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[First-line treatment of elderly patients with CLL: An innovative, chemo-free approach]. 老年CLL患者的一线治疗：一种创新的无化疗方法。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-10-01 Epub Date: 2025-10-10 DOI: 10.1055/a-2324-5473
Jan Christoph Banck, Johannes Förner, Manuela A Hoechstetter
{"title":"[First-line treatment of elderly patients with CLL: An innovative, chemo-free approach].","authors":"Jan Christoph Banck, Johannes Förner, Manuela A Hoechstetter","doi":"10.1055/a-2324-5473","DOIUrl":"https://doi.org/10.1055/a-2324-5473","url":null,"abstract":"<p><p>Nowadays, a wide range of targeted therapies are available for the treatment of chronic lymphocytic leukemia, offering superior efficacy and a longer-lasting responses compared to chemoimmunotherapy in both first- and second-line settings. Owing to the favorable tolerability of novel targeted agents, genetic factors have superseded age and fitness as key determinants in the selection of first-line therapy. Currently, high-risk genetic features include del(17p13) or TP53 mutations, complex karyotype (≥3 chromosomal aberrations), and unmutated IGHV status. Initial risk stratification focuses on detecting del(17p13)/TP53 mutations and assessing karyotype. This new strategy, along with the improved tolerability of these agents, offers particular benefit to older and frail patients, with dosing tailored to comorbidities and concomitant therapies.Given the heterogeneity in older patients' health status, geriatric assessments (e.g., CIRS, FRAIL score) are additional key for individualized therapy decisions and adverse events influence therapy choice (e.g. cardiovascular risk with BTK inhibitors. Beyond clinical factors, patient preferences-such as opting for continuous (e.g., BTK inhibitor monotherapy) versus time-limited therapy (e.g., venetoclax plus obinutuzumab or ibrutinib plus venetoclax)-and treatment tolerability are decisive.</p>","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 21","pages":"1294-1308"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Langerhans Cell Histiocytosis in Children and Adults - An Interdisciplinary Diagnostic and Therapeutic Challenge]. 儿童和成人的朗格汉斯细胞组织细胞增多症——一个跨学科的诊断和治疗挑战。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI: 10.1055/a-2665-9270
Anke Barnbrock, Luciana Porto, Johanna Schmoll, Thomas Lehrnbecher, Michael Girschikofsky
{"title":"[Langerhans Cell Histiocytosis in Children and Adults - An Interdisciplinary Diagnostic and Therapeutic Challenge].","authors":"Anke Barnbrock, Luciana Porto, Johanna Schmoll, Thomas Lehrnbecher, Michael Girschikofsky","doi":"10.1055/a-2665-9270","DOIUrl":"10.1055/a-2665-9270","url":null,"abstract":"<p><p>Langerhanscell histiocytosis (LCH) is a rare malignant disease, which commonly occurs during childhood and adolescence, but may also be seen in adult patients. Although LCH lesions are mostly found in bones, skin and the pituitary gland, the disease may affect almost each organ and cause a variety of symptoms. There are differences between pediatric and adult patients regarding diagnostics and therapy. Better insights in the pathophysiology of the disease resulted in the development of new therapeutic approaches such as the use of RAF or MAP-Kinase inhibitors and may help to guide therapy. Although each patient with LCH should be referred to a pediatric or internal oncologist, long-term interdisciplinary care is needed for many patients.</p>","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 20","pages":"1216-1225"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Treatment of tuberculosis in adults]. [成人肺结核的治疗]。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI: 10.1055/a-2612-2364
Niklas Köhler, Ralf Otto-Knapp, Norbert Heinrich, Christoph Lange, Thomas Theo Brehm
{"title":"[Treatment of tuberculosis in adults].","authors":"Niklas Köhler, Ralf Otto-Knapp, Norbert Heinrich, Christoph Lange, Thomas Theo Brehm","doi":"10.1055/a-2612-2364","DOIUrl":"10.1055/a-2612-2364","url":null,"abstract":"<p><p>Tuberculosis remains the leading cause of death from a single infectious pathogen. Despite global health initiatives and the WHO's \"End TB\" Strategy, progress toward TB elimination has been slow, particularly in low- and middle-income countries.The standard treatment for drug-susceptible tuberculosis involves a 6-month combination of rifampicin, isoniazid, pyrazinamide, and ethambutol. However, results from recent clinical trials suggest that with novel treatment regimens standard tuberculosis treatment can be shortened substantially in the majority of affected patients. In the field of drug-resistant tuberculosis, innovations include 6-9-month all-oral regimens with improved efficacy and tolerability.An integrated management approach includes patient support, culturally sensitive education, management of adverse drug reactions, and close clinical monitoring. Novel diagnostic tools and biomarkers may enhance treatment monitoring in the future. Additionally, 20 new drug candidates are currently in clinical development and may offer shorter, safer, and more effective therapies.</p>","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 20","pages":"1207-1215"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prevention of decompensation in advanced chronic liver disease]. [晚期慢性肝病失代偿的预防]。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-10-01 Epub Date: 2025-10-10 DOI: 10.1055/a-2532-6048
Marlene Reincke, Lukas Sturm, Robert Thimme, Dominik Bettinger
{"title":"[Prevention of decompensation in advanced chronic liver disease].","authors":"Marlene Reincke, Lukas Sturm, Robert Thimme, Dominik Bettinger","doi":"10.1055/a-2532-6048","DOIUrl":"https://doi.org/10.1055/a-2532-6048","url":null,"abstract":"<p><p>The transition from compensated to decompensated advanced chronic liver disease (ACLD) is associated with increased mortality. Clinically significant portal hypertension (CSPH), defined by a hepatic venous pressure gradient (HVPG) ≥10 mmHg, is the main precondition of decompensation. Non-invasive tools like transient elastography help identifying patients at risk. Preventing the first decompensation, especially ascites, is a key therapeutic goal. Non-selective beta-blockers (NSBBs), particularly carvedilol, reduce portal pressure and have shown efficacy in preventing decompensation, independent of variceal status. Lifestyle modification and treating underlying liver disease (e.g., alcohol abstinence, viral eradication) remain essential. Early identification and initiation of therapy in CSPH can change the natural history of cirrhosis and improve patient outcomes.</p>","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 21","pages":"1267-1275"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prevention of liver disease]. [预防肝脏疾病]。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-10-01 Epub Date: 2025-10-10 DOI: 10.1055/a-2679-7842
Dominik Bettinger, Robert Thimme
{"title":"[Prevention of liver disease].","authors":"Dominik Bettinger, Robert Thimme","doi":"10.1055/a-2679-7842","DOIUrl":"https://doi.org/10.1055/a-2679-7842","url":null,"abstract":"","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 21","pages":"1247"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial intelligence in cardiology]. [心脏病学中的人工智能]。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-09-01 Epub Date: 2025-09-09 DOI: 10.1055/a-2643-5163
Stefan Frantz
{"title":"[Artificial intelligence in cardiology].","authors":"Stefan Frantz","doi":"10.1055/a-2643-5163","DOIUrl":"https://doi.org/10.1055/a-2643-5163","url":null,"abstract":"","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 19","pages":"1115"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial Intelligence Methods - a Perspective for Cardiovascular Telemedicine?] 人工智能方法——心血管远程医疗的前景？］
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-09-01 Epub Date: 2025-09-09 DOI: 10.1055/a-2593-7851
Meike Hiddemann, Kerstin Köhler, Wilhelm Haverkamp, Juliane Köhler, Maximilian Bauser, Friedrich Köhler
{"title":"[Artificial Intelligence Methods - a Perspective for Cardiovascular Telemedicine?]","authors":"Meike Hiddemann, Kerstin Köhler, Wilhelm Haverkamp, Juliane Köhler, Maximilian Bauser, Friedrich Köhler","doi":"10.1055/a-2593-7851","DOIUrl":"10.1055/a-2593-7851","url":null,"abstract":"<p><p>Since 2022, an estimated 150000 to 200000 patients with heart failure (HF) in Germany have met the inclusion criteria for HF telemonitoring in accordance with the Federal Joint Committee's (G-BA) decision. Currently, only a few artificial intelligence (AI) applications are used in standard cardiovascular telemedicine care. However, AI applications could improve the predictive accuracy of existing telemedical sensor technology by recognising patterns across multiple data sources. AI-based biomarkers are also being developed for use in telemedical sensor technology. Voice analysis to recognise pulmonary congestion appears to be a promising approach. In the future, AI-based decision support systems could help optimise the diagnostic process in telemedicine centres. Large language models offer the potential to support the diagnostic process. The European Union's AI regulation has established the first framework for testing new AI-based technologies in healthcare. Real-world laboratories provide an opportunity to research innovative technologies in a protected environment.</p>","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 19","pages":"1135-1142"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Narrative review of clinical findings in patients with Post-COVID-19 and their relevance for occupational medical assessment]. [covid -19后患者临床表现的叙述性回顾及其与职业医学评估的相关性]。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-09-01 Epub Date: 2025-09-09 DOI: 10.1055/a-2648-3362
Ludwig Frei-Stuber, Dennis Nowak
{"title":"[Narrative review of clinical findings in patients with Post-COVID-19 and their relevance for occupational medical assessment].","authors":"Ludwig Frei-Stuber, Dennis Nowak","doi":"10.1055/a-2648-3362","DOIUrl":"10.1055/a-2648-3362","url":null,"abstract":"<p><p>The COVID-19 pandemic led to a sharp increase in the recognitions of COVID-19 as an occupational disease in Germany. The patients often report diverse symptoms, whereas causality and objectification remain difficult.A selective literature research in PubMed was carried out, assessment recommendations and guidelines were included, too.Long-term consequences of COVID-19 belong to various medical fields. Direct and indirect objectification are necessary. The latter requires concrete indications for the connection between COVID-19 and symptoms. An individual case assessment is also required regarding the reduction in earning capacity. Official recommendations for assessment were published shortly before this review in June 2025.Objectification is a crucial factor, whereas its implementation is complex. Effects on the degree of damage and the degree of disability should be taken into account.</p>","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 19","pages":"1151-1157"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[59-year-old woman with progressively distended abdomen]. [59岁女性，腹部逐渐膨胀]。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-09-01 Epub Date: 2025-09-09 DOI: 10.1055/a-2643-7029
Guido Michels, Nina Hauer-Kleis, Sebastian M Jud
{"title":"[59-year-old woman with progressively distended abdomen].","authors":"Guido Michels, Nina Hauer-Kleis, Sebastian M Jud","doi":"10.1055/a-2643-7029","DOIUrl":"https://doi.org/10.1055/a-2643-7029","url":null,"abstract":"","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 19","pages":"1127-1128"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Leptospirosis due to occupational activity in a sewage treatment plant - case report of a recognized occupational disease]. [污水处理厂职业活动引起的钩端螺旋体病——一种公认的职业病病例报告]。
IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-09-01 Epub Date: 2025-08-29 DOI: 10.1055/a-2612-3357
Ludwig Frei-Stuber, Dennis Nowak
{"title":"[Leptospirosis due to occupational activity in a sewage treatment plant - case report of a recognized occupational disease].","authors":"Ludwig Frei-Stuber, Dennis Nowak","doi":"10.1055/a-2612-3357","DOIUrl":"https://doi.org/10.1055/a-2612-3357","url":null,"abstract":"<p><p>The patient (male, two expert reports: 61 and 63 years old) experienced symptoms of a flu-like infection with rapid deterioration and cognitive complaints. He has been an employee of the municipal building yard with a sewage treatment plant for approximately 24 years.Acute renal insufficiency (creatinine 9.7 mg/dl), increased anti-Leptospira IgM antibodies and Leptospira DNA using PCR were detected. The CT neurocranium without contrast medium did not reveal any relevant abnormalities.Sepsis with multiorgan failure including a type 2 myocardial infarction and acute renal failure in the context of leptospirosis was diagnosed.Antibiotic therapies with piperacillin/tazobactam, clarithromycin and meropenem were given. Regarding acute renal failure, renal function was significantly improved by using temporary hemodialysis. After an assessment, leptospirosis was recognized as occupational disease No. 3102 in accordance with Appendix 1 of the Occupational Diseases Ordinance.Physicians should take a work history and, if there is reasonable suspicion, are legally obliged to report suspected occupational diseases. The primary infection and such a complex course (including costs) can be prevented by adequate occupational safety.</p>","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 18","pages":"1094-1099"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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