{"title":"Edge stoichiometry and percolation-governed two-dimensional scaling in amorphous IGZO transistors.","authors":"Tsai-Ming Huang, Chun-I Lu, Ming-Chun Hong, Yu-Hsin Tseng, Kuan-Yu Liu, Wei-Ning Chang, Kun-Jen Hsueh, Meng-Chen Lu, Wei-Kai Yu, Chuang-Ju Lin, Chien-Chung Hsu, Chao-Cheng Lin, Tuo-Hung Hou","doi":"10.1039/d6nh00214e","DOIUrl":"https://doi.org/10.1039/d6nh00214e","url":null,"abstract":"<p><p>Amorphous indium-gallium-zinc oxide (a-IGZO) transistors are promising back-end-of-line-compatible devices for monolithic three-dimensional logic and memory, but threshold-voltage control becomes challenging as both channel length and width are scaled to the nanoscale. Here, we investigate a-IGZO transistors with both dimensions reduced to 50 nm and show that threshold-voltage scaling is governed by the coupling between edge stoichiometry and percolation-limited transport. Ar- and Cl<sub>2</sub>-patterned devices exhibit distinct width-dependent threshold-voltage shifts, while length scaling produces an opposite trend. Energy-dispersive spectroscopy, technology computer-aided design simulations, and random telegraph noise measurements reveal that percolative transport amplifies or compensates the impact of edge stoichiometry depending on etch chemistry. These results provide a geometry-process-percolation framework for threshold-voltage engineering in nanoscale oxide electronics.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Nanoscale Horizons</i> 2025 Outstanding Paper Award.","authors":"","doi":"10.1039/d6nh90031c","DOIUrl":"https://doi.org/10.1039/d6nh90031c","url":null,"abstract":"<p><p>Recognizing some of the outstanding work published in <i>Nanoscale Horizons</i> in 2025, as well as the authors behind those articles. Discover our winners and their outstanding articles below.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Nanoscale Horizons</i> Emerging Investigator Series: Dr Joelle P. Straehla, Massachusetts Institute of Technology/Seattle Children's Research Institute/University of Washington, United States.","authors":"","doi":"10.1039/d6nh90037b","DOIUrl":"https://doi.org/10.1039/d6nh90037b","url":null,"abstract":"<p><p>Our Emerging Investigator Series features exceptional work by early-career nanoscience and nanotechnology researchers. Read Joelle P. Straehla's Emerging Investigator Series article 'Subcellular nanoparticle trafficking investigated with label-free, live cell imaging' (https://doi.org/10.1039/d5nh00749f) and read more about her in the interview below.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Engineering surface functional groups of MXenes for advanced catalysis and energy technology.","authors":"Wenkang Xu, Haoran Wang, Xiaoyan An, Changzhuo Xue, Zhiyang Yu, Chao Peng, Hao-Fan Wang, Yonghai Cao, Hongjuan Wang, Hao Yu","doi":"10.1039/d6nh00047a","DOIUrl":"10.1039/d6nh00047a","url":null,"abstract":"<p><p>MXenes, as an emerging class of two-dimensional transition metal carbides, nitrides, and carbonitrides, have attracted extensive attention in catalysis and energy technology owing to their unique properties, including metallic conductivity, hydrophilic surfaces, and structural diversity. A key distinguishing feature of MXenes lies in the richness and tunability of their surface functional groups (T<sub><i>x</i></sub>, <i>e.g.</i>, -O, -OH, -F), which serve as a powerful lever for precisely engineering the material's structural, electronic, mechanical, and chemical characteristics. The deliberate modulation of T<sub><i>x</i></sub>, achieved through T<sub><i>x</i></sub> engineering, including <i>in situ</i> synthesis control or post-synthetic treatments, directly governs critical properties such as work function, electrical conductivity, hydrophilicity, and oxidation stability. These tailored properties, in turn, drive performance enhancements in surface-sensitive applications: in electrocatalysis, T<sub><i>x</i></sub> engineering optimizes intermediate adsorption and charge transfer for reactions like hydrogen evolution and CO<sub>2</sub> reduction; in energy storage devices such as batteries and supercapacitors, it enhances ion accessibility, redox activity, and cycling stability. This review systematically summarizes recent advances in surface T<sub><i>x</i></sub> engineering of MXenes, elucidating the fundamental mechanisms linking T<sub><i>x</i></sub> customization to property evolution and application-specific performance. By discussing T<sub><i>x</i></sub> engineering strategies, structure-property-performance relationships, and mechanistic roles of distinct T<sub><i>x</i></sub>, we aim to provide a deep understanding of how T<sub><i>x</i></sub> tunability makes MXenes particularly suited for catalysis and energy technologies, while also outlining future directions for rational surface design in this rapidly evolving field.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"2071-2107"},"PeriodicalIF":6.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Won Kyung Park, Jae Won Park, Gunoh Lee, SeongCheol Jang, Hyun-Suk Kim, Kyung Jin Lee
{"title":"Polypyridinophane thin films <i>via</i> CVD for a polymeric dielectric layer on an oxide TFT with an ultrahigh dielectric constant.","authors":"Won Kyung Park, Jae Won Park, Gunoh Lee, SeongCheol Jang, Hyun-Suk Kim, Kyung Jin Lee","doi":"10.1039/d6nh00093b","DOIUrl":"10.1039/d6nh00093b","url":null,"abstract":"<p><p>High-k polymer gate dielectrics are desirable for oxide thin-film transistors but limited by low capacitance and interfacial instability. Pyridinophane-based polymers with main-chain heteroatoms were processed <i>via</i> a Gorham-type chemical vapor polymerization to form ultrathin, pinhole-free dielectrics with enhanced dielectric properties and reliable oxide transistor performance.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"2138-2146"},"PeriodicalIF":6.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding electrocatalysis at non-equilibrium steady states.","authors":"Alain R Puente Santiago, Emily Centino","doi":"10.1039/d5nh00830a","DOIUrl":"10.1039/d5nh00830a","url":null,"abstract":"<p><p>Electrocatalysis has traditionally relied on static reaction conditions, in which catalyst performance is determined by equilibrium surface states. However, many catalytic processes in Nature are inherently dynamic. Pulse-driven electrocatalysis (PE) offers temporal control over electrode potential, allowing real-time adjustments to adsorbate energetics, charge distribution, and selectivity. This perspective shows how voltage pulses can modulate the catalytic interface under dynamic conditions, alter mechanistic pathways, favor transient intermediate states, reorganize the electric double layer (EDL), and steer reaction networks beyond steady-state limits. It covers the physical chemistry principles behind PE processes using pivotal multistep electrocatalytic reactions. Finally, future directions involving artificial intelligence to develop efficient self-optimizing electrocatalytic systems are elegantly discussed.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"2108-2114"},"PeriodicalIF":6.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147985617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sukalyan Shyam, Sujeong Han, Hyunwoo Shim, Taesung Kim
{"title":"Fundamental and technical advances in bulk photovoltaics of 2D van der Waals materials.","authors":"Sukalyan Shyam, Sujeong Han, Hyunwoo Shim, Taesung Kim","doi":"10.1039/d6nh00127k","DOIUrl":"10.1039/d6nh00127k","url":null,"abstract":"<p><p>2D van der Waals (vdW) materials with exceptional electronic and optical properties have emerged as a hotspot of materials science research. Over the last few years, substantial growth has been observed in the engineering of these materials for the bulk photovoltaic effect (BPVE). BPVE is the conversion of electricity from light <i>via</i> an entirely distinct mechanism from the p-n junction photovoltaic device. The tunable crystal structures of 2D vdW materials, their ability to maintain clean interfaces, and the ease of forming heterostructures and heterojunctions facilitate the manipulation of crystal symmetry, electronic polarization, light-matter interactions, thereby providing an efficient platform for engineering the BPVE. Herein, we present a critical discussion of the fundamentals of engineering the BPVE using different material systems and innovative strategies based on previous scientific reports. The key challenges that can hinder device efficiency are also covered. The potential for a next-generation, self-powered, energy-efficient, flexible, and lightweight device utilizing the BPVE of 2D vdW materials is highlighted in this article.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"2027-2052"},"PeriodicalIF":6.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Qiu, Xin Ji, Jinrui Zhang, Jing Gao, Yan Shi, Yangang Pan, Guanghua Che, Haijiao Xu, Hongda Wang
{"title":"Actin-dependent regulation of RSV F-mediated cell-cell fusion revealed by visualizing its spatiotemporal dynamics.","authors":"Yu Qiu, Xin Ji, Jinrui Zhang, Jing Gao, Yan Shi, Yangang Pan, Guanghua Che, Haijiao Xu, Hongda Wang","doi":"10.1039/d6nh00043f","DOIUrl":"10.1039/d6nh00043f","url":null,"abstract":"<p><p>Respiratory syncytial virus (RSV) induces pathogenic syncytia <i>via</i> its fusion (F) protein, yet how it orchestrates fusion within the crowded plasma membrane remains unclear. By integrating live-cell and dSTORM imaging, we visualized the spatiotemporal dynamics of RSV F from secretion to membrane assembly. We show that RSV F efficiently traffics to the plasma membrane and triggers F-actin-enriched protrusions that facilitate fusion, depending on branched actin remodeling. Super-resolution imaging further reveals that RSV F reorganizes from nanoscale clusters into near-continuous ribbon-like nanodomains at cell-cell contacts, forming a stable fusion platform. This work directly visualizes the actin-driven nanoscale assembly of a viral fusogen, defining a key mechanism in RSV pathogenesis and revealing a nanoscale target for antiviral intervention, thereby underscoring the power of advanced nanoscopy to unravel complex host-pathogen interactions at the molecular level.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"2158-2166"},"PeriodicalIF":6.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acacetin-incorporated lipid nanoparticles for inhaled mRNA vaccines.","authors":"Xuefeng Huang, Kaiyu Fan, Yuxuan Zhang, Yuanjiao Yang, Yubo Wang, Xujia Yang, Zilin Meng, Qiang Guo, Yue Li, Ningqiang Gong, Shunhao Wang, Jinghong Li, Zhen Zhang","doi":"10.1039/d5nh00794a","DOIUrl":"10.1039/d5nh00794a","url":null,"abstract":"<p><p>Inhaled mRNA vaccines have shown great promise for the prevention of respiratory diseases. However, their broad application is still restricted by lipid nanoparticle (LNP)-induced oxidative stress, rapid clearance of LNPs from the lung, and limited mRNA expression. Here, we show that incorporating a natural compound, acacetin, into the LNP formulation can overcome these delivery barriers and greatly improve inhaled vaccine effectiveness. A natural compound library containing 242 compounds was used in an <i>in vitro</i> screening experiment, and acacetin was identified as the lead compound that substantially increased LNP-mediated mRNA expression in A549 cells. We then incorporated acacetin in LNPs as a fifth component. After optimizing the formulation of LNPs in <i>in vitro</i> transfection assays and <i>in vivo</i> pulmonary delivery assays, we find acacetin-incorporated LNPs increased lung transfection by 10.82-fold. A mechanistic study showed that acacetin reshaped the intracellular environment of lung cells by activating antioxidant stress pathways and suppressing pro-inflammatory signaling, thereby maintaining high levels of mRNA translation. Inhaled administration of acacetin-incorporated LNPs, delivering mRNA encoding the SARS-CoV-2 spike protein, induced higher antigen-specific IgG (14.95-fold) and IgA (2.38-fold) levels than a conventional LNP formulation, without inducing toxicity. We demonstrate that acacetin-incorporated LNPs offer a simple and scalable strategy to improve the efficacy of inhaled mRNA vaccines.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"2204-2214"},"PeriodicalIF":6.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William Emmanuel Ghann, Sk Md Atiqur Rahman, Shabib M Uddin, Rokshana Ara Ruhi, Md Anwarul Kabir Bhuiya, Md Shahnawaz Parvez, Mohsin Kazi, Mohammed Muzibur Rahman, Zmg Sarwar Jahangir, Mohammad Hossain Shariare, Md Abu Reza, Jamal Uddin
{"title":"Synthesis and characterization of silver nanowires and their promising anticancer effects.","authors":"William Emmanuel Ghann, Sk Md Atiqur Rahman, Shabib M Uddin, Rokshana Ara Ruhi, Md Anwarul Kabir Bhuiya, Md Shahnawaz Parvez, Mohsin Kazi, Mohammed Muzibur Rahman, Zmg Sarwar Jahangir, Mohammad Hossain Shariare, Md Abu Reza, Jamal Uddin","doi":"10.1039/d6nh00195e","DOIUrl":"10.1039/d6nh00195e","url":null,"abstract":"<p><p>Silver nanowires (AgNWs) were synthesized by a modified polyol method and evaluated for their structural features and anticancer activity against Ehrlich ascites carcinoma (EAC) cells <i>in vivo</i>. The AgNWs were characterized by UV-vis spectroscopy, zeta potential analysis, dynamic light scattering, FESEM, TEM, and EDS to confirm their optical response, morphology, and elemental composition. The nanowires showed a plasmonic absorption band at 385 nm, a near-neutral zeta potential, and a mean diameter of 71.58 ± 22.78 nm, although minor secondary morphologies were observed. In the EAC mouse model, AgNWs reduced viable EAC cell counts in a non-linear dose-dependent manner, with the lower dose showing stronger inhibition than the higher dose. These findings suggest that AgNWs possess measurable anticancer activity, while also indicating that dispersion state and dose-dependent behavior require further mechanistic study before translational use can be considered.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":"2167-2177"},"PeriodicalIF":6.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}