Endokrynologia Polska最新文献

{"title":"Clinical significance of miR-506-5p in type 2 diabetes mellitus and its regulatory effect on pancreatic β-cell proliferation.","authors":"Jianjian Lin, Peiyun Shen, Zhen Zhou, Jiang Guo, Shuli Zeng","doi":"10.5603/ep.111368","DOIUrl":"10.5603/ep.111368","url":null,"abstract":"<p><strong>Introduction: </strong>One of the core pathological features of type 2 diabetes mellitus (T2DM) is pancreatic β-cell dysfunction. MicroRNAs, askey regulatory molecules, have emerged as pivotal post-transcriptional regulators of β-cell homeostasis, but their specific regulatorymechanisms require further clarification. This study aimed to investigate the expression characteristics and diagnostic value of miR-506-5pin T2DM and its regulatory mechanism in pancreatic β-cell function.</p><p><strong>Material and methods: </strong>A total of 45 healthy controls and 48 patients with T2DM were enrolled. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to quantify peripheral blood miR-506-5p and p21-activated kinase 1 (PAK1) levels, and theircorrelations with clinical indicators and diagnostic efficacy were analyzed. Using INS-1 cells as the model, overexpression or knockdown ofmiR-506-5p was achieved by transfecting miR-506-5p mimic/inhibitor. Combined with a dual-luciferase reporter gene assay and functionalrescue experiment, the target molecule and regulatory role of miR-506-5p were clarified.</p><p><strong>Results: </strong>miR-506-5p expression was significantly elevated in patients with T2DM, whereas PAK1 expression was significantly decreased. The area under the curve (AUC) of miR-506-5p for diagnosing T2DM was 0.904, and it was positively correlated with fasting plasmaglucose (FPG) and glycated hemoglobin (HbA1c). Cell experiment results showed that high glucose could upregulate miR-506-5p expression. Overexpression of miR-506-5p suppressed pancreatic β-cell viability, promoted apoptosis, and reduced insulin secretion, whereas knockdown reversed these effects. miR-506-5p could directly target PAK1 and negatively regulate its expression, and knockdown of PAK1 could reverse the protective effect of miR-506-5p inhibitor.</p><p><strong>Conclusions: </strong>miR-506-5p is highly expressed in T2DM, regulates pancreatic β-cell function by targeting and inhibiting PAK1, and participatesin the pathogenesis of T2DM.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"371-379"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombolysis-induced pituitary tumor apoplexy: a rare neuroendocrine complication of peripheral arterial revascularization.","authors":"Kornel Jakub Witek, Tomasz Stanislaw Wieczorkiewicz, Joanna Sobolewska, Lukasz Dzialach, Jakub Stepien, Aleksandra Dubiel, Przemyslaw Witek","doi":"10.5603/ep.110329","DOIUrl":"10.5603/ep.110329","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"268-269"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When lymphadenopathy is not what it seems - coexistence of mantle cell lymphoma and pancreatic neuroendocrine tumor.","authors":"Weronika Wasyluk, Anna Wilczek, Marek Niewiedzioł, Aneta Szudy-Szczyrek, Magdalena Kozioł, Agnieszka Zwolak","doi":"10.5603/ep.109328","DOIUrl":"10.5603/ep.109328","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"120-121"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of incretin levels in patients with prolactinoma.","authors":"Gökçe Altunay Vurğun, Nusret Yılmaz, Sebahat Özdem, Ramazan Sarı","doi":"10.5603/ep.109775","DOIUrl":"10.5603/ep.109775","url":null,"abstract":"<p><strong>Introduction: </strong>Prolactin has been shown to play an important role in the regulation of glucose metabolism. The present study aimed toevaluate incretin hormones in patients with prolactinoma.</p><p><strong>Material and methods: </strong>The study included 13 patients with prolactinoma without a history of diabetes and in 13 healthy volunteers.All participants underwent a 75-g oral glucose tolerance test (OGTT). Serum glucose, insulin, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) were measured at 0, 30, 60, 90, and 120 minutes.</p><p><strong>Results: </strong>Serum glucose and insulin levels at baseline and during the OGTT were similar in both groups (p > 0.05). GLP-1 levels, including baseline values, area under the curve (AUC), and all time points during OGTT, were also comparable between the groups (p > 0.05).In contrast, baseline GIP (p = 0.024), AUC (p = 0.011), and GIP levels at 30, 90, and 120 minutes were significantly lower in patients withprolactinoma (p = 0.006, p = 0.015, and p = 0.035, respectively).</p><p><strong>Conclusions: </strong>These findings suggest that incretins may play a role in the mechanisms underlying glucose metabolism disorders in patientswith hyperprolactinemia due to prolactinoma. Larger studies are needed to confirm this potential association.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"112-119"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-4260 serves as a prognostic biomarker and suppresses thyroid cancer progression.","authors":"Hongyan Xuan, Defu Zhang, Qinghua Zhang, Zhao Liu, Zhiyong Li, Xiancun Hou, Changli Ouyang, Xiangwen Li","doi":"10.5603/ep.107982","DOIUrl":"10.5603/ep.107982","url":null,"abstract":"<p><strong>Introduction: </strong>MicroRNAs (miRNAs) play critical roles in tumorigenesis and malignant transformation. Studies indicate aberrant expressionof miR-4260 in various cancers. However, its specific function and underlying molecular mechanisms in thyroid cancer (TC) remainpoorly understood.</p><p><strong>Material and methods: </strong>Paired tumor and adjacent non-tumor tissues were collected from a cohort of 120 TC patients undergoing surgicalresection. Real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) quantified miR-4260 expression in clinical specimensand cell lines. The prognostic value of miR-4260 expression was evaluated using Kaplan-Meier survival analysis and multivariate Coxproportional hazards regression. The functional impact of miR-4260 on TC cell proliferation, migration, and invasion was assessed usingcell transfection, cell counting kit 8 (CCK-8) assays, and Transwell migration/invasion assays. The regulatory interaction between miR-4260and its potential target gene was validated by dual-luciferase reporter assay.</p><p><strong>Results: </strong>RT-qPCR analysis revealed significantly elevated miR-4260 expression in TC tissues compared to matched non-tumor tissues. High miR-4260 expression correlated significantly with larger tumor size (p = 0.035), deeper invasion depth (p = 0.038), advanced tumor-node-metastasis (TNM) stage (p = 0.022), and lymph node metastasis (LNM) (p = 0.025) compared to low expression. MultivariateCox analysis identified high miR-4260 expression as an independent predictor of poor prognosis [hazard ratio (HR) = 3.398, 95% confidenceinterval (CI): 1.559-7.406, p = 0.002]. Functional experiments demonstrated that inhibiting miR-4260 expression significantly attenuatedthe proliferative and invasive capacities of TC cells. Dual-luciferase assays validated ANK2 as a direct miR-4260 target. RT-qPCR quantification revealed significantly antagonistic expression patterns between ANK2 and miR-4260 in thyroid carcinoma specimens. Rescueexperiments further revealed that miR-4260 modulates the malignant phenotype of TC cells by negatively regulating ANK2, indicating their cooperative involvement in TC progression.</p><p><strong>Conclusions: </strong>miR-4260 is critically implicated in TC advancement and unfavorable patient outcomes, establishing its bifunctional value as a clinically significant prognostic indicator and viable therapeutic candidate.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenocortical oncocytic neoplasm of uncertain malignant potential in pregnancy.","authors":"Sabri Engin Altıntop, Irem Sonmezoglu Kutuk, Seda Alabas, Aylar Poyraz, Mehmet M Yalcın, Alev Altınova, Mujde Akturk, Fusun Toruner, Mehmet Karakoc, Ethem Cerit","doi":"10.5603/ep.111449","DOIUrl":"10.5603/ep.111449","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"264-265"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of retinal microvascular OCTA parameters for early detection of diabetic kidney disease in patients with non-proliferative diabetic retinopathy.","authors":"PingPing Liu, Wei Wang, ChunXia Zhou, HongJun Bian","doi":"10.5603/ep.110632","DOIUrl":"10.5603/ep.110632","url":null,"abstract":"<p><strong>Introduction: </strong>This study used optical coherence tomography angiography (OCTA) to investigate the early diagnostic value of OCTAparameters for diabetic kidney disease (DKD) in patients with non-proliferative diabetic retinopathy (NPDR).</p><p><strong>Material and methods: </strong>This prospective study enrolled patients with type 2 diabetes mellitus (T2DM) into three groups: those with T2DMwithout retinopathy (group A), those with non-proliferative diabetic retinopathy (NPDR) without DKD (group B), and those with NPDR andDKD (group C). All participants underwent OCTA imaging to measure vessel density (VD) in the superficial capillary plexus (SCP)and deep capillary plexus (DCP), as well as the foveal avascular zone (FAZ) area, perimeter (PERIM), and acircularity index (AI). Pearsonor Spearman correlation analysis was used to explore the relationships between OCTA parameters and renal function indicators, including24-hour urinary microalbumin, urinary albumin-to-creatinine ratio (UACR), and blood urea nitrogen (BUN). Multivariate logistic regressionwas performed to identify independent factors associated with NPDR with DKD. Receiver operating characteristic (ROC) curveswere generated to assess the diagnostic performance of individual and combined OCTA parameters.</p><p><strong>Results: </strong>Significant differences in OCTA parameters and renal function indicators were observed among the three groups. Correlation analysis revealed that SCP-VD and DCP-VD were negatively correlated with 24-hour urinary microalbumin, UACR, and BUN, whereas FAZ area, PERIM, and AI were positively correlated with these renal markers. Multivariate logistic regression identified SCP-VD [oddsratio (OR) = 0.67], DCP-VD (OR = 0.68), PERIM (OR = 1.30), and AI (OR = 1.04) as independent factors associated with NPDR and DKD.Analysis of diagnostic performance showed that among the single parameters, SCP-VD had the best diagnostic value [area under the curve(AUC) = 0.80]. Among the different combination models, the combination of all four parameters demonstrated the highest diagnosticperformance (AUC = 0.94).</p><p><strong>Conclusions: </strong>OCTA parameters (SCP-VD, DCP-VD, PERIM, AI) are closely associated with NPDR and DKD. A combined multiparametermodel demonstrated excellent diagnostic efficacy for early detection. Retinal OCTA parameters may reflect early microvascular alterationsassociated with diabetic kidney disease.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"380-389"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Helicobacter pylori infection and hyperandrogenism in women with polycystic ovary syndrome.","authors":"Joanna Wutke-Ostręga, Mateusz Szul, Paulina Tymińska, Julia Frączek, Dagmara Pluta, Grzegorz Franik","doi":"10.5603/ep.111845","DOIUrl":"10.5603/ep.111845","url":null,"abstract":"<p><strong>Introduction: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction,and metabolic disturbances. Chronic low-grade inflammation and insulin resistance are key components of its pathophysiology.Helicobacter pylori (H. pylori) infection has been associated with systemic inflammation and metabolic alterations and may potentially affectendocrine function. The aim of this study was to assess whether H. pylori infection is associated with changes in hormonal parameters,including increased severity of hyperandrogenism, in women with PCOS.</p><p><strong>Material and methods: </strong>A total of 150 patients aged 18-40 years were included and classified according to PCOS diagnosis and H. pyloriinfection status into four groups. PCOS was diagnosed based on the Rotterdam criteria. Active H. pylori infection was assessed usinga stool antigen test. Anthropometric measurements were obtained, and fasting blood samples were analyzed for hormonal (including totaland free testosterone, androstenedione, DHEAS, SHBG, LH, FSH, AMH, prolactin, cortisol) and metabolic parameters (glucose, insulin,HOMA-IR). Statistical analysis included non-parametric tests for between-group comparisons and categorical analyses, with correctionfor multiple comparisons where appropriate.</p><p><strong>Results: </strong>No significant differences in age, BMI, or WHR were observed between H. pylori-positive and H. pylori-negative groups. Amongpatients with PCOS, H. pylori infection was not associated with significant differences in androgen concentrations (total and free testosterone,androstenedione, DHEAS, 9FAI) or other hormonal parameters. No significant differences were observed in gonadotropins, AMH,prolactin, cortisol, or metabolic parameters, including glucose, insulin, and HOMA-IR. In patients without PCOS, minor differences inhormonal parameters were observed; however, these were not statistically significant after correction for multiple comparisons. The frequencyof abnormal laboratory results did not differ between groups.</p><p><strong>Conclusions: </strong>In this cohort of young women, H. pylori infection, detected using a stool antigen test, was not associated with clinicallymeaningful alterations in androgen levels or ovarian reserve in women with PCOS. These findings suggest that the endocrine profile inPCOS is primarily determined by intrinsic pathophysiological mechanisms of the syndrome, which may mask the potential impact ofchronic H. pylori infection.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"340-346"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral adrenal lesions as a manifestation of prolonged glucocorticoid withdrawal in classical adrenal hyperplasia.","authors":"Anna Klasa, Agnieszka Stefańska, Anna Grochowska, Alicja Hubalewska-Dydejczyk, Małgorzata Trofimiuk-Müldner","doi":"10.5603/ep.106547","DOIUrl":"10.5603/ep.106547","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 1","pages":"81-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of hypoparathyroidism (HypoPT): Position Statement of the Expert Group for Polish Society of Endocrinology - update 2026.","authors":"Waldemar Misiorowski, Beata Kos-Kudła, Alicja Hubalewska-Dydejczyk, Marek Ruchała, Wojciech Zgliczyński, Arkadiusz Zygmunt, John P Bilezikian","doi":"10.5603/ep.110591","DOIUrl":"10.5603/ep.110591","url":null,"abstract":"<p><p>Hypoparathyroidism (HypoPT) remains the last \"classic\" endocrine deficiency hormone disorder not routinely treated with hormone replacement. In November 2023, European Medicines Agency (EMA), and in August 2024, Food and Drug Administration (FDA) registered a new parathyroid hormone analogue: palopegteryparatide (TransCon PTH; YORVIPATH®) for the treatment of selected cases of hypoparathyroidism. As the Polish Society of Endocrinology Expert Panel, we recommend that parathyroid hormone (PTH) replacement therapy should be considered for HypoPT patients in whom conventional therapy is insufficient or poorly tolerated. PTH replacement therapy offers a more physiologic approach to treating HypoPT than conventional therapy. Palopegteriparatide can lead to eucalcemia, more effectively than conventional treatment, lowers serum phosphate and urinary calcium, and improves renal function and quality of life.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}