Endokrynologia Polska最新文献_第8页

Feasibility study of lncRNA DHRS4-AS1 sponge miR-222-3p in the diagnosis of thyroid cancer. lncRNA DHRS4-AS1 海绵状 miR-222-3p 在甲状腺癌诊断中的可行性研究

Endokrynologia Polska Pub Date : 2024-01-01 Epub Date: 2024-10-08 DOI: 10.5603/ep.99456

Shuai Xu, Xinyi Zheng, Haibin Wu, Xujun You, Junwei Wu, Hai Zhou, Junhua Wu, Qianqian Liu, Ren-Qun Ye

{"title":"Feasibility study of lncRNA DHRS4-AS1 sponge miR-222-3p in the diagnosis of thyroid cancer.","authors":"Shuai Xu, Xinyi Zheng, Haibin Wu, Xujun You, Junwei Wu, Hai Zhou, Junhua Wu, Qianqian Liu, Ren-Qun Ye","doi":"10.5603/ep.99456","DOIUrl":"10.5603/ep.99456","url":null,"abstract":"Introduction: Thyroid cancer is a commonly occurring malignant tumour within the endocrine system, the incidence of which has been increasing steadily in our country. It has been the focus and direction of research in recent decades to continuously explore the diagnostic markers and molecular mechanisms of thyroid cancer and provide new possibilities for the healing of patients. In this study, lncRNA DHRS4-AS1 was identified as the research target, and the regulatory function of abnormal expression of DHRS4-AS1 on thyroid cancer was discussed.Material and methods: Thyroid cancer (116) and non-cancer normal (82) tissue samples were collected in this paper, and the expression of DHRS4-AS1 and miR-222-3p in tissues and cells were evaluated by RT-qPCR. CCK-8 and flow cytometry were used to detect cell survival status. The mechanism of DHRS4-AS1 sponge miR-222-3p was analysed by dual-luciferase reporter gene detection.Results: In the present study, DHRS4-AS1 was down-regulated in both thyroid tissue and cell samples, while miR-222-3p expression was elevated. The ROC curve reflected the diagnostic value of DHRS4-AS1 in thyroid cancer [area under the curve (AUC) = 0.887, sensitivity = 76.7%, specificity = 95.1%]. DHRS4-AS1 regulates the development of thyroid cancer by targeting miR-222-3p. In addition, in vitro experiments demonstrated that overexpression of DHRS4-AS1 (pcDNA3.1-DHRS4-AS1) inhibited the proliferation of thyroid cancer cells and promoted cell apoptosis, while down-regulating the level of miR-222-3p.Conclusions: DHRS4-AS1 acts as a miR-222-3p sponge in thyroid cancer, and overexpression of DHRS4 AS1 down-regulates cell proliferation and promotes cell apoptosis. These findings demonstrate the potential of DHRS4-AS1 as a diagnostic factor for thyroid cancer.","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"494-500"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisystem inflammatory syndrome in children with Kawasaki disease-like manifestations in MMA. MMA中川崎病样表现的儿童多系统炎症综合征。

Endokrynologia Polska Pub Date : 2024-01-01 Epub Date: 2024-03-18 DOI: 10.5603/ep.98192

Miao Huang, Xiyan Lu, Yongmei Zeng, Wujin Wang, Jiyong Zhang, Liting Wang, Guoqing Dong

引用次数: 0

Metabolic-associated fatty liver disease and the role of hormones in its aetiopathogenesis. 代谢相关性脂肪肝及其发病机制中激素的作用。

Endokrynologia Polska Pub Date : 2024-01-01 Epub Date: 2024-06-26 DOI: 10.5603/ep.99689

Szymon Suwała, Roman Junik

{"title":"Metabolic-associated fatty liver disease and the role of hormones in its aetiopathogenesis.","authors":"Szymon Suwała, Roman Junik","doi":"10.5603/ep.99689","DOIUrl":"10.5603/ep.99689","url":null,"abstract":"Metabolic-associated fatty liver disease (MAFLD) is a newly coined term that links the presence of liver steatosis (characterised by the accumulation of lipids in at least 5% of liver cells) with a condition of overall systemic metabolic dysfunction. MAFLD impacts 24-36% of the global population. As per the official guidelines, a diagnosis of MAFLD can be made when hepatosteatosis is accompanied by type 2 diabetes mellitus, overweight, obesity, or at least 2 other specific metabolic abnormalities (increased waist circumference, hypertension, dyslipidaemia, prediabetes, elevated C-reactive protein level, or increased homeostasis model assessment of insulin resistance: HOMA-IR). MAFLD is a heterogeneous illness associated with multiple diseases that impact various organs, particularly endocrine organs. Endocrinopathies can significantly influence the progression and severity of MAFLD. This paper provides a brief overview of the existing research on the connection between liver steatosis and the functioning of endocrine organs. The authors also propose dividing endocrine diseases into those having a possible, strong, and clear relationship with hepatosteatosis (for the purpose of preliminary recommendations regarding the need for monitoring the possible progression of MAFLD in these groups of patients).","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"237-252"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A remission of Cushing's disease after pituitary tumour apoplexy. 垂体瘤中风后库欣氏症缓解。

Endokrynologia Polska Pub Date : 2024-01-01 Epub Date: 2024-06-26 DOI: 10.5603/ep.99199

Arnika Wydra, Jakub Wydra, Joanna Gątarek, Wojciech Zgliczyński, Izabella Czajka-Oraniec

引用次数: 0

Riedel's thyroiditis requiring an emergency surgery: rare manifestation of IgG4-related disease.

Endokrynologia Polska Pub Date : 2024-01-01 DOI: 10.5603/ep.102204

Przemysław Paul, Andrzej Hellmann, Jolanta Szade, Joanna Rejszel-Baranowska, Łukasz Obołończyk

引用次数: 0

Are ovarian cysts a coincidence after treatment for Van Wyk-Grumbach syndrome?

Endokrynologia Polska Pub Date : 2024-01-01 DOI: 10.5603/ep.101134

Haiying Fang, Hongxian Lv, Huiqin Wang, Linqian Zhang

引用次数: 0

Novel radiopharmaceuticals in endocrinology: a comprehensive review. 内分泌学中的新型放射性药物综述。

Endokrynologia Polska Pub Date : 2024-01-01 DOI: 10.5603/ep.99756

Mateusz Pocięgiel, Tomasz Saniewski, Kamil Wrzosek, Piotr Opyd, Edward Franek, Michał Lis

{"title":"Novel radiopharmaceuticals in endocrinology: a comprehensive review.","authors":"Mateusz Pocięgiel, Tomasz Saniewski, Kamil Wrzosek, Piotr Opyd, Edward Franek, Michał Lis","doi":"10.5603/ep.99756","DOIUrl":"10.5603/ep.99756","url":null,"abstract":"Endocrinology is the study of hormones and the endocrine glands that are responsible for maintaining homeostasis in the human body. Recently, there has been a surge of interest in the development of novel radiopharmaceuticals for diagnostic and therapeutic purposes in endocrinology. This comprehensive review explores the latest advances in novel radiopharmaceuticals with applications in the diagnosis and treatment of different endocrine disorders, including thyroid, adrenal, and pituitary disorders, as well as neuroendocrine tumours. The article discusses innovative approaches that leverage the decay characteristics of radioisotopes to enhance the accuracy of diagnostic imaging and the therapeutic capability of targeted interventions. It covers the fundamental principles underlying radiopharmaceutical design, synthesis, and imaging modalities, as well as the mechanisms that drive their efficacy in endocrine applications. Furthermore, the clinical implications of these novel radiopharmaceuticals are explored, along with their role in early detection, precise localisation, and personalised treatment strategies. Case studies and clinical trials are cited to highlight the practical utility and potential transformative impact of these advancements in the management of endocrine diseases. This review also notes current challenges, ongoing research and development, and future directions in the field. By providing a comprehensive overview of the evolving landscape of radiopharmaceuticals in endocrinology, this article aims to contribute to the collective knowledge base and foster a deeper understanding of the potential benefits and implications of these innovative technologies for both clinicians and researchers in the field of endocrine health.","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"75 6","pages":"617-629"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and progress of corneal confocal microscopy in the evaluation of diabetes-related peripheral neuropathy. 角膜共聚焦显微镜在评估糖尿病相关周围神经病变中的应用和进展。

Endokrynologia Polska Pub Date : 2024-01-01 DOI: 10.5603/ep.99842

Chi Zhang, Mei Ding, Xiuwen Liang, Lin Zhuo

引用次数: 0

Polycystic ovary syndrome and type 1 diabetes - the current state of knowledge. 多囊卵巢综合征与 1 型糖尿病--目前的知识状况。

Endokrynologia Polska Pub Date : 2024-01-01 Epub Date: 2024-10-08 DOI: 10.5603/ep.101392

Edyta Cichocka, Anna Maj-Podsiadło, Janusz Gumprecht

{"title":"Polycystic ovary syndrome and type 1 diabetes - the current state of knowledge.","authors":"Edyta Cichocka, Anna Maj-Podsiadło, Janusz Gumprecht","doi":"10.5603/ep.101392","DOIUrl":"10.5603/ep.101392","url":null,"abstract":"Type 1 diabetes mellitus (T1DM) is characterized by an increased prevalence of polycystic ovary syndrome (PCOS) with its negative metabolic consequences, including increased cardiovascular risk. Both diseases affect patients, significantly deteriorating the quality of life. During the treatment of patients with T1DM and PCOS, lifestyle modification and increased physical activity resulting in weight reduction should always be recommended. Pharmacological treatment should be applied in accordance with the current standards. In most of these patients metformin alone or with combined oral contraceptive pills could be considered for cycle regulation. In obese patients with T1DM and PCOS glucagon-like peptide-1 receptor agonists (GLP-1 Ras) (liraglutide, semaglutide) and dual glucose-dependent insulinotropic polypeptides (GIP)/GLP-1 RAs (tirzepatide) are regarded as a safe approach. Anti-androgens could also be considered especially to treat hirsutism and hyperandrogenism in women with PCOS. There are relatively limited evidence on anti-androgens in PCOS and we should consider use them in only selected cases. Some other substances may have a positive effect on patients with T1DM and PCOS include inositol, alpha-lipoic acid, folic acid, vitamins (B1, B6, B12, D, K, E, A), chromium and selenium compounds, as well as omega-3 fatty acids. The gut microbiome is also considered as a critical modulator of the predisposition to PCOS and T1DM and may be the future goal of the treatment. The proper treatment of PCOS will translate into a reduction in the severity of typical symptoms and also into the improvement in the metabolic control of diabetes and the patients' quality of life.","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"479-485"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid cancer and autoimmune connective tissue disorders. 甲状腺癌和自身免疫性结缔组织疾病。

Endokrynologia Polska Pub Date : 2024-01-01 Epub Date: 2024-10-08 DOI: 10.5603/ep.101007

Maria Aleksandra Komisarz-Calik, Alicja Hubalewska-Dydejczyk, Bogdan Batko, Małgorzata Trofimiuk-Müldner

{"title":"Thyroid cancer and autoimmune connective tissue disorders.","authors":"Maria Aleksandra Komisarz-Calik, Alicja Hubalewska-Dydejczyk, Bogdan Batko, Małgorzata Trofimiuk-Müldner","doi":"10.5603/ep.101007","DOIUrl":"10.5603/ep.101007","url":null,"abstract":"There are substantial data confirming the association between autoimmune disorders, including connective tissue diseases (CTDs), and an increased risk of thyroid malignancy. CTDs and thyroid cancer may co-exist as 2 separate diseases because of their relatively high incidence rates in the population. They can arise from each other due to the increased risk of thyroid cancer in patients with idiopathic inflammatory myositis, rheumatoid arthritis, systemic sclerosis, primary Sjögren's syndrome, and systemic lupus erythematosus. Moreover, in some scarce cases, CTDs may act as the paraneoplastic syndromes of thyroid cancer. The presence of CTDs may impact the diagnostic process, especially distorting the results of imaging tests or falsely indicating the increase of thyroglobulin or calcitonin. Finally, TSH suppression is a crucial element of the treatment of differentiated thyroid cancer, which may decrease bone mineral density and increase the risk of osteoporosis by accelerating bone turnover and shortening the bone remodeling cycle. The aim of this review is to emphasise the vital aspects of this interrelationship. The authors discuss this phenomenon aiming at the explanation of possible linking mechanisms. The impact of selected CTDs on thyroid cancer management is presented, as well as the possible effects of cancer therapy on skeletal health.","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"455-460"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0