Deutsche medizinische Wochenschrift (1946)最新文献

[Update on diagnostics and therapies in inflammatory bowel diseases]. [炎症性肠病诊断和治疗的最新进展]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2335-6154

Raja Atreya

引用次数: 0

[Secondary hemophagocytic lymphohistiocytosis due to icteric leptospirosis with acute renal failure]. [嗜血细胞性淋巴组织细胞增生症（secondary hemophagocytic lymphohistiocytosis），由冰冻型钩端螺旋体病引起，伴有急性肾功能衰竭。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2455-6902

Marvin Dumke, Nadine Wilsdorf, Iris Barndt

{"title":"[Secondary hemophagocytic lymphohistiocytosis due to icteric leptospirosis with acute renal failure].","authors":"Marvin Dumke, Nadine Wilsdorf, Iris Barndt","doi":"10.1055/a-2455-6902","DOIUrl":"https://doi.org/10.1055/a-2455-6902","url":null,"abstract":"A 51-year-old patient presented himself with fever, upper abdominal pain and exertional dyspnea. Hemodynamic instability accompanied by generalized icterus, hepatosplenomegaly, a morbilliform rash with petechia and bilateral conjunctivitis revealed in clinical examination.Laboratory results revealed elevated C-reactive protein and procalcitonin as well as pancytopenia and hyperbilirubinemia. Furthermore hypertriglyceridemia, hyperferritinemia and elevated soluble IL-2-receptor were found. Testing for infectious diseases detected IgM-antibodies to leptospires. Bone marrow cytology featured hemophagocytosis.Secondary hemophagocytic lymphohistiocytosis due to icteric leptospirosis (Weil's disease) was diagnosed.Immediate antibiotic therapy and circulatory support by fluid and vasopressors was initiated and non-invasive ventilation and hemodialysis stabilized the patient. With steroids and polyvalent immunoglobulins the organ functions recovered.Hemophagocytic lymphohistiocytosis is an important differential or concomitant diagnosis in sepsis and can be induced by rarely diagnosed infectious triggers like leptospirosis.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 8","pages":"434-437"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Multimorbidity - only solvable together]. [多重疾病-只能一起解决]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-04-08 DOI: 10.1055/a-2360-2794

Maria Cristina Polidori, Michael Denkinger

引用次数: 0

[43-year-old patient presenting with pulmonary masses following hysterectomy]. [43岁患者，子宫切除术后出现肺肿块]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-04-08 DOI: 10.1055/a-2455-7831

Patricia Walther, Sascha Bender, Michael Hainz

引用次数: 0

[Psyche in Climate Crisis? An Update on Ecological Psychiatry and Psychotherapy]. [气候危机中的心理？生态精神病学和心理疗法的最新进展]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-04-08 DOI: 10.1055/a-2447-2517

Eva-Lotta Brakemeier, Sebastian Karl, Sarah Stapel, Andreas Meyer-Lindenberg

引用次数: 0

[Lupus nephritis - does a lot help a lot?] [红斑狼疮肾炎-有很多帮助吗？］

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2375-2634

Cornelia Elisabeth Eckert, Bruno Reible, Zoran Popovic, Bernhard Hellmich, Christian Löffler

引用次数: 0

[New cases of botulism after intragastric injection of botulinum toxin]. [胃内注射肉毒杆菌毒素后肉毒中毒新病例]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-04-08 DOI: 10.1055/a-2506-6699

Werner Beermann

引用次数: 0

[Rheumatoid Arthritis]. (类风湿性关节炎)。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-04-08 DOI: 10.1055/a-2286-6620

Jutta Bauhammer, Christoph Fiehn

{"title":"[Rheumatoid Arthritis].","authors":"Jutta Bauhammer, Christoph Fiehn","doi":"10.1055/a-2286-6620","DOIUrl":"https://doi.org/10.1055/a-2286-6620","url":null,"abstract":"Rheumatoid arthritis (RA) is an inflammatory systemic disease that mainly, but not exclusively, affects the joints and other structures of the musculoskeletal system. It most typically manifests in polyarthritis due to a highly inflammatory autoimmune synovitis. Extra-articular manifestations might also show in the shape of an interstitial lung disease or vasculitis, mainly affecting the small vessels. Early, well-targeted treatment can have a major impact on the progression of the disease; without treatment, however, patients are most likely to experience an irreversible loss of functionality and increased mortality. The administration of a DMARD starting as soon as being diagnosed is recommended. The first choice in medication should be methotrexate whenever there are no contraindications. In most cases, glucocorticoids are added temporarily with administration coming to a complete stop after 3-6 months. Therapy follows the treat-to-target principle aiming at remission. Disease activity and remission are calculated in scores combining clinical findings, patients' statements and laboratory tests for inflammatory activity. Treatment is considered responsive with achieving a minimum of a 50% reduction of the score. Score responses are evaluated after 12 weeks, therapeutic targets after 24. If 1 of the 2 is not met and there are no risk factors present for a severe progression of the disease, then another strategy with conventional systemic (cs)DMARD will first be used after methotrexate; otherwise biological (b)DMARD or other targeted synthetic (ts)DMARD can be given. Re-evaluation is carried out as described above, and if the target is not met, other b- or ts-DMARDs will be used.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 9","pages":"508-520"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Update on drug therapy for ulcerative colitis]. [溃疡性结肠炎药物治疗的最新进展]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2368-7090

Elena Sonnenberg, Britta Siegmund, Carl Weidinger

{"title":"[Update on drug therapy for ulcerative colitis].","authors":"Elena Sonnenberg, Britta Siegmund, Carl Weidinger","doi":"10.1055/a-2368-7090","DOIUrl":"https://doi.org/10.1055/a-2368-7090","url":null,"abstract":"Ulcerative colitis (UC) is classified as a chronic inflammatory bowel disease (IBD) and can present in various degrees of severity. In addition to mild courses of the disease, such as uncomplicated proctitis, which can often be successfully treated with topical 5-ASA formulations, complicated courses can be observed, which can sometimes be life-threatening. Affected patients are often considerably burdened and often severely restricted in their quality of life, as they suffer from numerous, often bloody bowel movements, which are accompanied by abdominal cramps, urgency and sometimes even incontinence. In addition, many UC patients suffer from concomitant extraintestinal inflammatory manifestations including skin manifestations like psoriasis, erythema nodosum or joint involvement such as spondylarthritis. For many years, steroids and conventional immunosuppressants such as azathioprine were the only treatment options available. Twenty years ago, the approval of the first anti-TNF antibody, Infliximab, marked a significant turning point in IBD therapy. Despite the continuous progress in drug therapy, the rates of primary and/or secondary treatment failure are still considerable. With this in mind, a large number of additional substances have been developed and approved for the treatment of UC in the recent years. In addition to TNF antibodies and their biosimilars, the anti-integrin vedolizumab, various Janus kinase (JAK) inhibitors, an interleukin (IL)-12/-23p40 antibody, various IL-23p19 antibodies and sphingosine-1-phosphate receptor (S1PR) modulators have broadened the therapeutic landscape and found their way into the clinical treatment of UC patients. In this article we will discuss case-based decision paths for the selection of fitting anti-inflammatory treatments in UC patients and summarize the principles of the different therapeutic strategies for UC.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 8","pages":"412-418"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pneumococcal sepsis 2015-2022: considerations on vaccination strategies]. 肺炎球菌败血症2015-2022：疫苗接种策略的思考

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1055/a-2506-4928

Herbert Hof, Sabine Singer, Ika Steiner, Daniela Bertsch, Maria Kirstahler, Klaus Oberdorfer, Matthias Imöhl, Mark van der Linden

{"title":"[Pneumococcal sepsis 2015-2022: considerations on vaccination strategies].","authors":"Herbert Hof, Sabine Singer, Ika Steiner, Daniela Bertsch, Maria Kirstahler, Klaus Oberdorfer, Matthias Imöhl, Mark van der Linden","doi":"10.1055/a-2506-4928","DOIUrl":"10.1055/a-2506-4928","url":null,"abstract":"In spite of available vaccines the frequency of sepsis caused by Streptococcus pneumoniae still remains rather high.In the years 2015-2022 Streptococcus pneumoniae could be isolated from 925 blood cultures in our laboratory. Serotyping was performed from 754 strains. In addition, their in vitro susceptibility to some antibiotics was assessed.In this period 925 blood cultures were positive, predominantly from aged patients (older than 60 years) and more frequently from men than from women. In the years 2020 and 2021 less positive blood cultures were found, which could be interpreted as a result from non-pharmaceutical interventions preventing aerogenically transmitted diseases such as coronavirus infections during the epidemic. Children were also relatively susceptible in their first year of life. 653 strains were serotyped, with serotypes 3 and 8 predominating. 67% of the serotypes found were covered by the 20-valent conjugate vaccine whereas the polysaccharide vaccine (PPV23) included 75%. The vast majority of isolates was susceptible to penicillin, erythromycin as well as to doxycycline. Multi-drug resistant strains were not detected.A large part of the infections might have been prevented by vaccination assuming a high vaccine effectiveness. However, 27% of S. pneumoniae serotypes detected were not covered by any of the vaccines currently available.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":" ","pages":"e11-e17"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0