Nanoscale Horizons最新文献_第8页

Porous carbon nitride fullerenes: a novel family of porous cage molecules† 多孔氮化碳富勒烯：一种新型多孔笼状分子。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-04-02 DOI: 10.1039/D5NH00091B

Zacharias G. Fthenakis and Nektarios N. Lathiotakis

{"title":"Porous carbon nitride fullerenes: a novel family of porous cage molecules†","authors":"Zacharias G. Fthenakis and Nektarios N. Lathiotakis","doi":"10.1039/D5NH00091B","DOIUrl":"10.1039/D5NH00091B","url":null,"abstract":"A novel family of cage molecules, porous carbon nitride fullerenes (PCNFs), is designed, proposed and studied theoretically. PCNFs can be considered the zero-dimensional counterparts of two-dimensional porous graphitic carbon nitrides, in analogy with icosahedral fullerenes, being the zero-dimensional counterparts of graphene. The study is focused on two representative members of the PCNF family: icosahedral C60N60 and C120N60, which are the first members of the two main sub-families of these structures. Given the advanced potential of two-dimensional graphitic carbon nitrides for several interesting applications, it is reasonable to expect that this potential extends to their zero-dimensional counterparts. The present study demonstrates the electronic, vibrational, and thermal stability of the two representative PCNFs utilizing density functional theory and molecular dynamics simulations with ReaxFF potentials. In addition, their structural, vibrational, and electronic properties are revealed.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 6","pages":" 1184-1191"},"PeriodicalIF":8.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d5nh00091b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reinforced supercapacitor electrode via reduced graphene oxide encapsulated NiTe2–FeTe2 hollow nanorods† 通过还原氧化石墨烯封装NiTe2-FeTe2空心纳米棒增强超级电容器电极。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-04-01 DOI: 10.1039/D5NH00107B

Mohammad Ali Saghafizadeh, Akbar Mohammadi Zardkhoshoui and Saied Saeed Hosseiny Davarani

{"title":"Reinforced supercapacitor electrode via reduced graphene oxide encapsulated NiTe2–FeTe2 hollow nanorods†","authors":"Mohammad Ali Saghafizadeh, Akbar Mohammadi Zardkhoshoui and Saied Saeed Hosseiny Davarani","doi":"10.1039/D5NH00107B","DOIUrl":"10.1039/D5NH00107B","url":null,"abstract":"Metal telluride-based nanomaterials have garnered considerable interest as positive electrode materials for supercapacitors due to their plentiful redox-active sites, robust chemical stability, and excellent electrical conductivity. In this work, these advantageous properties are further enhanced by hybridizing NiTe2–FeTe2 (NFT) hollow nanorods with reduced graphene oxide (RGO), resulting in an NFT@RGO composite suitable for supercapacitor applications. The hollow rod-like structure promotes efficient ion diffusion and maximizes the exposure of electroactive sites, while the RGO network boosts conductivity and mitigates nanomaterial agglomeration, thus preserving structural integrity and prolonging material durability. The NFT@RGO-based electrode exhibits a notable capacity of 1388.5 C g−1 at 1 A g−1, with 93.82% capacity retention after 10 000 cycles. This remarkable performance arises from the synergistic contributions of the Ni and Fe metals, the electrically conductive Te element, the RGO framework, and the unique hollow morphology of the nanorods. Furthermore, a hybrid device employing activated carbon (AC) as the negative electrode (NFT@RGO//AC) achieves an energy density of 61.11 W h kg−1 and retains 89.85% of its capacity over 10 000 cycles, underscoring the promise of NFT@RGO for next-generation supercapacitors. These findings position the designed nanomaterial as an excellent candidate for high-performance energy storage systems.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 6","pages":" 1159-1172"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving highly efficient electrocatalytic hydrogen evolution with Co-doped MoS2 nanosheets† 利用共掺杂二硫化钼纳米片实现高效电催化析氢。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-03-28 DOI: 10.1039/D5NH00111K

Fengrui Sun, Kebin Yang, Xinbo Qin, Weibing Wu and Yizhong Lu

{"title":"Achieving highly efficient electrocatalytic hydrogen evolution with Co-doped MoS2 nanosheets†","authors":"Fengrui Sun, Kebin Yang, Xinbo Qin, Weibing Wu and Yizhong Lu","doi":"10.1039/D5NH00111K","DOIUrl":"10.1039/D5NH00111K","url":null,"abstract":"MoS2 is a promising hydrogen evolution reaction (HER) catalyst because of the Pt-like activity at the side edges, but the whole activity is restricted by the inert basal plane. Herein, Co-doped 1T-MoS2 nanosheets are grown on carbon cloth (CC) through hydrothermal synthesis and exhibit superior HER activity with an overpotential of 69 mV@10 mA cm−2 and a Tafel slope of 81.84 mV dec−1 as well as durability for over 100 h at 100 mA cm−2 in an alkaline medium. The detailed structural tests demonstrate that the improved HER activity is attributed to Co doping and the high 1T phase content. Co doping induces transformation from the 2H to the 1T phase (67%), and further TMA+ addition increases the doping amount and the 1T phase content (79%). The excellent durability is due to the strong interface binding between MoS2 nanosheets and CC associated with the heterogeneous nucleation and growth and the high growth temperature (230 °C). This provides an inspiration for developing efficient and stable MoS2 catalysts by element doping.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 6","pages":" 1120-1130"},"PeriodicalIF":8.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversing cancer immunosuppression via K+ capture and repolarization of tumor-associated macrophages† 通过K+捕获和肿瘤相关巨噬细胞的复极化逆转癌症免疫抑制。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-03-27 DOI: 10.1039/D5NH00050E

Si-Ye Tong, Cong-Min Huo, Yu-Cheng Zuo, Shuo Gao, David Tai Leong, Wei Xue and Jing-Yi Zhu

{"title":"Reversing cancer immunosuppression via K+ capture and repolarization of tumor-associated macrophages†","authors":"Si-Ye Tong, Cong-Min Huo, Yu-Cheng Zuo, Shuo Gao, David Tai Leong, Wei Xue and Jing-Yi Zhu","doi":"10.1039/D5NH00050E","DOIUrl":"10.1039/D5NH00050E","url":null,"abstract":"Immunosuppression from the tumor microenvironment plays a key role in the failure of cancer immunotherapy. The presence of potassium ions (K+) from dying tumor cells creates an immunosuppressive environment that encourages tumor-associated macrophages (TAMs) to adopt a pro-tumor M2-like phenotype. Alleviating immune suppression from the high K+ environment might boost innate immunity and fight tumor growth. Herein, disulfide-rich mesoporous silica modified with 18-crown-6 ether was developed as a nanocarrier (D-C) to load ML133, encapsulating with the DiR-embedded macrophage membrane (CM) to create D-C/M@CM/DiR. We first saturated the phagocytosis of the mononuclear phagocyte system (MPS) with blank nanocarriers to enhance the tumor accumulation of D-C/M@CM/DiR, which was coated with the same CM. 18-Crown-6 ether captures K+ to reduce immunosuppression, while ML133 promotes the polarization of TAMs to an anti-tumor M1 phenotype by targeting the K+ channel protein Kir2.1 on their membranes. This strategy activates the anti-tumor immune response and effectively inhibits tumor growth.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 6","pages":" 1107-1119"},"PeriodicalIF":8.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bioinspired helical hydrogel scaffold with real-time sensing for enhanced precision in gynecological digital vaginal examination† 一种具有实时传感的生物启发螺旋水凝胶支架，用于提高妇科数字阴道检查的精度。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-03-27 DOI: 10.1039/D4NH00636D

Weipeng Lu, Qing He, Zheng Mao, Songchao Fu, Yue Wang, Zhiwei Jiang, Ying Wang, Yue Cao, Sunlong Li, Cihui Liu and Qian Dong

{"title":"A bioinspired helical hydrogel scaffold with real-time sensing for enhanced precision in gynecological digital vaginal examination†","authors":"Weipeng Lu, Qing He, Zheng Mao, Songchao Fu, Yue Wang, Zhiwei Jiang, Ying Wang, Yue Cao, Sunlong Li, Cihui Liu and Qian Dong","doi":"10.1039/D4NH00636D","DOIUrl":"10.1039/D4NH00636D","url":null,"abstract":"Precise diagnostic and therapeutic modalities are of utmost significance in driving forward patient care within the sphere of gynecological medicine. Bionics, involving the application of nature-inspired designs in medical apparatus, has emerged as a highly promising approach in this field. Specifically, helical architectures observed in natural organisms like vines display remarkable adaptability and mechanical strength, presenting novel perspectives for the development of ergonomic and effective gynecological examination and surgical instruments. Harnessing these insights, this study presents a helical polydimethylsiloxane (PDMS) scaffold inspired by the deformability of vines. This scaffold not only integrates Janus wettability hydrogel properties to enhance tissue interaction, ensuring increased comfort and adaptability during clinical procedures, but also incorporates sensors for real-time monitoring and feedback, thereby overcoming the limitations of conventional gynecological devices that often lack such capabilities. We meticulously detail the fabrication of this helical finger scaffold, using a sandwich thermoplastic method to produce hydrogel fibers possessing shape memory, thermal responsiveness, and deformation sensing via relative resistance changes. Additionally, the study explores finger motion monitoring through surface electromyography (sEMG) signals, which advances the precision and safety of cervical palpation and related surgeries. Overall, our findings highlight the potential of these responsive and adaptable hydrogels to transform gynecological medical devices, providing a solid theoretical foundation and practical applications for future innovations in gynecological diagnostics and surgical support.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 6","pages":" 1131-1139"},"PeriodicalIF":8.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing sodium storage and durability in metal sulfide anodes with a 3D graphene architecture† 利用3D石墨烯结构优化金属硫化物阳极的钠储存和耐久性。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-03-26 DOI: 10.1039/D4NH00653D

Mujtaba Aminu Muhammad, Yangjie Liu, Baffa Haruna, Ahmed Abdel-aziz, Zul Qarnain, Amir Mahmoud Makin, Jiaqi Yu, Bo Zheng, Xiang Hu and Zhenhai Wen

{"title":"Optimizing sodium storage and durability in metal sulfide anodes with a 3D graphene architecture†","authors":"Mujtaba Aminu Muhammad, Yangjie Liu, Baffa Haruna, Ahmed Abdel-aziz, Zul Qarnain, Amir Mahmoud Makin, Jiaqi Yu, Bo Zheng, Xiang Hu and Zhenhai Wen","doi":"10.1039/D4NH00653D","DOIUrl":"10.1039/D4NH00653D","url":null,"abstract":"Transition metal chalcogenides (TMCs) with a high theoretical capacity are regarded as promising anodes for sodium-ion batteries (SIBs) but encounter several challenges because of the complex conversion process, which leads to numerous side reactions and the inevitable disintegration of active materials, thereby impeding their practical application. In this work, inspired by a three-dimensional (3D) structure design, stable 3D reduced graphene oxide with heteroatom-site coordinated carbon centers (3DNSrGO) is fabricated, which features uniform and abundant nickel sulfide (NiS) particles within the empty spaces, along with sufficient access to the liquid electrolyte, thereby enabling more efficient transfer of sodium ions. Nevertheless, the NiS/3DNSrGO electrode still suffers from unexpected cycling instability and failure issues because of the short-circuiting, resulting from sodium (Na) metal corrosion and the deterioration of the glass fiber (GF) separator. The issue of short cycle life is significantly mitigated at the cell configuration level (inclusion of the polypropylene membrane) by lowering the risks of Na–metal corrosion and protecting the GF membrane. This study holds considerable potential for addressing (1) the growing requirement for efficient and sustainable Na+ host materials and (2) a newfangled approach that optimizes the long-term cycling stability of SIBs via a better cell configuration.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 6","pages":" 1203-1214"},"PeriodicalIF":8.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biogenic fluorescent carbon dot-decorated mesoporous organosilica nanoparticles for enhanced bioimaging and chemotherapy†‡ 生物荧光碳点修饰的介孔有机二氧化硅纳米颗粒增强生物成像和化疗。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-03-25 DOI: 10.1039/D4NH00633J

Ky-Vien Le, Hanh-Vy Tran Nguyen, Phu-Quan Pham, Ngoc Hong Nguyen, Tan Le Hoang Doan, Linh Ho Thuy Nguyen, Bach Thang Phan, Lan Thi My Nguyen, Sungkyun Park, Ngoc Kim Pham, Philip Anggo Krisbiantoro, Kevin C.-W. Wu and Ngoc Xuan Dat Mai

{"title":"Biogenic fluorescent carbon dot-decorated mesoporous organosilica nanoparticles for enhanced bioimaging and chemotherapy†‡","authors":"Ky-Vien Le, Hanh-Vy Tran Nguyen, Phu-Quan Pham, Ngoc Hong Nguyen, Tan Le Hoang Doan, Linh Ho Thuy Nguyen, Bach Thang Phan, Lan Thi My Nguyen, Sungkyun Park, Ngoc Kim Pham, Philip Anggo Krisbiantoro, Kevin C.-W. Wu and Ngoc Xuan Dat Mai","doi":"10.1039/D4NH00633J","DOIUrl":"10.1039/D4NH00633J","url":null,"abstract":"Hybrid materials possess the unique properties of their individual components, enabling their use in multiple synergistic applications. In this study, we synthesized biogenic fluorescent carbon dots (CDs) decorated with biodegradable periodic mesoporous organosilica nanoparticles (BPMO), creating BPMO@CDs. The CDs, approximately 9.8 nm in diameter, were derived from Musa paradisiaca cv. Awak juice using a rapid microwave method, exhibiting a spherical shape and green and red luminescence. The resulting BPMO@CDs are spherical, around 100 nm in size, and maintain high pore volume and surface area. The elemental chemical state in the BPMO@CDs remains consistent with that of pure BPMO. Our findings demonstrate that BPMO@CDs achieve efficient cellular uptake rates of 46.74% in MCF7 cells and 17.07% in L929 cells, with preserved fluorescence within the cells. The optical properties of the CDs are retained in the BPMO@CDs, allowing for detection upon cellular uptake. Additionally, when loaded with anticancer drugs, the BPMO@CDs significantly enhance the cytotoxicity against MCF7 breast cancer cells, highlighting their potential for synergistic bioimaging and chemotherapy applications.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 5","pages":" 1000-1006"},"PeriodicalIF":8.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced piezoresponse in van der Waals 2D CuCrInP2S6 through nanoscale phase segregation† 通过纳米级相偏析增强二维CuCrInP2S6的压电响应。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-03-25 DOI: 10.1039/D4NH00580E

Sharidya Rahman, Sanika S. Padelkar, Lan Nguyen, Naufan Nurrosyid, Md Hemayet Uddin, Oleksandr Chernyavskiy, Junlin Yan, Chang Cao, Alexandr N. Simonov, Aftab Alam and Jacek J. Jasieniak

{"title":"Enhanced piezoresponse in van der Waals 2D CuCrInP2S6 through nanoscale phase segregation†","authors":"Sharidya Rahman, Sanika S. Padelkar, Lan Nguyen, Naufan Nurrosyid, Md Hemayet Uddin, Oleksandr Chernyavskiy, Junlin Yan, Chang Cao, Alexandr N. Simonov, Aftab Alam and Jacek J. Jasieniak","doi":"10.1039/D4NH00580E","DOIUrl":"10.1039/D4NH00580E","url":null,"abstract":"van der Waals metal chalcogen thiophosphates have drawn elevated interest for diverse applications, including energy harvesting, electronics and optoelectronics. Despite this progress, the role of nanoscale ion migration in complex intermediary thiophosphate compounds has not been well understood, resulting in their structure–property characteristics remaining elusive. Herein, we focus on copper-deficient CuCrInP2S6 as a prototypic layered thiophosphate compound to address this shortcoming. Piezo force microscopy reveals that this material exhibits unusual cage-like domain networks with an enhanced piezo response at the domain boundaries. The associated piezoelectric coefficient d33 is found to be among the highest across reported van der Waals multi-layered materials. These results are further complemented with Kelvin probe microscopy and second harmonic generation spectroscopy that disclose significantly elevated non-linear optical emission along these domain boundaries. Ab initio calculations performed in conjunction with nudge elastic theory provide a deeper insight into the diffusion processes responsible for these observed phenomena. These findings shed new light into intermediary thiophosphate based 2D compounds, highlighting future prospects towards their use in emergent piezoelectric based technological applications.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 5","pages":" 987-999"},"PeriodicalIF":8.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic nanosheets: from iron oxide nanocubes to polydopamine embedded 2D clusters and their multi-purpose properties† 磁性纳米片：从氧化铁纳米立方到聚多巴胺嵌入二维簇及其多用途性质。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-03-24 DOI: 10.1039/D4NH00566J

Giacomo Mandriota, Sahitya Kumar Avugadda, Ehsan Sadeghi, Niccolò Silvestri, Roberto Marotta, Helena Gavilán, Ulf Olsson, Cinzia Giannini, Yu Hsin Tsai, Anna Cristina S. Samia and Teresa Pellegrino

{"title":"Magnetic nanosheets: from iron oxide nanocubes to polydopamine embedded 2D clusters and their multi-purpose properties†","authors":"Giacomo Mandriota, Sahitya Kumar Avugadda, Ehsan Sadeghi, Niccolò Silvestri, Roberto Marotta, Helena Gavilán, Ulf Olsson, Cinzia Giannini, Yu Hsin Tsai, Anna Cristina S. Samia and Teresa Pellegrino","doi":"10.1039/D4NH00566J","DOIUrl":"10.1039/D4NH00566J","url":null,"abstract":"We here develop stable bidimensional magnetic nanoclusters (2D-MNCs) of iron oxide nanocubes (IONCs) arranged in thin nanosheets of closed-packed nanocubes. The assembly occurs by means of a two-step approach: in the first one, the ionic surfactant, sodium dodecyl sulfate (SDS), acts as a transient water transfer agent and as 2D clustering agent to induce formation of a monolayer of nanocubes arranged in thin nanosheets. Next, the addition of dopamine followed by solution basification, induces the in situ polymerization of dopamine with a tunable shell tickness depending on the dopamine amount, which helps to compact the clusters and ensures the long term water stability of the clusters. TEM, cryo-EM, and SAXS techniques helped to reveal structural features of the 2D-clusters. The pH-dependent degradation properties of polydopamine, enable to disassemble the clusters in acidic tumour microenviroment leading to a four-fold increase in the magnetic particle imaging signal and a concomitant increase of the magnetic heat losses of these clusters, makes them appealing in magnetic hyperthermia, while the shortening of T2 relaxation time suggests their use as contrast in magnetic resonance imaging. Finally, with crystal violet dye, used as drug molecule, the feasibility to release payloads pre-encapsulated with the polydopamine polymer shell has been also shown.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 6","pages":" 1140-1158"},"PeriodicalIF":8.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial-targeting miR-145 micelles restore barrier function and exhibit atheroprotective effects† 内皮靶向miR-145胶束恢复屏障功能并表现出动脉粥样硬化保护作用。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-03-21 DOI: 10.1039/D4NH00613E

Anisa Ashraf, Yi Huang, Auveen Choroomi, Kyla Johnson, Jocelynn Torres and Eun Ji Chung

{"title":"Endothelial-targeting miR-145 micelles restore barrier function and exhibit atheroprotective effects†","authors":"Anisa Ashraf, Yi Huang, Auveen Choroomi, Kyla Johnson, Jocelynn Torres and Eun Ji Chung","doi":"10.1039/D4NH00613E","DOIUrl":"10.1039/D4NH00613E","url":null,"abstract":"Atherosclerosis remains the leading cause of death worldwide and is characterized by the accumulation of plaque beneath the endothelium. MicroRNA-145-5p (miR-145), which is downregulated in atherosclerosis, has been shown to mitigate plaque development by promoting the contractile vascular smooth muscle cell (VSMC) phenotype. Previously, our lab found that miR-145 micelles conjugated with MCP-1 peptides were able to inhibit atherosclerosis by targeting diseased VSMC via C–C chemokine receptor 2 (CCR2). Diseased endothelial cells similarly express CCR2; however, the impact of miR-145 micelles on endothelial cell function has not been explored. Thus, in this study, the in vitro therapeutic effects of miR-145 micelles in modulating the endothelium during atherosclerosis are evaluated. To that end, the MCP-1 peptide density on the micelle surface was first optimized for activated endothelial cell binding, followed by loading miR-145 into micelles with the optimal MCP-1 ratio. Following characterization, miR-145 micelle treatment of activated endothelial cells resulted in efficient miR-145 transfection, upregulation of atheroprotective genes, and suppression of atherogenic genes. Furthermore, the treatment enhanced the integrity of endothelial tight junctions and reduced monocyte migration. This work establishes miR-145 micelles as an effective nanotherapeutic for restoring endothelial cell health in cardiovascular disease for the first time.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 5","pages":" 976-986"},"PeriodicalIF":8.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0