Nanoscale Horizons最新文献

{"title":"pH-Triggered delivery of pirarubicin–gemcitabine duo using polymeric nanoparticles for synergistic breast cancer therapy†","authors":"Priya Gupta, Harshdeep Kaur, Mohammad Anees, Sachchidanand Tiwari, Ankushi Bansal and Harpal Singh","doi":"10.1039/D4NH00654B","DOIUrl":"10.1039/D4NH00654B","url":null,"abstract":"<p >Combination chemotherapy using nanocarriers presents a promising approach to overcome the restrictions associated with conventional chemotherapy, particularly by enhancing drug stability in the bloodstream, modulating pharmacokinetics to improve therapeutic efficacy and minimizing adverse side effects on the patient's health. In pursuit of an optical treatment approach for breast cancer, various chemotherapeutic drug combinations with advanced nanocarriers are being extensively explored. This study investigated the development of pirarubicin and gemcitabine co-loaded polymeric nanoparticles for synergistic activity against breast cancer cells. To enable sustained and site-specific delivery within the tumor microenvironment, both pirarubicin and gemcitabine were chemically conjugated to a polylactic acid-based block copolymer <em>via</em> a pH-responsive “Schiff's base” linkage. The synthesized polymer–drug conjugates were subsequently formulated into Pira–Gem co-loaded block copolymeric nanoparticles, demonstrating good stability and minimal toxicity towards non-cancerous cells. Pira–Gem co-loaded nanoparticles exhibited a significantly higher percentage of drug release under acidic pH conditions, (characteristic of tumor microenvironments) compared with physiological pH conditions. Furthermore, they showed superior cellular uptake on 2D adherent cancer cell lines relative to free drugs in <em>in vitro</em> studies. Both apoptotic analysis and cell proliferation inhibition studies revealed that the co-loaded nanoparticles exhibited a synergistic therapeutic effect across multiple breast cancer cell lines, surpassing the efficacy of Pira/Gem single drug-loaded nanoparticles and their free drug counterparts. These findings suggest that the Pira–Gem co-loaded nanoformulation holds considerable promise for breast cancer therapy and requires further exploration as a potential treatment strategy.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 7","pages":" 1465-1477"},"PeriodicalIF":8.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High electrical conductivity in directionally polymerized C60 nanowires by grazing incidence of single particles†","authors":"Masaki Nobuoka, Shugo Sakaguchi, Minori Kawata, Akie Taguchi, Kosuke Kishida, Yusuke Tsutsui, Masayuki Suda, Haruka Inoue, Akira Idesaki, Tetsuya Yamaki and Shu Seki","doi":"10.1039/D5NH00228A","DOIUrl":"10.1039/D5NH00228A","url":null,"abstract":"<p >As organic electronics continue to evolve, there is a growing demand for nanometer-scale microfabrication techniques for organic semiconductors. Although precise 2D alignment and 3D integration are essential for future device applications, significant challenges remain, particularly with organic materials. Here, we demonstrate the successful fabrication of highly oriented nanowire arrays of fullerene (C<small>₆₀</small>) <em>via</em> directional polymerization, mediated by grazing incidence of high-energy charged particles. These C<small>₆₀</small> nanowires exhibit remarkably high electrical conductivity, comparable to that of undoped germanium, which is attributed to a unique polymerization process induced by particle irradiation. Field-effect transistor (FET) measurements revealed that electrons serve as the primary charge carriers in the nanowires. Temperature-dependent electrical measurements further indicate that the conduction mechanism follows a thermally activated hopping process, rather than conventional band conduction, reflecting the amorphous and crosslinked nature of the polymerized nanowires. Furthermore, a measurable change in conductivity upon nitrobenzene adsorption suggests their potential application as highly sensitive, electron-based organic gas sensors.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 7","pages":" 1345-1353"},"PeriodicalIF":8.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d5nh00228a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the intricacies of protein–nanoparticle interaction and its implications in chronic diseases: a comprehensive review","authors":"Pallavi Samal, Siddharth Satpathy, Lipsa Leena Panigrahi, Suman Jha and Manoranjan Arakha","doi":"10.1039/D5NH00076A","DOIUrl":"10.1039/D5NH00076A","url":null,"abstract":"<p >The protein and nanoparticle interaction is the basis of nanoparticle bio-reactivity. Nanoparticles upon interaction with proteins form a protein corona, altering their characteristics. This corona influences nanoparticles' biodistribution, pharmacokinetics, and therapeutic efficacy. The complex protein–nanoparticle interactions have a significant impact on the emergence of chronic inflammation and chronic diseases. This study is a comprehensive review that explores the dynamic nature of protein–nanoparticle interactions, emphasizing their long-term effects on sustained inflammatory responses and subsequent implications for various chronic conditions, and not an exhaustive review of all aspects. This study investigates the role of nanoparticle characteristics such as the size, shape, and surface charge in the formation of a protein corona, addressing the molecular aspects and cellular pathways involved. The connection between protein–nanoparticle interactions and chronic inflammation is deeply explored in the context of specific diseases, including cardiovascular disorders, neurological conditions, respiratory ailments, metabolic disorders, autoimmune conditions, and cancer. Insights from <em>in vivo</em> and clinical studies, coupled with discussions on genotoxicity, immunotoxicity, and mitigation strategies, contribute to a deeper understanding of the broader implications of these interactions. Nevertheless, this serves as a foundational framework for grasping the pivotal advancements and breakthroughs achieved <em>via</em> recent novel perspectives concerning the advanced methodologies for investigating protein–nanoparticle interaction and its correlation with chronic diseases. Additionally, this endeavour seeks to identify existing knowledge gaps demanding thorough exploration and offers insights for enhancing our knowledge of the interplay between protein–nanoparticle interactions and chronic disease pathogenesis. By addressing ethical considerations and public perceptions, this review outlines future research directions, highlighting the importance of extending our understanding of the safe and effective integration of nanotechnology into a broad range of applications.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1615-1641"},"PeriodicalIF":8.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d5nh00076a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoscale Horizons Emerging Investigator Series: Dr Mindaugas Juodėnas, Kaunas University of Technology, Lithuania","authors":"","doi":"10.1039/D5NH90027A","DOIUrl":"10.1039/D5NH90027A","url":null,"abstract":"<p >Our Emerging Investigator Series features exceptional work by early-career nanoscience and nanotechnology researchers. Read Mindaugas Juodėnas's Emerging Investigator Series article ‘Lasing in an assembled array of silver nanocubes’ (https://doi.org/10.1039/D4NH00263F) and read more about him in the interview below.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1491-1492"},"PeriodicalIF":8.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TMB (TM = Cr, Fe) monolayers: a new type of room temperature antiferromagnetic topological nodal line semimetal†","authors":"Chenqian Yan, Yuqing Mao, Jie Li, Zijin Wang, Ailei He, Yuanyuan Duan and Xiuyun Zhang","doi":"10.1039/D5NH00224A","DOIUrl":"10.1039/D5NH00224A","url":null,"abstract":"<p >Two-dimensional materials that combine magnetism and topology offer unique advantages in the fields of spintronics and quantum computing. However, the design of two-dimensional (2D) materials simultaneously integrating both properties remains a significant challenge. Through systematic first-principles calculations, we predict two highly stable two-dimensional transition metal borides (TMBs). Our results reveal that both structures are antiferromagnetic (AFM) Dirac nodal line semimetals (NLSMs) with multiple band crossings near the Fermi level. Under biaxial strain, FeB can be transformed into a ferromagnetic state under 2% tensile strain, which is further verified to possess Weyl nodal loops (Weyl NLs). This discovery provides novel insights for the regulation of magnetic topological materials and holds promising potential for applications in low-power-consumption spintronic devices.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 7","pages":" 1398-1404"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PVP pre-intercalation engineering combined with the V4+/V5+ dual-valence modulation strategy for energy storage in aqueous zinc-ion batteries†","authors":"Wenhui Mi, Bosi Yin, Haixi Gu, Hanyu Wen, Zhibiao Wang, Hui Li, Ziqian Yuan, Siwen Zhang and Tianyi Ma","doi":"10.1039/D5NH00236B","DOIUrl":"10.1039/D5NH00236B","url":null,"abstract":"<p >Aqueous zinc-ion batteries (AZIBs) have become a potential energy storage technology due to their inherent safety, environmental compatibility, and cost-effectiveness. Vanadate compounds have demonstrated considerable potential for AZIB applications among various cathode materials. However, their practical implementation is significantly constrained by intrinsic limitations, including sluggish ion diffusion kinetics, structural instability, and vanadium framework collapse during cycling. To address these challenges, we developed a novel strategy involving polyvinylpyrrolidone (PVP) pre-intercalation into CaV<small>₆</small>O<small>₁₆</small>·3H<small>₂</small>O (CaVO), resulting in a phase transformation to Ca<small>_0.24</small>V<small>₂</small>O<small>₅</small>·H<small>₂</small>O (PVP–CaVO). The embedded PVP acts as a “pillar” between the interlayer spaces, stabilizing the structural stability and thereby enhancing cycling performance. Incorporating PVP introduces additional functional advantages through its amide groups, which possess strong polar characteristics. These groups serve as hydrogen bond acceptors, with nitrogen and oxygen atoms acting as coordination sites. This unique configuration facilitates chemical bond rearrangement and promotes partial reduction of vanadium from higher oxidation states (V<small>⁵⁺</small>) to lower ones (V<small>⁴⁺</small>), establishing a V<small>⁴⁺</small>/V<small>⁵⁺</small> hybrid valence system. Such electronic structure modification not only enables multi-step redox reactions but also alleviates the strong polarization effect of Zn<small>²⁺</small> ions. Benefiting from these synergistic effects, the PVP–CaVO cathode demonstrates remarkable electrochemical performance in AZIBs, delivering a specific capacity of 323 mA h g<small>⁻¹</small> at 0.5 A g<small>⁻¹</small> and maintaining a specific capacity of 169 mA h g<small>⁻¹</small> at 10 A g<small>⁻¹</small>, coupled with excellent cycling stability. Comprehensive <em>ex situ</em> characterization studies further elucidated the energy storage processes, verifying a reversible Zn<small>²⁺</small>/H<small>⁺</small> co-insertion mechanism. This innovative approach of structural and phase engineering through PVP intercalation provides a valuable approach for optimizing vanadate-based materials.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 7","pages":" 1365-1376"},"PeriodicalIF":8.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable biosensors for health monitoring: advances in graphene-based technologies","authors":"Mohamed A. Abdelfattah, Sina S. Jamali, Navid Kashaninejad and Nam-Trung Nguyen","doi":"10.1039/D5NH00141B","DOIUrl":"10.1039/D5NH00141B","url":null,"abstract":"<p >The human body is an intelligent system, continuously generating signals that correlate with specific vital activities and indicate the state of our health and fitness. Therefore, accurate and real-time tracking of these signals is important for monitoring our health and timely medical interventions. The quantification of these signals in real-time is made possible by using skin wearable devices that detect disease-related biomarkers in bodily fluids, such as sweat and interstitial fluid. Integrating nanomaterials, particularly graphene, into wearable devices has dramatically enhanced the performance of wearable biosensors. The exemplary electrical properties, mechanical flexibility, and biocompatibility of graphene have made it a revolutionary material to shape the future of wearable devices. Graphene is versatile because its surface chemistry can be easily tuned to accommodate different biorecognition elements. This review provides an overview of flexible wearable biosensing devices, their sampling methods, and how microfluidic approaches enhance their performance. The paper also discusses the different strategies for the synthesis of graphene nanostructures, their integration into wearable systems, and their ability to improve sensing performance. Various surface chemistry modification techniques are also explored for the enhancement of the immobilisation of biomolecules. Finally, the paper discusses the challenges of graphene-based wearable technologies and their roles in continuous health monitoring and personalised medicine.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1542-1574"},"PeriodicalIF":8.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoscale Horizons Emerging Investigator Series: Dr Jiang Zhou, Central South University, Hunan, China","authors":"","doi":"10.1039/D5NH90026C","DOIUrl":"10.1039/D5NH90026C","url":null,"abstract":"<p >Our Emerging Investigator Series features exceptional work by early-career nanoscience and nanotechnology researchers. Read Jiang Zhou's Emerging Investigator Series article ‘An ionically cross-linked composite hydrogel electrolyte based on natural biomacromolecules for sustainable zinc-ion batteries’ (https://doi.org/10.1039/D4NH00243A) and read more about him in the interview below.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 7","pages":" 1240-1241"},"PeriodicalIF":8.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Layer-polarization-engineered ferroelectricity and anomalous valley hall effects in a van der Waals bilayer†","authors":"Nini Guo, Jie Li, Huijie Lian, Shu Wang, Yi Sun, Xiaojing Yao and Xiuyun Zhang","doi":"10.1039/D5NH00215J","DOIUrl":"10.1039/D5NH00215J","url":null,"abstract":"<p >Layertronics, engineering the electronic properties through the layer degree of freedom, has attracted considerable attention due to its promising applications in next-generation spintronic technologies. Here, by coupling sliding ferroelectricity with A-type antiferromagnetism, we demonstrate a mechanism for layer-polarization-engineered electronic property through symmetry analysis based on the tight-binding (TB) model. It is found that breaking the inversion symmetry and time-inversion symmetry in the model gives rise to ferroelectricity and a layer-polarized anomalous valley Hall effect. Crucially, this valley polarization is ferroelectrically switchable, enabling non-volatile electrical control of the layer-resolved Berry curvature. Using first-principles calculations, this mechanism and phenomenon are verified in the multiferroic bilayer Janus RuClF. Our findings provide a promising platform for 2D bilayer materials, which hold great potential for applications in nanoelectronic and spintronic devices.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 7","pages":" 1390-1397"},"PeriodicalIF":8.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-change wax integrated with a rapid carbon nanotube array for spatial light modulation†","authors":"Liwen Lai, Peng Liu, Chunhai Zhang, Duanliang Zhou, Qunqing Li and Shoushan Fan","doi":"10.1039/D5NH00007F","DOIUrl":"10.1039/D5NH00007F","url":null,"abstract":"<p >By integrating super-aligned carbon nanotube (SACNT) films with paraffin wax, an addressable optical valve composite array was created through screen printing and laser cutting. The temperature of the SACNT film can be controlled, which rapidly induces phase changes in the paraffin wax, leading to a swift change in optical transparency. The transmission spot exhibited significant differences, with a contrast degree reaching up to 0.65. At a paraffin wax surface density of 1.17 × 10<small>⁻⁴</small> g mm<small>⁻²</small>, the rise and fall times of the transmitted optical signal across the 350–1100 nm spectrum were 155 ± 2 ms and 135 ± 11 ms, respectively, enabling rapid spatial light modulation. A prototype was fabricated, capable of dynamically displaying letters, with the crosstalk effect of the current being significantly mitigated in spatial light modulation. This rapid spatial light modulation prototype can be customized to any shape and size, and it can either be freestanding or mounted on any substrate. This innovation offers a new approach to spatial light modulation.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 7","pages":" 1446-1452"},"PeriodicalIF":8.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}