影响接受新辅助治疗的局部晚期乳腺癌病理完全缓解的因素:综合文献综述。

IF 1.3 Q4 ONCOLOGY
European journal of breast health Pub Date : 2023-12-27 eCollection Date: 2024-01-01 DOI:10.4274/ejbh.galenos.2023.2023-11-2
Munaser Alamoodi
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引用次数: 0

摘要

确定病理完全反应(pCR)是规划个体治疗的重要一步,从而改善预后,提高生存率。乳腺癌病理完全缓解不仅能提高生存率,还与腋窝无病变有关,因此更有可能安全地避免腋窝手术。目前,通过外科手术或腋窝放疗来减轻腋窝治疗的趋势主要取决于乳腺癌(BC)患者是否达到 pCR。研究表明,某些特征可以预测 pCR,尽管确定这些要素仍然很困难。为了确定这些因素及其临床应用,我们对文献进行了综述。我们使用 PubMed、Google Scholar 和 EMBASE 在 MEDLINE 数据库中进行了搜索。结果发现有 1368 项研究,其中 60 项符合标准。这些研究根据其涉及的主题进行了分类。这些参数包括年龄、种族、亚型、临床病理学、免疫学、影像学、肥胖、Ki-67 状态、维生素 D 和遗传学。这些因素结合起来可用于特定亚型的个体化治疗和监测治疗反应。预测 pCR 的因素多种多样,应利用这些因素对患者进行个性化治疗,最终获得最佳疗效。这些决定因素还可用于监测对新辅助治疗的反应,从而调整治疗方法。针对 BC 亚型的多样性开发标准化标记物仍需进一步的研究。这些因素必须协同应用,才能达到最佳效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors Affecting Pathological Complete Response in Locally Advanced Breast Cancer Cases Receiving Neoadjuvant Therapy: A Comprehensive Literature Review.

Determining pathological complete response (pCR) could be an important step in planning individual treatment, hence improving the prognosis in terms of survival. Achieving breast pCR not only improves survival but is also linked to a disease-free axilla, therefore increasing the likelihood of avoiding axillary surgery safely. The current trend in de-escalating axillary management surgically or in applying radiotherapy to the axilla is dependent primarily on breast cancer (BC) patients achieving pCR. Studies have demonstrated that certain characteristics can predict pCR, even though it is still difficult to identify these elements. A review of the literature was carried out to determine these factors and their clinical applications. A search was carried out in the MEDLINE database using PubMed, Google Scholar, and EMBASE. This yielded 1368 studies, of which 60 satisfied the criteria. The studies were categorized according to the subject they dealt with. These parameters included age, race, subtypes, clinicopathological, immunological, imaging, obesity, Ki-67 status, vitamin D, and genetics. These factors, in combination, can be used for specific subtypes to individualize treatment and monitor response to therapy. The predictors of pCR are diverse and should be utilized to personalize patient treatment, ultimately inducing the best outcomes. These determinants can also be employed for monitoring responses to neoadjuvant therapy, thereby adjusting treatment. The development of standardized markers for the diversity of BC subtypes still needs additional future research. These factors must be applied in concert in order to provide optimal results.

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