Ear, nose, & throat journal最新文献_第3页

Rare Epiglottic Granulomatosis: Diagnostic Challenges and Therapeutic Implications. 罕见会厌肉芽肿病：诊断挑战和治疗意义。

Ear, nose, & throat journal Pub Date : 2025-05-21 DOI: 10.1177/01455613251343740

Majd Werda, Ahmed Ben Akacha, Salim Amouri, Malek Mnejja, Ilheme Charfeddine

{"title":"Rare Epiglottic Granulomatosis: Diagnostic Challenges and Therapeutic Implications.","authors":"Majd Werda, Ahmed Ben Akacha, Salim Amouri, Malek Mnejja, Ilheme Charfeddine","doi":"10.1177/01455613251343740","DOIUrl":"https://doi.org/10.1177/01455613251343740","url":null,"abstract":"We report a rare case of epiglottic granulomatosis with polyangiitis (GPA) in a 72-year-old woman presenting with 5 years of progressive dysphagia and dyspnea. Initial laboratory studies revealed leukocytosis (White Blood Cells 14.2 × 10³/µL), eosinophilia (8%), elevated inflammatory markers (C-Reactive Protein 42 mg/L, Erythrocyte Sedimentation Rate 78 mm/hour), and Proteinase 3 Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA) positivity (65 IU/mL). Laryngoscopy identified supraglottic edema with a right-sided mass, confirmed by Computed Tomography as localized epiglottic thickening without cartilage destruction. Histopathology of the biopsied lesion demonstrated necrotizing granulomas, vasculitis, and multinucleated giant cells, establishing the GPA diagnosis. Treatment with high-dose corticosteroids (1 mg/kg/day prednisone) and rituximab (375 mg/m²/week × 4) induced rapid symptom resolution within 2 weeks. Follow-up laryngoscopy at 1 month showed complete mucosal healing, and the patient remains recurrence-free during 18 month surveillance with maintenance immunosuppression (5 mg/day prednisone). This case highlights 3 critical insights: (1) isolated epiglottic GPA, although rare, should be considered in chronic upper airway obstruction unresponsive to conventional therapy; (2) PR3-ANCA serology and histopathology are indispensable for diagnosis; and (3) rituximab-based regimens achieve excellent outcomes in laryngeal GPA, but prolonged monitoring is essential given relapse risks. Our findings reinforce the need for multidisciplinary management of otolaryngologic GPA manifestations.","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251343740"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: The Role of Corticosteroids in Pediatric Ludwig's Angina. 致编辑的信：皮质类固醇在儿童路德维希心绞痛中的作用。

Ear, nose, & throat journal Pub Date : 2025-05-21 DOI: 10.1177/01455613251343488

Yasser Al-Ghabra

引用次数: 0

Survival Analysis and Prognostic Factors for Nasopharyngeal Mucoepidermoid Carcinoma. 鼻咽部粘液表皮样癌的生存分析及预后因素分析。

Ear, nose, & throat journal Pub Date : 2025-05-20 DOI: 10.1177/01455613251336876

Yuting Lai, Xiaole Song, Huankang Zhang, Wanpeng Li, Jingyi Yang, Xicai Sun, Quan Liu, Dehui Wang, Hongmeng Yu

{"title":"Survival Analysis and Prognostic Factors for Nasopharyngeal Mucoepidermoid Carcinoma.","authors":"Yuting Lai, Xiaole Song, Huankang Zhang, Wanpeng Li, Jingyi Yang, Xicai Sun, Quan Liu, Dehui Wang, Hongmeng Yu","doi":"10.1177/01455613251336876","DOIUrl":"https://doi.org/10.1177/01455613251336876","url":null,"abstract":"Purpose: This study aimed to explore survival outcomes of and prognostic factors in nasopharyngeal mucoepidermoid carcinoma (NPMEC).Patients and methods: We reviewed a total of 57 patients diagnosed with NPMEC, including 19 patients in our center and 38 patients with detailed individual survival data in the literature. The Kaplan-Meier method and the log-rank test were used to assess overall survival (OS) and progression-free survival (PFS). Furthermore, the multivariate survival analysis was evaluated using the Cox regression model.Results: The average age of the patients was 45.8 years (range 13-71 years), with a male-to-female ratio of 0.84. During the mean follow-up time of 49 months (range, 3-149 months), the OS rates at 1, 3 and 5 years were 96.1%, 78.7%, and 62.8%, respectively, and the PFS rates at 1, 3 and 5 years were 91.4%, 71.6%, and 51.3%, respectively. The log-rank test showed that lymphatic metastasis affected OS and PFS, while stage T affected PFS. Multivariate regression analysis showed that lymphatic metastasis was associated with worse OS and PFS, that stage T was associated with unfavorable PFS, and that combined therapy improved PFS independently.Conclusions: Patients with NPMEC have favorable 5 year OS and PFS. Lymphatic metastasis was the independent factor for OS, while lymphatic metastasis, stage T, and treatment modality were the independent factors for PFS.","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251336876"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Tympanostomy Tubes on Pediatric Otoacoustic Emission Testing. 鼓膜造瘘管对儿童耳声发射检测的影响。

Ear, nose, & throat journal Pub Date : 2025-05-20 DOI: 10.1177/01455613251343734

Avraham E Adelman, Akshay Tangutur, Amy Du, Erin Kelly, David Mandell

{"title":"Impact of Tympanostomy Tubes on Pediatric Otoacoustic Emission Testing.","authors":"Avraham E Adelman, Akshay Tangutur, Amy Du, Erin Kelly, David Mandell","doi":"10.1177/01455613251343734","DOIUrl":"https://doi.org/10.1177/01455613251343734","url":null,"abstract":"Background: Evaluate the impact of patent tympanostomy tubes (TT) on otoacoustic emissions (OAE) in patients with normal pure tone audiometry (PTA).Methods: Retrospective review of patients who underwent TT placement with paired postoperative audiogram and OAEs at 1, 2, 4, and 8 kHz were included. Frequencies with PTA >20 dB or nonpatent TTs were excluded. OAEs were graded by signal-to-noise ratio and distortion product as \"present,\" \"reduced,\" or \"absent.\"Results: In total, 124 patients (217 ears) were included with a mean age (SD) of 3.9 (3.2) years and OAE testing occurring 4.5 (4.7) months postoperatively. OAE absence rates were 85% at 1 kHz (n = 165), 57% at 2 kHz (n = 203), 56% at 4 kHz (n = 206), and 83% at 8 kHz (n = 135).Conclusion: Absent OAEs were the most common result at all frequencies, especially 1 and 8 kHz. Overall, 78.8% of patients failed at least one tested frequency, despite normal PTA and patent TTs, suggesting a potential direct impact of TTs on OAE outcomes. Clinicians may need to exercise caution when interpreting OAEs in patients with patent TTs, and further research may warrant a reevaluation of OAE utility in this context.","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251343734"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Laryngeal ALK-Positive Histiocytosis With PRKAR1A::ALK Fusion. 罕见的喉ALK阳性组织细胞增多症合并PRKAR1A::ALK融合1例。

Ear, nose, & throat journal Pub Date : 2025-05-20 DOI: 10.1177/01455613251342897

Lian Zhang, Daniel Fink, Zenggang Pan

引用次数: 0

Intracranial Dural Arteriovenous Fistula Can Mimic Sigmoid Sinus Wall Anomalies Induced Pulsatile Tinnitus: Caution Before Considering It's Venous. 颅内硬脑膜动静脉瘘可以模拟乙状窦壁异常引起的搏动性耳鸣：在考虑它是静脉之前要注意。

Ear, nose, & throat journal Pub Date : 2025-05-20 DOI: 10.1177/01455613251342851

Yue-Lin Hsieh, Xu Liu, Shenjiang Wang, Wuqing Wang

{"title":"Intracranial Dural Arteriovenous Fistula Can Mimic Sigmoid Sinus Wall Anomalies Induced Pulsatile Tinnitus: Caution Before Considering It's Venous.","authors":"Yue-Lin Hsieh, Xu Liu, Shenjiang Wang, Wuqing Wang","doi":"10.1177/01455613251342851","DOIUrl":"https://doi.org/10.1177/01455613251342851","url":null,"abstract":"Objective: To highlight that dural arteriovenous fistula (DAVF) can exist in subjects with unilateral vascular pulsatile tinnitus (PT), positive internal jugular vein (IJV) compression tests, and radiologic evidence of sigmoid sinus wall anomalies (SSWA).Methods: A retrospective analysis was conducted on 80 subjects with PT as the primary symptom and intracranial DAVF detected based on magnetic resonance angiography results. Among them, IJV and retroauricular compression tests and temporal bone computed tomography (CT) were performed. The moth-eaten sigmoid plate sign and DAVF-induced SSWA were defined, and their correlation with PT duration was studied.Results: Significant differences were observed between ipsilateral IJV and retroauricular compression outcomes in DAVFs located at the transverse-sigmoid sinus (P < .001) and hypoglossal canal (P = .026). Among 71 subjects with CT data, the moth-eaten sign was found in 29 of 37 subjects (sensitivity 78.4%, 95% CI 0.63-0.89) with DAVFs at the transverse-sigmoid sinus. SSWA and jugular bulb (JB) anomalies were observed in 40.8% of subjects. PT duration significantly differed between subjects with SSWA and those without SSWA (P < .0026).Conclusion: The presence of SSWA on CT and a positive IJV compression test should not be considered conclusive for diagnosing venous PT. The \"moth-eaten sigmoid plate\" sign on non-contrast CT and positive retroauricular compression are strong indicators of DAVF as the primary cause of PT.","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251342851"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Quasi-Experimental Study on the Impact of Blended Assessment on Performance and Anxiety Levels of Otorhinolaryngology Clinical Interns. 混合评估对耳鼻喉科临床实习生工作表现和焦虑水平影响的准实验研究。

Ear, nose, & throat journal Pub Date : 2025-05-20 DOI: 10.1177/01455613251339760

Shuo Wu, Feitong Jian, Qintai Yang

{"title":"A Quasi-Experimental Study on the Impact of Blended Assessment on Performance and Anxiety Levels of Otorhinolaryngology Clinical Interns.","authors":"Shuo Wu, Feitong Jian, Qintai Yang","doi":"10.1177/01455613251339760","DOIUrl":"https://doi.org/10.1177/01455613251339760","url":null,"abstract":"Objective: Traditional assessments for otorhinolaryngology clinical interns primarily rely on closed-book examinations (CBE) to evaluate foundational knowledge and reinforce long-term retention. This quasi-experimental study investigates the impact of a blended assessment model-integrating both open-book and closed-book components-on academic performance, test anxiety, and preparation time, compared to the conventional CBE approach.Methods: A total of 240 medical students from the 2019 (CBE, n = 115) and 2020 (blended assessment, n = 125) cohorts at the Third Affiliated Hospital of Sun Yat-sen University were enrolled. Exam scores, preparation time, test format preferences, and Revised Test Anxiety Scale (RTA) scores were collected and analyzed. Statistical comparisons between the 2 groups were performed.Results: All 240 participants (123 males and 117 females) completed the study, achieving a 100% participation rate. No significant differences were found between the CBE and blended assessment groups in academic performance (P = .906) or anxiety levels (P = .411). However, the blended assessment group reported significantly longer preparation times (P = .027). RTA scores were not significantly correlated with gender (P = .416), exam scores (P = .282), or preparation time (P = .410), though female students exhibited slightly higher anxiety levels. Regarding exam format preferences, 19.2% of students favored CBE (70.8% female), while 80.2% preferred open-book exams (43.6% female).Conclusion: The blended assessment model, incorporating both CBE and open-book examinations, serves as a feasible alternative for evaluating clinical interns, fostering their problem-solving abilities. While it demands increased preparation time, it is well-received by students and holds promise for broader adoption in medical education.","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251339760"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Cutaneous Follicle Center Lymphoma of the Cheek: A Rare Cutaneous Malignancy. 脸颊原发性皮肤滤泡中心淋巴瘤：一种罕见的皮肤恶性肿瘤。

Ear, nose, & throat journal Pub Date : 2025-05-20 DOI: 10.1177/01455613251343741

Peiran Zhou, Zhao Ming Dong, Zain H Rizvi

引用次数: 0

Advances in Sinonasal Microbiome Analysis. 鼻腔微生物组分析进展。

Ear, nose, & throat journal Pub Date : 2025-05-19 DOI: 10.1177/01455613251341711

Cristian Roca, Yasine Mirmozaffari, W Jared Martin, Nicole Capps, Kelli M Sullivan, Brian D Thorp, Thomas W Ferkol, Stephanie D Davis, Adam Kimple, Matthew C Wolfgang

引用次数: 0

Hypopharyngeal and Laryngeal Actinomycosis Mimicking Malignancy-A Case Report. 下咽喉部模拟恶性放线菌病1例报告。

Ear, nose, & throat journal Pub Date : 2025-05-17 DOI: 10.1177/01455613241306020

Jamie Masliah, Richard Raad, Arnav Shah, Kerstin Stenson

{"title":"Hypopharyngeal and Laryngeal Actinomycosis Mimicking Malignancy-A Case Report.","authors":"Jamie Masliah, Richard Raad, Arnav Shah, Kerstin Stenson","doi":"10.1177/01455613241306020","DOIUrl":"https://doi.org/10.1177/01455613241306020","url":null,"abstract":"Actinomycosis is a rare bacterial infection caused by Actinomyces, a group of Gram-positive anaerobic bacilli. These bacteria are a normal component of human flora; however, they can become pathogenic in susceptible hosts by entering through mucosal defects and disseminating submucosally to involve the surrounding tissue. Cervicofacial actinomycosis is the most common presentation; however, Actinomyces can rarely involve other aspects of the head and neck. Actinomycosis in this region is often mistaken for other disease processes, given its tendency to mimic other pathologies. We present a unique case of a 72-year-old male presenting with acute respiratory compromise due to submucosal actinomycosis of both the hypopharynx and the larynx requiring an emergent surgical airway. Many aspects of this patient's presentation were highly suspicious of malignancy, including medical history, presenting symptoms, flexible laryngoscopy findings, CT results, and intraoperative appearance of the lesions. Actinomycosis should remain on the differential in patients with a submucosal laryngeal mass with clinical and radiographic evidence of extra laryngeal extension, especially in patients with a history of mucosal trauma, poor dentition, or an immunocompromised state. Multiple biopsies should be obtained, with definitive surgical treatment planning pending final pathology.","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241306020"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0