The Significance of Inflammation in Atrial Fibrillation.

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI:10.12865/CHSJ.50.01.08
Ciprian Rachieru, Daniel-Florin Lighezan, Lucian Petrescu, Georgică Târtea, Emilia Violeta Goanță, Roxana Buzas, Liviu Cirin, Dragoș Cozma
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Abstract

Aim: The aim of the study was to assess the inflammatory status in individuals diagnosed with atrial fibrillation (Afi) and establish an association between this status and the clinicopathological features.

Material and methods: Our study was conducted retrospectively and initially involved 278 patients. However, after excluding 27 patients, we ultimately ended up with 167 patients who had an inflammatory status and 84 patients who did not have an inflammatory status. These patients were then analyzed.

Results: Patients who had inflammation showed higher values for the CHA2DS2-VASc and HAS-BLED scores (P= 0.0132 for CHA2DS2-VASc and P= 0.0024 for HAS-BLED). Also, it was observed that patients with associated inflammation exhibited an increase in both the volume and the area of the left atrium. Patients with hypertension had a higher prevalence of inflammation, with heart failure and with ischemic heart disease. It is worth noting that patients with atrial fibrillation and increased inflammatory status exhibited higher rates of stroke (22.75% vs 10.71% in patients without inflammation, odds ratio = 2.455, 95% confidence interval 1.161 to 5.425, p = 0.0253).

Conclusions: Our research has demonstrated that patients diagnosed with atrial fibrillation and exhibiting a heightened inflammatory status also present association with other comorbidities, including hypertension, heart failure, ischemic heart disease, and stroke.

炎症在心房颤动中的意义
目的:本研究旨在评估被诊断为心房颤动(Afi)患者的炎症状态,并确定该状态与临床病理特征之间的关联:我们的研究以回顾性方式进行,最初涉及 278 名患者。然而,在排除了 27 名患者后,我们最终得出了 167 名有炎症状态的患者和 84 名没有炎症状态的患者。然后对这些患者进行了分析:有炎症的患者的 CHA2DS2-VASc 和 HAS-BLED 评分值较高(CHA2DS2-VASc 的 P= 0.0132,HAS-BLED 的 P= 0.0024)。此外,还观察到伴有炎症的患者左心房的体积和面积都有所增加。高血压患者、心力衰竭患者和缺血性心脏病患者的炎症发生率更高。值得注意的是,伴有心房颤动和炎症加重的患者中风率较高(22.75% 对无炎症患者的 10.71%,比值比 = 2.455,95% 置信区间为 1.161 至 5.425,P = 0.0253):我们的研究表明,确诊为心房颤动并表现出炎症加重的患者还伴有其他合并症,包括高血压、心力衰竭、缺血性心脏病和中风。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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