Current health sciences journal最新文献_第8页

Open Spina Bifida: The Role of Ultrasound Markers in the First Trimester and Morphopathology Correlation. 开放性脊柱裂：妊娠头三个月超声标记的作用与形态病理学相关性。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.20

Delia Roxana Ungureanu, Maria Cristina Comănescu, Anca-Maria Istrate-Ofiţeru, George-Lucian Zorilă, Roxana Cristina Drăgușin, Dominic Gabriel Iliescu

{"title":"Open Spina Bifida: The Role of Ultrasound Markers in the First Trimester and Morphopathology Correlation.","authors":"Delia Roxana Ungureanu, Maria Cristina Comănescu, Anca-Maria Istrate-Ofiţeru, George-Lucian Zorilă, Roxana Cristina Drăgușin, Dominic Gabriel Iliescu","doi":"10.12865/CHSJ.49.03.20","DOIUrl":"10.12865/CHSJ.49.03.20","url":null,"abstract":"Objectives-To evaluate ultrasound markers during a first-trimester (FT) routine ultrasound examination for an early detection of open spina bifida (OSB) and to correlate the sonographic findings with the morpho-histological ones.Materials and methods: This retrospective research was performed using data from foetuses that underwent FT anatomy scans (FTAS) with a gestational age between 11 weeks and 13 weeks and 6 days in the Prenatal Diagnostic Unit of the Clinical Emergency County Hospital Craiova from October 2022 until September 2023.Results: The study included 648 FT singleton pregnancies and 5 OSB cases were detected. In the OSB group, we found abnormal aspects of the fourth ventricle, also named intracranial translucency (IT) in 4 out of 5 cases of OSB (80%), a brain stem anteroposterior diameter, and brain stem to occipital bone ratio abnormal in all 5 cases (greater than 1) (100%), the crash sign was present in 80% (4 out of 5 cases) and the spinal defect was visualized in 4 out of 5 patients (80%). Medical termination of pregnancy (MTOP) was the preferred option in all cases of OSB. This allowed us to include an extended histological study to confirm the ultrasound diagnosis.Conclusions: A combined detailed FTAS that includes both cranial ultrasound markers of the posterior fossa and also a good visualization of the foetal spine offers an early optimal detection rate of spine abnormalities.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micronutrient Research in Autism Spectrum Disorder. A Clinical Study. 自闭症谱系障碍中的微量营养素研究。临床研究。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.14

Cătălina Mihaela Anastasescu, Eugen Stoicănescu, Oana Badea, Florica Popescu

{"title":"Micronutrient Research in Autism Spectrum Disorder. A Clinical Study.","authors":"Cătălina Mihaela Anastasescu, Eugen Stoicănescu, Oana Badea, Florica Popescu","doi":"10.12865/CHSJ.49.03.14","DOIUrl":"10.12865/CHSJ.49.03.14","url":null,"abstract":"Autistic spectrum disorders are part of the category of neurodevelopmental disorders, characterized by: difficulties in communication and social interaction, restrictive and repetitive patterns of behaviours and activities, which are present throughout the developmental period, and can be diagnosed in the first five years of life. Due to the increase in the incidence of this disorder in recent years, it has become a topic of great interest both to specialists in child and adolescent psychiatry and to researchers in the field. Given the polymorphism of Autism Spectrum Disorder and the need to discover factors that better explain the etiology of this disorder, studies related to biomarkers are extremely varied. One of the areas of study that have exercised particular interest is related to the involvement of metals in the pathology of autism spectrum disorder. Apart from the controversies related to heavy metals that according to studies affect the developmental process, there are studies that suggest that some micronutrients such as zinc, copper, selenium, iron, magnesium, may be involved in the etiology of autism spectrum disorder. Starting from these studies, we set out to investigate to what extent these essential metals for the body are involved in the etiology of autism spectrum disorder and how they influence the severity of symptoms.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multicenter Epidemiological Study of Nosebleeds Requiring Hospitalization. 需要住院治疗的鼻出血多中心流行病学研究

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.13

Andreea Nicoleta Vlaescu, Elena Ionita, Florin Anghelina, Carmen Aurelia Mogoanta, Sorin-Mircea Ciolofan, Andreea Rusescu, Irina-Gabriela Ionita, Catalina Voiosu, Razvan Hainarosie

引用次数: 0

Evaluation of Transient Ischemic Stroke Cases Admitted to a Tertiary Hospital in Mehedinți County, South-West of Romania. 对罗马尼亚西南部 Mehedinți 县一家三级医院收治的短暂性缺血性中风病例进行评估。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.04

Octavian Păun, Laurențiu Mogoantă

{"title":"Evaluation of Transient Ischemic Stroke Cases Admitted to a Tertiary Hospital in Mehedinți County, South-West of Romania.","authors":"Octavian Păun, Laurențiu Mogoantă","doi":"10.12865/CHSJ.49.03.04","DOIUrl":"10.12865/CHSJ.49.03.04","url":null,"abstract":"The transient ischemic attack (TIA) is a common cerebrovascular ischemic disease whose symptoms resolve within a maximum of 24 hours. The study carried out by us is a retrospective descriptive one, in which we sought to highlight the main characteristics of TIA in patients admitted to the Emergency Hospital in Turnu-Severin municipality in Mehedinți county, in the period 2016-2020, including a group of 53 patients, mainly from Mehedinți county. The analysis of the study group and the risk factors showed that TIA mainly affects the elderly, over 50 years old, with the highest incidence being recorded in the 60-80-year age groups, with an extremely low incidence under 40 years. Significant differences were found between the sexes and between the social environments, with women and people from the urban environment being more prone to suffer a TIA. Among the most important modifiable risk factors encountered in TIA patients included in the study, the following were highlighted: HTN, obesity and atherosclerosis. Knowing the modifiable factors and combating them can improve the prognosis of AIT.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and Myocardial Infarction-The Place of Obesity Among Cardiovascular Risk Factors-Retrospective Study. 肥胖与心肌梗死--肥胖在心血管风险因素中的地位--回顾性研究。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.11

Cristina-Elena Negroiu, Iulia Tudorascu, Cristiana Gianina Moise, Emilia Vinturis, Cristina Maria Bezna, Raluca Danoiu, Marinela Eugenia Gaman, Suzana Danoiu

{"title":"Obesity and Myocardial Infarction-The Place of Obesity Among Cardiovascular Risk Factors-Retrospective Study.","authors":"Cristina-Elena Negroiu, Iulia Tudorascu, Cristiana Gianina Moise, Emilia Vinturis, Cristina Maria Bezna, Raluca Danoiu, Marinela Eugenia Gaman, Suzana Danoiu","doi":"10.12865/CHSJ.49.03.11","DOIUrl":"10.12865/CHSJ.49.03.11","url":null,"abstract":"Since the 21st century, the leading cause of death is cardiovascular disease, with myocardial infarction being the most common. The incidence and prevalence of obesity has risen sharply in recent years, and it is commonly recognised as a cardiovascular risk factor among tobacco smoking, dyslipidemia (high LDL-C, high triglycerides, low HDL-C), hypertension, diabetes, age, gender, hereditary predisposition.Materials and methods: This study is a retrospective study conducted at the Craiova Emergency Clinical Hospital between October 2020 and January 2023. Enrolled patients are 60, 36 patients with ST-segment elevation myocardial infarction and 24 patients with non-ST-segment elevation acute myocardial infarction. The data was collected from the hospital's official database and then analyzed using Microsoft Excel and the Toolbar Data Analysis.Results: The mean age of the patients in the study was 62 years with a minimum of 34 years and a maximum of 84 years. 23(38.3%) of patients were smokers, 7(11.6%) were ex-smokers and 30(50%) were non-smokers. 49(81.6%) patients were hypertensive. 44(73%) had cholesterol greater than 200mg/dl. 54(90%) had LDL>100mg/dl, 18(30%) had HDL>45mg/gl, 24(40%) patients had serum TG>150mg/dl, 17(28%) were overweight and 13(22%) were obese, 30(50%) were normal weight. 18(30%) patients had type 2 diabetes.Conclusions: Among the cardiovascular risk factors in the patients studied, hypertension was the most common, followed by dyslipidemia, obesity, smoking, diabetes mellitus, and very rarely the use of drugs and anabolic substances.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLGA-The Smart Biocompatible Polimer: Kinetic Degradation Studies and Active Principle Release. PLGA--智能生物相容性聚合物：动力学降解研究和活性成分释放。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.15

Maria-Viorica Ciocîlteu, Rău Gabriela, Manuel Ovidiu Amzoiu, Denisa Constantina Amzoiu, Cătălina Gabriela Pisoschi, Beatrice Anne-Marie Poenariu

{"title":"PLGA-The Smart Biocompatible Polimer: Kinetic Degradation Studies and Active Principle Release.","authors":"Maria-Viorica Ciocîlteu, Rău Gabriela, Manuel Ovidiu Amzoiu, Denisa Constantina Amzoiu, Cătălina Gabriela Pisoschi, Beatrice Anne-Marie Poenariu","doi":"10.12865/CHSJ.49.03.15","DOIUrl":"10.12865/CHSJ.49.03.15","url":null,"abstract":"The aim of our research was the development of prolonged delivery systems for therapeutic agents with various properties (prevention and treatment of bone diseases, anti-neoplastic, anti-inflammatory, antioxidant) that would ensure sustained therapeutic levels of the active principle, above the minimum inhibitory concentration, without reaching toxic levels over a long period of time as alternatives to conventional routes of administration. PLGA (poly lactic-co-glycolic acid), a biodegradable and biocompatible synthetic polymer, FDA approved, with a 65:35 lactic acid (LA): glycolic acid (GA) copolymer ratio, was chosen as delivery system. Our studies have shown that in PBS it undergoes two simultaneous degradation processes, hydrolysis and autohydrolysis, degrading completely in about 40 days. The release of the active principle is determined by the diffusion from inside the polymer matrix to the outside, which occurs simultaneously with the erosion of the polymer, during 35 days.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Toxicity by Salvia Officinalis: A Rare Cause of Intestinal Sub-Occlusion. 丹参的急性毒性：一种罕见的肠道下闭塞病因。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.17

Alessandro Rapino, Giovanna Ceccuzzi, Benedetta Perna, Roberto DE Giorgio, Matteo Guarino

引用次数: 0

Hydrocephalus Resolution with Third Ventriculostomy with Floor Stenting: Technical Note and Literature Review. 第三脑室造口术加底部支架治疗脑积水：技术说明和文献综述。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.19

José Ricardo Vanzin, Artur Eduardo Martio, Moema Nene Santos, Nerio Dutra Azambuja, Octávio Ruschel Karam, Luciano Bambini Manzato

{"title":"Hydrocephalus Resolution with Third Ventriculostomy with Floor Stenting: Technical Note and Literature Review.","authors":"José Ricardo Vanzin, Artur Eduardo Martio, Moema Nene Santos, Nerio Dutra Azambuja, Octávio Ruschel Karam, Luciano Bambini Manzato","doi":"10.12865/CHSJ.49.03.19","DOIUrl":"10.12865/CHSJ.49.03.19","url":null,"abstract":"Introduction: The management of refractory obstructive hydrocephalus is a paramount neurosurgical challenge. The endoscopic third ventriculostomy (ETV) has been accepted as the procedure of choice for obstructive hydrocephalus, depending on the presence of certain risk factors, such as intracranial infections, young age, previous shunt failure and distorted anatomy of the ventricular floor, that predispose occlusion or obstruction of the CSF outflow through the stoma.Case report: A 20-year-old man with obstructive hydrocephalus due to primary aqueductal stenosis performed several neurosurgical procedures, including two previous ETV, without long term resolution. We performed another ETV, with stent placement at the stoma to prevent occlusion. After 25 months of asymptomatic follow-up, the patient presented with an enlarged fourth ventricle, and a new neuroendoscopic procedure showed a patent stoma and a well-placed stent.Discussion: Stent placement on the third ventricular floor was already reported 19 times in the literature. Its success rate is about 94,7%, and complications happened in 2 cases, with functional impaired in only one of them.Conclusion: Third ventriculostomy with floor stenting proved to be an effective procedure in our case of complex hydrocephalus. It is a viable option in cases where there is a greater chance of stoma occlusion.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic Profiling - A Need for Clinical Decision? -Case Reports. 基因组剖析--临床决策的需要？-案例报告。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.22

Ana-Maria Ciurea, Michael Schenker, Cristina Mihaela Ciofiac, Liliana Streba, Ramona Schenker, Costin Teodor Streba

{"title":"Genomic Profiling - A Need for Clinical Decision? -Case Reports.","authors":"Ana-Maria Ciurea, Michael Schenker, Cristina Mihaela Ciofiac, Liliana Streba, Ramona Schenker, Costin Teodor Streba","doi":"10.12865/CHSJ.49.03.22","DOIUrl":"10.12865/CHSJ.49.03.22","url":null,"abstract":"Cancer is still an important health issue worldwide due to increased incidence and mortality. Personalized medicine is the future of cancer treatment. Development in technology improved technical skills in DNA/RNA sequencing. NGS technology in solid-tumor samples can describe DNA or RNA analysis by including the entire genome to detect clinical relevant mutations. Genetic results may be considered having a dynamic impact because of heterogenous molecular alterations depending of time and treatment influence. We conducted a retrospective study of all NGS tests made in the last five years for the patients from 'Sf. Nectarie' Oncology Center, Craiova, Romania. We selected three relevant clinical cases where NGS analysis was performed and the results changed the perspective of the clinical decision. Our aim is to evaluate the importance of NGS results in clinical approach. Although medicine known an important development during the last decades, only a few patients can benefit of advanced personalized treatments. It is still hard to identify the alterations or gene mutations because of genetic tests are not easily available and only a small proportion of patients carries genetic alterations.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc-Boron Complex-Based Dietary Supplements for Longevity and Healthy Life. 基于锌硼复合物的膳食补充剂，促进长寿和健康生活。

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI: 10.12865/CHSJ.49.03.10

Andrei Biţă, Ion Romulus Scorei, Tudor Adrian Bălşeanu, Gabriela Rău, Maria Viorica Ciocîlteu, George Dan Mogoşanu

引用次数: 0