Deutsche medizinische Wochenschrift (1946)最新文献_第10页

[Oral anticoagulation with Edoxaban for stroke prevention in patients with atrial fibrillation: Analysis of 1-year follow-up data of routine clinical practice in Germany, Austria and Switzerland (DACH) from the ETNA-AF registry]. [使用埃多沙班口服抗凝药预防心房颤动患者中风：来自 ETNA-AF 登记处的德国、奥地利和瑞士 (DACH) 常规临床实践的 1 年随访数据分析]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-07-03 DOI: 10.1055/a-2328-7240

Leon Dinshaw, Jan Steffel, Andreas Götte, Thomas W Weiss, Johannes Waltenberger, Paulus Kirchhof

引用次数: 0

[Histo- and molecular pathology in gastroenteropancreatic neuroendocrine neoplasms]. [胃肠胰神经内分泌肿瘤的组织和分子病理学]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI: 10.1055/a-2157-5460

Franziska Kellers, Dominik Maria Schulte, Moritz Jesinghaus, Björn Konukiewitz

引用次数: 0

[Systemic treatment of patients with metastatic neuroendocrine Neoplasia]. [转移性神经内分泌肿瘤患者的系统治疗]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI: 10.1055/a-2173-0588

Anja Rinke, Friederike Eilsberger

{"title":"[Systemic treatment of patients with metastatic neuroendocrine Neoplasia].","authors":"Anja Rinke, Friederike Eilsberger","doi":"10.1055/a-2173-0588","DOIUrl":"https://doi.org/10.1055/a-2173-0588","url":null,"abstract":"Due to the complexity and heterogeneity of metastatic NEN an interdisciplinary expert team should be involved in an individualized treatment strategy. SSA is the mainstay of antisecretory treatment in most functioning tumors. In antiproliferative intention SSA are first line treatment in receptor positive low proliferative NET. In intestinal metastatic disease PRRT is best established second line treatment. Further options are Everolimus (labeled) and tyrosine kinase inhibitors (off-label). Everolimus is the only approved drug for antiproliferative treatment in patients with metastatic lung NET, whereas in pancreatic NET more therapeutic options are available (SSA, chemotherapy, PRRT, Sunitinib, Everolimus) without a standard of best sequence. In patients with metastatic NEC standard first line treatment (platinum + etoposide) has not changed for decades and new treatment options for this fatal disease are urgently needed. Benefit of immunotherapy is limited to a small subset of patients - new combinations are under investigation. This review summarizes the standard of care, criteria of treatment selection and new developments for systemic therapy in patients with metastatic NEN.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"149 15","pages":"879-886"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Chronic HBV and HDV infection]. [慢性 HBV 和 HDV 感染]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-08-02 DOI: 10.1055/a-2057-1840

Giuseppe Rusignuolo, Robert Thimme, Christoph Neumann-Haefelin

引用次数: 0

[Monitoring of cardiovascular emergencies in the emergency department]. [急诊科心血管急症监测]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-08-15 DOI: 10.1055/a-2105-9849

Christian Jung, Michael Bernhard

{"title":"[Monitoring of cardiovascular emergencies in the emergency department].","authors":"Christian Jung, Michael Bernhard","doi":"10.1055/a-2105-9849","DOIUrl":"https://doi.org/10.1055/a-2105-9849","url":null,"abstract":"In the emergency department, patients with potential or confirmed cardiovascular diseases constitute a significant portion of the overall patient population. Monitoring for cardiovascular surveillance of these patients, until and during the diagnostics and acute therapy often presents an interdisciplinary and interprofessional challenge. This is partly due to the limited number of monitoring spaces in emergency departments. Therefore, it is crucial to establish a differentiated indication for cardiovascular monitoring. Despite limited monitoring resources, ensuring high patient safety is paramount. The correct approach holds significant prognostic importance. For patients requiring extended monitoring, especially using invasive systems, close personnel monitoring is essential, in addition to appropriate staffing and medical equipment. The overarching goal for such patients is to ensure prompt transfer to a suitable destination unit. The provision of an intensive care bed for further care within one hour is aimed for according to the directive of the Federal Joint Committee on staged emergency care in hospitals. Often, at the beginning of the emergency department visit, a definitive diagnosis is not yet established - this is addressed accordingly with symptom-oriented considerations. The present review article focuses on the practical Implementation and modalities of monitoring, as well as its application in a selection of cardiovascular diagnoses in the emergency department.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"149 17","pages":"1034-1038"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Treatment of chronic limb-threatening ischemia (CLTI) based on BEST-CLI and BASIL-2]. [基于 BEST-CLI 和 BASIL-2 的慢性肢体缺血（CLTI）治疗方法]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-08-15 DOI: 10.1055/a-2153-6265

Marcus Thieme, Hans Krankenberg

{"title":"[Treatment of chronic limb-threatening ischemia (CLTI) based on BEST-CLI and BASIL-2].","authors":"Marcus Thieme, Hans Krankenberg","doi":"10.1055/a-2153-6265","DOIUrl":"https://doi.org/10.1055/a-2153-6265","url":null,"abstract":"The rate of vascular recanalizations in CLTI is increasing worldwide. Safety and efficacy of surgical versus endovascular treatment in CLTI patients was investigated in 2 prospective randomized trials with contrasting results. The BEST-CLI trial randomized 1830 patients with CLTI, the Bypass versus Angioplasty for Severe Ischaemia of the Leg (BASIL-2) trial included 345 patients with CLTI. Best-CLI evaluated outcome events as the primary endpoint, which includes major reinterventions in addition to major amputations and death. Only half of the CLTI patients received a crural intervention or surgery. There were no differences in major amputations or death. After a median follow-up (FU) of 2,7 years, the surgery group showed significantly better results compared to the endovascular group, due to fewer re-interventions. BASIL-2 used amputation-free survival as the primary outcome and only included patients with lower leg lesions. After a median FU of 40 months, endovascular therapy was found to be superior. The extremely high mortality rate was remarkable in both studies. The BEST-CLI study represents CLTI patients only to a limited degree, whereas the BASIL-2 study presents the treatment of CLTI patients with below-the-knee-lesions quite well. Both studies confirm that patients with CLTI should be treated in specialized centers that offer both crural surgery and endovascular therapy. Cardiovascular risk factor management must play a more important role in reducing the high mortality associated with CLTI.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"149 17","pages":"1002-1008"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Vaccinations in pulmonary diseases - part 1: Covid and influenza]. [肺部疾病的疫苗接种--第一部分：Covid 和流感]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-08-15 DOI: 10.1055/a-2115-0404

Cathrin Kodde, Leif Erik Sander

引用次数: 0

[Hepatitis C: From diagnosis to global virus elimination]. [丙型肝炎：从诊断到全球消除病毒]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-08-02 DOI: 10.1055/a-2057-1797

Annika Schmitt, Christoph Sarrazin

引用次数: 0

[Neuroendocrine neoplasia]. [神经内分泌肿瘤]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI: 10.1055/a-2173-5498

Judith Gebauer

引用次数: 0

[Kidney diseases: News from the KDIGO guidelines]. [肾脏疾病：来自 KDIGO 指南的新闻]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-08-15 DOI: 10.1055/a-2145-7564

Markus Ketteler

{"title":"[Kidney diseases: News from the KDIGO guidelines].","authors":"Markus Ketteler","doi":"10.1055/a-2145-7564","DOIUrl":"https://doi.org/10.1055/a-2145-7564","url":null,"abstract":"The KDIGO Update 2024 was supplemented by new \"Clinical Practice Points\", which were derived from the current evidence but are not necessarily comprehensively proven by prospective controlled studies. The most significant change in the Update 2024 for Lupus nephritis concerns the recommendations for induction therapy for lupus nephritis classes III and IV. The basis is still high-dose glucocorticoid treatment and the use of hydroxychloroquine. The 2 new developments in the 2024 Update concerning ANCA-associated nephritis are based on the studies on the use of the C5a receptor inhibitor Avacopan and the increasing data on induction protocols with reduced glucocorticoid dosage. Due to the inconsistency and variability of the conditions under which blood pressure measurements are carried out in practice, an international consensus statement was issued which defines 4 steps to achieve sufficient validity of the measurement results. CKD-MBD Controversies Conference 2023: The update for CKD-MBD, which was discussed in the Controversies Conference 2023, is in progress and has not been released yet. However, there were no serious contradictions between the 2023 data and the 2017 guidelines - the risk assessment regarding calcium-containing phosphate binders may have been put into perspective.","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"149 17","pages":"1039-1044"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0