Endokrynologia Polska最新文献

{"title":"Age, gender, and BMI in presentation of primary hyperparathyroidism: a single-center experience.","authors":"Katarina Mlekus Kozamernik, Gaj Vidmar, Mojca Jensterle Sever, Luka Lezaic, Marko Hocevar, Soncka Jazbinsek, Katarina Remec, Andrej Janez, Tomaz Kocjan","doi":"10.5603/ep.103968","DOIUrl":"https://doi.org/10.5603/ep.103968","url":null,"abstract":"<p><strong>Background: </strong>Primary hyperparathyroidism (PHPT) is a relatively common disease with considerable heterogeneity. We aimed to assess the impact of age, gender, and body mass index (BMI) on the presentation of PHPT.</p><p><strong>Material and methods: </strong>We retrospectively analyzed the baseline biochemical status, symptoms, renal manifestations, and bone mineral density (BMD) of patients diagnosed with PHPT at the national tertiary endocrine referral clinic from January 2004 to December 2016.</p><p><strong>Results: </strong>We included 415 patients (333 women [41 premenopausal, 292 postmenopausal] and 82 men) with PHPT, aged 64 years on average [standard deviation (SD)13, range 19-89 years], with an average BMI of 28.4 (SD 6.0, range 11.2-51.1 kg/m²). Older age was statisticallysignificantly associated with milder biochemical presentation - lower total and corrected calcium (standardized regression coefficient β = -0.17, p < 0.001 and β = -0.12, p = 0.018). In comparison with premenopausal women, postmenopausal women [estimated odds ratio (OR) = 8.6, 95% confidence interval (CI): 3.9-20.8; p < 0.001] and men (OR = 5.9, 95% CI: 2.5-15.6; p < 0.001) were more likely to suffer from skeletal manifestations of PHPT. Renal manifestations were less likely among postmenopausal than premenopausal women (OR = 0.4, 95% CI: 0.2-0.8; p = 0.014). BMI was negatively associated with skeletal and renal manifestations (OR = 0.94 per unit change, p = 0.002) and symptomatic presentation (OR = 0.96 per unit change, p = 0.012).</p><p><strong>Conclusion: </strong>Older patients with PHPT presented with a biochemically less florid disease. Postmenopausal women and men with PHPT were more likely to suffer from skeletal manifestations of PHPT than premenopausal women. Patients with higher BMI had fewer skeletal and renal manifestations of PHPT and were less likely to be symptomatic.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 4","pages":"450-456"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of radioligand therapy in a 76-year-old patient with metastatic grade 2 pancreatic neuroendocrine tumor.","authors":"Anna Zemczak, Olgierd Chrabański, Beata Kos-Kudła","doi":"10.5603/ep.109778","DOIUrl":"10.5603/ep.109778","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 6","pages":"680-681"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between stress hyperglycemia ratio and mortality in critically ill patients across different glucose metabolic status and diabetes mellitus subtypes.","authors":"Chong Zhang, Weiru Liang, Bin Su, Kun Hu, Wei Su, Yi Chen, Tingting Guo, Meng Ning, Fengkui Zhang, Yingwu Liu","doi":"10.5603/ep.105797","DOIUrl":"10.5603/ep.105797","url":null,"abstract":"<p><strong>Introduction: </strong>No study has specifically investigated the correlation between stress hyperglycemia ratio (SHR) and mortality in critically ill patients across different glucose metabolic status and diabetes mellitus (DM) subtypes.</p><p><strong>Material and methods: </strong>Analysis was conducted using the Medical Information Mart for Intensive Care-IV 2.2 database.</p><p><strong>Result: </strong>In this study, a total of 73,181 intensive care unit (ICU) patients were included, among whom 33,683 critically ill patients were included in the final analysis. Logistic model analysis revealed that the SHR was associated with elevated mortality rates in the ICU and in-hospital among patients with type 2 diabetes mellitus (T2DM) and those in the ICU with different glucose metabolism status, particularly in individuals with prediabetes mellitus (Pre-DM) and normal glucose regulation (NGR). In the Cox proportional hazards model, SHR was linked to an increased risk of one-year mortality, particularly among critically ill patients with Pre-DM. Mediation analysis revealed that the high SHR could account for 14.0% and 11.3% of the increased risk of ICU death and in-hospital mortality associated with DM, respectively.</p><p><strong>Conclusion: </strong>SHR is correlated with both short-term and long-term mortality in critically ill patients across various glucose metabolism status, particularly evident in those with NGR and Pre-DM. Moreover, SHR demonstrates an elevated risk of short-term and long-term mortality in critically ill patients with T2DM. Additionally, SHR plays a mediating role in the association between DM and mortality.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"552-561"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorders of the iron economy in females with Hashimoto's thyroiditis.","authors":"Marcin Gierach, Roman Junik","doi":"10.5603/ep.105209","DOIUrl":"10.5603/ep.105209","url":null,"abstract":"<p><strong>Introduction: </strong>Hashimoto's thyroiditis (HT) is the most common organ-specific autoimmune disorder. It is a chronic lymphocytic infiltration into the thyroid gland and is characterized by the production of anti-thyroid peroxidase antibodies (TPOAb) and anti-thyroglobulin antibodies (TgAb). HT is a polygenic disease with an incompletely defined etiopathogenesis. It affects 0.3-1.5/1000 subjects/year and is 4-10 times more frequent in women than in men (3.5-5/1000 subjects/year in women versus 0.6-1.0/1000 subjects in men).</p><p><strong>Material and methods: </strong>The study group included 482 females of childbearing age (18-45 years). The group was divided into 3 subgroups: (147 - healthy individuals, 152 - hypothyreosis, 183 - HT). All patients were recruited in a 24-months period from the Cardiometabolic Center Gierach-Med in Bydgoszcz, Poland, and the Department of Endocrinology and Diabetology Collegium Medicum University of Nicolaus Copernicus in Bydgoszcz, Poland, and provided verbal consent to participate in the study.</p><p><strong>Results: </strong>We noticed that a lower level of ferritin was connected with a higher level of thyroid-stimulating hormone (TSH) in each of the subgroups. Additionally, we marked the correlation between ferritin and TSH and anti-thyroid antibodies (TPOAb and TgAb). There was a strong, negative correlation between TSH and ferritin level in all the study groups. Moreover, there was a weak, negative correlation between anti-TPO, anti-TG, and ferritin level in females with HT.</p><p><strong>Conclusions: </strong>To sum up, we believe that hypothyroidism, especially in the course of Hashimoto's disease, leads to an increased risk of iron and ferritin deficiency and requires monitoring of these parameters.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"485-489"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocytic colitis as a new disease possibly associated with autoimmune polyendocrine syndrome type 2 (APS-2).","authors":"Lidia Ziobro, Wiktoria Suchy, Ewa Płaczkiewicz-Jankowska, Małgorzata Trofimiuk-Müldner, Alicja Hubalewska-Dydejczyk","doi":"10.5603/ep.107241","DOIUrl":"10.5603/ep.107241","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"571-572"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant therapy of unresectable anaplastic thyroid cancer.","authors":"Iwona Pałyga, Patrycja Krawczyk, Klaudia Nowak, Aldona Kowalska","doi":"10.5603/ep.108242","DOIUrl":"10.5603/ep.108242","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 6","pages":"686-687"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic difficulties in a 9-year-old boy with pituitary germinoma.","authors":"Elżbieta Moszczyńska, Katarzyna Pasternak-Pietrzak, Aleksandra Tutka, Paulina Chodnicka, Marta Perek-Polnik, Maria Maksymowicz, Grzegorz Zieliński","doi":"10.5603/ep.103156","DOIUrl":"https://doi.org/10.5603/ep.103156","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 6","pages":"684-685"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma amino acid profile in obese children, adolescents, and adults: similarities or differences - a narrative review.","authors":"Jolanta Bugajska, Krystyna Sztefko","doi":"10.5603/ep.108560","DOIUrl":"https://doi.org/10.5603/ep.108560","url":null,"abstract":"<p><p>Obesity, regardless of age, is associated with various metabolic disorders. Amino acids, as essential food ingredients, play a critical role in regulating glucose and energy metabolism. Thus, their plasma concentrations may reflect the metabolic state of the individual. This narrative review aims to find out similarities in plasma amino acid profiles across the selected obese individuals (children, adolescents, and adults). An analysis of 21 original studies revealed similar amino acid alterations regardless of the age group- in particular, elevated levels of branched-chain amino acids (BCAAs: isoleucine, leucine, valine), tyrosine, glutamic acid, alanine, and proline, as well as decreased concentrations of glutamine, serine, glycine, and asparagine. These findings suggest the presence of a common, age-independent metabolic signature of amino acids in obesity. Such changes may reflect impaired amino acid catabolism and have been linked to insulin resistance, increased risk of type 2 diabetes risk, and other metabolic complications. There is a need to establish age- and population-specific reference values for plasma amino acids to use amino acid profiling as a diagnostic and prognostic tool management of obesity. Accurate plasma amino acid profile measurements could support early detection of obesity-related metabolic disturbances and the implementation of targeted nutritional and therapeutic strategies.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 6","pages":"611-618"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world study of lenvatinib in patients with radioiodine‑refractory thyroid cancer treated in a tertiary reference center.","authors":"Jolanta Krajewska, Barbara Jarząb, Agata Wilk, Aleksandra Kukulska, Aleksandra Krol, Katarzyna Drosik-Rutowicz, Magdalena Kolton, Daria Handkiewicz-Junak","doi":"10.5603/ep.109670","DOIUrl":"https://doi.org/10.5603/ep.109670","url":null,"abstract":"<p><strong>Introduction: </strong>Radioiodine-refractory differentiated thyroid cancer (RAIR DTC), although rare, constitutes a real clinical challenge due to its prognosis despite a growing number of available treatment modalities. This study aimed to analyze the real-world efficacy and toxicity of lenvatinib therapy in a group of Polish patients with advanced RAIR DTC.</p><p><strong>Material and methods: </strong>A group of 27 patients was eligible for lenvatinib therapy due to measurable, progressive, RAIR DTC, of whom 21 ultimately received the treatment. Treatment outcomes were assessed in terms of Response Evaluation Criteria in Solid Tumors (RECIST) as well as Kaplan-Meier estimates of overall survival and progression-free survival (PFS) for the whole cohort and for subgroups receiving lenvatinib as the first or subsequent line of targeted therapy. PFS was reported using both intention-to-treat (ITT) and per-protocol (PP) definitions, depending on whether treatment discontinuation was treated as censoring. Treatment toxicity was evaluated according to Common Terminology Criteria for Adverse Events (CTCAE).</p><p><strong>Results: </strong>Median overall survival (OS) in the whole group was 38.9 months [95% confidence interval (CI): 23.8- not reached (NR)], while one-year and two-year survival rates were 0.85 (95% CI: 0.72-1.00) and 0.63 (95% CI 0.45-0.89), respectively. ITT-PFS was 21.3 months (95% CI: 12.2-NR). One-year ITT-PFS was 0.75 (95% CI: 0.57- .00), while 2-year ITT-PFS was 0.44 (95% CI: 0.22-0.76). Similar estimates were obtained using the PP-PFS definition. All patients reported treatment-related side effects, the most common being proteinuria, weight loss, hypertension, and mucositis.</p><p><strong>Conclusion: </strong>This retrospective analysis of a Polish RAIR thyroid cancer cohort demonstrated very good efficacy of lenvatinib in the first-line setting, while its activity in the second-line setting, although still present, was reduced. Based on these results, we suggest that lenvatinib should again be available for the treatment of RAIR thyroid cancer in Poland.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 6","pages":"649-658"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inconsistency in diagnosis of short stature in children according to two Polish height-for-age references.","authors":"Zbigniew Kułaga, Aneta Kotowska, Agnieszka Różdżyńska-Świątkowska","doi":"10.5603/ep.107106","DOIUrl":"https://doi.org/10.5603/ep.107106","url":null,"abstract":"<p><p>Notrequired for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 6","pages":"676-677"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}