{"title":"Theranostic Applications of Microrobots: Integrating Diagnostics and Precision Drug Delivery.","authors":"Pushpender Sharma, Chirag Jain, Shikha Baghel Chauhan, Indu Singh","doi":"10.2174/0115701638375694250703160236","DOIUrl":null,"url":null,"abstract":"<p><p>A game-changing strategy in precision medicine is theranostics, which is the combination of diagnostics and treatments on one platform. Microrobots have drawn a lot of interest as promising agents in theranostic applications because of their small size, agility, and multifunctionality. This anal-ysis highlights the potential of microrobots to transform illness management by examining how they can integrate precise medicine delivery and diagnostic capabilities. Advanced features like imaging for focused diagnostics, payload delivery for precision therapies, and biosensing for real-time disease monitoring can be built into microrobots. These microrobots can navigate intricate biological environ-ments and provide localized intervention at the cellular and subcellular levels. They are propelled by external pressures such as magnetic fields or biological mechanisms. Recent advancements in micro-robots, including biocompatible polymers and stimuli-responsive systems, offer potential for early dis-ease identification and targeted drug release in neurological, cardiovascular, and malignant diseases. Along with solutions, issues like scalability, regulatory approval, and biocompatibility are also cov-ered. With an emphasis on their role in influencing the development of integrated healthcare solutions, this paper offers a thorough summary of technological developments and potential applications of mi-crorobots in theranostics. The study authors examined databases such as PubMed, Scopus, Google Scholar, and Web of Science for peer-reviewed articles published within the last 10 years on theranostic microrobots, diagnostic tools, drug delivery systems, and precision medicine. It comprised empirical research on microrobot design, functioning, therapeutic applications, diagnostic capabilities, treatment results, and safety profiles. This methodical methodology found patterns, gaps, and advances in the discipline.</p>","PeriodicalId":93962,"journal":{"name":"Current drug discovery technologies","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current drug discovery technologies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115701638375694250703160236","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A game-changing strategy in precision medicine is theranostics, which is the combination of diagnostics and treatments on one platform. Microrobots have drawn a lot of interest as promising agents in theranostic applications because of their small size, agility, and multifunctionality. This anal-ysis highlights the potential of microrobots to transform illness management by examining how they can integrate precise medicine delivery and diagnostic capabilities. Advanced features like imaging for focused diagnostics, payload delivery for precision therapies, and biosensing for real-time disease monitoring can be built into microrobots. These microrobots can navigate intricate biological environ-ments and provide localized intervention at the cellular and subcellular levels. They are propelled by external pressures such as magnetic fields or biological mechanisms. Recent advancements in micro-robots, including biocompatible polymers and stimuli-responsive systems, offer potential for early dis-ease identification and targeted drug release in neurological, cardiovascular, and malignant diseases. Along with solutions, issues like scalability, regulatory approval, and biocompatibility are also cov-ered. With an emphasis on their role in influencing the development of integrated healthcare solutions, this paper offers a thorough summary of technological developments and potential applications of mi-crorobots in theranostics. The study authors examined databases such as PubMed, Scopus, Google Scholar, and Web of Science for peer-reviewed articles published within the last 10 years on theranostic microrobots, diagnostic tools, drug delivery systems, and precision medicine. It comprised empirical research on microrobot design, functioning, therapeutic applications, diagnostic capabilities, treatment results, and safety profiles. This methodical methodology found patterns, gaps, and advances in the discipline.
精准医疗的一个改变游戏规则的策略是治疗学,即在一个平台上结合诊断和治疗。微型机器人由于其体积小、敏捷性强和多功能性强,在治疗应用中作为有前途的代理人引起了人们的极大兴趣。这一分析强调了微型机器人的潜力,通过研究它们如何整合精确的药物输送和诊断能力,来改变疾病管理。先进的功能,如聚焦诊断的成像,精确治疗的有效载荷交付,以及实时疾病监测的生物传感,都可以内置到微型机器人中。这些微型机器人可以在复杂的生物环境中导航,并在细胞和亚细胞水平上提供局部干预。它们是由外部压力如磁场或生物机制推动的。微型机器人的最新进展,包括生物相容性聚合物和刺激反应系统,为神经、心血管和恶性疾病的早期疾病识别和靶向药物释放提供了潜力。除了解决方案,还包括可扩展性、监管批准和生物相容性等问题。本文重点介绍了微型机器人在影响综合医疗解决方案发展中的作用,对微型机器人在治疗学中的技术发展和潜在应用进行了全面的总结。该研究的作者检查了PubMed、Scopus、b谷歌Scholar和Web of Science等数据库,以获取近10年来发表的关于治疗微型机器人、诊断工具、药物输送系统和精准医学的同行评议文章。它包括对微型机器人的设计、功能、治疗应用、诊断能力、治疗结果和安全性的实证研究。这种有条理的方法论发现了该学科的模式、差距和进步。