Current drug discovery technologies最新文献

{"title":"Superfoods in Drug Discovery: Nutrient Profiles and their Emerging Health Benefits.","authors":"Ravi Kumar Mittal, Vikram Sharma, Gaurav Krishna","doi":"10.2174/0115701638355532250408095114","DOIUrl":"https://doi.org/10.2174/0115701638355532250408095114","url":null,"abstract":"<p><strong>Objective: </strong>This extensive review aims to cover the health and nutritional benefits of su-perfoods. It also discusses the macro- and micronutrients of amla, maca, jackfruit, Brazil nuts, and goji berries. Additionally, we explore the potential of superfoods to protect against chronic diseases, including diabetes, cardiovascular disease, cognitive decline, and cancer.</p><p><strong>Methods: </strong>A comprehensive investigation was carried out to find published literature using Web of Science, PubMed, and Scopus. In addition to Boolean operators (AND, OR), keywords such as \"su-perfood,\" \"bioactive compounds,\" \"functional foods,\" and \"health benefits\" were integrated. Super-foods, their bioactive ingredients, and potential health benefits based on preclinical or clinical data were the subject of permitted research. Research on isolated or synthesized substances unrelated to superfoods, articles without experimental data, and non-peer-reviewed databases were excluded.</p><p><strong>Results: </strong>Our research reveals that superfoods include health-promoting phytochemicals, carotenoids, flavonoids, and polyphenols. They may prevent diseases like diabetes, cardiovascular disease, cancer, and obesity. In conclusion, superfoods improve health and wellness in numerous ways.</p><p><strong>Conclusion: </strong>Superfoods prevent chronic illnesses and improve health. This review discusses the nu-tritional content and health advantages of superfoods, which may encourage their consumption. More research is needed to promote global health and wellness using superfoods.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-based Virtual Screening and Hit Identification of Novel designed Quinazolin-4(3H)-one Derivatives as Antitubercular Agent Against targets Polyketide Synthase 13 and DNA gyrase of Mycobacterium tuberculosis.","authors":"Revathi G, Sowmiya P, Girija K","doi":"10.2174/0115701638362095250402180030","DOIUrl":"https://doi.org/10.2174/0115701638362095250402180030","url":null,"abstract":"<p><strong>Background: </strong>After COVID-19, tuberculosis remained the world's second most infectious fatal disease in 2022, with about 410 million people developing MDR TB, according to WHO. The fast increase of MDR and XDR-TB has posed a significant clinical problem in tuberculosis treatment. Bedaquiline, the first FDA-approved medicine for MDR-TB treatment, has caused cardiotoxicity and hepatotoxicity due to high lipophilicity or hERG potassium channel blockage throughout the last four decades. To overcome medication resistance and toxicity, there is an urgent need to create innovative drugs with improved efficacy against specific enzymes.</p><p><strong>Methods: </strong>The work focused on the biological importance of the Quinazoline pharmacophore scaf-fold, and it involved the virtual screening and development of 180 novel Quinazoline derivatives in order to find potential hit candidates against molecular dual targets (Pks-13 esterase and DNA gy-rase). Based on docking scores lower than (-7.5, -7.6 kcal/mol) of the standard compound, 80 drug molecules were screened using AUTODOCK vina and filtered by ADMET profile. The top five HIT compounds developed with good binding interactions, acceptable ADME features that obeys the Lipinski Rule of Five, and no toxicity produced as compared to standard bedaquiline were chosen.</p><p><strong>Results: </strong>Docking scores showed that compound RBSI64 had a substantial binding affinity against dual targets (-11.6, -8.2 kcal/mol) than Bedaquiline (-7.5, -7.6 kcal/mol). MD simulation at 100 ns was carried out to investigate the protein's dynamic behaviour with the standard and ligand complex.</p><p><strong>Conclusion: </strong>The results indicated that RBSI64 could be a useful template for developing MDR and XDR-TB inhibitors. The current study contributes to the identification of promising antitubercular candidates against targeted enzymes.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Integration of Artificial Intelligence and Blockchain Technologies for Empowerment of Drug Discovery and Development.","authors":"Virendra S Gomase, Devendra L Visokar, Vitthal V Chopade","doi":"10.2174/0115701638361312250402125556","DOIUrl":"https://doi.org/10.2174/0115701638361312250402125556","url":null,"abstract":"<p><p>The effective integration of blockchain technology and artificial intelligence (AI) has the potential to change healthcare management. Two cutting-edge developments in the healthcare indus-try are blockchain and artificial intelligence. Blockchain, an open network for information sharing and permission, is being used in e-Health to apply artificial intelligence models. Healthcare workers will be able to view patient medical records on the blockchain. Artificial intelligence (AI) makes use of a wide range of suggested algorithms, decision-making power, and vast amounts of data. Health care services can be made more decentralized, transparent, safe, and impenetrable with the use of blockchain technology. AI needs cryptographic records to be stored, and blockchain makes this pos-sible. Applications of artificial intelligence in healthcare management include chatbots for diagnosis and treatment, predictive analytics, personalized medicine, and more. Blockchain technology has ap-plications in supply chain management, clinical trial management, interoperability, and data security and integrity in healthcare management. A more effective, safe, and patient-centered healthcare eco-system can be created by integrating blockchain technology and artificial intelligence (AI) into healthcare management. It can encourage the development of a wide range of applications in radiol-ogy, cancer treatment, cardiology, dermatology, and fundoscopy that may save patients' lives.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Development and Characterization of Nisoldipine Analogues for Enhanced Solubility and Therapeutic Potential in the Treatment of Angina Pectoris.","authors":"Pavankumar Krosuri, Mothilal Mohan","doi":"10.2174/0115701638359244250411045740","DOIUrl":"https://doi.org/10.2174/0115701638359244250411045740","url":null,"abstract":"<p><strong>Background: </strong>Angina pectoris, a common cardiovascular condition, necessitates the de-velopment of effective therapeutic agents. Nisoldipine, a calcium channel blocker, and its analogues have shown potential in treating this condition. However, the optimization of these compounds for enhanced therapeutic efficacy remains a critical challenge.</p><p><strong>Objective: </strong>This study aimed to investigate the therapeutic potential of Nisoldipine analogues through in silico analysis, with the goal of identifying lead compounds for the treatment of angina pectoris and optimizing their formulation for improved solubility and drug release.</p><p><strong>Methods: </strong>Eighteen Nisoldipine derivatives were screened using in silico techniques, including mo-lecular docking, SWISS ADME analysis, and molecular dynamics (MD) simulations. The top candi-date, ZINC26826387, was identified and further analyzed. A comprehensive gene set analysis was performed using OMIM, GeneCards, and STITCH databases to identify target hub genes associated with angina pectoris. PPI network analysis and CytoHubba ranking were used to prioritize key genes for further study. Additionally, the lead compound was optimized through nanoparticle formulation, and the resulting nanoparticle tablets were characterized for solubility, dissolution, particle size, en-trapment efficiency, and zeta potential. ANOVA was used to analyze the characterization data.</p><p><strong>Results: </strong>ZINC26826387 emerged as the most promising Nisoldipine analogue, exhibiting superior solubility, absence of AMES toxicity, strong molecular docking interaction with the target protein (docking score of -8.0 kcal/mol), and favourable pharmacokinetic properties. MD simulation con-firmed the stability of the ligand-receptor complex. The study also identified 88 target hub genes associated with angina pectoris, with PTGS2 prioritized as a key gene. The nanoparticle formulation of ZINC26826387 significantly enhanced solubility by 2.53-fold compared to the unformulated com-pound. The optimized nanoparticle tablets achieved a 98.53% drug release within 30 minutes, with an average particle size of 50 nm, entrapment efficiency of 98.89%, and zeta potential of -52 mV, indicating good stability and uniformity.</p><p><strong>Conclusion: </strong>The study demonstrates the therapeutic potential of ZINC26826387, a Nisoldipine ana-logue, through its enhanced solubility and reduced Crystallinity. The lead compound was made into Nanoparticles using Pluronic F407 as carrier. These nanoparticles were further formulated to oral disintegrating tablets for rapid drug release, good stability compared to conventional tablets. These findings suggest that ZINC26826387 could be a promising candidate for the treatment of angina pec-toris.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Activity and Therapeutic Potential of Coumarin Derivatives: A Comprehensive Review.","authors":"Shristi Singh, Niranjan Kaushik, Ajita Paliwal, Mridul Singh Sengar, Deepika Paliwal","doi":"10.2174/0115701638374546250323152450","DOIUrl":"https://doi.org/10.2174/0115701638374546250323152450","url":null,"abstract":"<p><p>Coumarins, naturally occurring benzopyrones, have garnered significant attention due to their diverse pharmacological activities and therapeutic potential. Derived from natural sources and synthetic routes such as the Perkin and Pechmann reactions, these compounds exhibit a broad spec-trum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, an-tidiabetic, and neuroprotective effects. The structure-activity relationship of coumarins highlights the critical role of substitutions at specific positions on the benzopyrone ring, enhancing their efficacy and selectivity. Notable applications include anticancer activities, with coumarin derivatives inhibit-ing tumor growth and inducing apoptosis in breast cancer and melanoma cells, and neuroprotection, particularly in Alzheimer's and Parkinson's diseases, through acetylcholinesterase inhibition and β-amyloid modulation. Additionally, coumarins show promise in combating drug-resistant pathogens and oxidative stress. Despite their potential, challenges such as toxicity and bioavailability remain. Future research should focus on optimizing coumarin scaffolds and advancing clinical evaluations to establish their role as next-generation therapeutic agents.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review of the Nutritional Value and Biological Properties of Mushrooms.","authors":"Monalisa Gochhi, Priyanka Dash, Niranjan Chinara, Hrudesh Priyadarsan Sahoo, Vineet K Rai, Jitu Halder, Chandan Das, Goutam Ghosh, Goutam Rath, Biswakanth Kar","doi":"10.2174/0115701638369335250317040625","DOIUrl":"https://doi.org/10.2174/0115701638369335250317040625","url":null,"abstract":"<p><p>The temperate, subtropical climates of Odisha state, India, provide significant benefits that can help it become a potent producer of many species of edible mushrooms. The importance of mush-rooms in diets has gained more attention in recent years due to their nutritional benefits. We aimed to update and discuss the current research information on nutritional components, including carbo-hydrates (β-glucans, trehalose, glucose), dietary fiber, proteins (ostreatin), amino acids (valine, glu-tamine, glutamic acid, aspartic acid, and arginine, lipids, vitamins (thiamine, riboflavin, pyridoxine, pantothenic acid, niacin, folic acid, nicotinic acid, and cobalamin), minerals (K, P, Na, Ca, Mg), flavor and taste contents of Odisha cultivated edible mushrooms. Additionally, their biological appli-cation in terms of antimicrobial action, antitumor, anti-inflammatory, anti-diabetic, cardioprotective properties, and antioxidant properties with mechanism of action are highlighted. Besides, we men-tioned the limitations and prospects of mushrooms.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In-Silico Investigation of the Potential of Vitamin D as a 5-HT1A Receptor Agonist: A Molecular Modeling Approach for Evaluating its Pharmacological Prospects.","authors":"Houda Filali, Mohammed Mouhcine, Ibtihal Segmani, Youness Kadil, Imane Rahmoune, Mohamed Agoub","doi":"10.2174/0115701638359333250314062331","DOIUrl":"https://doi.org/10.2174/0115701638359333250314062331","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D plays a crucial role in maintaining muscle and bone health and has been increasingly implicated in neurological disorders, including depression and anxiety, which are closely associated with dysregulation of the serotonin 1A receptor (5-HT1A receptor). This study employs molecular modeling techniques to investigate the potential agonistic activity of Vitamin D on the 5-HT1A receptor. Additionally, it seeks to elucidate the key structural motifs and molecular interactions that underline the binding affinity between Vitamin D and the receptor. The insights gained from this research may inform the design of Vitamin D-derived compounds with optimized pharmacological profiles, contributing to therapeutic advancements in related neurological condi-tions.</p><p><strong>Methods: </strong>We selected five structures of the 5-HT1A receptor (PDB IDs: 7E2Y, 7E2Z, 8W8B, 8JSP, and 8JT6) for Protein-Ligand Interaction Fingerprint (PLIF) analysis. We conducted molecular dock-ing to evaluate the binding efficiency of two forms of Vitamin D,ergocalciferol and cholecalciferol, to the 5-HT1A receptor. Following this, we performed Molecular Dynamics (MD) simulations to assess the stability of these interactions.</p><p><strong>Results: </strong>Docking results revealed binding energies below -6.64 kcal/mol for both forms of Vitamin D, with ergocalciferol achieving a maximum binding energy of -7.78 kcal/mol. ASP116 emerged as a pivotal residue in stabilizing these interactions. MD simulations indicated that the Vitamin D-5-HT1A complexes exhibited stability comparable to the serotonin-bound 5-HT1A receptor complex.</p><p><strong>Conclusion: </strong>Our study suggests that Vitamin D may function as an agonist for the 5-HT1A receptor, with ASP116 playing a critical role in binding. Yet, further in vitro and in vivo studies are necessary to validate these findings and explore the therapeutic potential of Vitamin D-derived compounds.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Biomarkers for Diagnosis and Prediction in Type 1 Diabetes: An Overview.","authors":"Omkar Janjire, Addepalli Veeranjaneyulu, Shivani Desai, Govind Kale","doi":"10.2174/0115701638319534250314075737","DOIUrl":"https://doi.org/10.2174/0115701638319534250314075737","url":null,"abstract":"<p><p>An autoimmune disorder known as type 1 diabetes (T1D) causes the pancreas to stop pro-ducing insulin. An autoimmune response against beta cells causes this metabolic condition, which is more typically observed in children and young adults and causes a shortage of insulin and hypergly-cemia.T1D development is influenced by a variety of variables, including physiological events, ge-netic, epigenetic, immunologic, and lifestyle variables. Biomarkers like glucose, glycated substances, C-peptides, autoantibodies, and genetic biomarkers can be used to diagnose and predict T1D. Due to the disease's growing incidence worldwide, it is essential to have biomarkers that can diagnose and predict the onset or progression of T1D. In previous years, significant work has been undertaken to find new markers and comprehend the etiology of T1D. In order to analyze proteins, nucleic acids, and metabolites, high-throughput and sensitive omics technology has been developed. This has made it possible to profile protein expression and gene modifications in T1D patients on a wide scale. These methods might aid in lowering the morbidity and mortality linked to T1D and its complications.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on the Role of Cellular Redox System in Health and Illness.","authors":"Manvi Karayat, Kalpana Rahate, Shristi Singh","doi":"10.2174/0115701638349511250121114323","DOIUrl":"https://doi.org/10.2174/0115701638349511250121114323","url":null,"abstract":"<p><p>An imbalance between Reactive Oxygen Species (ROS) and antioxidants in the circulatory system leads to oxidative stress, which has been linked to several pathological conditions, including cancer, aging, and neurological and cardiovascular diseases. Antioxidants play a crucial role in re-ducing oxidative damage by neutralizing harmful free radicals and preventing cellular injury. The processes generating cellular oxidative stress and the curative effects of antioxidants, the origins and effects of reactive oxygen species (ROS), the role that oxidative stress plays in the pathogenesis of disease, and the several kinds of antioxidants-including enzymatic and non-enzymatic antioxidants are thoroughly explored in this review. We also emphasized the medicinal uses of antioxidants, both natural and synthetic, in the prevention and treatment of disorders associated with oxidative stress. Furthermore, we discussed the challenges and potential paths ahead for antioxidant research, such as developing new antioxidant molecules with higher efficacy and improving antioxidant delivery sys-tems. This study provides information regarding the complicated dynamics of oxidative stress and the potential benefits of antioxidants for preserving cellular homeostasis and advancing human health.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Management: Unlocking the Crucial Role of PROTACs in Cancer Treatment.","authors":"Priyanka Gupta, Sumit Dutta, Prashant Kumar, Monika Kaushik, Sumel Ashique, Mithun Bhowmick","doi":"10.2174/0115701638324854250218053353","DOIUrl":"https://doi.org/10.2174/0115701638324854250218053353","url":null,"abstract":"<p><p>Targeted Protein Degradation (TPD) offers a solution, eliminating disease-related proteins and overcoming challenges associated with unintended toxicity and lack of precision. PROTACs (Proteolysis Targeting Chimeras) represent an innovative strategy for the specific degradation of tar-get proteins through the UPS (Ubiquitin-Proteasome System). In comparison to conventional protein inhibitor medications, PROTAC offers advantages in terms of efficacy, selectivity, and the ability to overcome drug resistance in cancer treatment, contributing novel perspectives to the field of anti-cancer drug discovery. Proteins play vital roles in an organism's health, and misfolded contributes to diseases like neurodegenerative disorders and cancer. Cells maintain protein balance through quality control systems, primarily the UPS and autophagy. Protac, a Targeted Protein Degradation (TPD) strategy, utilizes UPS, employing small molecules to induce targeted protein degradation. PROTAC exhibits promise in preclinical studies and clinical trials for diverse cancers. Notable examples in-clude breast cancer, where PROTAC targets CDK4/6 (cyclin-dependent kinase) and Estrogen Recep-tors (ER), prostate cancer, addressing Androgen Receptor (AR) degradation, hematologic malignan-cies, focusing on AURORA-A and CDKs, and NSCLC (Non-Small-Cell Lung Cancer), targeting Estimated Glomerular Filtration Rate (EGFR), and KRAS. Despite their potential, PROTAC faces challenges, including compensatory protein expression in response to targeted therapies. This com-prehensive review explores recent advancements in PROTAC and related technologies, emphasizing the mechanisms and structures of PROTAC and their applications in proteins targeting cancer.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}