Expert review of respiratory medicine最新文献_第4页

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1080/17476348.2025.2460601

Ádám Domonkos Tárnoki, Dávid László Tárnoki, Pál Maurovich-Horvat

引用次数: 0

Pulmonary function tests: an integrated approach to interpreting results in the search for treatable traits.

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-01-25 DOI: 10.1080/17476348.2025.2458607

Agnaldo José Lopes

{"title":"Pulmonary function tests: an integrated approach to interpreting results in the search for treatable traits.","authors":"Agnaldo José Lopes","doi":"10.1080/17476348.2025.2458607","DOIUrl":"10.1080/17476348.2025.2458607","url":null,"abstract":"Introduction: Technological advances have led to the proliferation of lung function assessment techniques beyond spirometry in most countries. At the same time, new knowledge of respiratory physiology has allowed an expansion of lung function parameters, requiring an integrated approach to interpreting results.Areas covered: This review addresses the major pulmonary function tests (PFTs) used in clinical practice, new concepts regarding reference values, and reformulations of terminology for defining standards of lung function impairment. It highlights the complexities and nuances inherent in the interpretation of PFT parameters, particularly in light of recent updates from the European Respiratory Society/American Thoracic Society.Expert opinion: In a new paradigm, PFTs should be used to classify the pathophysiology of treatable traits rather than to diagnose respiratory disease, given the considerable variation in the clinical patterns of PFTs. It is necessary to look not only at lung mechanics but also at lung volume, gas transfer, and small airway involvement to capture as much information as possible. In this context, it is also important to understand that racial/ethnic differences in lung function are not due to biological differences but may reflect socioeconomic status and represent health disparities.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"121-143"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of vitamins and nutrition in obstructive sleep apnea.

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-02-06 DOI: 10.1080/17476348.2025.2462192

Kostas Archontogeorgis, Evangelia Nena, Paschalis Steiropoulos

{"title":"Roles of vitamins and nutrition in obstructive sleep apnea.","authors":"Kostas Archontogeorgis, Evangelia Nena, Paschalis Steiropoulos","doi":"10.1080/17476348.2025.2462192","DOIUrl":"10.1080/17476348.2025.2462192","url":null,"abstract":"Introduction: Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder, with a prevalence that rises alongside with the increasing prevalence of obesity. OSA is characterized by a low-inflammatory state and is followed by cardiovascular and metabolic sequelae. Continuous positive airway pressure (CPAP) represents the cornerstone of treatment for severe OSA. However, poor compliance with CPAP treatment renders OSA treatment a challenging venture. Weight loss and exercise are recommended as adjunctive treatment options for OSA. Several diets have proven to facilitate weight loss, and to alleviate the inflammatory status in patients with OSA. Moreover, several vitamins exhibit antioxidant properties that beneficially affect OSA pathology and reduce the risk of cardiovascular complications.Area covered: This narrative review aims to summarize the current knowledge regarding the effect of nutrition and vitamin deficiencies on OSA. Included were publications, relevant to the topic, with different types of design (i.e. cross-sectional studies, cohort studies, clinical trials, systematic reviews, meta-analyses, etc.) and indexed in PubMed database until 31 March 2024.Expert opinion: In addition to weight loss, other food components, such as proteins, carbohydrates, anti-inflammatory agents, vitamins A, B, C, D, E, and sodium, may play a beneficial role in the incidence and severity of OSA.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"145-163"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The usefulness of the forced oscillation technique in the diagnosis of bronchial asthma in seniors.

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-02-02 DOI: 10.1080/17476348.2025.2461229

Martyna Miodońska, Andrzej Bożek, Ewa Urbaniec, Aleksandra Mitka, Eliza Wasilewska

{"title":"The usefulness of the forced oscillation technique in the diagnosis of bronchial asthma in seniors.","authors":"Martyna Miodońska, Andrzej Bożek, Ewa Urbaniec, Aleksandra Mitka, Eliza Wasilewska","doi":"10.1080/17476348.2025.2461229","DOIUrl":"10.1080/17476348.2025.2461229","url":null,"abstract":"Background: Obstructive pulmonary diseases are common in the elderly but often remain underdiagnosed due to limited spirometry availability or challenges with patient cooperation during testing. This study evaluated the potential of the forced oscillation technique (FOT) as a diagnostic tool for bronchial asthma in individuals over 60 years old.Research design and methods: A total of 189 patients diagnosed with asthma after age 60 and a control group of nonasthmatic seniors were included. Participants underwent spirometry, FOT, and bronchial reversibility testing using both methods. The primary outcomes were correlations between positive results from resting spirometry and FOT in asthmatics and the agreement between reversibility test results across the two methods.Results: FOT parameters (FEV1, V5, R5) effectively distinguished asthmatics from nonasthmatics. Positive reversibility test results were observed in 71 (73.2%) patients using FOT and 68 (70.1%) using spirometry, with both methods aligning in 64 (66%) cases.Conclusion: These results highlight the value of FOT, particularly for bronchial reversibility testing, in improving asthma diagnosis in seniors. FOT offers a practical alternative for patients who face difficulties performing spirometry, addressing a critical need in this population.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"175-182"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of noninvasive positive pressure ventilation for severe asthma: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. 使用无创正压通气治疗严重哮喘：随机对照试验的系统回顾和荟萃分析。

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-01-19 DOI: 10.1080/17476348.2025.2454947

Luigi La Via, Giuseppe Cuttone, Giovanni Misseri, Massimiliano Sorbello, Federico Pappalardo, Antonino Maniaci, Gilberto Duarte-Medrano, Natalia Nuño-Lámbarri, Christian Zanza, Cesare Gregoretti

{"title":"The use of noninvasive positive pressure ventilation for severe asthma: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.","authors":"Luigi La Via, Giuseppe Cuttone, Giovanni Misseri, Massimiliano Sorbello, Federico Pappalardo, Antonino Maniaci, Gilberto Duarte-Medrano, Natalia Nuño-Lámbarri, Christian Zanza, Cesare Gregoretti","doi":"10.1080/17476348.2025.2454947","DOIUrl":"10.1080/17476348.2025.2454947","url":null,"abstract":"Introduction: To evaluate the effectiveness of noninvasive positive pressure ventilation (NPPV) versus standard therapy in severe asthma exacerbations through meta-analysis.Methods: Nine randomized controlled trials (344 patients) were analyzed from inception to August 2024. Primary outcomes included respiratory rate, forced expiratory volume in first second (FEV1), and oxygen saturation (SpO2). Random effect models and trial sequential analyses were employed.Results: NPPV demonstrated significant reduction in respiratory rate versus standard therapy (mean difference [MD] -3.97, 95% CI -7.32 to -0.61, p = 0.02), though with high heterogeneity (I2 = 87%). FEV1 showed significant improvement with NPPV (MD 15.56%, 95% CI 6.86 to 24.26, p < 0.001) based on two studies. SpO2 showed no significant improvement (MD 0.62%, 95% CI -0.14 to 1.37, p = 0.11). No differences were found between pediatric and adult populations. Trial sequential analyses indicated insufficient evidence for definitive conclusions regarding respiratory rate and SpO2 improvements.Conclusions: While NPPV may benefit severe asthma patients, particularly in reducing respiratory rate and improving FEV1, current evidence is insufficient for recommending routine clinical use. Larger randomized controlled trials are needed to establish NPPV's effectiveness in severe asthma exacerbation treatment.Protocol registration: registration ID CRD42024580051.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"165-173"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards the integrated care of COPD, asthma and bronchiectasis: description and objectives of a treatable trait-based complex obstructive airway disease unit. 实现慢性阻塞性肺病、哮喘和支气管扩张综合治疗：基于可治疗性状的复杂阻塞性气道疾病单元的描述和目标。

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1080/17476348.2025.2453652

Borja G Cosio, Alexandre Palou, Meritxell López, Ruth Engonga, Jose Luis Valera, Nuria Toledo-Pons

{"title":"Towards the integrated care of COPD, asthma and bronchiectasis: description and objectives of a treatable trait-based complex obstructive airway disease unit.","authors":"Borja G Cosio, Alexandre Palou, Meritxell López, Ruth Engonga, Jose Luis Valera, Nuria Toledo-Pons","doi":"10.1080/17476348.2025.2453652","DOIUrl":"10.1080/17476348.2025.2453652","url":null,"abstract":"Introduction: Expert management of Complex Obstructive Airway Diseases (COAD) requires knowledge, resources, and skills that are commonly shared in the management of the different conditions usually included in the acronym, namely asthma, bronchiectasis, and Chronic Obstructive Pulmonary Disease (COPD). We discuss the basis to shift the paradigm of single-disease management into a holistic approach and describe its potential benefits.Areas covered: The prevalence and significance of the overlap between the different conditions is reviewed. Literature research on the topic of treatable traits in airway diseases is analyzed, with special emphasis in the role of an expert nurse and the multidisciplinary team approach for the management of asthma, bronchiectasis, and COPD. Finally, we describe the experience and organization of a COAD unit addressing desirable clinical outcomes and patient-related outcome measures.Expert opinion: The division between different airway diseases generates confusion when the diseases present features common to various airway conditions. We describe here how a holistic approach of the airway disease process based on treatable traits regardless the diagnostic label reverts in a more efficient use of resources and better clinical outcomes. The role of an expert respiratory nurse and a multidisciplinary team are key areas for improvement.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"87-95"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The changing role of opioids for symptom management in people with advanced lung disease.

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1080/17476348.2025.2459304

Amy Pascoe, Natasha Smallwood

引用次数: 0

Night-to-night variability in obstructive sleep apnoea: when might a multi-night measurement be helpful? 阻塞性睡眠呼吸暂停的夜间变异性：多夜测量何时可能有用？

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-01-23 DOI: 10.1080/17476348.2025.2457370

Esther Irene Schwarz

引用次数: 0

Multifaceted pulmonary manifestations of amyloidosis: state-of-the-art update. 淀粉样变的多面肺部表现：最新进展。

Expert review of respiratory medicine Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1080/17476348.2025.2457374

Antonios Charokopos, Misbah Baqir, Anja C Roden, Jay H Ryu, Teng Moua

{"title":"Multifaceted pulmonary manifestations of amyloidosis: state-of-the-art update.","authors":"Antonios Charokopos, Misbah Baqir, Anja C Roden, Jay H Ryu, Teng Moua","doi":"10.1080/17476348.2025.2457374","DOIUrl":"10.1080/17476348.2025.2457374","url":null,"abstract":"Introduction: Amyloidosis, a polymeric deposition disease classified according to protein subtype, may have varied pulmonary manifestations. Its anatomic-radiologic phenotypes include nodular, cystic, alveolar-septal, and tracheobronchial forms. Clinical presentation may range from asymptomatic parenchymal nodules to respiratory failure from diffuse parenchymal infiltration or diaphragmatic deposition.Areas covered: In this review, we systematically describe the molecular subtypes of amyloidosis and their clinical and radiologic findings in the lungs as well as key extrapulmonary organ systems. We detail novel treatment approaches to systemic amyloidosis. We also discuss prognostic elements for each subtype. We identify key clinical scenarios where reaching a precise diagnosis can be complicated, and we offer insights on the varied presentations of pulmonary amyloidosis.Expert opinion: Pulmonary amyloidosis is often difficult to diagnose as it may mimic other conditions, including fibrotic interstitial lung diseases and neoplasms, or can co-exist with certain connective tissue diseases. Despite some early artificial intelligence screening tools, improved familiarity among clinicians can aid in the more accurate and timely diagnosis of this multidimensional clinical entity. We additionally believe that multidisciplinary clinical pathwaysto diagnose and/or treat pulmonary amyloidosis have the potential to improve awareness, decrease diagnostic delay, and further elucidate knowledge on this multifaceted disease.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"107-120"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the potential of lung transplantation for situs inversus. 揭示逆位肺移植的潜力。

Expert review of respiratory medicine Pub Date : 2025-01-01 Epub Date: 2024-12-26 DOI: 10.1080/17476348.2024.2447513

Yudai Miyashita, Taisuke Kaiho, Chitaru Kurihara

{"title":"Unveiling the potential of lung transplantation for situs inversus.","authors":"Yudai Miyashita, Taisuke Kaiho, Chitaru Kurihara","doi":"10.1080/17476348.2024.2447513","DOIUrl":"10.1080/17476348.2024.2447513","url":null,"abstract":"Introduction: Situs inversus is a rare congenital condition where the organs in the chest and abdomen are reversed, thus complicating surgeries such as lung transplantation. Kartagener syndrome (KS), associated with situs inversus, includes chronic sinusitis and bronchiectasis, which can progress to end-stage lung disease requiring transplantation. This review discusses the unique surgical considerations, technical challenges, and outcomes of lung transplantation in patients with situs inversus, particularly KS.Areas covered: The review highlights anatomical and physiological challenges in lung transplantation due to reversed organ positioning, requiring customized surgical approaches and intraoperative modifications. Preoperative imaging, anesthesia adjustments, and tailored surgical techniques are crucial for successful transplantation. Postoperative care focuses on managing complications such as primary graft dysfunction, infections, and anastomotic issues. Literature on survival rates, chronic lung allograft dysfunction, and quality of life is analyzed, indicating outcomes comparable to other lung transplant recipients.Expert opinion: Despite significant challenges, lung transplantation in patients with situs inversus and KS is feasible with outcomes similar to traditional cases. Advances in imaging, surgical planning, and minimally invasive techniques offer promise for improved outcomes. Ongoing research, collaboration, and ethical considerations are essential to optimizing care and expand treatment possibilities for this high-risk patient population.","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":" ","pages":"43-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0