Cureus最新文献

{"title":"A Rare Manifestation of a Rare Disease: Nodular Lymphocyte-Predominant Hodgkin Lymphoma Presenting As Paraneoplastic Aseptic Meningitis.","authors":"Aishwarya Saripalli, Elaine Deemer, Kasey Fox","doi":"10.7759/cureus.86327","DOIUrl":"10.7759/cureus.86327","url":null,"abstract":"<p><p>Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon form of Hodgkin lymphoma (HL). It commonly presents as chronic, asymptomatic, slow-growing peripheral lymphadenopathy. Central nervous system involvement in NLPHL is rare. Here we report a case of a 28-year-old male patient who presented with a seven-week history of headache and neck pain. The evaluation revealed a diagnosis of subacute meningitis. He was newly diagnosed with NLPHL on lymph node biopsy. With this presentation of subacute aseptic meningitis with a negative workup for infectious, autoimmune etiology, and absence of malignant cells in the CSF, in the setting of newly diagnosed NLPHL, a diagnosis of paraneoplastic aseptic meningitis was made. The patient improved symptomatically with the treatment of his cancer.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86327"},"PeriodicalIF":1.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Odyssey of Dissociative Identity Disorder: A Case Report of Prolonged Misrecognition.","authors":"Enoch Chi Ngai Lim, Chi Eung Danforn Lim","doi":"10.7759/cureus.86278","DOIUrl":"10.7759/cureus.86278","url":null,"abstract":"<p><p>Dissociative identity disorder (DID) is characterised by two or more distinct personality states, often resulting from severe childhood trauma. The disorder is frequently misdiagnosed as depression, anxiety, or borderline personality disorder. This case study is regarding a 28-year-old Caucasian woman with mental health challenges since primary school, including a bullying and domestic violence history, who received multiple incorrect diagnoses (depression, anxiety, panic disorder) given by various psychiatrists, psychologists and general practitioners over several years. Patient treatment with tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors failed to produce any improvements. At age 16, a specialist general practitioner considered the former diagnoses were incorrect and recognised the need for multidisciplinary assessment, leading to referral to a specific psychiatry diagnostic service at a tertiary teaching hospital, where she was correctly diagnosed with DID. Psychologists with a special interest in DID provided the patient with intensive psychotherapy sessions. Her 12-year journey through therapy resulted in significant mental health recovery in addition to finishing her university degree and obtaining a job. This case highlights the importance of recognising DID, challenges in differential diagnosis, and the need for specialised multidisciplinary care.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86278"},"PeriodicalIF":1.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden Cardiac Arrest With Ventricular Fibrillation in a Patient With Epilepsy and a Vagus Nerve Stimulator.","authors":"Abdelhalim Eltaib, Ahmed Abdelmageed, Aftab Gill","doi":"10.7759/cureus.86182","DOIUrl":"10.7759/cureus.86182","url":null,"abstract":"<p><p>Sudden cardiac arrest (SCA) in patients with epilepsy, particularly those with vagus nerve stimulators (VNS), is rare but clinically significant. We report the case of a 36-year-old woman with known epilepsy and a VNS implant who suffered an out-of-hospital cardiac arrest (OHCA) following a witnessed tonic-clonic seizure. Emergency services identified ventricular fibrillation (VF), and successful defibrillation led to the return of spontaneous circulation (ROSC). Initial investigations, including imaging and laboratory studies, were unremarkable. A multidisciplinary evaluation involving neurology and cardiology was undertaken to explore potential seizure-related cardiac mechanisms and the possible role of the VNS device. This case highlights the complex interplay between epilepsy, autonomic dysfunction, and arrhythmia, emphasising the importance of integrated care and further research into neurocardiac interactions in patients with epilepsy.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86182"},"PeriodicalIF":1.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Musculoskeletal and Neurological Toxicities Associated With the BPaLM Regimen: A Clinical Evaluation of Arthralgia and Peripheral Neuropathy in Patients With Multidrug-Resistant Tuberculosis (MDR-TB).","authors":"Zahir Khan, Gohar Ali, Rumman, Ashraf, Akmal Naveed, Shahid Salam, Ubaid Ullah, Ahmad Ismail, Afrasyab Altaf","doi":"10.7759/cureus.86248","DOIUrl":"10.7759/cureus.86248","url":null,"abstract":"<p><strong>Background: </strong>Musculoskeletal and neurological toxicities are common side effects of the BPaLM (bedaquiline, pretomanid, linezolid, and moxifloxacin) regimen, an emerging treatment for multidrug-resistant tuberculosis (MDR-TB). These toxicities, particularly arthralgia and peripheral neuropathy, can significantly impair the quality of life of patients undergoing treatment. Despite the promising therapeutic benefits of the BPaLM regimen, the prevalence and severity of these side effects remain underexplored. Understanding these toxicities is crucial to improving patient management strategies and ensuring better treatment adherence.</p><p><strong>Objective: </strong>This study aims to determine how common and severe musculoskeletal and neurological toxicities, particularly arthralgia and peripheral neuropathy, are among MDR-TB patients treated with the BPaLM regimen.</p><p><strong>Materials and methods: </strong>This prospective observational study was conducted at the Programmatic Management of Drug-Resistant Tuberculosis in Mardan Medical Complex between January 2024 and April 2025. Patients with MDR-TB undergoing treatment with the BPaLM regimen were monitored for musculoskeletal and neurological toxicities, specifically arthralgia and peripheral neuropathy. Clinical evaluations included assessing the onset, severity, and impact of joint pain and nerve damage, as well as evaluating the effectiveness of pain management and physical therapy interventions. Data collection included demographic information, comorbidities, and baseline physical activity levels. Statistical analysis was performed using SPSS Statistics version 26 (IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp.), Python (Python Software Foundation, Beaverton, OR, USA), and R 4.4.5 (R Foundation for Statistical Computing, Vienna, Austria) to identify significant predictors of toxicity severity through descriptive statistics, chi-square tests, and decision tree modeling. Kaplan-Meier survival analysis was also conducted to assess the relationship between toxicity severity and treatment outcomes.</p><p><strong>Results: </strong>Among the 44 MDR-TB patients, 35 (79.54%) experienced mild to moderate arthralgia, with knee pain being most common (34, 77.27%). Peripheral neuropathy was reported in 26 (59.09%) patients, with the lower limbs (20, 45.45%) being most affected. Kaplan-Meier survival analysis revealed a significant difference in survival times based on the severity of arthralgia and peripheral neuropathy, with more severe symptoms correlating with reduced survival duration.</p><p><strong>Conclusions: </strong>The findings underscore the importance of early identification, regular monitoring, and personalized management strategies to mitigate the burden of these toxicities and enhance patient outcomes.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86248"},"PeriodicalIF":1.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-Related Differences in the Hospitalization Outcomes for Gastroparesis.","authors":"Ahmed Ali Aziz, Rehan Shah, Muhammad Ali Aziz, Muhammad Amir, Ijlal Akbar Ali","doi":"10.7759/cureus.86239","DOIUrl":"10.7759/cureus.86239","url":null,"abstract":"<p><p>Background Gastroparesis (GP) is a chronic condition in which the stomach takes too long to empty its contents into the small intestine, despite the absence of any physical blockage. Females are generally more susceptible to developing GP than males. The objective of this study was to compare clinical outcomes between male and female patients hospitalized with GP using the Nationwide Inpatient Sample (NIS) database. Methods Using the NIS databases from 2020 to 2022 and the International Classification of Diseases, Tenth Edition Revision (ICD-10) codes, we performed a retrospective study of adult patients admitted with GP. We compared inpatient outcomes of GP between males and females. All-cause in-hospital mortality was the primary outcome. Secondary outcomes were total hospitalization cost adjusted to the year 2022, length of stay (LOS), incidence of sepsis, acute renal failure (ARF), shock, and need for intensive care unit (ICU) admission. We used STATA, version 16.1 (StataCorp LLC, College Station, TX), to perform the statistical analyses. Multivariate logistic regression analysis was conducted to assess whether gender was an independent predictor for these outcomes and to adjust for any confounders. Results It was noted that 31,114 adult patients were admitted for GP from 2020 to 2022; 23,886 (76.77%) were females, and 7,228 (23.23%) were males. The mean age of both males and females was 47.2 years. Males had a higher prevalence of diabetes mellitus type 1 (DM1), diabetes mellitus type 2 (DM2), congestive heart failure (CHF), chronic kidney disease (CKD), and smoking/tobacco use. Females had a higher prevalence of prior cerebrovascular accident (CVA) and obesity. We found that female patients with GP had significantly longer LOS (+0.88 days, 95% CI: 0.53 - 1.29, P <0.01), higher total hospitalization costs (+$9,129.4, 95% CI: 4,946.0-13,312.7, P <0.01), and higher likelihood of venous thromboembolism (VTE) (adjusted odds ratio (aOR) 1.69, 95% CI: 0.83-3.44, P=0.147) as compared to males. Female patients had lower odds of developing sepsis (aOR: 0.60, 95% CI: 0.43-0.85, P <0.01), ARF (aOR 0.48, 95% CI: 0.41-0.56, P <0.01), shock (aOR: 0.54, 95% CI: 0.24-1.22, P=0.143), ICU admission (aOR 0.73, 95% CI: 0.57-0.92, P <0.01), and in-hospital mortality (aOR: 0.15, 95% CI: 0.05-0.45, P <0.01) as compared to males.  Conclusions We found that female patients had longer hospital LOS, total hospitalization charges, and a higher risk of VTE, while males had a higher risk of ARF, sepsis, shock, ICU admission, and all-cause in-hospital mortality. Although females are more frequently hospitalized for GP, males had significantly poorer clinical outcomes as compared to females. Our findings indicate that male patients with GP experience worse inpatient outcomes and require more aggressive treatment to reduce the risk of mortality and morbidity.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86239"},"PeriodicalIF":1.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing Patterns and Pharmacotherapeutic Risk Among Community-Dwelling Older Adults in Brazil: A Cross-Sectional Study.","authors":"Isadora F Odebrecht, Ana Beatriz F Nascimento, Diogo N Silveira, Isadora B Fernandes, Caroline L Harada, Gabriel M de Paula, Augusto L Nunes, Rodolfo Barriviera, Paulo R Bignardi, Karen B Fernandes","doi":"10.7759/cureus.86139","DOIUrl":"10.7759/cureus.86139","url":null,"abstract":"<p><p>Background Prescribing for older adults can be particularly challenging, as treatment regimens are often complex in geriatric patients, increasing the likelihood of polypharmacy, escalating the risk of exposure to potentially inappropriate medications (PIMs), and to a pharmacotherapeutic risk. Therefore, this study aims to identify prescribing patterns and the pharmacotherapeutic risk in community-dwelling older adults in Brazil. Methodology This cross-sectional study included 504 physically independent older individuals who self-reported sociodemographic characteristics, comorbidities, and data on current pharmacologic therapies. To analyze the pharmacotherapy, all medications used by the patients were recorded, including complementary alternative medications and over-the-counter medications (OTC). The Beers 2023 criteria were used to identify PIMs. Pharmacotherapeutic risk was stratified into two categories based on the presence of PIMs or OTC on the medication regimen. Results This study included 504 older adults (mean age = 69.5 ± 6.4 years), 339 women (67.3%), and 165 men (32.7%). Polypharmacy was observed in 136 (26.98%) individuals, while 180 (36.0%) individuals were using PIMs. Moreover, 97 (19.2%) individuals used OTC medication. Notably, 205 (40.7%) older individuals were classified as being at pharmacotherapeutic risk. In logistic regression, individuals with polypharmacy had nearly five times increased risk of being at pharmacotherapeutic risk (odds ratio = 4.9, p = 0.001), after controlling for sociodemographic and clinical variables. Conclusions A marked pharmacotherapeutic risk was observed, driven chiefly by polypharmacy among community-dwelling older adults. Thus, medical education regarding rational use of medication and deprescribing practices can help mitigate adverse outcomes in older adults. Moreover, future research should focus on user-centered design of technological solutions to support clinicians and patients in safely managing and discontinuing high-risk medications.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86139"},"PeriodicalIF":1.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Experience With an Aragonite-Based Scaffold Implant for Knee Cartilage Repair: A Multicenter Case Series.","authors":"Nirav H Amin, Scott C Faucett, Charles Qin, Chaitu S Malempati, Ronak M Patel, Christopher P Dougherty, Arnold Lim, Corey Kendall, R Kyle Martin, Cassandra A Lee","doi":"10.7759/cureus.86127","DOIUrl":"10.7759/cureus.86127","url":null,"abstract":"<p><p>Background There is a growing interest in the use of biomaterials to treat chondral and osteochondral knee lesions, given their ability to replicate the biological and functional properties needed for simultaneous cartilage and bone regeneration. A novel aragonite-based, cell-free biomimetic scaffold (CARTIHEAL AGILI-C^TM, Smith + Nephew, UK) was developed for treating chondral and osteochondral defects in traumatic and osteoarthritic joints. A short-term follow-up study was designed to assess the safety and feasibility of this scaffold.  Materials and methods This retrospective review included data from nine centers in the United States (US) between August 22, 2023 and December 30, 2024. Adult patients (≥18 years of age) who received the aragonite-based scaffold as standard of care for the treatment of knee chondral/osteochondral lesions in accordance with the manufacturer's instructions for use were eligible. There were no prespecified exclusion criteria. All patients underwent magnetic resonance imaging (MRI) for radiologic assessment of knee cartilage lesions, which informed the development of presurgical plans. A diagnostic arthroscopy was performed before arthrotomy to confirm the radiographic findings obtained for preoperative planning. The primary endpoint was the incidence of early clinical and radiographic complications occurring within at least 30 days after the operation. Secondary endpoints included an assessment of the accuracy of presurgical planning relative to intraoperative findings, proportion of implants determined to be improperly implanted based on the first postoperative X-rays, change in the numeric pain rating score from baseline, and the proportion of patients cleared for various postoperative activities. Results A total of 33 patients (34 knees; mean age, 47.2 years; 18 (52.9%) male) were included. After a mean postoperative follow-up of 45.7 days (standard deviation, 14.4), one patient (2.9%) experienced a postoperative complication (pain, with no associated infection). Success rate was 96.97% (95% CI, 84.24-99.92). In 27 (79.4%) cases, the presurgical plan based on MRI was modified following arthroscopic visualization of the knee joint surface. Postoperative radiography revealed no complications for the 28 patients with data. Mean postoperative numeric pain rating significantly improved from 6.6 at baseline to 3.9 at follow-up (p<0.05). The majority of patients (n=24; 70.6%) were cleared for partial or full weightbearing by the 30-day postoperative follow-up visit.  Conclusions This case series across multiple centers in the US demonstrates the clinical safety and feasibility of aragonite scaffold implantation. The flexibility of the scaffold in accommodating intraoperative findings and the low rate of early complications are encouraging.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86127"},"PeriodicalIF":1.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Chorionic Gonadotropin as a Marker of Parathyroid Carcinoma: Findings From a Scoping Review.","authors":"Maxim J Barnett, Sarah Eidbo, Carlo Casipit, Justin Lam, Catherine Anastasopoulou","doi":"10.7759/cureus.86141","DOIUrl":"10.7759/cureus.86141","url":null,"abstract":"<p><p>Parathyroid carcinoma is an extremely uncommon cause of primary hyperparathyroidism; however, it is associated with excess morbidity and mortality. With the similarity in presentation from benign etiologies (such as an adenoma or hyperplasia), there is often a delay in diagnosis and initiation of treatment. Currently, there are no approved biomarkers to assist in the diagnosis of carcinoma. Over the last century, limited studies have investigated the role of human chorionic gonadotropin (hCG), particularly in its ability to differentiate cancerous from benign parathyroid disease. We performed a scoping review to analyze the existing literature regarding hCG (serum, urine, and histochemical staining) and its role in identifying malignant parathyroid disease. Across three databases and an endocrine abstract repertoire, we identified seven relevant articles meeting the prespecified inclusion criteria. We highlighted the normal physiology of hCG, alongside the pathophysiological expression and the rationale for its use as a biomarker for parathyroid cancer. Each article was analyzed, with emphasis on the methodologies, outcomes, and limitations. Although promising, the role of hCG as a biomarker has not been established due to heterogeneous methodologies and limited studies, which prohibit a firm conclusion. Further research (including larger prospective studies) is required to validate the role of hCG as a biomarker for parathyroid carcinoma.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86141"},"PeriodicalIF":1.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Illness-Associated Cerebral Microbleed in a Young Patient With Sickle Cell Disease.","authors":"Ruth Pius, Moustafa M Shaaban, Jose A Suarez","doi":"10.7759/cureus.86166","DOIUrl":"10.7759/cureus.86166","url":null,"abstract":"<p><p>Critical illness-associated cerebral microbleeds (CICMs) are a recent clinical entity described as occurring in critically ill and mechanically ventilated patients, especially those with a risk of cerebral hypoxia. CICMs have been associated with progressive cognitive decline, and the management is supportive. We report the case of a 29-year-old male patient with sickle cell disease admitted for vaso-occlusive crises, which was complicated by multifocal pneumonia, and acute chest syndrome requiring intensive care unit admission and mechanical ventilation. He was noted to have poor mental status off sedation, with a brain MRI showing innumerable microhemorrhages throughout the bilateral cerebral and cerebellar hemispheres, suggestive of CICM.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86166"},"PeriodicalIF":1.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masson's Hemangioma of the Vastus Medialis: A Rare Case Involving the Musculoarticular Branch of the Descending Genicular Artery.","authors":"Christos Lyrtzis, Alexandra Arhonidu, Nikolaos Anastasopoulos, Anastasia Fotiadou, George Paraskevas","doi":"10.7759/cureus.86038","DOIUrl":"10.7759/cureus.86038","url":null,"abstract":"<p><p>Masson's hemangioma, or intravascular papillary endothelial hyperplasia (IPEH), is a rare, benign vascular lesion that can mimic malignancies such as angiosarcoma. Although commonly found in the head, neck, and extremities, intramuscular involvement near joints is unusual. This report presents a rare case of IPEH originating within the vastus medialis muscle and involving the musculoarticular branch of the descending genicular artery in an adolescent male. An 18-year-old male presented with right knee pain and a palpable mass without prior trauma or systemic disease. MRI revealed a vascular lesion within the vastus medialis in proximity to the knee joint. Surgical excision was performed, and histopathology confirmed the diagnosis of IPEH with no malignant features. Postoperatively, the patient regained full knee function without recurrence at 10-month follow-up. Recognition of IPEH in atypical intramuscular and periarticular locations is essential to avoid misdiagnosis and overtreatment. Histopathological examination remains the cornerstone for distinguishing this benign entity from aggressive vascular malignancies.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 6","pages":"e86038"},"PeriodicalIF":1.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}