European journal of breast health最新文献

{"title":"Personalized Treatment Outcomes in Idiopathic Granulomatous Mastitis: A Retrospective Study of Ninety-Two Patients.","authors":"Rashad Jafarov, Altay Aliyev, Iqbal Babazade, Rena Abdullayeva, Khayala Sharifova, Nihad Asadov, Elgun Samedov","doi":"10.4274/ejbh.galenos.2026.2025-9-15","DOIUrl":"10.4274/ejbh.galenos.2026.2025-9-15","url":null,"abstract":"<p><strong>Objective: </strong>Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast disease with a high risk of relapse. The study objective was to evaluate relapse predictors and treatment outcomes in a large cohort of IGM patients.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed female patients diagnosed with IGM (2018-2024) at the Central Military Hospital, Baku. Diagnosis was confirmed by core needle biopsy. Patients were managed with systemic therapy (corticosteroids and/or immunosuppressants) when clinically indicated; local measures (e.g., aspiration/drainage, intralesional steroid) were used selectively in localized disease. Relapse was defined as reappearance of clinical or radiological findings after remission. Univariable and multivariable logistic regression models were applied to identify independent predictors.</p><p><strong>Results: </strong>The cohort consisted of 92 patients. Relapse occurred in 22/85 methotrexate-treated patients (25.9%), with most relapses occurring between the third and fifth months. No relapse events were observed in the azathioprine subgroup (<i>n</i> = 7). However, this finding should be considered observational only due to the small numbers and zero-event data. In multivariable analysis, erythrocyte sedimentation rate (ESR) >20 mm/h (and angiotensin converting enzyme >52 U/L, where applicable) were associated with relapse, whereas apparent associations with tumor necrosis factor alpha inhibitors and cyclosporine likely reflect confounding by indication because these agents were used as rescue therapy in refractory/relapsing disease. Elevated ESR was also associated with prolonged treatment duration (<i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>A structured and individualized treatment approach may contribute to favorable clinical outcomes in patients with IGM. Observed relapse patterns support the importance of risk-adapted management rather than a uniform therapeutic strategy. Given the retrospective design and limited subgroup sizes, these findings should be interpreted cautiously and considered hypothesis-generating. Prospective, multicenter studies are required to validate relapse-associated factors and optimize treatment strategies.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"270-278"},"PeriodicalIF":2.1,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Internal Validation of a Clinical Data-Based Machine Learning Web Calculator for Predicting Recurrence in Granulomatous Lobular Mastitis: A Multicenter Retrospective Study.","authors":"Jiao Feng, Ruiyang Wu, Jin Chen, Yi Li","doi":"10.4274/ejbh.galenos.2026.2026-1-10","DOIUrl":"10.4274/ejbh.galenos.2026.2026-1-10","url":null,"abstract":"<p><strong>Objective: </strong>Granulomatous lobular mastitis (GLM) is a disease characterized by a high recurrence rate and the absence of a standard treatment, making prognostic prediction crucial. While promising, existing machine learning models are limited by single-center data and small sample sizes. This study aimed to develop and validate machine learning models using a large multicenter dataset to predict GLM recurrence and build a clinical web calculator.</p><p><strong>Materials and methods: </strong>In this retrospective cohort study, data from 318 GLM patients at two tertiary hospitals (diagnosed between 2019 and 2024) were used to train and evaluate five machine learning models. Performance was assessed by accuracy, area under the curve (AUC), F1-score, sensitivity, and specificity.</p><p><strong>Results: </strong>The five models demonstrated comparable discriminatory performance, with AUCs ranging from 0.778 to 0.808 and no statistically significant differences among them. Among them, random forest (RF) excelled in composite and sensitivity metrics (F1 score: 0.639; accuracy: 76.2%; sensitivity: 50%), whereas logistic regression achieved the top AUC (0.808), and the support vector machine achieved the best specificity (95.3%). Based on its balanced performance across multiple metrics, RF was selected for deployment to develop a publicly accessible web application platform (https://w12251393.shinyapps.io/predictGLM/). In the RF model, white blood cell count emerged as the top predictor, followed by age at diagnosis, the origin of the primary tumor, surgical excision, antitubercular therapy, corticosteroid therapy, and abscess drainage, in descending order of importance.</p><p><strong>Conclusion: </strong>Although retrospective in design, this study developed a multicenter RF model and implemented it as an accessible web calculator, providing a valuable tool for personalized recurrence prediction and treatment decision-making in GLM. The model should be used as a risk stratification aid to support clinical decision-making rather than as a definitive predictive instrument.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 3","pages":"307-317"},"PeriodicalIF":2.1,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of the Senologic International Society (SIS) on the Use of Preoperative Breast MRI in Early-Stage Breast Cancer: A Global Perspective on Current Practice.","authors":"Alexander Mundinger, Carolin Mundinger, Darius Dian, Thorsten Heilmann, Shigeru Imoto, Atilla Soran, Wendie A Berg, Tolga Ozmen, Mitsuhiro Tozaki, Katja Siegmann-Luz, Ayfer Kamali Polat, Salete de Jesus Fonseca Rêgo, Pieter De Visschere, Sylvia H Heywang-Köbrunner, Dionysios Koufoudakis, Bolivar Arboleda-Osorio, Maurício Magalhães Costa, Tadeusz Pieńkowski, Paula Podolski, Vahit Ozmen, Schlomo Schneebaum, Constanze Elfgen, Lydia Ioannidou-Mouzaka, Marianna Telesca, Manisha Bahl, Makus Müller-Schimpfle, Vaidotas Cesna, Siarhei Kharuzhyk, Carole Mathelin","doi":"10.4274/ejbh.galenos.2026.2026-2-10","DOIUrl":"10.4274/ejbh.galenos.2026.2026-2-10","url":null,"abstract":"<p><strong>Objective: </strong>To map global practice patterns and disparities in the use of preoperative breast magnetic resonance imaging (MRI) for early breast cancer (EBC) among members of the Senologic International Society (SIS) and SIS Working Group.</p><p><strong>Materials and methods: </strong>A cross-sectional, web-based survey was distributed to SIS members worldwide. The questionnaire captured respondent demographics, center characteristics, local/national breast MRI use, guideline perceptions and personal practice, specific indications for MRI, and decision-making influences.</p><p><strong>Results: </strong>We analyzed 114 responses from 17 countries. Significant variations were observed. While 36/46 (78.3%) of Japanese respondents perceived national guidelines as recommending preoperative MRI, only 18/60 (30%) of Europeans did. Overall, 96/114 (84.2%) of all respondents believed preoperative MRI provided a patient benefit, with none believing it caused harm. The most frequent indications in the total cohort were invasive lobular carcinoma (106/114, 93.0%), mammographic/sonographic suspicion of multifocality/multicentricity (96/114, 84.2%) and planned neoadjuvant therapy (89/114, 78.1%), while in Japan ductal carcinoma <i>in situ</i> (DCIS) or accompanying DCIS component was the most frequent indication (45/46, 97.8%). Half of respondents stated that national guidelines recommend preoperative breast MRI for EBC (57/114, 50%). Furthermore, 30/57 (52.6%) of these \"guideline-positive\" respondents reported performing more MRIs than advised while most guidelines recommending only selected preoperative indications such as invasive lobular histopathology, dense breasts, suspicion of multifocality/multicentricity or imaging inconsistencies. Key influencing factors included specialty, reimbursement, and time to access preoperative MRI.</p><p><strong>Conclusion: </strong>This SIS-based international survey revealed heterogeneous global adoption of preoperative breast MRI for EBC, highlighting a significant gap between evidence-based guidelines and real-world practice. Clinical decisions are heavily influenced by geography, culture and resources, and belief in patient benefit. These findings highlight the need to tailor guidelines to local contexts, and strengthen awareness and dissemination efforts, together with further research to clarify the role of MRI in the modern multidisciplinary management of EBC.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 3","pages":"328-339"},"PeriodicalIF":2.1,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Synovial Sarcoma of the Breast Initially Mimicking Dermatofibrosarcoma Protuberans: A Case Report.","authors":"Ines Mkhinini, Hammadi Jawaher, Samar Knaz, Nour Rouis, Chayma Selmi, Amira Ounissi, Rania Boukadida, Yosra Fejji, Salwa Mejri, Ridha Fatnassi","doi":"10.4274/ejbh.galenos.2026.2025-10-6","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2026.2025-10-6","url":null,"abstract":"<p><p>Primary synovial sarcoma of the breast is an extremely rare malignancy, representing less than 1% of breast tumors. Its clinical presentation can mimic other spindle cell neoplasms, including dermatofibrosarcoma protuberans (DFSP), making diagnosis challenging. We report the case of a 60-year-old postmenopausal woman presenting with a firm, mobile 10 cm mass in the upper outer quadrant of the left breast, classified on imaging as breast ımaging reporting and data System 4. A core needle biopsy initially suggested DFSP because of strong CD34 positivity. A simple mastectomy revealed a highly cellular, spindle-cell tumor arranged in fascicles, forming a characteristic whorled pattern. Immunohistochemistry showed CD34 negativity, transducin-like enhancer of split 1 positivity, B-cell lymphoma 2 positivity, and focal epithelial membrane antigen positivity. Molecular analysis confirmed SYT-SSX1 fusion, establishing the diagnosis of monophasic synovial sarcoma. Surgical margins were negative, and one-year follow-up showed that the patient remained disease-free. This case highlights the importance of immunohistochemistry and molecular testing for accurate diagnosis and appropriate management.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Surgical Approach and Overall Survival in Young Women With Breast Cancer.","authors":"Christine V Pestana, Sally J Trufan, Wei Sha, Courtney R Schepel, Michelle L Wallander, Richard L White, Lejla Hadzikadic-Gusic","doi":"10.4274/ejbh.galenos.2026.2025-8-7","DOIUrl":"10.4274/ejbh.galenos.2026.2025-8-7","url":null,"abstract":"<p><strong>Objective: </strong>Mastectomy rates are increasing in young patients despite few data supporting improved outcomes. We investigated the association between surgical approach and survival in young patients with breast cancer.</p><p><strong>Materials and methods: </strong>Retrospective review identified women ≤40 years old with operable, non-metastatic invasive breast cancer treated between 2010-2019. Cox proportional hazard analyses, stratified by hormone receptor and human epidermal growth factor receptor 2 (HER2) status, identified factors associated with increased risk of recurrence and death.</p><p><strong>Results: </strong>Of 588 patients, 65% underwent mastectomy and 35% breast conserving surgery (BCS). Median follow-up was 5.9 years. Overall recurrence and mortality rates were 15% and 12%, respectively. On multivariable analysis, black race [hazard ratio (HR), 2.14 (1.26-3.61), <i>p</i> = 0.005], lymphovascular space invasion (LVSI) [HR, 1.98 (1.17-3.36), <i>p</i> = 0.01], and extranodal extension [HR, 2.12 (1.09-4.12), <i>p</i> = 0.03] were associated with increased risk of death. Stage III disease [HR, 2.06 (1.05-4.03), <i>p</i> = 0.04] and LVSI [HR, 2.18 (1.43-3.32), <i>p</i><0.001] were associated with increased risk of recurrence. Increasing age decreased the risk of death [HR, 0.94 (0.88-0.99), <i>p</i> = 0.02] and recurrence [HR, 0.95 (0.90-0.99), <i>p</i> = 0.02]. Mastectomy versus BCS did not impact recurrence [HR, 1.18 (0.73-1.92), <i>p</i> = 0.51] or overall survival (OS) [HR, 0.86 (0.46-1.58), <i>p</i> = 0.62] in the entire cohort. BCS was associated with increased risk of recurrence in the hormone receptor-/HER2+ subtype [HR, 9.06 (1.03-80.00), <i>p</i> = 0.047] but did not affect survival.</p><p><strong>Conclusion: </strong>OS does not differ by surgery type in young patients with breast cancer. Future research should focus on racial disparities in breast cancer care.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 2","pages":"171-183"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid-Rich Carcinoma of the Breast: A Rare but Aggressive Mammary Malignancy.","authors":"Omar Tluli, Giridhara Rathnaiah Babu, Semir Vranic","doi":"10.4274/ejbh.galenos.2025.2025-8-2","DOIUrl":"10.4274/ejbh.galenos.2025.2025-8-2","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 2","pages":"237-239"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Video Health Education on Breast Cancer Awareness and Self-Examination in the New Age of Digitalisation: Community-Based Evidence from a Developing Nation.","authors":"Rajashekhar Rao Muthineni, Suhani Suhani, Ravneet Kaur, Maroof A Khan, Mohit Kumar Joshi, Hemanga Kumar Bhattacharjee, Rajinder Parshad","doi":"10.4274/ejbh.galenos.2025.2025-9-4","DOIUrl":"10.4274/ejbh.galenos.2025.2025-9-4","url":null,"abstract":"<p><strong>Objective: </strong>Developing nations with resource limited settings see a higher proportion of presentation at advanced stages of breast cancer compared to developed nations because of poor public awareness and lack of screening guidelines. This study aimed to assess the impact of a video-based teaching module on breast cancer awareness and self-examination among literate women in a developing country.</p><p><strong>Materials and methods: </strong>This quasi-experimental, community-based, intervention study was conducted among literate women of a metropolitan city in a developing country, to evaluate the impact of a video-based teaching module on breast cancer awareness and self-examination. Female school teachers over 25 years old with virtual platform access were included. Simple random sampling was used to select participant schools. The target sample size was 103 based on a reference study. An educational video and questionnaires were validated through expert and volunteer feedback, followed by baseline and follow-up surveys at 6 weeks and 10 weeks after intervention. The Friedman test for overall change in scores and Wilcoxon signed-rank test were used for pairwise comparison between time points.</p><p><strong>Results: </strong>The survey was completed by 181 participants. Mean (standard deviation) age was 41.79 (9.20) years. Median (interquartile range) cumulative score for the knowledge domain was 18 (14-21), 24 (19-32) and 25 (20-33) at baseline, 6 weeks and 10 weeks respectively with significant differences between each of these time points (<i>p</i><0.001). There was a significant increase in the number of participants with a median score of 3 at 6 and 10 weeks compared to baseline in the attitude domain after intervention. The proportion of study participants with a score of ≥3 points in the practices domain increased from 22% (40/181) at baseline to 41.2% (74/181) at 6 weeks and 49.1% (89/181) at 10 weeks of educational intervention.</p><p><strong>Conclusion: </strong>A video-based educational intervention may enhance breast cancer knowledge, attitudes, and self-examination practices in educated women with access to electronic media. This may contribute to early breast cancer detection in resource-constrained settings with limited screening options.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 2","pages":"147-155"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes Zoster of the Nipple: A Rare Diagnostic Challenge.","authors":"Maria Kleanthi Arkoumani, Despoina Valaora, Maria Gkaravellou, Theano Perri, Andreas Zografidis, Georgios Karavitis, Emmanouel Lagoudianakis","doi":"10.4274/ejbh.galenos.2025.2025-10-11","DOIUrl":"10.4274/ejbh.galenos.2025.2025-10-11","url":null,"abstract":"<p><p>The breast constitutes an essential component of a woman's identity, body image, and self-esteem. The objective of this article is to present a rare case of breast skin pathology and to examine its differential diagnosis. A fifty-year-old woman consulted our department for a burning sensation in her right breast in combination with a rash involving the nipple-areola complex. The patient received treatment for evolving bacterial mastitis; however, a zosteriform vesicular rash subsequently developed over the right scapular region. The diagnosis of varicella zoster virus infection was confirmed, and oral medication was adjusted to antivirals, resulting in progressive reduction of the rash. To the best of our knowledge, reports on herpes zoster involving the nipple are scarce in the literature. This article presents such an atypical manifestation, underscoring the importance of including herpes zoster in the differential diagnosis of nipple-areolar complex lesions, and provides a brief review of the relevant literature.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 2","pages":"231-233"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Role of Artificial Intelligence in Enhancing Multidisciplinary Team Decisions for Breast Cancer Management.","authors":"Merve Tokoçin, Turan Pehlivan, Selçuk Cin, Bülent Toksöz, Onur Tokoçin, Eda Cingöz, Nigar Erkoç, Aynur Özen, Nida Sünnetçi Arıkan, Şahin Bedir, Atilla Çelik","doi":"10.4274/ejbh.galenos.2026.2025-10-4","DOIUrl":"10.4274/ejbh.galenos.2026.2025-10-4","url":null,"abstract":"<p><strong>Objective: </strong>Multidisciplinary teams (MDTs) are essential for optimizing breast cancer treatment, yet the role of general-purpose artificial intelligence (AI), such as ChatGPT, in supporting these teams remains underexplored. This study compared ChatGPT versions 3.5 and 4 with a hospital-based MDT in making treatment and follow-up recommendations, using St. Gallen, European Society for Medical Oncology, National Comprehensive Cancer Network, and American Society of Clinical Oncology guidelines as a reference.</p><p><strong>Materials and methods: </strong>A retrospective analysis of 100 consecutive breast cancer patients diagnosed between January 2023 and January 2024 at a training hospital in İstanbul, Türkiye, was conducted. The MDT provided consensus-based recommendations, while anonymized patient data were processed by ChatGPT using English prompts based on guideline summaries. Two experienced breast surgeons independently rated recommendation appropriateness on a five-point scale post-treatment, focusing on clinical outcomes, with agreement assessed using weighted Cohen's kappa across cancer stage, molecular subtype, and proliferation index.</p><p><strong>Results: </strong>ChatGPT-4 (with a knowledge cut-off of March 2023) demonstrated substantial agreement with the MDT for primary treatments (weighted κ = 0.712), whereas ChatGPT-3.5 showed moderate agreement (κ = 0.600). Agreement for additional recommendations, such as genetic counseling, was lower (GPT-4: κ = 0.398; GPT-3.5: κ = 0.302), with better performance in early-stage and less aggressive subtypes compared to advanced or aggressive cases. Discrepancies were noted in complex or aggressive cases.</p><p><strong>Conclusion: </strong>The study suggests ChatGPT, particularly version 4, may serve as a supportive tool for breast cancer teams, especially in early-stage cases, though clinical expertise remains vital for complex scenarios, warranting further research to refine AI integration.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 2","pages":"184-189"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncoplastic Approach to Juvenile Giant Fibroadenoma: A Case Series.","authors":"Marcelo Chávez Díaz, Gabriel De la Cruz Ku, Carla Carina Cedrón Lenci, Maria Del Rosario Cueva Perez","doi":"10.4274/ejbh.galenos.2025.2025-9-6","DOIUrl":"10.4274/ejbh.galenos.2025.2025-9-6","url":null,"abstract":"<p><p>Juvenile giant fibroadenoma (GFA) is defined as a benign tumor larger than 5 cm, 500 grams, and/or involving at least 80% of the breast. It typically occurs in young patients and causes breast deformity and asymmetry. Surgical treatment involves resection of the tumor (enucleation), rearrangement of the skin envelope, and repositioning of the nipple-areola complex. However, the expected re-expansion of the breast following tumor removal, often managed through periareolar approaches, can be unpredictable and prolonged in certain cases. For this reason, oncoplastic surgery techniques have been developed, which allow for immediate partial reconstruction and are now among the available therapeutic options. This report describes three cases in which an oncoplastic approach was used for the treatment of GFA.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 2","pages":"226-230"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}