Nanoscale Horizons最新文献_第6页

Outstanding Reviewers for Nanoscale Horizons in 2024 2024年《纳米尺度视野》优秀审稿人。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-06-10 DOI: 10.1039/D5NH90028J

引用次数: 0

Hyperconjugated linker design in giant dimeric donors enabled superior short-circuit current in organic solar cells† 在巨大二聚体供体中的超共轭连接体设计使有机太阳能电池具有优越的短路电流。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-06-07 DOI: 10.1039/D5NH00223K

Caixuan Wang, Mengying Wu, Dan Deng, Ruixiang Fang, Jianqi Zhang, Ruimin Zhou and Zhixiang Wei

{"title":"Hyperconjugated linker design in giant dimeric donors enabled superior short-circuit current in organic solar cells†","authors":"Caixuan Wang, Mengying Wu, Dan Deng, Ruixiang Fang, Jianqi Zhang, Ruimin Zhou and Zhixiang Wei","doi":"10.1039/D5NH00223K","DOIUrl":"10.1039/D5NH00223K","url":null,"abstract":"Giant dimeric donors possess definite chemical structures and regulatable molecular skeletons and are expected to become alternative photovoltaic materials for polymer donors with batch differences. However, the design of giant dimeric donors is still at an early stage and needs to be further explored. Here, through creative semi-flexible and flexible linker design, we synthesized three interesting giant dimeric donors with relative monomer positions ranging from parallel to staircase to perpendicular in their optimized conformation. Unusually, the hyperconjugation effect in the semi-flexible linker stabilizes the perpendicular conformation, which results in the strongest homo-molecular interactions exhibiting non-planar molecular conformation. Combining calculations and multiple morphology characterization on dynamic and thermal packing, we systematically analyze the hyperconjugation effects, flexibility, and hetero-molecular interaction on the assembly. As a result, applying Y6 as an acceptor, the giant dimeric donor of BDT-Dimer3 with a semi-flexible non-planar linker achieved a satisfactory efficiency of 15.68% with a cutting-edge short-circuit current of 27.39 mA cm−2 and an improved photostability with a T80 of 630 hours. Our results provide hyperconjugated linker design for efficient and stable OSC devices with definite structures, as well as a deep understanding of the assembly in both pure and mixed systems.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1731-1740"},"PeriodicalIF":8.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats† 盐桥介导的串联谱蛋白重复序列的协同性和机械稳定性。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-06-03 DOI: 10.1039/D5NH00112A

Yanzhong Wang, Yuhang Zhang, Miao Yu, Peng Xiu, Yanwei Jia, Hu Chen, Shimin Le, Jin Qian and Jie Yan

{"title":"Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats†","authors":"Yanzhong Wang, Yuhang Zhang, Miao Yu, Peng Xiu, Yanwei Jia, Hu Chen, Shimin Le, Jin Qian and Jie Yan","doi":"10.1039/D5NH00112A","DOIUrl":"10.1039/D5NH00112A","url":null,"abstract":"Spectrin superfamily proteins play essential roles in cells by interlinking various cytoskeletal components and bridging the cytoskeleton to both the cell membrane and the nucleus. Characterized by the spectrin repeat (SR) domain, this superfamily features a unique bundle of three antiparallel α-helices. These SRs often appear as tandem repeats linked by short segments, serving as tension-bearing structural units that support the cytoskeleton and act as signaling hubs for numerous proteins. Although the cooperative force-dependent unfolding of tandem spectrin repeats is well-documented, the precise molecular mechanisms remain unclear. In this study, we used the paradigmatic tandem SR (SR3–SR4) of α-actinin as our model system. Our results reveal that cooperativity arises from the salt bridges on the linker between the two domains. Additionally, we found that the salt bridge mechanically stabilizes the two domains, extending the lifetime of SR3–SR4 by 10 to 100 times compared to individual domains. Our full-atom MD simulations show that the linker salt bridge is a major force-bearing point, and its disruption leads to the mechanical unfolding of the domains. Finally, combining AlphaFold structural prediction and single-molecule manipulation studies of other spectrin superfamily proteins, we demonstrate that linker salt bridge-mediated cooperativity and stabilization is a potentially conserved molecular mechanism governing the mechanical responses of SRs in spectrin superfamily proteins.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1749-1759"},"PeriodicalIF":8.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nanoscale quality control framework for assessing FFPE DNA integrity in cancer research† 癌症研究中评估FFPE DNA完整性的纳米级质量控制框架。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-06-02 DOI: 10.1039/D5NH00176E

Zixuan Huang, Yunpei Si, Yi Zhang, Zicheng Huang, Xuehao Xiu, Yunshan Wang, YuDong Wang, Chunhai Fan and Ping Song

{"title":"A nanoscale quality control framework for assessing FFPE DNA integrity in cancer research†","authors":"Zixuan Huang, Yunpei Si, Yi Zhang, Zicheng Huang, Xuehao Xiu, Yunshan Wang, YuDong Wang, Chunhai Fan and Ping Song","doi":"10.1039/D5NH00176E","DOIUrl":"10.1039/D5NH00176E","url":null,"abstract":"Formalin-fixed paraffin-embedded (FFPE) samples are widely used in cancer research and clinical diagnostics for preserving tissue morphology and enabling long-term storage. However, FFPE-induced DNA degradation, crosslinking, and inconsistent quality control significantly hinder their utility in molecular analyses. In this study, we established a robust nanoscale quality control (QC) framework incorporating gel electrophoresis and quantitative polymerase chain reaction (qPCR) to evaluate DNA integrity in clinical tissue FFPE samples. Our findings demonstrate a quantifiable inverse correlation between the degree of DNA fragmentation and amplification efficiency in FFPE samples. Further analysis of 26 single nucleotide polymorphism loci using targeted next-generation sequencing demonstrated substantial improvements in DNA integrity after enzymatic repair. A comparative whole-exome sequencing analysis of endometrial carcinoma samples with different archival durations demonstrated significantly increased damage levels across multiple genomic features in long-term stored specimens, highlighting the cumulative impact of archival duration. These findings emphasize the detrimental effects of prolonged storage on FFPE DNA quality. Our QC framework enables effective sample stratification, facilitating the selection of high-integrity specimens for sequencing and guiding heavily degraded samples toward targeted short-amplicon assays. This strategy provides a standardized approach to assess the integrity of FFPE-derived DNA, supporting accurate and reproducible use of archival biospecimens in clinical genomics.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1692-1702"},"PeriodicalIF":8.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle characterisation via 2D classification using single particle averaging† 纳米粒子表征通过二维分类使用单粒子平均。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-06-02 DOI: 10.1039/D5NH00094G

Iain Harley, Anke Kaltbeitzel, Francesca Mazzotta, Kaloian Koynov, Sarah S. Lembke, Thao P. Doan-Nguyen, Katharina Landfester and Ingo Lieberwirth

{"title":"Nanoparticle characterisation via 2D classification using single particle averaging†","authors":"Iain Harley, Anke Kaltbeitzel, Francesca Mazzotta, Kaloian Koynov, Sarah S. Lembke, Thao P. Doan-Nguyen, Katharina Landfester and Ingo Lieberwirth","doi":"10.1039/D5NH00094G","DOIUrl":"10.1039/D5NH00094G","url":null,"abstract":"Characterising the size and morphology of nanoparticles (NPs), especially in complex systems like core–shell particles and nanocapsules, remains a significant challenge due to limitations in resolution and applicability of traditional methods. Here, we explore a novel approach to image-based NP characterisation using 2D class averaging (2D-CA) techniques used in single particle analysis. By leveraging well-established software originally developed in structural biology, our method provides detailed size distribution analysis for diverse NP systems, including bimodal particle size distributions, nanocapsules and nanorods. To validate the efficacy and accuracy of this technique, we conduct a comparative study against established characterisation methods, highlighting the potential of 2D-CA to enhance the analysis of challenging NP systems that are otherwise inaccessible using conventional methods, such as highly agglomerated NPs. Our results indicate that single particle averaging techniques offer a sound statistical basis for NP size distribution determination, coupled with a streamlined workflow that utilises established software. This method facilitates the processing of large numbers of micrographs, yielding statistically robust results with minimal human bias through automated particle identification.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1642-1652"},"PeriodicalIF":8.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d5nh00094g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic fiber-spinning chemistry for hydrophilic–hydrophobic Janus membranes towards efficient interfacial solar evaporation† 亲疏水Janus膜的微流控纤维纺丝化学研究。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-05-28 DOI: 10.1039/D5NH00186B

Yin Li, Kebing Chen, Liangliang Zhu, Qing Li and Su Chen

{"title":"Microfluidic fiber-spinning chemistry for hydrophilic–hydrophobic Janus membranes towards efficient interfacial solar evaporation†","authors":"Yin Li, Kebing Chen, Liangliang Zhu, Qing Li and Su Chen","doi":"10.1039/D5NH00186B","DOIUrl":"10.1039/D5NH00186B","url":null,"abstract":"Janus nanofiber membrane has emerged as a promising solar-driven interfacial evaporator for seawater desalination. However, salt ion accumulation and crystallization persist during long-term operation, which remains a key challenge. In this work, we report a hydrophilic–hydrophobic Janus nanofiber membrane evaporator, which is prepared via continuous microfluidic electrospinning. This method allows in situ chemical reaction of tannin (TA) and Fe3+ to be carried out in a “Y” chip during the spinning process, enabling rapid, facile, and flexible fabrication of the nanofiber membrane. TA is rich in hydroxyl groups, which endows the bottom layer with hydrophilicity and electronegativity, thereby enhancing the water transport and Donnan effect. Thus, a high evaporation rate of 1.73 kg m−2 h−1 in pure water is achieved. More importantly, long-term stability in seawater desalination is realized with an evaporation rate of 1.68 kg m−2 h−1, and there is no salt crystallization on the surface during continuous evaporation for 8 hours in 10 wt% NaCl solution. On the one hand, the bottom layer shows electronegativity, which is liable to immobilize cations Na+ and repel anions Cl−, achieving the purpose of salt resistance. On the other hand, the Janus structure also favors the redissolution of concentrated salts into raw water, further avoiding salt accumulation. This work offers a promising common strategy for constructing high-performance Janus evaporator, which will stimulate the development of seawater desalination.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1741-1748"},"PeriodicalIF":8.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probing the spin spiral in Fe chains on Ir(001) using magnetic exchange force microscopy† 用磁交换力显微镜探测Ir（001）上铁链的自旋螺旋。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-05-28 DOI: 10.1039/D5NH00162E

Yuuki Adachi, Yuuki Yasui, Atsushi Iiyama, Wataru Kurahashi, Rihito Nagase and Yoshiaki Sugimoto

引用次数: 0

Colloidal synthesis and etching yield monodisperse plasmonic quasi-spherical Mg nanoparticles† 胶体合成和蚀刻制备单分散等离子体准球形镁纳米颗粒。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-05-22 DOI: 10.1039/D5NH00205B

Andrey Ten, Christina Boukouvala, Vladimir Lomonosov and Emilie Ringe

引用次数: 0

AlphaFold 3 modeling of DNA nanomotifs: is it reliable?† DNA纳米基的AlphaFold 3建模：可靠吗？

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-05-22 DOI: 10.1039/D5NH00059A

Mauricio Cortes, Xindi Sun, Anusha, Emile Joseph Batchelder-Schwab, Jinyue Li, Naseem Siraj, Rishab Jampana, Yuchen Zhang, Yuntian Bai and Chengde Mao

{"title":"AlphaFold 3 modeling of DNA nanomotifs: is it reliable?†","authors":"Mauricio Cortes, Xindi Sun, Anusha, Emile Joseph Batchelder-Schwab, Jinyue Li, Naseem Siraj, Rishab Jampana, Yuchen Zhang, Yuntian Bai and Chengde Mao","doi":"10.1039/D5NH00059A","DOIUrl":"10.1039/D5NH00059A","url":null,"abstract":"Being able to accurately predict structures is highly desirable for nanoengineering with DNA and other biomolecules. The newly launched AlphaFold 3 (AF3) provides a potential platform for this purpose. In this work, we have used AF3 to model a list of commonly used DNA nanomotifs and compared the AF3 structures with the experimentally observed structures reported in the literature. For asymmetric motifs, AF3 structures are consistent with the experimental observations; but for symmetric motifs, AF3 structures are often substantially different from experimental observations. However, the fails can be rescued if the symmetric motifs are converted into corresponding asymmetric motifs by breaking DNA sequence symmetry while maintaining the backbone symmetry. This study suggests that while AF3 is immensely helpful, we as experimentalists should use it (as it currently stands) with caution. In addition, AF3 needs further development to incorporate the existing experimental data in the training dataset for AF3. At the current stage, a hybrid approach might be beneficial: theoretical modeling softwares calculate the detailed, 3D DNA structures based on secondary DNA structures inspired by experimental observations.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 7","pages":" 1428-1435"},"PeriodicalIF":8.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d5nh00059a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional CMOS-integrable and reconfigurable 2D ambipolar tellurene transistors for neuromorphic and in-memory computing† 用于神经形态和内存计算的多功能cmos可积和可重构二维双极性碲晶体管。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-05-22 DOI: 10.1039/D5NH00113G

Bolim You, Jihoon Huh, Yuna Kim, Mino Yang, Unjeong Kim, Min-Kyu Joo, Myung Gwan Hahm and Moonsang Lee

{"title":"Multifunctional CMOS-integrable and reconfigurable 2D ambipolar tellurene transistors for neuromorphic and in-memory computing†","authors":"Bolim You, Jihoon Huh, Yuna Kim, Mino Yang, Unjeong Kim, Min-Kyu Joo, Myung Gwan Hahm and Moonsang Lee","doi":"10.1039/D5NH00113G","DOIUrl":"10.1039/D5NH00113G","url":null,"abstract":"Despite significant efforts to eliminate the von Neumann bottleneck with new two-dimensional (2D) nanomaterial-based cutting-edge device structures, there remains room for exploring alternative computing architectures that leverage 2D nanomaterials. This study introduced a groundbreaking strategy featuring a complementary metal-oxide semiconductor (CMOS)-integrable and reconfigurable ambipolar 2D tellurene (Te) transistor toward non-von Neumann computing architecture. The innovative scenario integrated seamlessly with CMOS technology, utilizing the p/n-switchable ambipolar characteristics inherited from precise Fermi-level alignment via thermal atomic layer deposition. Further, the architecture exhibited remarkable synaptic behavior while maintaining the conventional inverter performance within a compact single 2D Te device architecture. Expanding these findings, we demonstrated a compact programmable CMOS inverter with reduced spatial complexity and also visualized the construction of diverse complementary logic-in-memory computing. The results of this study pave the way for revolutionary in-memory computing that transcends the boundaries of the von Neumann architecture based on 2D nanomaterials.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 8","pages":" 1760-1770"},"PeriodicalIF":8.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0