Nanoscale Horizons最新文献

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Nanoscale Horizons Emerging Investigator Series: Dr Mohammad Malakooti, University of Washington, USA 纳米地平线新兴研究者系列:美国华盛顿大学 Mohammad Malakooti 博士。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-18 DOI: 10.1039/D4NH90077D
{"title":"Nanoscale Horizons Emerging Investigator Series: Dr Mohammad Malakooti, University of Washington, USA","authors":"","doi":"10.1039/D4NH90077D","DOIUrl":"10.1039/D4NH90077D","url":null,"abstract":"<p >Our Emerging Investigator Series features exceptional work by early-career nanoscience and nanotechnology researchers. Read Mohammad Malakooti’s Emerging Investigator Series article ‘Green synthesis of iron-doped graphene quantum dots: an efficient nanozyme for glucose sensing’ (https://doi.org/10.1039/D4NH00024B) and read more about him in the interview below.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 2","pages":" 201-202"},"PeriodicalIF":8.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging 2D materials hardware for in-sensor computing 用于传感器内计算的新兴二维材料硬件。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-12 DOI: 10.1039/D4NH00405A
Yufei Shi, Ngoc Thanh Duong and Kah-Wee Ang
{"title":"Emerging 2D materials hardware for in-sensor computing","authors":"Yufei Shi, Ngoc Thanh Duong and Kah-Wee Ang","doi":"10.1039/D4NH00405A","DOIUrl":"10.1039/D4NH00405A","url":null,"abstract":"<p >The advent of the novel in-sensor/near-sensor computing paradigm significantly eliminates the need for frequent data transfer between sensory terminals and processing units by integrating sensing and computing functions into a single device. This approach surpasses the traditional configuration of separate sensing and processing units, thereby greatly simplifying system complexity. Two-dimensional materials (2DMs) show immense promise for implementing in-sensor computing systems owing to their exceptional material properties and the flexibility they offer in designing innovative device architectures with heterostructures. This review highlights recent progress and advancements in 2DM-based in-sensor computing research, summarizing the unique physical mechanisms that can be leveraged in 2DM-based devices to achieve sensory responses and the essential biomimetic synaptic characteristics for computing functions. Additionally, the potential applications of 2DM-based in-sensor computing systems are discussed and categorized. This review concludes with a perspective on future development directions for 2DM-based in-sensor computing.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 2","pages":" 205-229"},"PeriodicalIF":8.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein corona potentiates the recovery of nanoparticle-induced disrupted tight junctions in endothelial cells† 蛋白电晕可促进内皮细胞中纳米粒子诱导的紧密连接破坏的恢复。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-08 DOI: 10.1039/D4NH00178H
Muhammad Daniyal Ghouri, Ayesha Tariq, Jabran Saleem, Abdul Muhaymin, Rong Cai and Chunying Chen
{"title":"Protein corona potentiates the recovery of nanoparticle-induced disrupted tight junctions in endothelial cells†","authors":"Muhammad Daniyal Ghouri, Ayesha Tariq, Jabran Saleem, Abdul Muhaymin, Rong Cai and Chunying Chen","doi":"10.1039/D4NH00178H","DOIUrl":"10.1039/D4NH00178H","url":null,"abstract":"<p >Nanoparticle interactions with biological systems are intricate processes influenced by various factors, among which the formation of protein corona plays a pivotal role. This research investigates a novel aspect of nanoprotein corona–cell interactions, focusing on the impact of the protein corona on the recovery of disrupted tight junctions in endothelial cells. We demonstrate that the protein corona formed on the surface of star-shaped nanoparticles induces the aggregates of ZO-1, which is quite important for the barriers’ integrity. Our research emphasizes that the APOA1 pre-coating on the nanoparticles reduces the ZO-1 expression of endothelial cells offering a promising strategy for overcoming the bio barriers. These findings contribute to our understanding of the interplay between nanoparticles, protein corona, and endothelial cell junctions, offering insights for developing innovative therapeutic approaches targeting the blood–brain barrier integrity. Our study holds promise for the future of nanomedicine, nano drug delivery systems and development of strategies to mitigate potential adverse effects.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 1","pages":" 179-189"},"PeriodicalIF":8.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concealable physical unclonable function generation and an in-memory encryption machine using vertical self-rectifying memristors† 利用垂直自校正忆阻器生成可隐藏的物理不可克隆函数和内存加密机。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-07 DOI: 10.1039/D4NH00420E
Jea Min Cho, Seung Soo Kim, Tae Won Park, Dong Hoon Shin, Yeong Rok Kim, Hyung Jun Park, Dong Yun Kim, Soo Hyung Lee, Taegyun Park and Cheol Seong Hwang
{"title":"Concealable physical unclonable function generation and an in-memory encryption machine using vertical self-rectifying memristors†","authors":"Jea Min Cho, Seung Soo Kim, Tae Won Park, Dong Hoon Shin, Yeong Rok Kim, Hyung Jun Park, Dong Yun Kim, Soo Hyung Lee, Taegyun Park and Cheol Seong Hwang","doi":"10.1039/D4NH00420E","DOIUrl":"10.1039/D4NH00420E","url":null,"abstract":"<p >The importance of hardware security increases significantly to protect the vast amounts of private data stored on edge devices. Physical unclonable functions (PUFs) are gaining prominence as hardware security primitives due to their ability to generate true random digital keys by exploiting the inherent randomness of the physical devices. Traditional approaches, however, require significant data movement between memory units and PUF generation circuits to perform encryption, presenting considerable energy efficiency and security challenges. This study introduces an innovative approach where PUF key generation and encryption are accomplished in the same vertically integrated resistive random access memory (V-RRAM), alleviating the data movement issue. The proposed V-RRAM encryption machine offers concealable PUFs, high area efficiency, and multi-thread data handling using parallel XOR logic operations. The encryption machine is compared with other machines, demonstrating the highest spatiotemporal cost-effectiveness.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 1","pages":" 113-123"},"PeriodicalIF":8.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles of different cellular origin feature distinct biomolecular corona dynamics†‡ 不同细胞来源的细胞外囊泡具有不同的生物分子电晕动力学特征。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-07 DOI: 10.1039/D4NH00320A
Angelo Musicò, Andrea Zendrini, Santiago Gimenez Reyes, Valentina Mangolini, Lucia Paolini, Miriam Romano, Andrea Papait, Antonietta Rosa Silini, Paolo Di Gianvincenzo, Arabella Neva, Marina Cretich, Ornella Parolini, Camillo Almici, Sergio E. Moya, Annalisa Radeghieri and Paolo Bergese
{"title":"Extracellular vesicles of different cellular origin feature distinct biomolecular corona dynamics†‡","authors":"Angelo Musicò, Andrea Zendrini, Santiago Gimenez Reyes, Valentina Mangolini, Lucia Paolini, Miriam Romano, Andrea Papait, Antonietta Rosa Silini, Paolo Di Gianvincenzo, Arabella Neva, Marina Cretich, Ornella Parolini, Camillo Almici, Sergio E. Moya, Annalisa Radeghieri and Paolo Bergese","doi":"10.1039/D4NH00320A","DOIUrl":"10.1039/D4NH00320A","url":null,"abstract":"<p >Initially observed on synthetic nanoparticles, the existence of biomolecular corona and its role in determining nanoparticle identity and function are now beginning to be acknowledged in biogenic nanoparticles, particularly in extracellular vesicles – membrane-enclosed nanoparticle shuttling proteins, nucleic acids, and metabolites which are released by cells for physiological and pathological communication – we developed a methodology based on fluorescence correlation spectroscopy to track biomolecular corona formation on extracellular vesicles derived from human red blood cells and amniotic membrane mesenchymal stromal cells when these vesicles are dispersed in human plasma. The methodology allows for tracking corona dynamics <em>in situ</em> under physiological conditions. Results evidence that the two extracellular vesicle populations feature distinct corona dynamics. These findings indicate that the dynamics of the biomolecular corona may ultimately be linked to the cellular origin of the extracellular vesicles, revealing an additional level of heterogeneity, and possibly of bionanoscale identity, that characterizes circulating extracellular vesicles.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 1","pages":" 104-112"},"PeriodicalIF":8.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d4nh00320a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling energetics and states of adsorbing oxygen species with MoS2 for modulated work function† 用 MoS2 揭示吸附氧物种的能量和状态,实现调制功函数。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-06 DOI: 10.1039/D4NH00441H
Hejin Yan, Hongfei Chen, Xiangyue Cui, Qiye Guan, Bowen Wang and Yongqing Cai
{"title":"Unraveling energetics and states of adsorbing oxygen species with MoS2 for modulated work function†","authors":"Hejin Yan, Hongfei Chen, Xiangyue Cui, Qiye Guan, Bowen Wang and Yongqing Cai","doi":"10.1039/D4NH00441H","DOIUrl":"10.1039/D4NH00441H","url":null,"abstract":"<p >MoS<small><sub>2</sub></small> and related transition metal dichalcogenides (TMDs) have recently been reported as having extensive applications in nanoelectronics and catalysis because of their unique physical and chemical properties. However, one practical challenge for MoS<small><sub>2</sub></small>-based applications arises from the easiness of oxygen contamination, which is likely to degrade performance. To this end, understanding the states and related energetics of adsorbed oxygen is critical. Herein, we identify various states of oxygen species adsorbed on the MoS<small><sub>2</sub></small> surface with first-principles calculations. We reveal a “dissociative” mechanism through which a physisorbed oxygen molecule trapped at a sulfur vacancy can split into two chemisorbed oxygen atoms, namely a top-anchoring oxygen and a substituting oxygen, both of which show no adsorbate induced states in the bandgap. The electron and hole masses show an asymmetric effect in response to oxygen species with the hole mass being more sensitive to oxygen content due to a strong hybridization of oxygen states in the valence band edge of MoS<small><sub>2</sub></small>. Alteration of oxygen content allows modulation of the work function up to 0.5 eV, enabling reduced Schottky barriers in MoS<small><sub>2</sub></small>/metal contact. These results show that oxygen doping on MoS<small><sub>2</sub></small> is a promising method for sulfur vacancy healing, carrier mass controlling, contact resistance reduction, and anchoring of surface electron dopants. Our study suggests that tuning the chemical composition of oxygen is viable for modulating the electronic properties of MoS<small><sub>2</sub></small> and likely other chalcogen-incorporated TMDs, which offers promise for new optoelectronic applications.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 2","pages":" 359-368"},"PeriodicalIF":8.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d4nh00441h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Edge-doped substituents as an emerging atomic-level strategy for enhancing M–N4–C single-atom catalysts in electrocatalysis of the ORR, OER, and HER† 边缘掺杂取代基作为一种新兴的原子级策略,可增强 M-N4-C 单原子催化剂在 ORR、OER 和 HER 电催化中的作用。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-06 DOI: 10.1039/D4NH00424H
Liang Xie, Wei Zhou, Zhibin Qu, Yuming Huang, Longhao Li, Chaowei Yang, Junfeng Li, Xiaoxiao Meng, Fei Sun, Jihui Gao and Guangbo Zhao
{"title":"Edge-doped substituents as an emerging atomic-level strategy for enhancing M–N4–C single-atom catalysts in electrocatalysis of the ORR, OER, and HER†","authors":"Liang Xie, Wei Zhou, Zhibin Qu, Yuming Huang, Longhao Li, Chaowei Yang, Junfeng Li, Xiaoxiao Meng, Fei Sun, Jihui Gao and Guangbo Zhao","doi":"10.1039/D4NH00424H","DOIUrl":"10.1039/D4NH00424H","url":null,"abstract":"<p >M–N<small><sub>4</sub></small>–C single-atom catalysts (MN<small><sub>4</sub></small>) have gained attention for their efficient use at the atomic level and adjustable properties in electrocatalytic reactions like the ORR, OER, and HER. Yet, understanding MN<small><sub>4</sub></small>'s activity origin and enhancing its performance remains challenging. Edge-doped substituents profoundly affect MN<small><sub>4</sub></small>'s activity, explored in this study by investigating their interaction with MN<small><sub>4</sub></small> metal centers in ORR/OER/HER catalysis (Sub@MN<small><sub>4</sub></small>, Sub = B, N, O, S, CH<small><sub>3</sub></small>, NO<small><sub>2</sub></small>, NH<small><sub>2</sub></small>, OCH<small><sub>3</sub></small>, SO<small><sub>4</sub></small>; M = Fe, Co, Ni, Cu). The results show overpotential variations (0 V to 1.82 V) based on Sub and metal centers. S and SO<small><sub>4</sub></small> groups optimize FeN<small><sub>4</sub></small> for peak ORR activity (overpotential at 0.48 V) and reduce OER overpotentials for NiN<small><sub>4</sub></small> (0.48 V and 0.44 V). N significantly reduces FeN<small><sub>4</sub></small>'s HER overpotential (0.09 V). Correlation analysis highlights the metal center's key role, with Δ<em>G</em><small><sub>*H</sub></small> and Δ<em>G</em><small><sub>*OOH</sub></small> showing mutual predictability (<em>R</em><small><sup>2</sup></small> = 0.92). <em>E</em><small><sub>g</sub></small> proves a reliable predictor for Sub@CoN<small><sub>4</sub></small> (Δ<em>G</em><small><sub>*OOH</sub></small>/Δ<em>G</em><small><sub>*H</sub></small>, <em>R</em><small><sup>2</sup></small> = 0.96 and 0.72). Machine learning with the KNN model aids catalyst performance prediction (<em>R</em><small><sup>2</sup></small> = 0.955 and 0.943 for Δ<em>G</em><small><sub>*OOH</sub></small>/Δ<em>G</em><small><sub>*H</sub></small>), emphasizing M–O/M–H and the d band center as crucial factors. This study elucidates edge-doped substituents' pivotal role in MN<small><sub>4</sub></small> activity modulation, offering insights for electrocatalyst design and optimization.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 2","pages":" 322-335"},"PeriodicalIF":8.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full-color peptide-based fluorescent nanomaterials assembled under the control of amino acid doping† 在氨基酸掺杂控制下组装的全彩肽基荧光纳米材料。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-05 DOI: 10.1039/D4NH00400K
Yuhe Shen, Yulin Sun, Yaoyu Liang, Xiaojian Xu, Rongxin Su, Yuefei Wang and Wei Qi
{"title":"Full-color peptide-based fluorescent nanomaterials assembled under the control of amino acid doping†","authors":"Yuhe Shen, Yulin Sun, Yaoyu Liang, Xiaojian Xu, Rongxin Su, Yuefei Wang and Wei Qi","doi":"10.1039/D4NH00400K","DOIUrl":"10.1039/D4NH00400K","url":null,"abstract":"<p >Peptide-based biofluorescents are of great interest due to their controllability and biocompatibility, as well as their potential applications in biomedical imaging and biosensing. Here, we present a simple approach to synthesizing full-color fluorescent nanomaterials with broad-spectrum fluorescence emissions, high optical stability, and long fluorescence lifetimes. By doping amino acids during the enzyme-catalyzed oxidative self-assembly of tyrosine-based peptides, we can precisely control the intermolecular interactions to obtain nanoparticles with fluorescence emission at different wavelengths. The synthesized peptide-based fluorescent nanomaterials with excellent biocompatibility and stable near-infrared fluorescence emission were shown to have potential for bioimaging applications. This research provides new ideas for the development of new bioluminescent materials that are cost-effective, environmentally friendly, and safe for biomedical use.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 1","pages":" 158-164"},"PeriodicalIF":8.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
XeF2 gas assisted focused electron beam induced etching of niobium thin films: towards direct write editing of niobium superconducting devices† XeF2 气体辅助聚焦电子束诱导蚀刻铌薄膜:实现铌超导设备的直接写入编辑。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-05 DOI: 10.1039/D4NH00407H
Spencer Gellerup, Reece Emery, Scott T. Retterer, Steven J. Randolph and Philip D. Rack
{"title":"XeF2 gas assisted focused electron beam induced etching of niobium thin films: towards direct write editing of niobium superconducting devices†","authors":"Spencer Gellerup, Reece Emery, Scott T. Retterer, Steven J. Randolph and Philip D. Rack","doi":"10.1039/D4NH00407H","DOIUrl":"10.1039/D4NH00407H","url":null,"abstract":"<p >In this work, we explore focused electron beam induced etching (FEBIE) of niobium thin films with the XeF<small><sub>2</sub></small> precursor as a route to edit, on-the-fly, superconducting devices. We report the effect of XeF<small><sub>2</sub></small> pressure, electron beam current, beam energy, and dwell time on the Nb etch rate. To understand the mass transport and reaction rate limiting mechanisms, we compare the relative electron and XeF<small><sub>2</sub></small> gas flux and reveal the process is reaction rate limited at low current/short dwell times, but shifts to mass transport limited regimes as both are increased. The electron stimulated etching yield is surprisingly high, up to 3 Nb atoms/electron, and for the range studied has a maximum at 1 keV. It was revealed that spontaneous etching accompanies the electron stimulated process, which was confirmed by varying the etched box size. An optimized etch resolution of 17 nm was achieved. Given that the Nb superconducting coherence length is 38 nm and scales with thickness, this work opens the possibility to direct write Nb superconducting devices <em>via</em> low-damage FEBIE.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 2","pages":" 369-378"},"PeriodicalIF":8.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Sweet MOFs”: exploring the potential and restraints of integrating carbohydrates with metal–organic frameworks for biomedical applications "甜味 MOFs":探索将碳水化合物与金属有机框架整合用于生物医学应用的潜力和限制。
IF 8 2区 材料科学
Nanoscale Horizons Pub Date : 2024-11-04 DOI: 10.1039/D4NH00525B
Alessio Zuliani, Victor Ramos, Alberto Escudero and Noureddine Khiar
{"title":"“Sweet MOFs”: exploring the potential and restraints of integrating carbohydrates with metal–organic frameworks for biomedical applications","authors":"Alessio Zuliani, Victor Ramos, Alberto Escudero and Noureddine Khiar","doi":"10.1039/D4NH00525B","DOIUrl":"10.1039/D4NH00525B","url":null,"abstract":"<p >The unique features of metal–organic frameworks (MOFs) such as biodegradability, reduced toxicity and high surface area offer the possibility of developing smart nanosystems for biomedical applications through the simultaneous functionalization of their structure with biologically relevant ligands and the loading of biologically active cargos, ranging from small drugs to large biomacromolecules, into their pores. Aiming to develop efficient, naturally inspired biocompatible systems, recent research has combined organic and materials chemistry to design innovative composites that exploit carbohydrate chemistry for the functionalization and structural modification of MOFs. Scientific investigation in the field has seen a significant rise in the past five years, and it is becoming crucial to acknowledge both the limits and benefits of this approach for future investigation. In this review, the latest research results merging carbohydrates and MOFs are discussed, with a particular emphasis on the advances in the field and the remaining challenges, including addressing sustainability and real-case applicability.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 2","pages":" 258-278"},"PeriodicalIF":8.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d4nh00525b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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