Deutsche medizinische Wochenschrift (1946)最新文献_第9页

[Fever, abdominal livedo and eosinophilia in a 79-year-old man with pronounced vascular risk profile]. [一例79岁男性伴有明显血管危险的发热、腹部肿胀和嗜酸性粒细胞增多]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.1055/a-2564-2355

Simona Jahnke, Lars Christian Huber, Cédric Steinmann

引用次数: 0

[Melanoma prevention - to screen or not to screen?] 黑色素瘤预防——筛查还是不筛查？］

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1055/a-2500-0825

Elisabeth V Gössinger, Alina M Müller, Alexander A Navarini, Anne-Katharina Sonntag

{"title":"[Melanoma prevention - to screen or not to screen?]","authors":"Elisabeth V Gössinger, Alina M Müller, Alexander A Navarini, Anne-Katharina Sonntag","doi":"10.1055/a-2500-0825","DOIUrl":"https://doi.org/10.1055/a-2500-0825","url":null,"abstract":"Melanoma is one of the most common cancers worldwide with a high mortality rate. However, the smaller the melanoma is when it is first diagnosed, the better the prognosis. Since skin melanomas can be detected relatively easy with the naked eye, systematic skin cancer screening could theoretically reduce melanoma mortality by diagnosing it as early as possible. Evaluations of skin cancer early detection programs show an increase in the incidence of detection of the skin cancer and especially thins melanomas, but so far, no evidence of a decrease in mortality. Current data on patient-related factors show that fewer men and people with lower socioeconomic status participate in skin cancer screening and knowledge about skin cancer-associated factors is low.Based on the current study situation, it is therefore not possible to recommend or advise against skin cancer screening for the asymptomatic population. Screening is recommended for all people at increased risk: fair skin type according to Fitzpatrick I-II, under immunosuppression, more than 50 melanocytic nevi and history of dysplastic and/or large nevi, family history of melanoma, frequent severe sunburns in childhood. In addition, targeted educational campaigns among risk groups (men, people with low levels of education) are needed.New imaging techniques such as 3D whole-body photography with additional computer-based, AI-assisted risk assessment of digital dermoscopic images, when integrated into clinical decision-making processes (as \"augmented intelligence\" - AI), clearly have the potential to improve skin cancer screening, particularly in high-risk and melanoma patients. In combination with human expertise, they can potentially offer a more effective and comprehensive approach to detecting and monitoring skin cancer. Randomized controlled studies must show to what extent this promising technique has proven itself in the clinic and is also suitable for other populations.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 10","pages":"548-554"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Treatment of metastatic melanoma: update 2025]. [转移性黑色素瘤的治疗：更新于2025年]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1055/a-2500-0927

Georg Lodde, Lea Jessica Albrecht, Dirk Schadendorf

{"title":"[Treatment of metastatic melanoma: update 2025].","authors":"Georg Lodde, Lea Jessica Albrecht, Dirk Schadendorf","doi":"10.1055/a-2500-0927","DOIUrl":"https://doi.org/10.1055/a-2500-0927","url":null,"abstract":"Immune checkpoint inhibition and targeted therapy with BRAF/MEK inhibition for BRAF-mutated melanoma have significantly improved progression-free and overall survival in patients with metastatic melanoma. Current research focuses on novel treatment strategies for PD-1 resistance, neoadjuvant approaches, and cellular therapies. 10-year follow-up data of randomized clinical trials show that both combined CTLA-4 and PD-1 immune checkpoint inhibition and PD-1 immune checkpoint inhibition alone can achieve long-term survival in metastatic melanoma. Potential surrogate markers of long-term response include a progression-free survival at 3 years after start of treatment and a reduction in tumour burden of at least 80%. The management of PD-1 resistance remains a challenge. Advances in molecular pathology have led to the identification of new therapeutic targets. Several cellular therapies are currently being evaluated in clinical trials as alternatives for melanoma patients refractory to immune checkpoint inhibition or targeted BRAF/MEK inhibition. In BRAF-mutant melanoma, combined BRAF/MEK inhibition is an alternative to immune checkpoint inhibition. Real-world data and clinical trial results on treatment sequencing suggest that immune checkpoint inhibition may improve survival in the first line setting, particularly in the absence of prior adjuvant systemic therapy. Adjuvant treatment leads to improved progression-free survival in melanoma patients while overall survival data are still pending. Neoadjuvant treatment seems to be a promising alternative to conventional adjuvant therapy for specific subgroups of melanoma patients. Participation in clinical trials offers patients the best opportunity to benefit from the latest treatment options.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 10","pages":"562-569"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[83-year-old female patient with unusual vascular changes on the abdomen and chest]. [83岁女性患者，腹部和胸部血管异常改变]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2497-6626

Sven Burmann, Ulrich Peter Wehry, Alexander Kreuter

引用次数: 0

[Nutritional screening and assessment]. [营养筛选和评估]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1055/a-2490-1971

Beate Schlegel, Nikolaus Lubomierski

引用次数: 0

[Unusual manifestation of varicose veins: a 69-year-old patient with finger pain]. [静脉曲张的不寻常表现：69岁手指疼痛患者]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1055/a-2506-6795

Frank Stammler, Marion Wenzler

{"title":"[Unusual manifestation of varicose veins: a 69-year-old patient with finger pain].","authors":"Frank Stammler, Marion Wenzler","doi":"10.1055/a-2506-6795","DOIUrl":"https://doi.org/10.1055/a-2506-6795","url":null,"abstract":"Varicose veins of the hand and fingers are an unusual presentation and are little known in the consultation as a differential diagnosis of hand complaints.A 69-year-old female patient, who had worked as a cleaner for a long time, presented to our practice because of pain in the palm of her hand. She had been observing bluish changes on the volar side of the hand and fingers for more than 10 years. A few days ago, painful nodules had appeared on the middle and ring fingers of her right hand.The clinical examination revealed the suspicion of an extensive palmar hand and finger varicosis on both sides, with indurated nodules on D3 and 4 on the right, which was confirmed by duplex sonography as partially thrombosed finger varices. The varicose vein thrombosis developed under anticoagulation with Rivaroxaban 20mg, which was indicated due to atrial fibrillation.Analgesia with 600-1200mg Ibuprofen led to a rapid regression of pain. Remedial treatment options for finger varicosis such as sclerotherapy, ablative procedures or surgical excision were discussed as experimental approaches and were not desired by the patient.Unlike in the lower extremities, hands and fingers are less well-known manifestations of varicosis. Finger varicosis usually appears asymptomatically, but can cause pain if finger hematomas and variceal thrombosis occur. Varicose veins of the hand occur more frequently in aged patients and are favored by mechanical stress. Treatment is usually symptomatic.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 10","pages":"571-574"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Obesity in intensive care]. [重症监护中的肥胖症]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2286-6542

Michael Haap

引用次数: 0

[Generation X and millennials are at greater cancer risk than previous generations: Possible causes and implications]. [X一代和千禧一代比前几代人患癌症的风险更高：可能的原因和影响]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1055/a-2531-9761

Hans Scherübl

引用次数: 0

[Diagnostic of the chronic coronary syndrome]. 【慢性冠脉综合征的诊断】。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2463-2902

Katharina A Riedl, Renate Schnabel

引用次数: 0

[Invasive treatment of chronic coronary syndrome]. 慢性冠状动脉综合征的侵入性治疗。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-05-06 DOI: 10.1055/a-2430-0255

Julinda Mehilli, Arben Perani

引用次数: 0