 L, 95% CI: 0.11-0.14, p < 0.001; Placebo: 2 RCTs, MD = 0.33 L, 95% CI: 0.3-0.35, p < 0.001], with no effect on physical activity levels.Conclusion: Tio/Olo 5/5 μg FDC compared to Tio 5 μg or placebo may improve exercise tolerance and lung function, but not physical activity levels in COPD.Protocol registration: The systematic review protocol is registered on PROSPERO (International Prospective Register of Systematic Reviews): number CRD42024598553.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between female asthma and fertility. 女性哮喘与生育能力的关系。

Expert review of respiratory medicine Pub Date : 2025-06-25 DOI: 10.1080/17476348.2025.2525912

Anne Vejen Hansen, Charlotte Suppli Ulrik

{"title":"The relationship between female asthma and fertility.","authors":"Anne Vejen Hansen, Charlotte Suppli Ulrik","doi":"10.1080/17476348.2025.2525912","DOIUrl":"https://doi.org/10.1080/17476348.2025.2525912","url":null,"abstract":"Introduction: Asthma and fertility represent two health-related challenges for women of reproductive age. Women with asthma experience prolonged time to pregnancy and an increased likelihood of requiring fertility treatment, with age, severity of asthma and uncontrolled asthma being important factors, compared to women without asthma, suggesting complex interplay between asthma and fertility.Areas covered: While evidence on the association between asthma and pregnancy loss is conflicting, pregnancy itself is associated with additional risks of maternal and fetal complications, including preeclampsia, preterm birth, and low birth weight. However, well-controlled asthma reduces these risks, underscoring the critical importance of proper management according to generally accepted asthma treatment guidelines.Age influences not only fertility but also the control of asthma during pregnancy, an increasing age correlates with a higher likelihood of uncontrolled asthma and exacerbations during pregnancy. Although systemic corticosteroid exposure during first trimester may be associated with risks, the consequences of uncontrolled asthma and hypoxemia pose greater threats to fetal well-being and should therefore be administered according to guidelines if required.Expert opinion: This review explores the relationship between asthma, fertility and pregnancy outcomes, emphasizing the importance of asthma control and medication adherence. Practical recommendations are provided for women with asthma planning pregnancy, along with proposed future research directions to improve understanding and care in this population. In conclusion, women with asthma should be encouraged to plan pregnancies earlier in life, given the impact of age on fertility and asthma-related risks. While some may experience pregnancy loss, asthma does not reduce overall offspring numbers. Effective asthma management is essential to ensuring the health and well-being of both mother and fetus.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social determinants of health, early diagnosis, and ageing in patients with interstitial lung disease. 间质性肺病患者健康、早期诊断和老龄化的社会决定因素。

Expert review of respiratory medicine Pub Date : 2025-06-24 DOI: 10.1080/17476348.2025.2523501

Abebaw Mengistu Yohannes

{"title":"Social determinants of health, early diagnosis, and ageing in patients with interstitial lung disease.","authors":"Abebaw Mengistu Yohannes","doi":"10.1080/17476348.2025.2523501","DOIUrl":"10.1080/17476348.2025.2523501","url":null,"abstract":"Introduction: Interstitial lung disease (ILD) is a heterogenous, chronic, progressive lung disease characterized by thickening and scar fibrosis of lung tissue, interstitial alveolar damage, severe airways limitations, and impaired gas exchange which leads to breathlessness and fatigue.Areas covered: Based on the available literature, only a few studies were identified that examined social determinants of health (SDOH) in the early diagnosis of ILD. The findings highlighted that those patients from low socioeconomic status and highly deprived communities had greater barriers in accessing healthcare, delayed diagnosis of ILD, and receiving lung transplant surgery. We discuss the challenges encountered by both patients and physicians for early diagnosis and suggest potential strategies to identify and accelerate treatment of patients with ILD.Expert opinion: SDOH exerts substantial burdens upon patients with ILD. Delays in the diagnosis of ILD are associated with increased disease burden, elevated stress, anxiety, depression, frequent acute exacerbations, and premature death. SDOH heavily affect patients from low socioeconomic status and disadvantaged communities. Innovative strategies are required to address healthcare disparities on early diagnosis and treatment of ILD. Thus, patients with ILD and with identified SDOH may need dedicated additional support to improve care and focused areas for future research.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0