Endokrynologia Polska最新文献

{"title":"Assessment of serum concentrations of the \"satiety hormone\" - peptide YY concentration in body weight disorders in girls with anorexia nervosa and obesity.","authors":"Katarzyna Gołąb-Jenerał, Małgorzata Blaska, Karolina Ziora-Jakutowicz, Elżbieta Świętochowska, Agnieszka Zachurzok, Katarzyna Ziora","doi":"10.5603/ep.108016","DOIUrl":"10.5603/ep.108016","url":null,"abstract":"<p><strong>Introduction: </strong>Peptide YY (PYY), a key satiety hormone, exhibits altered serum concentrations in body weight disorders, although its role remains debated. Conflicting adult studies highlight the need to clarify PYY 1-36 dynamics in pediatric populations with anorexia nervosa (AN) and obesity (OB).</p><p><strong>Material and methods: </strong>Fasting serum PYY 1-36 concentrations were analyzed in 199 girls: 58 with restrictive AN [median age 15.0 (interquartile range; IQR): 14.0-16.0 years], 52 with OB [14.3 (12.3-16.3) years], and 89 healthy controls (C) [16.5 (15.5-17.5) years]. Anthropometric and metabolic/hormonal parameters were assessed. Group differences were evaluated using the Kruskal-Wallis rank-sum test. Relationships between fasting serum peptide YY (PYY) 1-36 concentrations and demographic/clinical parameters were examined using Spearman rank correlation coefficients.</p><p><strong>Results: </strong>AN patients had significantly higher PYY 1-36 levels [77.2 (71.1-82.4) pg/mL] compared to OB [36.0 (34.3-38.5) pg/mL] and C [49.7 (46.7-51.5) pg/mL; p < 0.001]. A strong inverse correlation between PYY and body mass index (BMI) was observed across all subjects (Rho = -0.8, p < 0.001). Receiver operating characteristic (ROC)-derived cut-offs differentiated AN (> 59.04 pg/mL; sensitivity 95%, specificity 100%) and OB (< 43.18 pg/mL; sensitivity 89%, specificity 90%) from C.</p><p><strong>Conclusions: </strong>1. Our research underscores significant PYY concentration disparities among weight disorders. 2. Significant differences in PYY concentrations in girls with body weight disorders as compared to healthy girls with normal body weight may indicate a role of this peptide in the body's adaptation to maintain energy homeostasis in connection with the ongoing disease.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"72-80"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between socioeconomic factors and fracture risk.","authors":"Rafał M Hebel, Wojciech Pluskiewicz, Piotr Adamczyk, Hanna Hupsch","doi":"10.5603/ep.111719","DOIUrl":"10.5603/ep.111719","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to present the role of socioeconomic factors in fracture risk among postmenopausal women.</p><p><strong>Material and methods: </strong>The study group consisted of 508 consecutive postmenopausal women recruited from three osteoporotic outpatient clinics. The mean age was 69.8 ± 7.5 years. Data on clinical factors, as well as urban/rural residence, education, occupation, and maritalstatus, were collected. Bone status was assessed at the hip using a Lunar Prodigy device. Fracture risk over the next 10 years, expressedas a percentage, was established using the FRAX (major fractures), Garvan (any fractures), and POL-RISK (any fractures) algorithms.</p><p><strong>Results: </strong>The mean risk was 8.95 ± 6.43% for FRAX and 29.71 ± 20.53% and 28.1 ± 14.85% for Garvan and POL-RISK, respectively. Fracture risk calculated by any of the analyzed calculators was not influenced by place of residence or level of education. The type of job was relatedto fracture risk according to the FRAX major calculator only; the risk was significantly higher in the unemployed group compared with thethree remaining subgroups - those performing sedentary work, physical work, or standing work. The type of work had no effect onthe risk according to the other calculators. Although marital status, particularly widowhood, was associated with higher fracture risk inunivariate analysis, this effect was not significant after adjustment for age, suggesting that age is the underlying factor.</p><p><strong>Conclusions: </strong>Socioeconomic factors were associated with fracture risk, and data on socioeconomic status should be incorporated into patient assessment for osteoporosis.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"256-259"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary management of radioiodine-refractory follicular thyroid carcinoma: insights from three decades of survival.","authors":"Zofia Leszczyńska, Joanna Januszkiewicz-Caulier, Marek Dedecjus","doi":"10.5603/ep.111349","DOIUrl":"10.5603/ep.111349","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"260-261"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of stress and cortisol on thyroid dysfunction.","authors":"Marcin Gierach, Roman Junik","doi":"10.5603/ep.109784","DOIUrl":"10.5603/ep.109784","url":null,"abstract":"<p><p>Chronic stress and sustained activation of the hypothalamic-pituitary-adrenal (HPA) axis result in elevated cortisol secretion, which caninterfere with regulation of the hypothalamic-pituitary-thyroid (HPT) axis and affect thyroid hormone metabolism and immune-mediatedmechanisms. The aim of this review is to present current evidence on the influence of stress and cortisol on thyroid function, including their effects onthe HPT axis, peripheral thyroid hormone metabolism, and autoimmunity, and to discuss potential clinical implications. A comprehensive literature search was conducted covering the last decade's clinical, population-based, and experimental studies addressingthe associations between psychological stress, cortisol levels, thyroid axis dysregulation, deiodinase activity, and autoimmune thyroiddisease. Mechanistic pathways and therapeutic perspectives are summarized. Evidence indicates that cortisol suppresses TRH and TSH secretion and disrupts the circadian rhythm of TSH secretion, while also influencingthyroid hormone transport proteins and deiodinase activity (↓ D1/↓ D2, ↑ D3), leading to reduced T3 and increased rT3. Thesemechanisms contribute to subclinical hypothyroidism and the non-thyroidal illness syndrome (NTIS) phenotype. Chronic stress alsodisturbs immune homeostasis (Treg/Th17 imbalance, elevated IL-6, TNF-α), increasing susceptibility to autoimmune thyroid diseases suchas Hashimoto's thyroiditis and Graves' disease. Emerging data suggest that stress-reduction interventions, optimization of micronutrientstatus (selenium, vitamin D, zinc), and modulation of the HPA axis may complement standard thyroid therapy. Stress and cortisol are significant but often underrecognized moderators of thyroid regulation through endocrine, metabolic, and immunologicalpathways. Incorporating assessment of chronic stress and HPA-axis activity into the diagnostic workup of thyroid disordersmay enhance clinical evaluation, and stress-targeted adjunctive interventions may improve management, particularly in patients withautoimmune thyroid disease.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 3","pages":"127-133"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of neuropsychological impairments between Cushing's disease and non-functioning pituitary adenoma patients: the roles of HPA axis hormones and inflammatory markers in a prospective cohort study.","authors":"Hao Shen, Xiao Zang, Junpeng Xu, Peng Wang, Tao Zhou, Fuyu Wang, Qingzhen Yuan, Yanyang Zhang, Xianghui Meng","doi":"10.5603/ep.108500","DOIUrl":"10.5603/ep.108500","url":null,"abstract":"<p><strong>Introduction: </strong>This prospective cohort study systematically compared neuropsychological impairments in Cushing's disease (CD),non-functioning pituitary adenomas (NFPA), and healthy controls (HCs), and investigated the roles of HPA axis hormones (ACTH, cortisol)and inflammatory markers in cognitive dysfunction.</p><p><strong>Material and methods: </strong>A total of 107 CD patients, 110 NFPA patients, and 84 HCs were enrolled from the Chinese PLA General Hospital.Participants underwent preoperative comprehensive neuropsychological assessments, including the Mini-Mental State Examination(MMSE) and Montreal Cognitive Assessment (MoCA), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), PittsburghSleep Quality Index (PSQI), and Quality of Life (QOL) Scale. Clinical data were also collected. Longitudinal neuropsychological changeswere evaluated in 90 CD patients post-surgery. Statistical analyses included FDR-corrected group comparisons, correlation analyses,and multivariable regression.</p><p><strong>Results: </strong>Cushing's disease patients exhibited significantly greater deficits in global cognition (MMSE/MoCA, q < 0.001), depression/anxiety (SDS/SAS, q < 0.006), and quality of life compared with NFPA and HCs. Critically, morning ACTH levels (8 A.M.) predicted cognitive decline, whereas cortisol showed no significant correlation. Paradoxically, inflammatory markers (WBC, neutrophils, lymphocytes) positively correlated with MMSE scores (q < 0.024), suggesting compensatory neuroprotection, which needs further investigation. Postoperatively, significant improvements occurred in affective symptoms and cognition, with maximal recovery in memory and attention.</p><p><strong>Conclusions: </strong>The CD-specific neuropsychological impairments exceed tumor mass effects in NFPA, driven by HPA hyperactivation. ElevatedACTH is an associated predictor of cognitive decline, advocating for its prioritization in clinical monitoring. Surgical remission partiallyreverses deficits, while neuroendocrine-immune crosstalk bidirectionally modulates cognition. Adrenocorticotropic hormone-centricmanagement and targeted rehabilitation may optimize long-term outcomes.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 3","pages":"182-194"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial lipodystrophy as a late complication of bone marrow transplantation for acute lymphoblastic leukemia.","authors":"Andreia Pataco, Maria Ponte, Isabel Sousa, Catarina Senra Moniz","doi":"10.5603/ep.112131","DOIUrl":"10.5603/ep.112131","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"398-399"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum adipocytokine levels in patients with renal cell carcinoma.","authors":"Szymon Słomian, Krystyna Młynarek-Śnieżek, Andrzej Potyka, Kamil Polok, Dariusz Kajdaniuk, Bogdan Marek","doi":"10.5603/ep.109911","DOIUrl":"10.5603/ep.109911","url":null,"abstract":"<p><strong>Introduction: </strong>Renal cell carcinoma (RCC) is a common neoplasm with well-characterized risk factors, including obesity. The relationshipbetween adipocytokines and neoplasms remains an area of ongoing research. This study aimed to evaluate the activity of the adipocytokinenetwork in patients with RCC.</p><p><strong>Material and methods: </strong>The study group comprised 28 patients with newly diagnosed RCC and 20 controls. Serum levels of adipocytokines (adiponectin, irisin, omentin, visfatin, chemerin, resistin, apelin, vaspin, and nesfatin-1) were measured using enzyme-linkedimmunosorbent assay (ELISA). All subjects had a BMI < 30 kg/m² and normal renal function and did not have any of the diseases listedin the exclusion criteria.</p><p><strong>Results: </strong>Patients in the RCC group had lower serum levels of irisin (3.78 vs. 5.34 μg/mL, p < 0.001), adiponectin (4.92 vs. 6.89 μg/mL, p = 0.013), and nesfatin-1 (1291.0 vs. 1884.3 pg/mL, p = 0.019) than those in the control group. Resistin levels were higher in the RCC group (7.64 vs. 6.38 ng/mL, p = 0.044). We found no significant differences in the concentrations of chemerin, visfatin, apelin, vaspin, and omentin.We observed differences in correlations among adipocytokines across the study groups. In patients with RCC, positive correlations wereobserved between resistin and chemerin, resistin and vaspin, resistin and omentin, and vaspin and omentin; negative correlationswere observed between chemerin and adiponectin, resistin and irisin, and vaspin and irisin. In controls, positive correlations were observedbetween visfatin and resistin, visfatin and vaspin, chemerin and nesfatin-1, resistin and vaspin, and nesfatin-1 and apelin.</p><p><strong>Conclusions: </strong>The adipocytokine profile in patients with RCC differs from that of controls. This suggests their potential role as prognostic, diagnostic, and monitoring tools in RCC. It also suggests that patients with RCC have distinct metabolic profiles.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"310-318"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role and clinical diagnostic value of the lncRNA NEAT1//miR-30e-5p/FLT1 axis in diabetic cognitive dysfunction.","authors":"Aige Yang, Xincheng Zhang, Yuqing Guo, Shanshan Dong, Lina Wang, Yaru Zhou, Huimin Zhou","doi":"10.5603/ep.109481","DOIUrl":"10.5603/ep.109481","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive dysfunction is a common complication of the central nervous system in diabetic patients. To explore the molecularmechanism of diabetic cognitive dysfunction (DCD).</p><p><strong>Material and methods: </strong>The db/db mice and high-glucose (HG)-treated human brain astrocytes (SVG p12) and mouse hippocampalneuron cells (mHNCs) were used for mechanistic exploration. Learning and memory abilities in mice were tested using the Morris watermaze assay. The expression of lncRNA NEAT1 and miR-30e-5p and the mRNA levels of FLT1, NGF, and GPX4 were detected by RT-qPCR.Western blotting was used to analyze FLT1 and p-tau protein levels. Cell viability and apoptosis were evaluated using the CCK-8 methodand flow cytometry. Ferroptosis was assessed by measuring Fe2+ and 4-HNE levels and GPX4 expression. Target sites among NEAT1,miR-30e-5p, and FLT1 were detected using a dual-luciferase reporter assay, and their predictive value for DCD was assessed using ROCcurves and binary logistic regression analysis.</p><p><strong>Results: </strong>The db/db mice showed significant cognitive deficits. NEAT1 and FLT1 were highly expressed in the hippocampus of db/db mice and HG-treated nerve cells, whereas miR-30e-5p was expressed at low levels. Silencing NEAT1 rescued HG-induced nerve cell viabilityimpairment and ferroptosis. NEAT1 directly targeted miR-30e-5p and negatively regulated it, and miR-30e-5p directly targeted FLT1.The miR-30e-5p inhibitor partially reversed the effects of NEAT1 silencing, whereas silencing FLT1 rescued the effects of the miR-30e-5pinhibitor. NEAT1, miR-30e-5p, and FLT1 were classifiers for differentiating patients with diabetes mellitus from those with DCD, withareas under the curves (AUCs) of 0.718, 0.816, and 0.716, respectively. Their combination showed more reliable diagnostic performance(AUC = 0.896).</p><p><strong>Conclusions: </strong>The NEAT1/miR-30e-5p/FLT1 axis may mediate DCD pathogenesis by regulating ferroptosis in brain nerve cells under HG conditions. These molecules may serve as new biomarkers of DCD occurrence.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"360-370"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypophosphatemic rickets in children: current knowledge and a proposal for a diagnostic algorithm.","authors":"Dorota Roztoczyńska, Jerzy Starzyk","doi":"10.5603/ep.110111","DOIUrl":"https://doi.org/10.5603/ep.110111","url":null,"abstract":"<p><p>Hypophosphatemic rickets (HR) are a heterogeneous group of disorders characterized by chronic hypophosphatemia, impaired mineralizationof bone and growth plates, and lifelong skeletal complications. This review summarizes the current knowledge on genetic and acquiredforms of HR in children, including X-linked hypophosphatemia (XLH), autosomal dominant and recessive forms, tumor-induced osteomalacia,and other rare syndromes. Clinical presentation typically includes limb deformities, growth retardation, bone pain, and dentalabnormalities, while complications in adulthood may involve osteomalacia, enthesopathies, and cardiovascular issues. Diagnosis relies ondetailed medical history, physical examination, biochemical evaluation, radiological imaging, and genetic testing. We propose a diagnosticalgorithm for children to facilitate early recognition, appropriate differentiation of FGF23-dependent and -independent forms, and timely intervention. The review also outlines conventional and targeted therapies, highlighting the role of burosumab in FGF23-mediated formsand the need for individualized management in rare or FGF23-independent HR. Early diagnosis and a multidisciplinary approach arecrucial to optimize outcomes and improve quality of life.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 4","pages":"271-282"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity interval training identifies lipocalin 2 as a potential therapeutic target for hypothalamic neuroprotection in obesity.","authors":"Ruiyu Yang, Siyan Zhang, Yi Chen, Meng Wang, Jiayi Song, Liu Ye, Dingqun Bai, Dandong Wu","doi":"10.5603/ep.109900","DOIUrl":"10.5603/ep.109900","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is characterized by hypothalamic dysfunction and metabolic dysregulation. While high-intensity interval training (HIIT) effectively treats obesity, the underlying central mechanisms remain unclear. This study aims to investigate HIIT's effects onmetabolic parameters and hypothalamic gene expression, exploring possible pathways linking central and peripheral adaptations.</p><p><strong>Material and methods: </strong>Our study evaluated HIIT-induced metabolic changes in male diet-induced obese (DIO) mice. Body weightand caloric intake were recorded throughout the intervention period, and glucose regulation was assessed via glucose tolerance test(GTT) and insulin tolerance test (ITT). Following the HIIT intervention, blood was collected for cytokine assessment and hypothalamictissue was harvested for molecular characterization. RNA sequencing (RNA-seq) was employed to analyze gene expression, with enrichmentanalysis to identify biological pathways, and reverse transcription quantitative polymerase chain reaction (RT-qPCR) to validate keyfindings. Protein expression was examined through Western blotting, and circulating cytokine levels were quantified using enzyme-linkedimmunosorbent assay (ELISA).</p><p><strong>Results: </strong>High-intensity interval training significantly reduced caloric intake while improving glucose metabolism and insulin sensitivity in DIO mice, accompanied by hypothalamic transcriptomic remodeling. RNA-seq identified 178 upregulated and 292 downregulated genes post-HIIT,with pathway enrichment analysis revealing activation of interleukin 17 (IL-17) signaling. Notably, HIIT increased hypothalamic lipocalin 2(Lcn2) mRNA and protein expression, which correlated with decreased hypothalamic apoptosis and elevated hypothalamic pro-opiomelanocortin(POMC) expression in DIO mice. Consistently, circulating IL-17 levels were elevated following HIIT intervention.</p><p><strong>Conclusions: </strong>Collectively, our findings identify hypothalamic Lcn2 as a prominent molecular responder to short-term HIIT training, whoseupregulation parallels enhanced IL-17 signaling and coincides with the recovery of POMC neurons.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"195-205"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148058929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}