Endokrynologia Polska最新文献

{"title":"Correlation analysis of FT3/FT4 and frailty in elderly patients with coronary heart disease.","authors":"Jiling Qu, Siqi Ji, Ting Zhou, Chuntao Wang, Yongbing Liu","doi":"10.5603/ep.100711","DOIUrl":"10.5603/ep.100711","url":null,"abstract":"<p><strong>Introduction: </strong>In previous studies on thyroid hormones and frailty, most of the target population were elderly, and there were relatively few studies on elderly patients with coronary heart disease (CHD). Inflammation, oxidative stress, and haemodynamic instability in cardiovascular disease (CVD) can influence fluctuations in thyroid hormone (TH) levels and increase the incidence of frailty. The purpose of the present study was to explore the effect of TH on the risk of frailty in elderly patients with CHD.</p><p><strong>Material and methods: </strong>The Fried scale was used to assess the frailty of participants. The predictive value of TH for frailty was determined using the patient's operating characteristic curve. Multivariate logistic regression model was utilised to analyse the relationship between TH and frailty.</p><p><strong>Results: </strong>A total of 277 elderly patients with CHD were included in the study, of whom 29.96% were in a state of frailty. Free triiodothyronine (FT3)/free thyroxine (FT4) predicted frailty with the largest area under the curve of 0.634. Unordered multinomial logistic regression analysis showed that a lower T3 level was a risk factor for pre-frailty (p < 0.05). Lower levels of T3, FT3, and FT3/FT4 were risk factors for frailty (p < 0.05) after adjusting for demographic variables and blood indexes.</p><p><strong>Conclusion: </strong>The predictive value of FT3/FT4 for frailty was more accurate than that of a single index. Moreover, T3 ≤ 1.095 nmol/L, FT3 ≤ 4.085 pmol/L, and FT3/FT4 ≤ 0.336 were shown to be the influencing factors of frailty, while T3 ≤ 1.095 nmol/L is an independent risk factor pre-frailty. Clinicians should focus on timely identification of the risk of frailty in order to improve patient quality of life and to reduce the risk of complications.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"510-516"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The functional DIAPH3-FOXM1 interaction modulates the aggressive transformation of anaplastic thyroid carcinoma cells and Wnt/β-catenin signalling.","authors":"Ping Shi, Hao Fang, Kai Fu, Zhen Zhao, Fei Yang, Yan Liu","doi":"10.5603/ep.100719","DOIUrl":"10.5603/ep.100719","url":null,"abstract":"<p><p>Anaplastic thyroid carcinoma (ATC) is reckoned as an infrequent but extremely advanced neoplasm of the endocrine system. Diaphanous-related formin 3 (DIAPH3) has been extensively implicated in carcinogenic events, but it has not been introduced in ATC. Herein, the role of DAPIH3 and the interrelated functional mechanism are characterised in ATC. The Gene Expression Omnibus (GEO) database was checked for differential DIAPH3 expression in ATC samples and noncancerous samples. Western blotting examined DIAPH3 and forkhead box M1 (FOXM1) expression in ATC cells. In vitro cell counting kit 8 (CCK-8) method, 5-ethynyl-2'-deoxyuridine (EdU) incorporation, Scratch, Matrigel invasion, and terminal-deoxynucleotidyl transferase mediated nick end labelling (TUNEL) assays were used to assess the potential of cells to proliferate, migrate, and invade as well as the cellular apoptotic rate. Co-IP was applied to access DIAPH3-FOXM1 protein interaction. Western blotting also disclosed the expression of proteins associated with apoptosis and Wnt/β-catenin signalling. DIAPH3 was hyper-expressed in papillary cell carcinoma (PTC) tissues and cells. Depleting DIAPH3 strongly eliminated the proliferative, migratory, as well as invasive capabilities of PTC cells while intensifying the apoptotic ability. FOXM1 also harboured elevated expression in PTC cells. FOXM1 was the binding partner with DIAPH3, and the 2 were positively correlated. FOXM1 upregulation again exacerbated the potentials to proliferate, migrate, and invade but it repressed the apoptotic rate of DIAPH3-depleted cells. Furthermore, loss of DIAPH3 downregulated FOXM1 to block Wnt/b-catenin signalling in PTC cells. Combined with these findings, DIAPH3 might favour the aggressive advancement of ATC and motivate the Wnt/β-catenin signalling via binding with FOXM1.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"501-509"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of anti-Müllerian hormone and insulin resistance in adolescent girls with polycystic ovary syndrome.","authors":"Gang Guo, Huan Zheng, Xia Wu","doi":"10.5603/ep.96323","DOIUrl":"10.5603/ep.96323","url":null,"abstract":"<p><strong>Introduction: </strong>Insulin resistance (IR) is confirmed as an important feature among polycystic ovary syndrome (PCOS) patients. Anti-Müllerian hormone (AMH), a vital marker of ovarian dysfunction, is proposed for inclusion in the diagnosis of PCOS in adolescents. We sought to investigate the relationship between the AMH level and IR in Chinese girls with PCOS.</p><p><strong>Material and methods: </strong>92 girls with PCOS aged 14-18 years were enrolled and divided into 2 subgroups: PCOS with IR group (n = 25) and PCOS without IR group (n = 67). A homeostasis model assessment-insulin resistance (HOMA-IR) value ≥ 2.5 was defined as IR. Clinical data and biochemical indexes were compared between the 2 groups. Multivariate logistic regression analysis and multivariate linear regression analysis were performed to determine which clinical variables were independently associated with IR and AMH level, respectively.</p><p><strong>Results: </strong>PCOS girls with IR had higher levels of AMH than those of PCOS girls without IR (p < 0.01). Moreover, body mass index, triglyceride, and AMH values were shown to be independent risk factors for HOMA-IR after multivariate analysis. Meanwhile, age, insulin, and follicle-stimulating hormone levels were significantly related to AMH levels in those girls.</p><p><strong>Conclusions: </strong>Our findings show that AMH is an independent determinant of IR in PCOS adolescents, and the fasting insulin level is closely associated with the AMH level, which indicates that the AMH pathway might play a role in the development of IR in PCOS adolescents. The interaction between AMH and IR in PCOS girls warrants further large-scale evaluation.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"75 1","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic ACTH syndrome caused by thymic neuroendocrine tumour - stages of treatment.","authors":"Magdalena Londzin-Olesik, Agata Walter","doi":"10.5603/ep.103717","DOIUrl":"10.5603/ep.103717","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"75 6","pages":"699-700"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidentally detected breast cancer in [68Ga]Ga-DOTA-TATE PET/CT in a patient with diagnosed pancreatic neuroendocrine tumour.","authors":"Anna Zemczak, Olgierd Chrabański","doi":"10.5603/ep.103949","DOIUrl":"https://doi.org/10.5603/ep.103949","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"75 6","pages":"703-704"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive significance of the triglyceride glucose index and associated indicators for hepatic steatosis in type 2 diabetes patients with diverse body mass index.","authors":"Miao Congqing, Yingzi Chen, Peng Du, Jingjing Liu, Xin Sun, Yue Zhao","doi":"10.5603/ep.102028","DOIUrl":"https://doi.org/10.5603/ep.102028","url":null,"abstract":"<p><strong>Introduction: </strong>The objective was to explore the value of triglyceride glucose index and related indicators in predicting hepatic steatosis in type 2 diabetes patients (T2DM) with different body mass indexes (BMI).</p><p><strong>Material and methods: </strong>Clinical data from 221 hospitalised patients withT2DM, diagnosed with hepatic steatosis via transient elastography, were collected and analysed. Patients with a BMI of 24 kg/m² or higher were designated as the high-BMI group, while those with a BMI below 24 kg/m² comprised the low-BMI group. Relevant indicators, including triglyceride glucose index (TyG), TyG-BMI index (TyG-BMI), and TyG-waist circumference (TyG-WC), were obtained.</p><p><strong>Results: </strong>TyG, TyG-BMI, and TyG-WC were all significantly elevated in the high-BMI group relative to the low-BMI group (p < 0.01).Within both high- and low-BMI categories of T2DM patients, TyG, TyG-BMI, and TyG-WC were markedly higher in patients with hepatic steatosis than in those without the condition (p < 0.01 or p < 0.05). Multivariate logistic regression analysis identified TyG-BMI as an independent risk factor for hepatic steatosis in high-BMI T2DM patients (p < 0.01), while glycosylated haemoglobin (HbA1c) and TyG-WC emerged as independent risk factors in low-BMI T2DM patients (p < 0.01 or p < 0.05). Receiver operating characteristic curve analysis for predicting hepatic steatosis in high-BMI T2DM patients demonstrated that TyG-BMI had an area under the curve of 0.84 (p < 0.01) with a cut-off value of 241.36, yielding a sensitivity of 79.80% and a specificity of 83.30%. For low-BMI T2DM patients, the TyG-WC index had an area under the curve of 0.80 (p < 0.01), a cut-off value of 824.63, a sensitivity of 68.30%, and a specificity of 84.90%.</p><p><strong>Conclusion: </strong>In T2DM patients, TyG-BMI can predict hepatic steatosis in high-BMI patients, and TyG-WC can predict hepatic steatosis in low-BMI patients. The latter is negatively correlated with HbA1c.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"75 6","pages":"643-648"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role and diagnostics of miR-181d-5p in polycystic ovary syndrome in insulin-resistant women.","authors":"Min Sang, Ying Yu, Yaqi Zhang, Haiping Chang","doi":"10.5603/ep.99021","DOIUrl":"https://doi.org/10.5603/ep.99021","url":null,"abstract":"<p><strong>Introduction: </strong>To promote the research progress of polycystic ovary syndrome (PCOS), this study analysed the role of micro RNA (miRNA) in PCOS, to provide new ideas for the development of PCOS.</p><p><strong>Material and methods: </strong>A total of 101 PCOS patients and 95 healthy controls (HC) were enrolled in this study, and according to body mass index (BMI), the subjects were divided into overweight (ow) and non-overweight (non-ow), and analyses were performed to compare the statistical differences of clinically related indexes in each group. Serum miR-181d-5p expression was determined by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), and the diagnostic capability of miR-181d-5p for PCOS ow and non-ow was evaluated by receiver operating characteristic curve (ROC). The effect of miR-181d-5p on PCOS combined with insulin resistance (PCOS-IR) was analysed by multivariate logistic regression. The effects of miR-181d-5p on KGN cells under insulin resistance (IR) were analysed by proliferation and apoptosis experiments.</p><p><strong>Results: </strong>In both ow and non-ow populations, miR-181d-5p expression was higher in PCOS patients than in the HC. miR-181d-5p can be a better aid in the diagnosis of PCOS ow and non-ow. miR-181d-5p can be used as a risk predictor of PCOS-IR (p = 0.014). It was highly expressed in PCOS-IR and had high predictive ability [area under the curve (AUC): 0.898] with high specificity (83.33%) and sensitivity (82.93%) in assisting the diagnosis of PCOS-IR. IR-inhibited proliferated and induced apoptosis of KGN cells, which was improved by miR-181d-5p downregulation.</p><p><strong>Conclusions: </strong>This study proposed the role of miR-181d-5p in PCOS for the first time, providing a new reference for improving PCOS-IR.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"75 6","pages":"655-664"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron and ferritin deficiency in women with hypothyroidism and chronic lymphocytic thyroiditis - systematic review.","authors":"Marcin Gierach, Monika Rudewicz, Roman Junik","doi":"10.5603/ep.97860","DOIUrl":"10.5603/ep.97860","url":null,"abstract":"<p><p>Iron is one of the essential microelements necessary for maintaining the body's homeostasis. It serves various roles, including being a crucial component in the proper structure of many enzymes and supporting the transport of oxygen and electrons. Its deficiency can lead to anaemia, which is a common clinical condition often associated with thyroid diseases. Iron deficiency is one of the most common nutritional deficiencies, and its prevalence is strongly associated with socioeconomic status. It is the primary cause of anaemia in 42% of children and 50% of women. Importantly, iron deficiency is placed among the top 5 causes of disability in women. Thyroid peroxidase (TPO) is an enzyme essential for the production of thyroid hormones, and iron is a key factor in its proper functioning. Therefore, in the case of iron deficiency, the activity of this enzyme is also reduced. Iron is also a factor that is important in epigenetic modification processes, and its deficiency may contribute to genomic changes potentially promoting the development of autoimmune thyroid diseases. Adequate supplementation in patients with Hashimoto's disease is one of the crucial elements of effective therapy. In addition to iodine, selenium, and magnesium supplementation, attention should be paid to proper iron intake. Iron is an element that is a component of the heme enzyme- thyroid peroxidase, which owes its activity to the binding of haem, and its function is the production of thyroid hormones. Iron can be delivered to the body in haem and non-haem forms. The haem form is found particularly in haemoglobin-rich red meat, but also in eggs, fish, and poultry. On the other hand, non-haem iron can be found in legumes, grains, fruits, and vegetables. Our study aimed to gather and summarise knowledge from scientific literature regarding iron deficiency anaemia and its association with hypothyroidism in women, as well as the possible mechanisms and pathogenesis of these conditions. The paper also aims to highlight that considering the high risk of iron deficiency, assessing iron status along with ferritin should be an integral part of additional diagnostic measures in cases of hypothyroidism, particularly Hashimoto's disease.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"253-261"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MYB/LINC00092 regulatory axis promotes the progression of papillary thyroid carcinoma.","authors":"Lian Cheng, Xian Deng, Yuan Le","doi":"10.5603/ep.98120","DOIUrl":"10.5603/ep.98120","url":null,"abstract":"<p><strong>Introduction: </strong>Thyroid carcinoma is the most frequent malignancy in different endocrine-related tumours. In this study, we demonstrated a long non-coding RNA LINC00092-associated molecular mechanism in promoting the progression of papillary thyroid carcinoma (PTC).</p><p><strong>Material and methods: </strong>The expression of LINC00092 was analysed in the The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) patient cohorts and further determined by q-PCR. (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) (MTT) assay, and wound healing assay confirmed the function of LINC00092 in migration and proliferation. Q-ChIP validated the transcriptional target. Luciferase reporter assay validated the miRNA-mRNA target.</p><p><strong>Results: </strong>The analysis in patient cohorts and in PTC TPC-1 cells showed that the expression of LINC00092 was repressed in thyroid carcinoma. In addition, the expression of LINC00092 was negatively associated with the advanced thyroid TNM stages. LINC00092 repressed epithelial-mesenchymal transition (EMT), migration, and proliferation of TPC-1 cells. Interestingly, we identified that MYB, a well-studied tumour promoter, is a transcription factor of LINC00092, thereby the expression of LINC00092 was directly repressed by MYB. Furthermore, miR-4741 was also validated as a direct target of MYB and was induced by MYB. Notably, LINC00092 was repressed by miR-4741 through the direct 3'-untranslational region (3'-UTR) target. Therefore, MYB induced EMT of TPC-1 cells by repressing LINC00092 directly or indirectly via miR-4741.</p><p><strong>Conclusions: </strong>Our study validated that LINC00092 is a tumour suppressor lncRNA in PTC. MYB directly or indirectly represses LINC00092, which contributes to the PTC progression. MYB, LINC00092, and miR-4741 form a coherent feed forward loop. The axis of MYB-LINC00092 promotes progression of PTC.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"75 1","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary apoplexy as the first manifestation of non‑functioning pituitary neuroendocrine tumour.","authors":"Lukasz Dzialach, Joanna Sobolewska, Wioleta Respondek, Agnieszka Wojciechowska-Luzniak, Przemyslaw Witek","doi":"10.5603/ep.96305","DOIUrl":"10.5603/ep.96305","url":null,"abstract":"<p><p>Not required for a Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"75 1","pages":"111-112"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}