Advancements in Drug Discovery Techniques for Cancer Treatment: Clinical Progress and Future Directions.

Abstract

Cancer has emerged as one of the most pressing public health issues in the world and has led to extensive research in novel treatment techniques. Among them, cancer treatment strategies targeting disease-specific pathways have become a focus area. Targeted therapy, based on the premise that tumor cells rely on specific biological pathways, which drugs can block, has dramatically im-proved therapeutic outcomes with reduced systemic toxicity. Molecule targeted treatment that in-cludes interference with signaling pathway through the small molecule medication, or therapeutic monoclonal antibody, has exceptional anti-cancer effect on most different cancer types that it is pri-marily prescribed as front-line treatment at this time; and, instead of chemotherapy and conventional therapy treatment, it entails less side-effect risk and the benefit of delivering the killing to cancer cells as it should: namely, far better anti-cancer efficacy. The main problems in conducting molecular targeted therapies include rapid induction of drug-resistant states. For addressing this issue, research-ers have taken up many approaches, which include combination therapy, next-generation targeted agents, and adaptive therapy. This review provides a comprehensive overview of the recent advances in targeted therapeutic medications, classifies them, and provides a short description of the target kinases along with mechanisms of action. Clinical examples of targeted therapies are provided and discussed along with potential future research areas. This article also brings to the discussion the need to further investigate mechanisms that would aid in making anti-cancer treatment more efficient, which includes emerging technologies such as nanomedicine, precision oncology, and personalized therapies, making the future bright for cancer care.