当前3D打印技术及其在药物输送、个性化医疗和制药科学方面的潜在应用。

Virendra S Gomase, Arjun P Ghatule, Rupali Sharma, Sarang Pathak
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引用次数: 0

摘要

导读:医药3D打印已经成为一项革命性的技术,正在彻底改变药物研究、个性化治疗和给药方法。本文探讨了3D打印如何使精确的剂量、复杂的给药方法和个性化的药物配方成为可能,这有助于制药行业克服主要障碍。3D打印通过个性化治疗和加速开发过程,为更有效和针对患者的治疗打开了大门。本研究的目的是探索当前3D打印技术在药物输送、个性化医疗和制药科学方面的潜在应用,以提高治疗效果和患者护理。方法:深入研究了3D打印技术在制药领域的最新进展。研究的主要技术是熔融沉积建模(FDM)、立体光刻(SLA)和选择性激光烧结(SLS),重点是它们在药物输送装置、定制剂型和生物打印组织生产中的应用。该研究还研究了一系列材料,即水凝胶、生物墨水和聚合物,以评估它们在制药应用中的适用性。结果:研究结果表明,在定制药物配方的创建方面取得了重大进展,可以通过3D打印实现精确的剂量和修改的释放模式。此外,生物打印在再生医学和组织工程方面也显示出了前景。3D打印正在加速复杂的药物输送系统的创建,如植入物和贴片,尽管存在技术和法律障碍,但仍能提高治疗效果和患者的依从性。讨论:这项研究强调了3D打印在制药科学中的变革作用,特别是在实现个性化医疗和先进的药物输送系统方面。FDM、SLA和SLS等3D打印技术在生产定制剂型和复杂的给药设备方面显示出了很好的应用前景。量身定制药物的能力,以个别病人的需要提高治疗效果,并尽量减少副作用。3D打印已经成为再生医学和患者特定解决方案的潜在工具。结论:制药3D打印为定制治疗和药物创造提供了突破性的潜力。它能够根据每个患者的需求开发解决方案,提高治疗效果并最大限度地减少不良反应。即使仍然存在问题(主要是可扩展性和法规遵从性),材料和技术的不断改进也为其在医疗保健领域的应用提供了增长的可能性。凭借其以患者为中心,有效和创造性的药物生产选项,3D打印将彻底改变医疗领域。本研究展示了3D打印技术的最新进展及其在药物输送、个性化医疗和制药科学方面的新兴应用,突出了创新的、针对患者的治疗解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current 3D Printing Technologies and Their Potential Applications in Drug Delivery, Personalized Medicine & Pharmaceutical Sciences.

Introduction: Pharmaceutical 3D printing has become a revolutionary technique that is revolutionizing drug research, personalized treatment, and medication delivery methods. This article examines how accurate dosing, complicated drug delivery methods, and personalized drug formulations are made possible by 3D printing, which helps the pharmaceutical sector overcome major obstacles. 3D printing opens the door to more efficient and patient-specific treatments by personalizing therapies and accelerating the development process. The purpose of this study is to explore the potential applications of current 3D printing technologies in drug delivery, personalized medicine, and pharmaceutical sciences to enhance treatment results and patient care.

Method: The latest advancements in 3D printing technology utilized in the pharmaceutical sector were thoroughly examined. The main techniques studied are fused deposition modelling (FDM), stereolithography (SLA), and selective laser sintering (SLS), with a focus on their usage in the production of drug delivery devices, customized dosage forms, and bioprinted tissues. The study also looked at a range of materials, i.e., hydrogels, bioinks, and polymers, to assess their suitability for use in pharmaceutical applications.

Results: The findings demonstrate significant advancements in the creation of customized pharmaceutical formulations which may be 3D printed to allow for exact dosages and modified release patterns. Additionally, bioprinting has demonstrated promise in regenerative medicine and tissue engineering. 3D printing is speeding up the creation of intricate drug delivery systems, like implants and patches, which improve treatment results and patient adherence in spite of technological and legal obstacles.

Discussion: This study highlights the transformative role of 3D printing in pharmaceutical sciences, particularly in enabling personalized medicine and advanced drug delivery systems. 3D printing techniques like FDM, SLA, and SLS have shown promising applications in producing customized dosage forms and complex drug delivery devices. The ability to tailor medications to individual patient needs enhances therapeutic outcomes and minimizes side effects. 3D printing has emerged as a potential tool in regenerative medicine and patient-specific solutions.

Conclusion: Pharmaceutical 3D printing offers ground-breaking potential for customized treatment and medication creation. It enables the development of solutions that are tailored to the requirements of every patient, increasing therapeutic efficacy and minimizing adverse effects. Even if there are still issues, mainly with scalability and regulatory compliance, continuous improvements in materials and technology hold out the possibility of growing its use in healthcare. With its patient-centered, effective, and creative pharmaceutical production options, 3D printing is set to revolutionize the medical field. This study presents a current advancement in 3D printing technologies with their emerging applications in drug delivery, personalized medicine, and pharmaceutical sciences, highlighting innovative, patient-specific therapeutic solutions.

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