Cureus最新文献

{"title":"MUC5B (rs35705950) Polymorphism and Its Association With Serum Krebs Von Den Lungen-6 (KL-6) and Matrix Metalloproteinase-7 (MMP7) in Patients With Interstitial Lung Disease (ILD) From India.","authors":"Tanya Athavale, Amita U Athavale, Trisha Samant, Tanaya Tipnis, Namrata Neman, Amrutha Jose, Pooja Jaiswal, Anshu Priya, Manisha Madkaikar, Vandana Pradhan","doi":"10.7759/cureus.93801","DOIUrl":"10.7759/cureus.93801","url":null,"abstract":"<p><p>Purpose Krebs von den Lungen-6 (KL-6) and matrix metalloproteinase-7 (MMP7) are established serum biomarkers for interstitial lung disease (ILD). A combination of KL-6 and MMP7 may be a useful screening tool for patients at risk of ILD. However, data on their association with MUC5B promoter polymorphism (rs35705950) in Indian ILD patients are lacking. There is a gap in knowledge of MUC5B genotypes in different subtypes of ILD and the diagnostic cut-offs of serum KL-6 and MMP7 in ILD patients from India. The primary aims of this study were to evaluate the proportion of MUC5B promoter polymorphism in different subtypes of ILD and to establish diagnostic cut-offs for serum KL-6 and MMP7 to distinguish ILD patients from healthy controls. The secondary aim was to investigate whether there was any genotype-phenotype association between the MUC5B genotype and serum biomarker levels. Methods This cross-sectional study was conducted in 200 ILD patients from a tertiary care institute in India. Serum KL-6 and MMP7 levels were measured using ELISA. Genotyping for MUC5B (rs35705950) was performed using DNA extracted from peripheral blood leukocytes. Results Connective tissue disease-associated interstitial lung disease (CTD-ILD) was the most common ILD subtype (45%). KL-6 levels were higher in idiopathic pulmonary fibrosis (IPF) than fibrotic hypersensitivity pneumonitis (fHP) (105.6 ng/mL vs. 65.87 ng/mL; p=0.0409), in patients who died (109.8 ng/mL vs. 68.6 ng/mL; p=0.022), and in the MUC5B (rs35705950) GT/TT genotype (85.07 ng/mL vs. 65.58 ng/mL; p=0.019). MMP7 levels were higher in IPF than CTD-ILD and fHP (14.01 ng/mL vs. 8.690 ng/mL and 7.970 ng/mL; p=0.0175 and p=0.0118, respectively). The minor MUC5B T allele was more frequent in all ILD subtypes. Conclusion This study established an association between MUC5B (rs35705950) promoter polymorphism and higher serum KL-6 levels. The T minor allele had a higher frequency in all ILD subtypes. The study also established cut-offs of serum KL-6 and MMP7 to distinguish between Indian ILD patients and controls.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"e93801"},"PeriodicalIF":1.3,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A Systematic Review and Meta-Analysis Assessing the Role of Oral Health as a Risk Factor in Oral Cancer.","authors":"Amit V Mahuli, Vidya Sagar, Amit Kumar, Simpy A Mahuli, Anit Kujur","doi":"10.7759/cureus.c344","DOIUrl":"https://doi.org/10.7759/cureus.c344","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.7759/cureus.39786.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"c344"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Evaluation and Grading of Varicoceles: A Two-Cycle Clinical Audit.","authors":"Ibrahim Abuelbeh, Mohammed B Nawaiseh, Hussam Nawaiseh, Rohan Mehra, Qais Nawaiseh, Mohamed Arabiyat, Luke Robinson, Vinotha Nadarajah, Ian Pearce, Vaibhav Modgil","doi":"10.7759/cureus.93794","DOIUrl":"10.7759/cureus.93794","url":null,"abstract":"<p><p>Introduction Varicoceles are a common cause of male infertility, and ultrasound (US) is the primary imaging modality used for diagnosis and grading. However, variability in reporting practices can hinder clinical decision-making. This clinical audit aimed to improve adherence to standardized US reporting guidelines for varicoceles, as recommended by the European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) and the Royal College of Radiologists (RCR). Materials and methods A two-cycle retrospective clinical audit was conducted in Manchester University NHS Foundation Trust. Testicular US reports were assessed before and after a targeted intervention that included a multidisciplinary meeting and the implementation of a structured reporting template. Reports were evaluated against ESUR-SPIWG and RCR guidelines, focusing on documentation of testicular volume, varicocele location, largest vein diameter, reflux assessment, and varicocele grading using the Sarteschi classification. Statistical analysis was performed using the chi-square test. Results A total of 66 testicular US reports were reviewed across two audit cycles. Statistically significant improvements were observed post-intervention in the documentation of key parameters (all p < 0.001): testicular volume (0.0% to 91.6%), varicocele location (0% to 91.6%), largest vein diameter (50.0% to 100%), and Valsalva/varicocele grading (0% to 97.2%). Conclusions The introduction of a structured reporting template and interdisciplinary collaboration significantly improved compliance with international varicocele US reporting standards. This approach enhances diagnostic quality and supports more effective urological triage. The findings suggest a scalable model for broader adoption and future integration into electronic systems, promoting consistency, auditability, and improved patient outcomes.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"e93794"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Hyponatremia in Acute Stroke: A Comparative Study of Ischemic and Hemorrhagic Stroke Subtypes.","authors":"Zahid Hasan, Murad Ali, Zia Ur-Rehman, Imran Qadar Khattak, Hamza Israr, Aansa Amin, Asim Ali, Amjad Ali","doi":"10.7759/cureus.r192","DOIUrl":"https://doi.org/10.7759/cureus.r192","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.7759/cureus.91396.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"r192"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Aspirin Plus Dipyridamole Versus Clopidogrel in Preventing Recurrent Ischemic Stroke: A Systematic Review.","authors":"Agbonmwanre E Osayagbon, Aliyu O Olaniyi, Japheth Oyovwi, Anup Banerjee, Olabisi P Lawal, Muhammad A Butt","doi":"10.7759/cureus.93790","DOIUrl":"10.7759/cureus.93790","url":null,"abstract":"<p><p>This systematic review evaluated the comparative effectiveness of aspirin plus extended-release dipyridamole (Asp+Dp) versus clopidogrel in preventing recurrent ischemic stroke. Three eligible studies were included, enrolling a total of 21,752 participants with a cumulative follow-up of 32 months. Many participants were recruited from the large-scale PROFESS trial (20,332 participants). Intervention dosing consisted of aspirin 25 mg combined with extended-release dipyridamole 200 mg administered twice daily, while the comparator was clopidogrel 75 mg once daily. In the PROFESS trial, recurrent stroke occurred in 916 patients (9.0%) in the Asp+Dp group and 898 patients (8.8%) in the clopidogrel group. The combined risk of recurrent stroke or major haemorrhagic events was comparable between groups, affecting 1,194 participants (11.7%) receiving Asp+Dp and 1,156 participants (11.4%) receiving clopidogrel. With respect to antiplatelet activity, one randomised pilot study demonstrated that Asp+Dp was associated with a delayed but significant reduction in the expression of several activation-dependent platelet receptors. Conversely, clopidogrel monotherapy was associated with earlier and more potent antiplatelet activity. Clinically, these study findings suggest that clopidogrel exerts more potent and earlier antiplatelet effects, whereas Asp+Dp produces broader but delayed downregulation of multiple platelet activation pathways. Regarding functional outcome recurrence, mortality, bleeding risk, or serious adverse events in patients with acute, mild ischemic stroke, no significant differences were observed between Asp+Dp and clopidogrel, with both regimens being practical and feasible for clinical use. In conclusion, while both therapies demonstrate comparable clinical effectiveness, further research is warranted to evaluate their long-term impact on quality of life in patients with ischemic stroke.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"e93790"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A Dynamic Foundation: Aberrations of Sleep Architecture and Its Association With Clinical and Sub-clinical Psychopathology.","authors":"Richard C Todd","doi":"10.7759/cureus.c346","DOIUrl":"https://doi.org/10.7759/cureus.c346","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.7759/cureus.55262.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"c346"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Social Impacts of the American Red Cross (ARC) Disaster Interventions: A Scoping Review.","authors":"Mishayla A Harve, Dan Li","doi":"10.7759/cureus.c345","DOIUrl":"https://doi.org/10.7759/cureus.c345","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.7759/cureus.55265.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"c345"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Balancing Act: A Comprehensive Review of Vestibular Evaluation in Cochlear Implants.","authors":"Andrea Moreno, Melissa Castillo-Bustamante, Jose A Prieto","doi":"10.7759/cureus.c347","DOIUrl":"https://doi.org/10.7759/cureus.c347","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.7759/cureus.55261.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"c347"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Recent Clinical Studies on the Effects of Tumor Necrosis Factor-Alpha (TNF-α) and Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) Antibody Therapies in Refractory Cutaneous Sarcoidosis: A Systematic Review.","authors":"Stacy L Toriola, Travis Satnarine, Zareen Zohara, Ademiniyi Adelekun, Kofi D Seffah, Korlos Salib, Lana Dardari, Maher Taha, Purva Dahat, Sai Sri Penumetcha","doi":"10.7759/cureus.c343","DOIUrl":"https://doi.org/10.7759/cureus.c343","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.7759/cureus.44901.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"c343"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Preanalytical Errors in Hematology: Insights From a Tertiary Care Hospital.","authors":"Vallal Kani, Kavitha Kannan, Sumithra Arumugam, Sulochana Sonti","doi":"10.7759/cureus.c342","DOIUrl":"https://doi.org/10.7759/cureus.c342","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.7759/cureus.69641.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"c342"},"PeriodicalIF":1.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}