Endokrynologia Polska最新文献

{"title":"Analysis of the SGLT2-independent off-target dapagliflozin activity using model organism Caenorhabditis elegans.","authors":"Katarzyna D Arczewska, Magdalena Kucharczyk, Małgorzata Grzanka, Joanna Życka-Krzesińska, Alex Białas, Beata Rybicka, Helena Kossowska, Marta Koblowska, Joanna Bogusławska, Hilde Nilsen, Agnieszka Piekiełko-Witkowska, Ryszard Gellert","doi":"10.5603/ep.110917","DOIUrl":"10.5603/ep.110917","url":null,"abstract":"<p><strong>Introduction: </strong>Flozins, an emerging class of antidiabetic agents, selectively target the SGLT2 sodium/glucose cotransporter in the renalproximal tubule, thereby preventing glucose reabsorption and reducing hyperglycemia. Beyond lowering glucose levels, flozins exhibitsignificant benefits in heart failure and chronic kidney disease. This expanded therapeutic utility is noteworthy, particularly given the absenceof SGLT2 expression in cardiac tissue, suggesting the involvement of additional targets or mechanisms affected by flozins.</p><p><strong>Material and methods: </strong>Here, we utilized Caenorhabditis elegans as a model organism devoid of an SGLT2 orthologue to analyze the off-targetactivity of flozins, specifically following dapagliflozin treatment. Glucose-fed worms were treated with dapagliflozin, and lifespan analyseswere performed. Transcriptomic profiling was conducted to compare glucose- and dapagliflozin-treated worms with glucose-only-treatedcontrols. In vivo glucose transport was assessed using the fluorescent glucose analogue 2-NBDG. Additionally, smvt-1 (sodium-dependentmultivitamin transporter) expression was downregulated to evaluate its role in dapagliflozin-mediated effects.</p><p><strong>Results: </strong>Although C. elegans lacks an SGLT2 orthologue, dapagliflozin remarkably mirrored observations from murine models by significantlyprolonging lifespan under glucose-fed conditions. Transcriptomic analyses revealed gene expression profiles closely resemblingthose observed in mammalian systems. Furthermore, we observed that dapagliflozin inhibits glucose transport in vivo, as demonstratedby reduced 2-NBDG uptake. Notably, this inhibitory effect was abolished upon downregulation of smvt-1, indicating its involvement indapagliflozin-mediated glucose transport inhibition.</p><p><strong>Conclusions: </strong>Our findings suggest that dapagliflozin exerts SGLT2-independent effects on glucose transport and longevity. In C. elegans, the sodium-dependent multivitamin transporter SMVT-1 represents a relevant target of dapagliflozin, providing insight into potentialalternative mechanisms underlying the pleiotropic benefits of flozins observed in mammals.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"224-233"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The sodium-glucose cotransporter 2 inhibitor empagliflozin reverses hyperglycemia-triggered vascular endothelial cell dysfunction by regulating mitochondria dynamics.","authors":"Qian Cheng, Rui Du, Jing Liu, Ping Qiu, Yonghe Hu","doi":"10.5603/ep.110841","DOIUrl":"10.5603/ep.110841","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperglycemia-induced endothelial injury is a major contributor to diabetic vasculopathy. While sodium-glucose transporter2 (SGLT2) in renal proximal tubules plays a critical role in diabetes, its expression and function in kidney endothelial cells, particularly regarding sex-specific disease progression, remain unclear.</p><p><strong>Material and methods: </strong>SGLT2 expression in kidney endothelial cells was examined in male streptozotocin (STZ)-induced diabetic miceusing immunostaining. In human umbilical vein endothelial cells (HUVECs) treated with high glucose, we investigated the impact ofSGLT2 on mitochondrial dynamics following empagliflozin treatment. Molecular mechanisms were elucidated using qRT-PCR and Westernblot. Therapeutic efficacy was evaluated by histological analysis.</p><p><strong>Results: </strong>SGLT2 was significantly upregulated in kidney endothelial cells of diabetic male mice. High glucose increased SGLT2 expressionin HUVECs, promoting mitochondrial fission and reducing fusion. Both SGLT2 siRNA knockdown and empagliflozin treatment markedlyenhanced mitochondrial fusion. Mechanistically, empagliflozin activated AMPK, increasing KLF4 expression and promoting mitochondrialfusion, thereby protecting against endothelial dysfunction. AMPK inhibition abrogated empagliflozin's protective effects in diabetic mice.</p><p><strong>Conclusions: </strong>SGLT2 critically regulates endothelial dysfunction under hyperglycemic conditions through the AMPK/KLF4-mitochondrialdynamics axis. Empagliflozin protects both proximal tubules and kidney endothelial cells in diabetes. Given accelerated diabetic kidneydisease progression in males, our male mouse model findings provide clinically relevant insights into sex-specific therapeutic responsesto SGLT2 inhibitors in diabetic vasculopathy.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"245-255"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between multiple inflammatory indices and gout: a cross-sectional study based on clinical and NHANES data.","authors":"Chenjing Xu, Qing Liu, Zhiwu Kuai, Aifeng He","doi":"10.5603/ep.107820","DOIUrl":"10.5603/ep.107820","url":null,"abstract":"<p><strong>Introduction: </strong>Gout has placed a significant burden on healthcare expenditures and society in recent decades. The systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) have been used as new non-specific inflammatory markers. This study aims to investigate the possible association between these markers and gout.</p><p><strong>Material and methods: </strong>Gout patients and non-gout participants were recruited from our hospital and the 2007-2016 National Health and Nutrition Examination Survey (NHANES) database. The differences in clinical data, SII, and SIRI between the two groups were compared. Logistic regression analysis was used to examine the relationship between each variable and the occurrence of gout. After adjusting for confounding factors, the relationship between multiple inflammatory indices and gout risk was further evaluated and visualized by the restricted cubic spline (RCS) model.</p><p><strong>Results: </strong>There were significant differences in gender, age, education level, body mass index, smoking status, alcohol consumption, hypertension, and diabetes between gout patients and healthy controls (p < 0.05). Male patients, older age, married, low education level, smoking, drinking, diabetes, high neutrophil count, high monocyte count, high platelet count, and high Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) index are risk factors for gout. Spearman correlation analysis revealed that lymphocyte count and platelet count were negatively correlated with serum uric acid levels, whereas neutrophil count, monocyte count, and SIRI index were positively correlated with serum uric acid levels. The results were further validated through analysis of the NHANES database.</p><p><strong>Conclusions: </strong>Our findings suggest that SII and SIRI are positively correlated with a high risk of gout and can be used as novel inflammatory markers for gout.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"62-71"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological changes in Cushing's disease from diagnosis to remission: comparison with non-functioning pituitary adenomas.","authors":"Sebnem Burhan, Aysel Unver Ozkahraman, Ebubekir Akpinar, Didem Acarer Bugun, Aslihan Pekmezci, Esra Hatipoglu","doi":"10.5603/ep.111457","DOIUrl":"10.5603/ep.111457","url":null,"abstract":"<p><strong>Introduction: </strong>Cushing's disease (CD) results in chronic hypercortisolism with multisystem complications. Although glucocorticoids affecthematopoiesis, sex-specific hematological alterations and their reversibility following treatment remain incompletely characterized.Most previous studies have compared patients with CD with healthy controls, limiting the ability to isolate cortisol-specific effects fromtumor- or surgery-related confounders. We investigated hematological parameters in patients with CD at diagnosis and after remission,using patients with non-functioning pituitary adenoma (NFA) as controls to specifically identify hypercortisolism-driven changes.</p><p><strong>Material and methods: </strong>This retrospective study included 117 patients: 59 with CD and 58 with NFA who underwent transsphenoidal surgery. Complete blood count and hormonal parameters were evaluated at diagnosis and 3 months postoperatively. Changes in hematologicalparameters were compared between groups using repeated-measures analysis of variance, with subgroup analyses examiningremission status and sex-specific differences.</p><p><strong>Results: </strong>At baseline, patients with CD showed significantly elevated white blood cell (WBC) counts (9.50 ± 2.67 vs. 7.32 ± 1.71 × 10³/μL, p < 0.001), neutrophil counts (6.41 ± 2.35 vs. 4.30 ± 1.44 × 10³/μL, p < 0.001), neutrophil-to-lymphocyte ratio (NLR) (3.27 ± 2.03 vs.2.04 ± 0.91, p < 0.001), and red blood cell (RBC) counts (4.70 ± 0.50 vs. 4.51 ± 0.46 × 10⁶/μL, p = 0.03), with significantly lower eosinophilcounts (0.111 ± 0.093 vs. 0.166 ± 0.140 × 10³/μL, p = 0.01) compared with NFA patients. No sex-specific differences were observed inbaseline hematological parameters within the CD group. At 3 months postoperatively, significant decreases in hemoglobin (p = 0.02),WBC (p < 0.001), neutrophil counts (p < 0.001), and NLR (p = 0.006) were observed in patients with CD compared with NFA controls. Importantly, the magnitude of postoperative reductions in WBC (p = 0.01) and neutrophil counts (p = 0.009), as well as increases in eosinophil counts (p = 0.03), was significantly associated with achieving biochemical remission. Neutrophil recovery was greater in women (p = 0.03). No correlations were found between baseline cortisol levels and hematological parameters.</p><p><strong>Conclusions: </strong>Cushing's disease demonstrates specific hematological alterations - elevated WBC, neutrophils, NLR, and RBC, with decreasedeosinophils - that are attributable to hypercortisolism rather than the presence of a pituitary tumor. These parameters normalizerapidly following surgical remission, with changes correlating with biochemical cure. Routine complete blood counts may serve as accessiblebiomarkers for monitoring disease activity and treatment response in CD.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"319-326"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: an update.","authors":"Małgorzata Bobrowicz, Zuzanna Roszkowska, Jan Domański, Maria Ginalska-Malinowska, Beata Rak-Makowska, Piotr Gastoł, Joanna Betlejewska, Adrianna Gładka, Joanna Hubska, Urszula Ambroziak","doi":"10.5603/ep.110211","DOIUrl":"https://doi.org/10.5603/ep.110211","url":null,"abstract":"<p><p>Congenital adrenal hyperplasia (CAH) represents a group of autosomal recessive disorders characterized by enzyme deficiencies thatimpair adrenal steroidogenesis, most commonly due to 21-hydroxylase deficiency. The biochemical defects in CAH translate to a spectrumof clinical consequences, which include adrenal insufficiency, genital ambiguity or disordered sex development, infertility, short stature,and an increased risk of metabolic syndrome during adolescence and adulthood. The severity and clinical features of CAH vary dependingon the enzymatic defect, residual enzymatic activity, the age of presentation, and genotype. This review comprehensively covers the genetic background, classification, and clinical spectrum of CAH, including classical and non-classical forms. We discuss the importance and implementation of neonatal screening programs for early diagnosis and intervention. Specialattention is given to differences in treatment approaches between children and adolescents, highlighting the challenges of optimizingglucocorticoid and mineralocorticoid therapy across developmental stages. Furthermore, we present emerging novel pharmacologicalagents currently in clinical trials aimed at improving disease management. The review also addresses potential complications associatedwith CAH, such as metabolic syndrome, cardiovascular risks, and bone health issues. Emphasizing a patient-centered approach, wehighlight the critical role of experienced endocrinologists in delivering individualized care to improve long-term outcomes. Our review summarizes the current knowledge, aims to guide clinicians in evidence-based management and highlights ongoing research into innovativetherapies for CAH.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 5","pages":"473-496"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149290681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between skeletal muscle mass to visceral fat area ratio (SVR) with bone mineral density (BMD) and 10-year probability of fracture risk in Chinese patients with type 2 diabetes mellitus (T2DM): a cross-sectional study.","authors":"Yuning Guo, Renxuan Li, Na Xu, Yan Wang, Wentong Jiang, Jianxia Wei, Xiaolian Zhou, Yanwei Liang, Lei Zhu, Yanman Zhou, Jin Xu","doi":"10.5603/ep.102613","DOIUrl":"https://doi.org/10.5603/ep.102613","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with type 2 diabetes mellitus (T2DM) have a higher risk of fracture, higher visceral fat, and lower muscle mass. The combined effect of skeletal muscle mass and visceral fat area [skeletal muscle mass to visceral fat area ratio (SVR)] on bone mineral density (BMD) and fracture risk in T2DM patients is still unknown.</p><p><strong>Materials and methods: </strong>A cross-sectional study was performed on 422 patients. The associations between SVR with BMD and the 10-year probability of fractures [included major osteoporotic fracture (MOF), and hip fracture (HF)] were analyzed using R studio 4.2.3. Generalized additive models (GAMs) were used to identify the associations between SVR and BMD and fracture risk.</p><p><strong>Results: </strong>There was a lower SVR in patients with osteoporosis/osteopenia than in controls. SVR was an independent determinant for BMD and MOF and HF, and SVR was positively associated with BMD and negatively associated with 10-year fracture risk in non-elderly men or elderly women with T2DM. SVR had an approximately positive linear association with BMD in elderly males and females, and it had an N-shaped curve association with BMD in non-elderly males. In addition, the associations between SVR and MOF/HF were negative linear in females and elderly men, and non-linear in non-elderly men.</p><p><strong>Conclusion: </strong>Our study provided a novel viewpoint on the relationship between SVR and BMD/fracture risk. Relatively high SVR is a protective factor for bone in T2DM patients, but the osteoprotective effect of SVR was mediated by age and gender, and it persisted only in non-elderly men and elderly women with T2DM.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 2","pages":"202-211"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-thyroid axis: investigating the causality between the gut microbiota and autoimmune thyroid disease based on a Mendelian randomization study.","authors":"Ting Zheng, Xin Li, Hongyu Xiang","doi":"10.5603/ep.102030","DOIUrl":"https://doi.org/10.5603/ep.102030","url":null,"abstract":"<p><strong>Introduction: </strong>Current studies have identified a close connection between the gut microbiota (GM) and autoimmune thyroid disease (AITD), indicating that the dysregulation of the GM could play a crucial bridging role in AITD. However, the causality between them has not been definitively defined.</p><p><strong>Material and methods: </strong>We utilized the summary statistics of GM from the largest available meta-analysis of genome-wide association studies conducted by the MiBioGen consortium. The data on AITD were derived from the Genome-Wide Association Study (GWAS) database. We investigated the causality between GM and AITD through various analytical methods in a bidirectional Mendelian randomization (MR) analysis. This encompassed methods like inverse variance weighted, MR-Egger, weighted median, weighted mode, and simple mode.</p><p><strong>Results: </strong>Our findings revealed a protective effect of genus Methanobrevibacter [odds ratio (OR) = 0.791, p = 0.044], order Rhodospirillales(OR = 0.775, p = 0.019) on Graves' disease (GD). However, the family Clostridiales vadin BB60 group (OR = 1.222, p = 0.038), genus Anaerofilum (OR = 1.243, p = 0.038), genus Barnesiella (OR = 1.405, p = 0.021), genus Intestinibacter (OR = 1.777, p = 0.000), and order NB1n (OR = 1.270, p = 0.003) were identified as risk factors for GD. In addition, family Alcaligenaceae (OR = 0.691, p= 0.004), family Rhodospirillaceae (OR = 0.813, p = 0.013), genus Butyrivibrio (OR = 0.877, p = 0.019), genus Prevotella 7 (OR = 0.835, p = 0.026), genus Ruminococcaceae UCG011 (OR = 0.883, p = 0.032), genus Ruminococcaceae UCG013 (OR = 0.797, p = 0.048), and order Lactobacillales (OR = 0.759, p = 0.009) had a protective effect on Hashimoto's thyroiditis (HT). Genus Intestinimonas (OR = 1.247, p = 0.010) was a risk factor for HT. Based on the findings from the reverse MR analysis, AITD did not exert a significant causal influence on the GM. There waere no observed remarkable instrumental variables of heterogeneity or horizontal pleiotropy.</p><p><strong>Conclusion: </strong>Our study offered evidence of causal relationship between certain GM and AITD using two-sample MR analysis. This may provide novel perspectives on diagnosis and latent therapeutic targets for AITD.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 2","pages":"153-164"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in imaging examination of bone density and bone quality.","authors":"Junyan Li, BiYan She, MingLi He, Chuyue Yuan, Na Li","doi":"10.5603/ep.100805","DOIUrl":"10.5603/ep.100805","url":null,"abstract":"<p><p>Bone mineral density is the primary basis for the diagnosis of osteoporosis. Bone mineral density measurement methods include dual-energy X-ray (DXA) and quantitative computed tomography (QCT). Based on traditional bone density detection equipment, the newly developed imaging detection technology can further detect the microstructures and geometric features of bones, providing important reference for exploring the pathophysiological changes, sensitive clinical diagnosis, and disease monitoring of osteoporosis.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 1","pages":"29-39"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to use properly the POL-RISK algorithm developed for 10-year prediction of osteoporotic fractures in daily practice.","authors":"Wojciech Pluskiewicz, Piotr Adamczyk, Bogna Drozdzowska","doi":"10.5603/ep.103617","DOIUrl":"10.5603/ep.103617","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis is one of the most common diseases in elderly subjects. Accurate assessment of fracture risk is essential in the management of osteoporotic patients. The aim of the study was to present the optimal manner of using a method designed for fracture risk prediction, e.g. POL-RISK, in daily practice.</p><p><strong>Material and methods: </strong>Methods for fracture prediction were presented, especially those which allow easy and quick online assessment. In addition to true medical aspect, e.g. the ability to accurately detect high fracture risk patients who need therapy, the economic aspects were also presented. Due to the enormous number of osteoporotic patients the therapy should be indicated mainly in patients with high fracture risk. The optimal threshold of fracture risk for the initiation of reimbursed therapy should be established as a compromise of prior established medical threshold and economic aspects. The expected endpoint is the reduction of new fractures noted in longitudinal observation.</p><p><strong>Conclusion: </strong>Implementation of the described scenario should enable the development of the optimal model of care in osteoporotic subjects. Broad use of fracture risk thresholds to initiate reimbursed therapy, encompassing both true medical and economic aspects, should result in the reduction of osteoporotic fractures and decrease overall osteoporosis-related costs to the healthcare system.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 1","pages":"82-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic follicular thyroid carcinoma with excellent response to radioiodine therapy.","authors":"Andreia Martins Fernandes, Ana Rita Elvas, Leandro Augusto Silva, Bernardo Marques, Eugénia Rovira, Fernando Jc Rodrigues","doi":"10.5603/ep.104971","DOIUrl":"10.5603/ep.104971","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 3","pages":"341-342"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}