Current drug discovery technologies最新文献

{"title":"Challenges and Countermeasures for Ensuring Health and Drug Stability During Long-Term Space Missions.","authors":"Santhosh Kumar Venugopalan, Sneha Sri R, Harikrishnan N, Pavithra T, Uma Maheshwari G, Abdul Sameer S, Evelyn Sharon, Ankul Singh","doi":"10.2174/0115701638355031250508080213","DOIUrl":"https://doi.org/10.2174/0115701638355031250508080213","url":null,"abstract":"<p><p>Microgravity, space radiation, and pharmaceutical degradation are all long-term chal-lenges for astronauts traveling through space. Radiation exposure is one of the greatest health risks to astronauts in space. Associated with these conditions are acute radiation syndromes, degenerative tissue effects, damage to the central nervous system (CNS), and carcinogenesis. Microgravity and the stress people experience as astronauts cause immunological dysregulation. This study explores strat-egies to counteract the problems of microgravity and its related health risks, including protection against space radiation, prevention of pharmaceutical degradation, and advancements in the emerging field of astropharmacy.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymus atlanticus (Ball) Roussine Exerted Anti-Hyperlipidemic, Anti-Hyperglycemic, and Hepatoprotective Effects in High-Fat and Sucrose Diet-Fed Rats.","authors":"Hamza Elbouny, Brahim Ouahzizi, Imane Elhassani, Khalid Sellam, Chakib Alem","doi":"10.2174/0115701638335977241228171318","DOIUrl":"https://doi.org/10.2174/0115701638335977241228171318","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease continues to be a major global health challenge, characterized by high rates of mortality and morbidity. Medicinal plants, rich in bioactive compounds, offer potential avenues for reducing the incidence of cardiovascular disease.</p><p><strong>Objective: </strong>The objective of this research was to evaluate the efficacy of Thymus atlanticus (T. atlanticus) aqueous extract in preventing hyperlipidemia induced by a high-fat and sugar diet (HFSD) in a rat model.</p><p><strong>Methods: </strong>Male Wistar rats were divided into three groups (n=5). The first group (normal control group) received a normal basal diet. The second group (HFSD group) received a HFSD containing a normal diet (68.5%), lard (15%), cholesterol (1.5%), and sucrose (15%). The third group (HFSD treated with thyme extract) received the HFSD and was administered orally with T. atlanticus extract (500 mg/kg bw). After 8 weeks, blood and liver samples were taken for biochemical analysis.</p><p><strong>Results: </strong>The results showed that HFSD intake elevated plasmatic lipids, blood fasting glucose, hepatic biochemical parameters, and inflammation. Moreover, HFSD resulted in increased liver weight, hepatic lipids, and oxidative stress. However, the treatment with T. atlanticus extract attenuated the altered parameters by lowering or restoring the levels of plasmatic lipids (TGs: -12.21 %; LDL-C: - 21.49 %), glycated hemoglobin (-23.33 %), hepatic parameters (AST: --25.04 %; ALT: -10.42%; ALP: -42.81%), and inflammation. Additionally, thyme extract reduced the levels of hepatic lipids (TGs: -21.13 %; TC: -12.77 %) and ameliorated hepatic oxidative status by reducing malondialdehyde levels (-10.87 %) and enhancing the antioxidant effect (+25.71 %) of hepatic extract.</p><p><strong>Conclusion: </strong>We conclude that the traditionally used aqueous extract of T. atlanticus protected against the detrimental effects of HFSD intake, and its supplementation would be an effective strategy to protect the liver and cardiovascular system. While promising, these benefits need to be validated through clinical trials.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabigerol and Cannabinoid Receptors in Major Depressive Disorder: Network Pharmacology, Molecular Docking, and In-vivo Analysis.","authors":"Abhishek Sharma, Rahul Singh, Shivkant Sharma, Rohit Dutt, Neha Rana, Saud O Alshammari, Qamar A Alshammari, Abdulkarim Alshammari, Saahil Arora, Md Azhar Iqbal, Rubina Bhutani","doi":"10.2174/0115701638363093250324035540","DOIUrl":"https://doi.org/10.2174/0115701638363093250324035540","url":null,"abstract":"<p><strong>Introduction: </strong>Cannabigerol (CBG), being one of the non-psychotropic phyto-cannabinoid, has been labelled and recognized to be antioxidant and neuroprotective; it may conceivably hold depression-relieving activity. Consequently, the objective of the present research procedure was to explore the depression-alleviating competence of cannabigerol in both stressed and unstressed mice using computational/in-silico modelling, followed by in-vivo analysis.</p><p><strong>Method: </strong>Target genes for Major Depressive Disorder (MDD) were identified using GeneCards and Swiss Target Prediction, with common targets screened via Venny software. STRING database anal-ysis established protein-protein interactions (PPI), identifying CNR2 (CB2 receptor) as a key target. Molecular docking of CBG with CB2 (PDB ID: 8GUR) showed strong binding, prompting in vivo evaluation. ADME profiling via Schrödinger Maestro v10.5 confirmed CBG's high oral absorption and favorable pharmacokinetics. Male Swiss albino mice underwent chronic unpredictable mild stress (CUMS) for three successive weeks, with CBG (10, 20, 40 mg/kg) and imipramine (15 mg/kg) administered and various behavioral and biochemical parameters being analyzed.</p><p><strong>Results: </strong>Cannabigerol demonstrated maximum oral absorption in ADME predictions using Schrö-dinger's Maestro (v10.5). Wayne diagram illustrated MDD-related targets, with CB2 (CNR2) rank-ings in top targets, based on SwissADME and Venny software analysis. Docking analysis revealed a high binding affinity (-10.53) for CB2, outperforming cannabidiol (-9.56) and comparable to Δ9-THC (-10.11). During in vivo evaluation, CBG (40 mg/kg) and Imipramine 15mg/kg significantly reduced CUMS-induced exalted plasma corticosterone, nitrite quantities, and monoamine oxidase-A action in the brain of stressed mice. Additionally, both treatments substantially reversed the unpre-dictable chronic stress-induced decline in catalase action, demonstrating CBG's possible potential in alleviating depression-like symptoms in mice.</p><p><strong>Conclusion: </strong>Cannabigerol has shown significant depressive alleviating potential in mice exposed to chronic and unpredictable stress regimes, possibly via interaction with cannabinoid receptors as in-dicated by in-silico modelling, which has been validated by our findings of the in-vivo protocol.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Compounds as a Potential Inhibitor of Biofilm Production: An In silico Study to Identify Natural Hindrance Resources.","authors":"Jai Gupta, Avi Gupta, Debasmita Bhattacharya, Moupriya Nag, Dibyajit Lahiri, Debanjan Mitra","doi":"10.2174/0115701638367145250418033053","DOIUrl":"https://doi.org/10.2174/0115701638367145250418033053","url":null,"abstract":"<p><strong>Background: </strong>Biofilm formation by microorganisms, specifically bacteria, threatens vari-ous fields, including biomedicine and the environment. The development of biofilms has associations with increased resistance to antimicrobial agents and immune responses; it poses a significant threat to human health. ESKAPE pathogens, a group of bacteria known for their multidrug resistance, are particularly adept at biofilm formation. This research explores strategies to combat biofilm-associated infections, with a focus on natural compounds as potential anti-biofilm agents.</p><p><strong>Methods: </strong>The study investigates 23 natural compounds for their druglike properties in fighting against antibiotic-resistant biofilms. These compounds include flavonoids, terpenes, and alkaloids, and exhibit promising bioavailability and usage potential as ligands. Molecular docking analysis em-ploying AutoDock Vina was used to evaluate the binding affinities of these ligands to key biofilm-forming genes and membrane proteins in ESKAPE pathogens.</p><p><strong>Results: </strong>Despite a few violations of a variety of established criteria, the overall safety and efficiency of oral drug reception are maintained, emphasizing their potential for further drug development. The results show specific ligands, such as Baicalin, Apigenin, Azadirachtin, Curcumin, Hyperforin, etc., demonstrating high binding energies against biofilm-associated proteins. This approach aligns with the pursuit of sustainable alternatives to combat biofilm-related infections.</p><p><strong>Conclusion: </strong>Natural compounds like Baicalin, Apigenin, Azadirachtin, Curcumin, Hyperforin not only exhibit broad-spectrum coverage but also show reduced risks of resistance development com-pared to synthetic antibiotics. The integration of natural compounds into multifaceted strategies con-siders the complexities of the biofilm matrix, bacterial diversity, and pathogen characteristics, offer-ing a sustainable approach to address biofilm-associated infections.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Flavonoids and Phenolic Acids of Petroselinum Crispum as a Potential Inhibitor of α-amylase: An in silico Evaluation.","authors":"Ishita Biswas, Trishanjan Biswas, Debanjan Mitra","doi":"10.2174/0115701638361734250414033830","DOIUrl":"https://doi.org/10.2174/0115701638361734250414033830","url":null,"abstract":"<p><strong>Background: </strong>Type II diabetes mellitus is treated as one of the detrimental diseases and the drugs used for its treatment often lead to several side effects. Therefore, herbal medication of plant origin with lesser offshoot is a significant concern. Petroselinum crispum is a plant of pharma-ceutical interest. The present work aims to explore the potentiality assessment of flavonoids of Pe-troselinum crispum as an α-amylase inhibitor.</p><p><strong>Methods: </strong>Compounds were extracted from the database and evaluated through drug likeliness prop-erties, ADMET and toxicity assessment. Molecular docking was done to identify the best ligand, and the dynamics simulation study was performed with the leading ligand-protein complex.</p><p><strong>Results: </strong>Amongst the 15 bioactive compounds, apigenin appeared as the best ligand among all the studied compounds. Moreover, drug likeliness, physiochemical characteristics, and ADMET anal-yses revealed that apigenin does not deviate from Lipiniski's rule of five. Non-toxic apigenin showed a satisfactory docking score of -9.5 kcal/mol with human pancreatic α-amylase compared to the ref-erence molecule acarbose. Apigenin- α-amylase complex and apoprotein were subjected to 100ns molecular dynamics simulation to analyze the stability of the docked protein-ligand complex. The values of RMSD, RMSF, Rg, SASA and hydrogen bonding of the screened complexes showed high stability and less fluctuations of the apigenin- α-amylase complex.</p><p><strong>Conclusion: </strong>This finding suggests apigenin as alternative therapeutics in treating diabetes mellitus by targeting the enzyme α-amylase which can be used for in vitro cross-validation studies. This study is the first documentation of the antidiabetic potentiality of the flavonoid compounds of Petroselinum crispum through in silico investigation.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Techniques and Strategies for Engineering Vaccine Adjuvants: A Comprehensive Review.","authors":"Suman Sharma, Rajani Chauhan, Qumar Negar, Pragya Sharma","doi":"10.2174/0115701638351666250405070745","DOIUrl":"https://doi.org/10.2174/0115701638351666250405070745","url":null,"abstract":"<p><p>Vaccines are biological products used to prevent diseases and ailments caused by viruses, bacteria, and fungi. Vaccine adjuvants increase the potency of the vaccine. The vaccine adjuvants like gold nanoparticle, silver nanoparticle, Lentinan-calcium carbonate microsphere, Aluminium nano metal-organic framework, Poly[di(carboxylatomethylphenoxy)phosphazene] macromolecule, Lignin nanoparticle, Nanostructured hydroxy phosphate synthesized by Chemical and Biosynthesis and their evaluation method have been discussed. Evaluations for physical parameters like particle size and biological evaluation to find out the potency of adjuvants have been discussed. The adjuvant synthesis discussed is a potential method for improvement of the marketed vaccine.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of Potent Telomerase Inhibitors Using Ligand-based Approaches and Molecular Dynamics Simulations Studies.","authors":"Shalini Bajaj, Manikanta Murahari, Mayur Yc","doi":"10.2174/0115701638352883250414054348","DOIUrl":"https://doi.org/10.2174/0115701638352883250414054348","url":null,"abstract":"<p><strong>Background: </strong>Telomerase is a well-recognised and a promising target for cancer therapy. In this study, we selected ligand-based approaches to design telomerase inhibitors for the develop-ment of potent anticancer agents for future cancer therapy.</p><p><strong>Methods: </strong>To investigate the chemical characteristics required for telomerase inhibitory activity, a ligand-based pharmacophore model of oxadiazole derivatives reported from the available literature was generated using the Schrodinger phase tool. This selected pharmacophore hypothesis is validated by screening a dataset of reported oxadiazole derivatives. The pharmacophore model was selected for virtual screening using ZINCPharmer against the ZINC database. The ZINC database molecules with pharmacophore features similar to the selected pharmacophore model and good fitness score were taken for molecular docking studies. With the pkCSM and SwissADME tools we predicted the pharmacokinetic and toxicity of top ten ZINC database compounds based on docking score, binding interactions and identified two in-silico potential compounds with good absorption, distribution, me-tabolism, and less toxicity. Then both the hit molecules were exposed to molecular dynamic simula-tion integrated with MM-PBSA binding free energy calculations using GROMACS tools.</p><p><strong>Results: </strong>The generated pharmacophore model displayed five features, two hydrophobic and three aro-matic rings. The MM-PBSA calculations exhibited that the free binding energy of selected protein-lig-and complexes were found stable and stabilized with non-polar and van-der walls free energies.</p><p><strong>Conclusion: </strong>Our study suggests that ZINC82107047 and ZINC8839196 can be used as hit molecules for future biological screening and for discovery of safe and potent drugs as telomerase inhibitors for cancer therapy.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Darunavir: A Versatile Protease Inhibitor against Microbial Infections.","authors":"Mridul Singh Sengar, Kalpana Rahate, Megha Verma","doi":"10.2174/0115701638336144250331174407","DOIUrl":"https://doi.org/10.2174/0115701638336144250331174407","url":null,"abstract":"<p><p>Microbial infections continue to pose significant threats to global health, necessitating the development of innovative therapeutic strategies. One promising avenue is the use of protease inhib-itors, with darunavir (DRV) emerging as a potent candidate in the field. Designed to combat re-sistance to standard HIV therapy, DRV is a second-generation protease inhibitor. Regarding micro-bial infections, this study sheds light on the internal processes behind the impact of DRV within cells. Novel protease inhibitor DRV targets essential proteolytic enzymes that are essential for microbial survival and growth in order to achieve its antimicrobial actions. By interfering with the proteolytic digestion of important microbial proteins, its inhibitory effect prevents infectious particles from being assembled and maturing. DRV is a viable treatment option for microbial infections as its selective suppression reduces the possibility of off-target consequences. DRV efficiently penetrates the intra-cellular milieu of host cells, where it prevents the proteolytic cleavage of vital viral and bacterial proteins, hence combating pathogenic infections. Microbial infections may be treated in a variety of ways using DRV as it disrupts the cycle of pathogen reproduction. The present review explores the molecular principles behind the effectiveness of DRV against microbial infections, emphasizing the drug's ability to fight a wide range of pathogens. The comprehension of the intracellular activity of DRV is promising for the creation of novel treatment approaches, providing encouragement in the continuous fight against microbial diseases.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Cancer Potential of Scopoletin Derivatives Across Diverse Cancer Cell Lines: A Comprehensive Review.","authors":"Manvi Karayat, Niranjan Kaushik, Deepika Paliwal, Sachin Chaudhary","doi":"10.2174/0115701638379522250412162643","DOIUrl":"https://doi.org/10.2174/0115701638379522250412162643","url":null,"abstract":"<p><p>Scopoletin, a naturally occurring coumarin derivative, has garnered significant attention for its diverse pharmacological properties, including potent anticancer activity. This review provides a comprehensive examination of scopoletin's anticancer effects across a wide range of tumor cell lines. The paper explores its modulation of apoptotic pathways, inhibition concentration (IC50) of cancer cell proliferation, and suppression of metastasis and angiogenesis. Additionally, the review discusses the role of scopoletin in regulating oxidative stress, inflammation, and cell cycle arrest in cancer cells. A detailed analysis of in vitro and in vivo studies highlights its efficacy, specificity, and potential for synergistic effects when used in combination with conventional chemotherapeutics. Hence, this comprehensive review aims to provide a foundation for future research and development of scopoletin as a promising anticancer agent.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superfoods in Drug Discovery: Nutrient Profiles and their Emerging Health Benefits.","authors":"Ravi Kumar Mittal, Vikram Sharma, Gaurav Krishna","doi":"10.2174/0115701638355532250408095114","DOIUrl":"https://doi.org/10.2174/0115701638355532250408095114","url":null,"abstract":"<p><strong>Objective: </strong>This extensive review aims to cover the health and nutritional benefits of su-perfoods. It also discusses the macro- and micronutrients of amla, maca, jackfruit, Brazil nuts, and goji berries. Additionally, we explore the potential of superfoods to protect against chronic diseases, including diabetes, cardiovascular disease, cognitive decline, and cancer.</p><p><strong>Methods: </strong>A comprehensive investigation was carried out to find published literature using Web of Science, PubMed, and Scopus. In addition to Boolean operators (AND, OR), keywords such as \"su-perfood,\" \"bioactive compounds,\" \"functional foods,\" and \"health benefits\" were integrated. Super-foods, their bioactive ingredients, and potential health benefits based on preclinical or clinical data were the subject of permitted research. Research on isolated or synthesized substances unrelated to superfoods, articles without experimental data, and non-peer-reviewed databases were excluded.</p><p><strong>Results: </strong>Our research reveals that superfoods include health-promoting phytochemicals, carotenoids, flavonoids, and polyphenols. They may prevent diseases like diabetes, cardiovascular disease, cancer, and obesity. In conclusion, superfoods improve health and wellness in numerous ways.</p><p><strong>Conclusion: </strong>Superfoods prevent chronic illnesses and improve health. This review discusses the nu-tritional content and health advantages of superfoods, which may encourage their consumption. More research is needed to promote global health and wellness using superfoods.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}