Current health sciences journal最新文献_第8页

Purine Derivatives in the Management of Antiresorptive Drug-Related Osteonecrosis of the Jaw. 嘌呤衍生物在抗吸收药物相关性颌骨骨坏死治疗中的应用。

Current health sciences journal Pub Date : 2025-04-01 Epub Date: 2025-06-30 DOI: 10.12865/CHSJ.51.02.08

Nader Farajollah, Octavian Marius Dinca, Mihai Bogdan Bucur, George Cristian Vladan, Alexandru Bucur

{"title":"Purine Derivatives in the Management of Antiresorptive Drug-Related Osteonecrosis of the Jaw.","authors":"Nader Farajollah, Octavian Marius Dinca, Mihai Bogdan Bucur, George Cristian Vladan, Alexandru Bucur","doi":"10.12865/CHSJ.51.02.08","DOIUrl":"10.12865/CHSJ.51.02.08","url":null,"abstract":"Purinic derivatives has recently attracted attention as a potential therapeutic agent, with preliminary evidence suggesting its utility in the management of osteonecrosis of the jaw. work aims at providing an update of the current literature, shedding light on the purinic derivatives treatment for patients who received intravenous antiresorptive drugs and developed osteonecrosis of the jaw. A retrospective study was conducted at the Oral and Maxillofacial Surgery Department of \"Prof. Dr. Dan Theodorescu\" Clinical Hospital in Bucharest, Romania, involving 160 consecutive patients diagnosed with refractory, established antiresorptive drug-related osteonecrosis of the jaw between 2022 and 2024. A study group of 23 consecutive patients was selected to receive adjunctive therapy with pentoxifylline (800 mg/day) and vitamin E (1000 IU/day) for six months, while the remaining 137 patients who were not eligible for pentoxifylline tretament formed the control group. Bone healing outcomes were assessed based on the extent of exposed necrotic bone. The study results indicate the fact that 100% of patients in the study group experienced symptomatic improvement, despite a higher prevalence of stage III medication-related osteonecrosis of the jaw, provides strong evidence supporting the therapeutic efficacy observed in this sample population. Post-hoc power analysis showed that the study was strongly powered to detect the observed differences, supporting the reliability of the results. Treatment with purine derivatives demonstrates significant therapeutic potential in the management of antiresorptive drug-related osteonecrosis of the jaw and should be considered as complementary to the standard therapy, particularly in advanced stages of the disease.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 2","pages":"233-238"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12625785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosafety and Selective Cytotoxicity of Kojic and Ellagic Acids in Salivary Gland Carcinoma: A Preclinical Perspective. 曲酸和鞣花酸在唾液腺癌中的生物安全性和选择性细胞毒性：临床前研究。

Current health sciences journal Pub Date : 2025-04-01 Epub Date: 2025-06-30 DOI: 10.12865/CHSJ.51.02.09

Florin Iacob, Diana Haj Ali, Doina Chioran, Laura-Cristina Rusu, Stefania Dinu, Iulia Muntean, Codruta Victoria Tigmeanu

{"title":"Biosafety and Selective Cytotoxicity of Kojic and Ellagic Acids in Salivary Gland Carcinoma: A Preclinical Perspective.","authors":"Florin Iacob, Diana Haj Ali, Doina Chioran, Laura-Cristina Rusu, Stefania Dinu, Iulia Muntean, Codruta Victoria Tigmeanu","doi":"10.12865/CHSJ.51.02.09","DOIUrl":"10.12865/CHSJ.51.02.09","url":null,"abstract":"Salivary gland carcinomas (SGCs) are rare, aggressive tumors with high histopathological diversity and resistance to conventional therapies. The need for novel therapeutic approaches has drawn attention to natural compounds with antitumor potential. Objective: This study aims to investigate the in vitro and in ovo cytotoxic and safety profiles of two natural agents, kojic acid (KA) and ellagic acid (EA), on human submandibular salivary gland carcinoma (A253) cells and human immortalized keratinocytes (HaCaT), as well as to assess their irritant potential via the HET-CAM assay. The cytotoxicity and morphological changes of A253 and HaCaT cells were evaluated using the MTT assay and brightfield microscopy. The HET-CAM assay was applied to evaluate the irritant effects of the compounds in ovo. Both KA and EA reduced A253 cell viability in a dose-dependent manner, with the highest cytotoxicity observed at 100 µM. In contrast, HaCaT cells maintained high viability and exhibited no notable morphological alterations post-treatment, supporting the selectivity of the compounds. HET-CAM scores for both KA and EA fell within the non-irritant range (IS=0.07), further confirming their biosafety. KA and EA exhibit promising antitumor activity against A253 salivary gland carcinoma cells, with minimal toxicity toward normal epithelial cells and no significant irritation potential. These findings justify further investigation of these compounds for their potential use as adjuvant agents in the treatment of salivary gland carcinoma (SGC).","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 2","pages":"239-248"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12625790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Radiological Spectrum in Cleidocranial Dysplasia: A Case Series. 锁骨颅骨发育不良的临床和放射谱：一个病例系列。

Current health sciences journal Pub Date : 2025-04-01 Epub Date: 2025-06-30 DOI: 10.12865/CHSJ.51.02.14

Fakir Mohan Debta, Kunal Agarwal, Basudha Bera, Romali Panda, Sebati Murmu

引用次数: 0

Spectrum of Post Tuberculosis Chronic Lung Disease in Patients with Previous Bacteriologically Confirmed Pulmonary Tuberculosis. 细菌学证实的肺结核患者结核后慢性肺病谱

Current health sciences journal Pub Date : 2025-04-01 Epub Date: 2025-06-30 DOI: 10.12865/CHSJ.51.02.13

Ioan Anton Arghir, Oana Cristina Arghir, Iulia Tania Andronache, Ileana Ion

{"title":"Spectrum of Post Tuberculosis Chronic Lung Disease in Patients with Previous Bacteriologically Confirmed Pulmonary Tuberculosis.","authors":"Ioan Anton Arghir, Oana Cristina Arghir, Iulia Tania Andronache, Ileana Ion","doi":"10.12865/CHSJ.51.02.13","DOIUrl":"10.12865/CHSJ.51.02.13","url":null,"abstract":"The discovery of anti- tuberculosis (TB) drugs, in the middle of last century, did not resolve the goal of a better healing, and the most important cause is represented by delayed diagnosis of TB disease. We conducted a single-center case control study, from January, 1st, 2017 to December, 31st, 2024, including 400 adult symptomatic inpatients diagnosed with post TB lung disease (PTLD), after a previous episode of treated TB disease. There were excluded 168 patients without pulmonary function testing (PFT), those with significant occupational exposure, and/or diseases autoimmune, COVID-19 or HIV infection, which might interfere lung function assessment. All demographics, behavioral and baseline PTB characteristics (relapses, clinical, imagistic, endoscopic, microbiologic, PFT, evolution) were assessed in order to inventorying sequelae and lung damage, types of lung function impairment. Eligible patients (n=232), mean aged 60.94+/-11.895 years, males (55.17%), were divided into 129 cases with previous bacteriologically confirmed PTB (mean age 58.37+/-11.86 years; 55.81% males) and 103 controls with previous clinically diagnosed PTB (mean age 60.04+/-11.222; 54.37% males). Delayed diagnosis and relapses of PTB had greater impact on PTLD development in cases (p=0.000), as well as previous cavitary PTB (p=0.000). The risk of death, during hospitalization, was greater in cases (p=0.000). Spectrum of PTLD, in cases, was dominated by bronchiectasis (p=0.000), suppurative episodes (p=0.004), open healing cavitation (p=0.000), intracavitary aspergilloma (p=0.002), fibrothorax (p=0.000), lung function impairment (p=0.030). In conclusion, PTLD severity is related to delayed diagnosis of previous contagious PTB, permanent lung damage, impairment of lung function, having a higher risk of death.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 2","pages":"279-288"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12625793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in the Etiology and Neural Pathways Underlying Attention-Deficit and Hyperactivity Disorder. 注意缺陷和多动障碍的病因学和神经通路研究进展。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.02

Monica Grigore, Marius Viorel Ionică, Liliana Pătru, Victor Gheorman, Aurel Popa Wagner

{"title":"Recent Advances in the Etiology and Neural Pathways Underlying Attention-Deficit and Hyperactivity Disorder.","authors":"Monica Grigore, Marius Viorel Ionică, Liliana Pătru, Victor Gheorman, Aurel Popa Wagner","doi":"10.12865/CHSJ.51.01.02","DOIUrl":"10.12865/CHSJ.51.01.02","url":null,"abstract":"The prevalence of mental disorders is increasing across the European Union, with at least one in four individuals expected to experience a psychiatric condition at some point in their lifetime. Notably, men and women often present with distinct symptomatology. Among neuropsychiatric disorders, attention-deficit/hyperactivity disorder (ADHD) is the most common and functionally impairing condition in childhood, affecting approximately 5% of minors. Its persistence into adulthood is substantial, with prevalence estimates reaching up to 3% in adult populations. ADHD is characterized by dysregulated dopaminergic signaling, which disrupts reward processing and motivation. Additionally, disturbances in circadian rhythms contribute to sleep dysregulation and metabolic dysfunction, further exacerbating symptom severity. While both mechanisms have been well-documented, their interaction remains insufficiently explored, particularly regarding its implications for diagnosis and treatment optimization. Future research should systematically examine the interplay between dopaminergic and noradrenergic dysfunction and circadian disruptions in ADHD, particularly in relation to symptom expression and comorbid conditions. Experimental paradigms assessing reward processing may provide valuable insights into dopamine and norepinephrine system alterations, while chronotherapeutic interventions-such as light therapy, sleep regulation, and behavioral adjustments-hold promise as potential therapeutic strategies. By integrating perspectives from neurobiology, chronobiology, and psychopharmacology, a more refined and individualized approach to ADHD management can be developed. Advancing this understanding may not only enhance ADHD treatment strategies but also yield novel therapeutic avenues for addressing its frequently co-occurring conditions.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"14-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Outcome of Intra-Articular Fracture of Distal End Radius Treated with External Fixator; A Prospective Study. 外固定架治疗桡骨远端关节内骨折的功能效果前瞻性研究。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.15

Pardeep Siwach, Surya Vijay Singh, Gyanendra Puri, Jitendra Singh

{"title":"Functional Outcome of Intra-Articular Fracture of Distal End Radius Treated with External Fixator; A Prospective Study.","authors":"Pardeep Siwach, Surya Vijay Singh, Gyanendra Puri, Jitendra Singh","doi":"10.12865/CHSJ.51.01.15","DOIUrl":"10.12865/CHSJ.51.01.15","url":null,"abstract":"Fracture distal end radius is one of the most common fracture treated in orthopedic emergencies. Nearly 1/6th (16%) of all fractures in orthopedic emergencies involve the distal end of the Radius. This is a prospective-interventional study conducted in the department of Orthopedic Surgery, Sanjay Gandhi Memorial Hospital, Mangolpuri, New Delhi with a sample size of the study is thirty patients treated with an external fixator from January 2021 to June 2022. Out of 30 patients, the number of female patients was 16 (53.33%) and the number of male patients was 14 (46.67%). The mean age of the patient was 50.5 years. 27 (90%) out of 30 patients were right-handed people which was a common behavioral finding and thus we expect more right side distal radius fracture in our study. Functional outcome was evaluated with the Gartland & Werley scoring system. 14 patients (46.67%) showed excellent results, 11 patients (36.67%) showed good, 3 patients (10%) showed fair, whereas 2 (6.67%) patients showed poor results. Stiffness was the most common complication seen in 6 patients (20%). From this study, it is concluded that an external fixator is a simple, safe, and cost-effective method for the treatment of distal end radius fracture with a lesser duration of hospital stay. It reduces the fracture by means of ligamentotaxis and maintains the reduction as well as restores the radial length without interfering with the fracture healing process.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"141-150"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymethyl-Methacrylate Hypersensitivity with Associated Folliculitis Decalvans After Cranioplasty: A Case Report. 头颅成形术后聚甲基丙烯酸甲酯过敏伴Decalvans毛囊炎1例报告。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.18

Artur Eduardo Martio, Octávio Ruschel Karam, Laura Zambonato Costamilan, Valeska Balen Ronsoni, Renan Mathias Ferreira Saltiél, Paulo Moacir Mesquita Filho

引用次数: 0

The Role of miRNAs and Epigenetic Factors in Non-Alcoholic Fatty Liver Disease - a Systematic Review. mirna和表观遗传因子在非酒精性脂肪性肝病中的作用——系统综述

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.04

Victor Constantin Stoica, Mihai Mircea Diculescu, Mircea Mănuc, Ileana Constantinescu, Iuliana Petronela Gârdan, Adrian Daniel Gârdan

{"title":"The Role of miRNAs and Epigenetic Factors in Non-Alcoholic Fatty Liver Disease - a Systematic Review.","authors":"Victor Constantin Stoica, Mihai Mircea Diculescu, Mircea Mănuc, Ileana Constantinescu, Iuliana Petronela Gârdan, Adrian Daniel Gârdan","doi":"10.12865/CHSJ.51.01.04","DOIUrl":"10.12865/CHSJ.51.01.04","url":null,"abstract":"Non-alcoholic liver disease is affecting approximately a quarter of the global population, with a significant morbidity and mortality rate. The present paper takes into discussion a systematic review of the literature concerning the role that microRNAs (miRNAs) and epigenetic factors can have in relation with NAFLD. Using PRISMA methodology guidelines, the systematic review offers a comprehensive image of the relevant scientific literature that explains the complex role of miRNAs in relation with NAFLD. Throughout the process of reviewing there has been highlighted seven different subtopics that can synthetize the nature and the content of the different studies: the role of miRNAs in fibrosis and liver disease progression; use of microRNAs as biomarkers for diagnosing steatotic liver disease; microRNAs and targeted therapies for NAFLD (Nonalcoholic fatty liver disease) /NASH (Non-alcoholic Steatohepatitis); metabolic regulation and obesity via microRNAs; interaction of miRNAs with other factors at the molecular level in disease pathogenesis; the role of miRNAs in systemic inflammation and effects on various other organs and the role of miRNAs as regulators and highly specialized epigenetic factors affecting NAFLD pathogenesis and evolution. Overall, this review presents diverse approaches on microRNAs and gives a background for future applied research that can explain and test their potential as biomarkers for diagnosing and understanding disease mechanisms, particularly in populations exposed to historical nutritional imbalances.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"37-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosome Abnormality Detection Rates of QF-PCR in Early Pregnancy Loss. QF-PCR对早期妊娠丢失染色体异常检出率的影响。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.06

Gabriela Popescu-Hobeanu, Mihai-Gabriel Cucu, Anca-Lelia Riza, Ioana Streata, Razvan Mihail Plesea, Stefania Dorobantu, Adina Barbu, Lucian George Zorila, Marina Dinu, Anda Lorena Dijmarescu, Stefania Tudorache, Dominic Iliescu, Florin Burada

{"title":"Chromosome Abnormality Detection Rates of QF-PCR in Early Pregnancy Loss.","authors":"Gabriela Popescu-Hobeanu, Mihai-Gabriel Cucu, Anca-Lelia Riza, Ioana Streata, Razvan Mihail Plesea, Stefania Dorobantu, Adina Barbu, Lucian George Zorila, Marina Dinu, Anda Lorena Dijmarescu, Stefania Tudorache, Dominic Iliescu, Florin Burada","doi":"10.12865/CHSJ.51.01.06","DOIUrl":"10.12865/CHSJ.51.01.06","url":null,"abstract":"Early pregnancy loss (EPL) is the most common form of miscarriage and establishing its exact etiology is vital for the proper prognosis and management of possible future pregnancies. The aim of our study was to assess the incidence and types of chromosome abnormalities in product-of-conception (POC) samples analyzed by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR). Two hundred fifty-seven POC samples meeting EPL criteria were referred to the Human Genomics Laboratory of the University of Medicine and Pharmacy of Craiova, Romania. DNA was extracted from both POC tissue and maternal blood samples, while PCR products were migrated on the ABI3730xl platform. A total of 124 samples were successfully analyzed, 46 cases (37.1%) showing various types of abnormalities, while no aneuploidies were found in the remaining 78 samples (62.9%). The most common abnormalities were monosomy X, followed by triploidy, trisomy 18, 16 and 15. The basic QF-PCR kit had an overall detection rate of 25.8%, but the detection rate rose to 37.1% when employing the extended kit. Our study proves that QF-PCR can be used as a first approach in the genetic analysis of POC, followed by conventional karyotyping (KT) or Chromosomal Microarray Analysis (CMA) as follow-up. QF-PCR is able to identify maternal cell contamination, as well as provide timely results.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"62-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlations of Peri-Implant Parameters with Plaque and Inflammation Indices in Posterior Fixed Implant-Prosthetic Rehabilitation: A Cross-Sectional Study. 后路固定种植体-假体康复中种植体周围参数与斑块和炎症指数的相关性：一项横断面研究。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.12

Alexandra Davidescu, Norina Forna, Doriana Agop-Forna, Cristina Dascălu, Mihaela-Monica Scutariu

{"title":"Correlations of Peri-Implant Parameters with Plaque and Inflammation Indices in Posterior Fixed Implant-Prosthetic Rehabilitation: A Cross-Sectional Study.","authors":"Alexandra Davidescu, Norina Forna, Doriana Agop-Forna, Cristina Dascălu, Mihaela-Monica Scutariu","doi":"10.12865/CHSJ.51.01.12","DOIUrl":"10.12865/CHSJ.51.01.12","url":null,"abstract":"Purpose: The aim of the study was to analyze the peri-implant clinical and radiological parameters and their correlations with the plaque index (mPI) and the inflammation index (GI) in fixed implant-prosthetic therapy.Materials and method: This research was a retrospective study including 48 patients with posterior partial edentulism (age: mean 63.04±10.723 years) treated by implant-supported metal-ceramic bridges, with a mean 6.19 years follow-up. A total of 166 implants were evaluated by clinical (peri-implant pocket depth-PPD) and radiological (peri-implant marginal bone loss-MBL) examen. Plaque index (mPI) and inflammation index (GI) were recorded for each implant site. Mean values of PPD, MBL (mesial), MBL (distal) were assessed. A comparative analysis was conducted regarding relation between PPD and MBL values (distal and mesial) in relation to the mPI and GI indices using the non-parametric Mann-Whitney and Kruskal-Wallis tests. Correlations between the variables PPD, MBL (mesial), and MBL (distal) for the entire study group were calculated by Pearson linear correlation coefficient.Results: There were very high positive correlations between pocket depth and mesial marginal bone loss (r=0.951, p<0.001; 95% CI: 0.934-0.964); pocket depth and distal marginal bone loss (r=0.961, p<0.001; 95% CI: 0.947-0.971), and mesial and distal bone loss values (r=0.935, p<0.001; 95% CI: 0.913-0.952).Conclusion: The findings indicate that peri-implant bone loss and pocket depth are strongly correlated and significantly influenced by plaque accumulation and inflammation, highlighting the critical role of the patients' oral hygiene in maintaining peri-implant tissue health.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"112-120"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0