Nanoscale Horizons最新文献

筛选
英文 中文
TEM analysis of dicarboxylic acid-induced transition from unilamellar to multilamellar MEL-A vesicles. 二羧酸诱导的单层MEL-A囊泡向多层MEL-A囊泡转变的TEM分析。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-07 DOI: 10.1039/d6nh00084c
Tran Ngoc Linh, Hirohmi Watanabe, Takashi Arimura, Masato Kawasaki
{"title":"TEM analysis of dicarboxylic acid-induced transition from unilamellar to multilamellar MEL-A vesicles.","authors":"Tran Ngoc Linh, Hirohmi Watanabe, Takashi Arimura, Masato Kawasaki","doi":"10.1039/d6nh00084c","DOIUrl":"10.1039/d6nh00084c","url":null,"abstract":"<p><p>The internal structure of vesicles formed solely by mannosylerythritol lipid-A (MEL-A), a glycolipid produced by basidiomycetous yeasts of the genus <i>Pseudozyma</i>, was visualized by liquid cell and cryogenic transmission electron microscopy. Moreover, it was shown for the first time that their morphology can be controlled by dicarboxylic acids acting as molecular signals, combined with the pH of the solution. MEL-A formed nano-sized unilamellar vesicles (200 nm diameter, 5 nm bilayer thickness) at pH 7 and pH 4 without dicarboxylic acids. Upon addition of dicarboxylic acids at pH 7, divalent dicarboxylate anions engage with the hydroxyl groups of the erythritol moiety in MEL-A, driving the growth of unilamellar vesicles with diameters of 250-300 nm. At pH 4, the addition of dicarboxylic acids (oxalic, maleic, fumaric or malonic acids), which exist predominantly as monoanions, induced the expansion to micro-sized vesicles (0.8-2.1 µm in diameter) and the transition into a multilamellar structure consisting of up to 18 layers. For oxalic acid, the vesicular membrane exhibited a thickness of 80 nm and consisted of 16 layers, of which both the outermost and the innermost layer thickness was 5 nm. Vesicle multilayering in MEL-A assemblies is driven by cooperative dissociated/undissociated carboxyl interactions in dicarboxylate monoanions.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"1921-1927"},"PeriodicalIF":6.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modular design of dual-targeted, enzyme-responsive peptide carriers for gene drug delivery. 用于基因药物递送的双靶向酶反应肽载体的模块化设计。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-07 DOI: 10.1039/d5nh00803d
Xinhao Jiao, Mingshan Han, Zixuan Wang, Jie Min, Rongxin Su, Hang Tie, Wei Qi, Yuefei Wang
{"title":"Modular design of dual-targeted, enzyme-responsive peptide carriers for gene drug delivery.","authors":"Xinhao Jiao, Mingshan Han, Zixuan Wang, Jie Min, Rongxin Su, Hang Tie, Wei Qi, Yuefei Wang","doi":"10.1039/d5nh00803d","DOIUrl":"10.1039/d5nh00803d","url":null,"abstract":"<p><p>Gene-based therapeutics, including siRNA and mRNA, offer promising strategies for disease-related gene modulation but remain limited by challenges in systemic delivery and intracellular release. We report a modularly designed peptide-based carrier capable of delivering both siRNA and mRNA <i>in vitro</i> and <i>in vivo</i>. The carrier self-assembles from three functional peptide sequences incorporating modules for lysosomal escape (RRGK and leucine repeats), tumor-associated targeting (RGDK and GYQTI), and enhanced structural stability (long-chain serine). <i>In vitro</i>, the siRNA@peptide complex achieved 97% cellular uptake and 75% GFP gene silencing efficiency in HeLa cells. For mRNA delivery, the carrier promoted robust GFP expression <i>in vitro</i> and enabled tumor-associated luciferase expression <i>in vivo</i>. Furthermore, systemic administration of siRNA formulated with the optimized carrier resulted in measurable gene silencing in multiple organs, confirming its <i>in vivo</i> functional delivery capability. Collectively, these results establish a modular peptide platform for systemic gene delivery, demonstrating effective <i>in vivo</i> gene expression and gene silencing while maintaining acceptable biosafety. This study provides a versatile framework for the rational development of peptide-based nucleic acid delivery systems.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"1928-1938"},"PeriodicalIF":6.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An acoustic sensing fabric based on PVDF-HFP nanofiber core-shell yarns for respiratory acoustic signal monitoring. 基于PVDF-HFP纳米纤维芯壳纱的呼吸声信号监测织物。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-07 DOI: 10.1039/d6nh00126b
Jinjin Song, Haifan Tang, Junyun Zhang, Jiaxue Yu, Dailin Yuan, Yanqiu Zhang, Jinyang Wang, Di Pan, Weixu Tian, Jingye Jin, Jian Fang, Chenhong Lang
{"title":"An acoustic sensing fabric based on PVDF-HFP nanofiber core-shell yarns for respiratory acoustic signal monitoring.","authors":"Jinjin Song, Haifan Tang, Junyun Zhang, Jiaxue Yu, Dailin Yuan, Yanqiu Zhang, Jinyang Wang, Di Pan, Weixu Tian, Jingye Jin, Jian Fang, Chenhong Lang","doi":"10.1039/d6nh00126b","DOIUrl":"10.1039/d6nh00126b","url":null,"abstract":"<p><p>Respiratory acoustic signals provide a crucial insight for assessing respiratory system health and diagnosing related diseases. Flexible acoustic sensors hold promise for continuous, wearable monitoring but often face trade-offs between performance, comfort, and integration into daily textiles. Herein, we present an acoustic sensing fabric (ASF) woven from silver-plated nylon warps and PVDF-HFP nanofibrous core-shell wefts, which form piezoelectric/triboelectric units at yarn interlacing points to efficiently convert micro-amplitude vibrations into electrical signals. The optimized ASF exhibits a high output of up to 38.3 V at 170 Hz/118 dB, and shows notable sensitivity, reaching 15 mV Pa<sup>-1</sup> at 1000 Hz/94 dB and even reaching 2.5 × 10<sup>3</sup> mV Pa<sup>-1</sup> at 170 Hz/90-95 dB. Through systematic investigation of structural parameters, supported by laser Doppler vibrometry and finite element simulation, we elucidate how the fabric structure influences forced vibration and signal output. The ASF accurately records the directly produced respiratory sounds, the playback of pathological cardiopulmonary acoustics, and daily speech, demonstrating its capability for respiratory disease diagnosis. Moreover, it can be seamlessly integrated into common textiles using standard weaving processes. This work thus provides a practical, scalable platform for designing everyday wearable systems for applications such as respiratory monitoring, remote cardiopulmonary auscultation, and voice-assisted human-machine interfaces.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"1978-1987"},"PeriodicalIF":6.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of the local environment on mid-infrared photothermal contrast. 局部环境对中红外光热对比的影响。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-07 DOI: 10.1039/d5nh00801h
Linda Biondelli, Eduard Podshivaylov, Yang Ding, Walker Stradley, Umberto Filippi, Pavel Frantsuzov, Masaru Kuno
{"title":"Influence of the local environment on mid-infrared photothermal contrast.","authors":"Linda Biondelli, Eduard Podshivaylov, Yang Ding, Walker Stradley, Umberto Filippi, Pavel Frantsuzov, Masaru Kuno","doi":"10.1039/d5nh00801h","DOIUrl":"10.1039/d5nh00801h","url":null,"abstract":"<p><p>Mid-infrared (MIR) photothermal microscopy/spectroscopy represents a new, ultrasensitive, superresolution infrared absorption technique. The origin of its signal contrast is complex, containing competing contributions from photothermal-induced changes to specimen refractive indices and volumes as well as those of the local environment. In this study, we investigate the interplay between abovementioned contributions to observed contrast in MIR photothermal microscopy images and spectra. This entails size-dependent measurements on individual polystyrene and polymethylmethacrylate nanoparticles with radii below 100 nm and as low as 25 nm. From this, we now establish that sizable photothermal contrast arises from the interference between light scattered from a specimen's local dielectric medium and backreflected light from an air/substrate interface. This is particularly important for small specimens embedded in media. Attesting to this, we observe, for the first time, a predicted, small nanoparticle size crossover in signal contrast between particles embedded in air <i>versus</i> a dielectric medium with a refractive index greater than one.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"1939-1946"},"PeriodicalIF":6.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147961575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic insights into electrochemical nitrate reduction over d- and p-block Cu-based single-atom alloy catalysts: a DFT study. 在d-和p-嵌段铜基单原子合金催化剂上电化学还原硝酸盐的机理:一项DFT研究。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-07 DOI: 10.1039/d6nh00116e
Jianhui Yi, Qing Jiang
{"title":"Mechanistic insights into electrochemical nitrate reduction over d- and p-block Cu-based single-atom alloy catalysts: a DFT study.","authors":"Jianhui Yi, Qing Jiang","doi":"10.1039/d6nh00116e","DOIUrl":"10.1039/d6nh00116e","url":null,"abstract":"<p><p>The electrocatalytic nitrate reduction reaction (NO<sub>3</sub>RR) is of great significance for wastewater remediation and ammonia (NH<sub>3</sub>) synthesis. However, efficient NO<sub>3</sub>RR catalysts and a clear mechanistic understanding are still lacking. A single-atom alloy (SAA) offers a new design space for the NO<sub>3</sub>RR with its unique atomic and electronic structures. Here, high-throughput density functional theory (DFT) calculations were performed to systematically investigate the catalytic potential and reaction mechanism of Cu-based SAAs for the NO<sub>3</sub>RR to NH<sub>3</sub>. A volcano relationship between the descriptor Δ<i>E</i><sub>*NO</sub> - Δ<i>E</i><sub>*OH</sub> and the limiting potential (<i>U</i><sub>L</sub>) was established. The results show that Al/Cu (111) achieves an ultra-low <i>U</i><sub>L</sub> of -0.18 V. The strong hybridization between Al-p and O-p orbitals enables p electrons to be injected more readily into anti-bonding orbitals, thereby effectively weakening the N-O bond and lowering the reaction energies of protonation steps. The stronger O affinity of the Al site allows Al/Cu (111) to break free from the constraints imposed by conventional linear scaling relations and exhibit excellent NO<sub>3</sub>RR activity. Moreover, Al/Cu (111) protects the active sites from competitive H adsorption, leading to enhanced selectivity. This work establishes p-orbital engineering as a design principle for Cu-based single-atom alloys beyond conventional d-band tuning, providing valuable theoretical guidance for NO<sub>3</sub>RR catalyst design.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"1956-1964"},"PeriodicalIF":6.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147985599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STORM as a tool to track cargo release from polymeric nanocarriers at the single-particle level. STORM作为一种工具,可以在单颗粒水平上跟踪聚合物纳米载体上的货物释放。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-07 DOI: 10.1039/d5nh00855g
Anna Solé-Porta, Silvia Pujals, Pietro Delcanale, Anna Roig
{"title":"STORM as a tool to track cargo release from polymeric nanocarriers at the single-particle level.","authors":"Anna Solé-Porta, Silvia Pujals, Pietro Delcanale, Anna Roig","doi":"10.1039/d5nh00855g","DOIUrl":"10.1039/d5nh00855g","url":null,"abstract":"<p><p>Recent advances in super-resolution microscopy have enabled unprecedented visualization of cellular structures, tracking of nanomaterials in biological environments, or the elucidation of specific nano-bio interactions. Yet, dynamic quantification of cargo release from individual nanocarriers remains unexplored. Here, we leverage the high spatial resolution of direct stochastic optical reconstruction microscopy (dSTORM) to monitor protein release at the single-nanocarrier level. Poly(lactic-<i>co</i>-glycolic acid) (PLGA) nanocapsules labelled with Cyanine5 and loaded with bovine serum albumin (BSA) tagged with Alexa Fluor 488 are characterized using dSTORM alongside other characterization techniques. dSTORM allowed us to simultaneously observe changes in nanocarrier size and cargo localization over time. Our results demonstrate a time-dependent increase in nanocapsule diameter and a decrease in nanocarrier concentration. The quantitative analysis of individual nanocarriers reveals single-particle protein release profiles, characterized by an initial burst followed by sustained release, with complete release achieved after 30 days. This study represents the first application of super-resolution microscopy to spatially and temporally resolve protein release from nanocarriers, offering single-molecule sensitivity and nanometric resolution, and capturing heterogeneity that ensemble-averaged techniques overlook. Our approach complements other pharmacokinetic analyses and establishes a robust method to evaluate the cargo release from other nanocarriers by super-resolution microscopy.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"1902-1911"},"PeriodicalIF":6.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147757641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferroelectricity in wurtzite atomic layer annealed aluminum nitride thin films. 纤锌矿原子层退火氮化铝薄膜中的铁电性。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-07 DOI: 10.1039/d6nh00035e
Dominic A Dalba, Dilan M Gamachchi, Indeewari M Karunarathne, Bipin Bhattarai, Xiaoman Zhang, Wangwang Xu, Somayeh Saadat Niavol, Dongmei Cao, W J Meng, Andrew C Meng
{"title":"Ferroelectricity in wurtzite atomic layer annealed aluminum nitride thin films.","authors":"Dominic A Dalba, Dilan M Gamachchi, Indeewari M Karunarathne, Bipin Bhattarai, Xiaoman Zhang, Wangwang Xu, Somayeh Saadat Niavol, Dongmei Cao, W J Meng, Andrew C Meng","doi":"10.1039/d6nh00035e","DOIUrl":"10.1039/d6nh00035e","url":null,"abstract":"<p><p>Investigation of aluminum nitride-based ferroelectric thin films for non-volatile memory applications has largely focused on various thin film solid solutions grown by reactive sputtering. The growth process leads to significant DC electrical leakage related to mosaic disorder and point defects in this class of materials; extrinsic alloying elements such as scandium or boron are used to facilitate ferroelectric switching at lower electric fields to limit these deleterious effects. We take a different approach focusing on growth <i>via</i> atomic layer annealing using a nitrogen remote inductively coupled plasma (ICP). We demonstrate ferroelectric behavior in nanocrystalline wurtzite aluminum nitride (AlN) films with neither additional alloying components nor post-process annealing grown using a 350 °C CMOS-compatible growth process. The films do not exhibit hard dielectric breakdown even under electric fields in excess of 10 MV cm<sup>-1</sup>. Electrical property characterization using positive-up-negative-down (PUND) measurements shows remanent polarization (P<sub>r</sub>) in excess of 30 µC cm<sup>-2</sup>. Piezoresponse force microscopy (PFM) DC bias poling experiments yield behavior consistent with ferroelectricity. Structural characterization was performed using scanning/transmission electron microscopy, X-ray photoelectron spectroscopy depth profiling, and spectroscopic ellipsometry. An ALD-based growth approach to ferroelectric aluminum nitride-based films holds significant advantage from a device scaling standpoint and provides an alternative route towards aluminum nitride-based thin films.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"1883-1891"},"PeriodicalIF":6.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catch-and-display immunoassay for digital biomarker detection. 用于数字生物标志物检测的捕获和显示免疫分析法。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-07 DOI: 10.1039/d6nh00038j
Yuxuan Liu, Samuel N Walker, Michael E Klaczko, Ahmet Gurcan, Benjamin H Singer, Michel Godin, Vincent Tabard-Cossa, Jonathan D Flax, James L McGrath
{"title":"Catch-and-display immunoassay for digital biomarker detection.","authors":"Yuxuan Liu, Samuel N Walker, Michael E Klaczko, Ahmet Gurcan, Benjamin H Singer, Michel Godin, Vincent Tabard-Cossa, Jonathan D Flax, James L McGrath","doi":"10.1039/d6nh00038j","DOIUrl":"10.1039/d6nh00038j","url":null,"abstract":"<p><p>Digital immunoassays provide exceptional analytical sensitivity for detecting low-abundance biomarkers, but their broad adoption is limited by practical barriers. Commercial platforms are prohibitively expensive for routine use in individual laboratories, and laboratory-scale concepts typically describe specialized biosensors and sophisticated workflows. Here, we introduce a nanomembrane-based Catch-and-Display Immunoassay (CAD-IA), a cost-effective and laboratory-friendly digital immunoassay for common research settings. In CAD-IA, fluorescent nanoparticles are \"captured\" by the nanoscale pores of ultrathin silicon nitride membranes through a pipette powered filtration. The captured nanoparticles serve as optically isolated 'hotspots' for fluorescent immunocomplex formation when target antigen is present. Co-localization of the fluorescent particles and fluorescent immunocomplexes are then \"displayed\" and quantified by standard confocal microscopy to generate digital signals. CAD-IA is implemented using the µSiM-DX (microfluidic device featuring an ultrathin silicon membrane for diagnostics) platform, which is manually assembled from mass produced, cost-effective components. Using the traumatic brain injury (TBI) biomarker S100B as a model, we demonstrate that CAD-IA provides consistent digital outputs and linear quantification over a dynamic range of at least two orders of magnitude when digital and analog analyses are combined on the same image sets. We further demonstrate that the assay maintains linearity in serum matrices and achieves suitable sensitivity (LoD = 0.02 µg mL<sup>-1</sup>) for clinically relevant diagnostic with the addition of tyramide signal amplification (TSA). While further optimization of CAD-IA is possible, these results constitute a proof-of-concept demonstration of a novel digital immunoassay deployable in most research laboratories.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"1965-1977"},"PeriodicalIF":6.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outstanding Reviewers for Nanoscale Horizons in 2025. 2025年《纳米尺度视野》杰出审稿人。
IF 6.4 2区 材料科学
Nanoscale Horizons Pub Date : 2026-07-03 DOI: 10.1039/d6nh90032a
{"title":"Outstanding Reviewers for <i>Nanoscale Horizons</i> in 2025.","authors":"","doi":"10.1039/d6nh90032a","DOIUrl":"https://doi.org/10.1039/d6nh90032a","url":null,"abstract":"<p><p>We would like to take this opportunity to thank all of <i>Nanoscale Horizons</i>' reviewers for helping to preserve quality and integrity in the nanoscience literature. We would also like to highlight the Outstanding Reviewers for <i>Nanoscale Horizons</i> in 2025.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148373916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disrupting the metastatic cascade: nanoparticle-based innovations in antimetastatic therapy 破坏转移级联:基于纳米粒子的抗转移治疗创新。
IF 6.6 2区 材料科学
Nanoscale Horizons Pub Date : 2026-04-21 DOI: 10.1039/D6NH00023A
Tamara Meňhertová, Martina Raudenská, Michal Masařík and Michaela Fojtů
{"title":"Disrupting the metastatic cascade: nanoparticle-based innovations in antimetastatic therapy","authors":"Tamara Meňhertová, Martina Raudenská, Michal Masařík and Michaela Fojtů","doi":"10.1039/D6NH00023A","DOIUrl":"10.1039/D6NH00023A","url":null,"abstract":"<p >Antimetastatic therapy represents a transformative shift in oncology, addressing one of the greatest challenges in cancer care: the prevention and management of metastasis. By targeting the critical steps of the metastatic cascade and integrating them into multimodal treatment strategies, these therapies have the potential to greatly improve patient survival, enhance quality of life, and advance cancer care worldwide. Each stage of the metastatic cascade presents unique therapeutic vulnerabilities and opportunities for targeted intervention. Nanoparticle-based therapies have emerged as a promising frontier for disrupting the process of metastasis due to their ability to deliver therapeutic agents with high precision, reduce off-target effects of treatment, and overcome biological barriers. This review explores key targets suitable for antimetastatic therapy and recent advances in strategies using these modalities, highlighting their potential to improve treatment specificity and efficacy. By examining the integration of nanotechnology into antimetastatic therapy, we aim to underscore its transformative potential in combating metastatic cancer and improving patient outcomes.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 6","pages":" 1456-1482"},"PeriodicalIF":6.6,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/nh/d6nh00023a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书