Clinical hemorheology and microcirculation最新文献_第2页

A.L. Copley Best Paper Prize 2024. 2024年A.L.科普利最佳论文奖。

Clinical hemorheology and microcirculation Pub Date : 2026-08-01 Epub Date: 2026-09-17 DOI: 10.1177/13860291261484283

Christian Lehmann, Philippe Connes

引用次数: 0

Blood viscosity values for predicting pathological stroke types (ischemic stroke, hemorrhagic stroke, and stroke mimic) at DR. Cipto Mangunkusumo National Referral Hospital. 在DR. Cipto Mangunkusumo国立转诊医院预测病理性中风类型（缺血性中风、出血性中风和模拟中风）的血液粘度值。

Clinical hemorheology and microcirculation Pub Date : 2026-05-01 Epub Date: 2026-06-12 DOI: 10.1177/13860291261456431

Marco Lius, Sri Suryo Adiyanti, Al Rasyid, Yusra, Astuti Giantini, Ro Shinta Christina Solin

{"title":"Blood viscosity values for predicting pathological stroke types (ischemic stroke, hemorrhagic stroke, and stroke mimic) at DR. Cipto Mangunkusumo National Referral Hospital.","authors":"Marco Lius, Sri Suryo Adiyanti, Al Rasyid, Yusra, Astuti Giantini, Ro Shinta Christina Solin","doi":"10.1177/13860291261456431","DOIUrl":"10.1177/13860291261456431","url":null,"abstract":"IntroductionStroke is the leading cause of morbidity and mortality, and its management differs among ischemic stroke, hemorrhagic stroke, and stroke mimics. Non-contrast CT has limited sensitivity for early ischemia. This study compared blood and plasma viscosity across different stroke types and identified cutoff values for predicting stroke type.MethodA cross-sectional study at the Emergency Department of Dr. Cipto Mangunkusumo National Referral Hospital (March-June 2025). Blood and plasma viscosity were measured using the Neo Digital Microcapillary device then compared using appropriate statistic tests. A p-value < 0.05 was considered statistically significant.ResultsSeventy of 97 suspect stroke patients were included (36 ischemic, 16 hemorrhagic, 18 mimics). There were significant differences of blood viscocity between ischemic and hemorrhagic stroke compared with stroke mimic (median 5.65 cP ischemic; 5.29 cP hemorrhagic; 4.84 cP mimic; p < 0.0001), whereas no significant difference was observed in plasma viscosity across the groups (p = 0.411). A blood viscosity cutoff of 5.17 cP yielded an AUC of 0.84 (p < 0.0001), 71.2% sensitivity, 94.4% specificity, 97.37% PPV, and 53.13% NPV for stroke prediction.ConclusionBlood viscosity shows potential as an adjunctive diagnostic tool for distinguishing stroke from stroke mimics with high specificity, aiding in predicting types of stroke.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"47-56"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impairment of cutaneous microcirculation and vasoreactivity in primary hypothyroidism. 原发性甲状腺功能减退症的皮肤微循环和血管反应性损害。

Clinical hemorheology and microcirculation Pub Date : 2026-05-01 Epub Date: 2026-05-25 DOI: 10.1177/13860291261443895

Ekaterina G Ryzhkova, Tatyana B Morgunova, Ivan A Ryzhkov, Ilya I Amergoolov, Valentin V Fadeyev

{"title":"Impairment of cutaneous microcirculation and vasoreactivity in primary hypothyroidism.","authors":"Ekaterina G Ryzhkova, Tatyana B Morgunova, Ivan A Ryzhkov, Ilya I Amergoolov, Valentin V Fadeyev","doi":"10.1177/13860291261443895","DOIUrl":"10.1177/13860291261443895","url":null,"abstract":"The aimof this study was to identify potential diagnostic markers of microcirculation disorders in patients with primary hypothyroidism.Materials and methodsThis cross-sectional study included patients with overt (OH, n = 14) and subclinical (SH, n = 37) hypothyroidism, and healthy volunteers (HV, n = 50). Using laser Doppler flowmetry (LDF), mean cutaneous blood flow in the dorsal forearm was assessed at rest (M), during cooling to 10 °C (M10°C), heating to 35 °C (M35°C) and to 42 °C (M42°C). The standard deviation (σ) and the coefficient of variation of cutaneous blood flow (Kv=σ/M) at rest were calculated. The amplitudes of microvascular blood flow oscillations in frequency ranges corresponding to the neurogenic, myogenic, respiratory, and pulse mechanisms of microcirculation modulation were also calculated (An, Am, Aresp, Acard). Laboratory parameters were evaluated.ResultsThe OH group had reduced blood flow variability (σ) compared to the HV (p=0.025) and SH (p=0.037) groups. Kv was lower in OH compared to SH (p=0.041). Acard was decreased in the OH group compared to the HV (p=0.001) and SH (p=0.012) groups. M42°C was reduced in OH compared to HV (p=0.014). Hypercholesterolemia and increased IL-6 were found in the OH and SH groups compared to HV. In OH, the red blood cell distribution width (RDW) was increased compared to HV (p=0.026).ConclusionOvert hypothyroidism is associated with decreased total and pulse variability of cutaneous microvascular blood flow, decreased cutaneous hyperemia during local heating to 42 °C, and increased RDW. These microcirculatory disorders are accompanied by hypercholesterolemia and increased IL-6 levels.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"15-31"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulation of PCAF inhibits vascular smooth muscle cells senescence by reducing oxidative stress injury via activating the Nrf2/ARE pathway. PCAF的下调通过激活Nrf2/ARE通路减少氧化应激损伤，从而抑制血管平滑肌细胞衰老。

Clinical hemorheology and microcirculation Pub Date : 2026-05-01 Epub Date: 2026-07-02 DOI: 10.1177/13860291261456146

Liqiang Qiu, Wenjing Li, Xiaoxiong Liu, Zhigang Che, Yi Liu, Changjiang Zhang, Changwu Xu

{"title":"Downregulation of PCAF inhibits vascular smooth muscle cells senescence by reducing oxidative stress injury via activating the Nrf2/ARE pathway.","authors":"Liqiang Qiu, Wenjing Li, Xiaoxiong Liu, Zhigang Che, Yi Liu, Changjiang Zhang, Changwu Xu","doi":"10.1177/13860291261456146","DOIUrl":"10.1177/13860291261456146","url":null,"abstract":"Vascular aging represents the common pathological basis of aging-related diseases, with vascular smooth muscle cells (VSMCs) senescence playing a pivotal role. P300/CBP-associated factor (PCAF), a transcriptional coactivator linked to diverse physiological processes, has an undefined role in VSMCs aging. This study investigated PCAF's function in VSMC senescence and its underlying mechanisms. Using siRNA adenovirus to downregulate PCAF and angiotensin II (AngII) to induce senescence, we assessed β-galactosidase activity, senescence-associated secretory phenotypes (SASP), and cell cycle proteins (p53, p21, p16). Transcriptomic analysis revealed PCAF's association with oxidative stress and the Nrf2-ARE pathway. Results demonstrated that PCAF downregulation significantly attenuated VSMCs senescence and AngII-induced oxidative stress by enhancing Nrf2-ARE pathway activity. Crucially, Nrf2 silencing reversed these protective effects. In conclusion, PCAF inhibition mitigates VSMCs senescence via Nrf2-ARE-mediated antioxidant activation, identifying PCAF as a promising therapeutic target for vascular aging.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"3-14"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppression of macrophage enriched miRNA 210-3p improves cardiac fibrosis and cardiac function following myocardial infarction. 抑制巨噬细胞富集miRNA 210-3p可改善心肌梗死后的心肌纤维化和心功能。

Clinical hemorheology and microcirculation Pub Date : 2026-05-01 Epub Date: 2026-07-03 DOI: 10.1177/13860291261459308

Seongtae Jeong, Hanbyeol Moon, Hojin Kim, Byeong-Wook Song, Il-Kwon Kim, Sang Woo Kim, Soyeon Lim, Seahyoung Lee

{"title":"Suppression of macrophage enriched miRNA 210-3p improves cardiac fibrosis and cardiac function following myocardial infarction.","authors":"Seongtae Jeong, Hanbyeol Moon, Hojin Kim, Byeong-Wook Song, Il-Kwon Kim, Sang Woo Kim, Soyeon Lim, Seahyoung Lee","doi":"10.1177/13860291261459308","DOIUrl":"10.1177/13860291261459308","url":null,"abstract":"BackgroundAlthough it is well-known that immune cells such as monocytes or macrophages play important roles during the early phase of inflammatory response following cardiac damage, little is known about the role of immune cell-derived exosomes, especially their contents such as micro RNAs (miRNAs), in the immune cell-mediated regulation of cardiac remodeling. This study investigated the role of macrophage-derived exosomal miR-210-3p, which was found to be increased following cardiac damage, on cardiac fibroblast activation using a rat myocardial infarction (MI) model.MethodsCell population change in the heart following MI was assessed by single cell analysis. Differentially expressed miRNAs in the exosomes derived from THP-1 cultured under hypoxia/ischemia condition was evaluated by miRNA sequencing. The effect of macrophage exosome enriched miR-210-3p on cardiac fibroblast was examined. The effect of anti-miR-210-3p administration on the MI-induced cardiac fibrosis, cardiac function, and macrophage infiltration were evaluated.ResultsMacrophages were identified as the major type of immune cells present in the ischemic tissue following MI. miR-210a-3p was one of the 10 miRNAs increased (>10-fold) in THP-1 in response to hypoxia/ischemia condition, and it exerted pro-fibrotic effect in cardiac fibroblasts. Conditioned media of THP-1 cultured under hypoxia/ischemia condition also activated cardiac fibroblasts, and this was abrogated by anti-miR-210 treatment. Intramuscular injection of anti-miR-210-3p improved cardiac fibrosis and cardiac function 14 day after MI.ConclusionsMacrophage derived exosomes were enriched with miR-210-3p under hypoxia/ischemic condition, and they activated cardiac fibroblast. Suppression of miR-210-3p improved cardiac fibrosis and cardiac function following MI. Macrophage-derived exosomal miR-210-3p may play a significant role in the regulation of early inflammatory response following cardiac injury.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"32-46"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in whole blood viscosity in patients undergoing percutaneous or surgical intervention for aortic stenosis. 经皮或外科介入治疗主动脉瓣狭窄患者全血粘度的变化。

Clinical hemorheology and microcirculation Pub Date : 2026-03-01 Epub Date: 2026-05-25 DOI: 10.1177/13860291261442998

Zeynep Esra Güner, Ahmet Karaduman, İsmail Balaban, Barkın Kültürsay, Ravza Betül Akbaş, Uğur Özkan, Regayip Zehir

{"title":"Changes in whole blood viscosity in patients undergoing percutaneous or surgical intervention for aortic stenosis.","authors":"Zeynep Esra Güner, Ahmet Karaduman, İsmail Balaban, Barkın Kültürsay, Ravza Betül Akbaş, Uğur Özkan, Regayip Zehir","doi":"10.1177/13860291261442998","DOIUrl":"10.1177/13860291261442998","url":null,"abstract":"ObjectiveAortic stenosis is a common valvular disease in the elderly. This study aimed to investigate changes in whole blood viscosity (WBV), which reflects hemodynamic load and blood flow and is associated with cardiovascular diseases, after percutaneous and surgical interventions for aortic stenosis.MethodsFrom 2019 to 2022, 200 patients undergoing Transcatheter Aortic Valve Implantation (TAVI) (n = 100) or bioprosthetic Aortic Valve Replacement (bAVR) (n = 100) were analyzed. WBV at low shear rate (LSR, 0.5 s-1) and high shear rate (HSR, 208 s-1) was calculated from the hematocrit and total protein using the De Simone formula. Pre- and 3-month values were compared using paired and independent t-tests, and correlations and multivariable regression were performed.ResultsThe aortic valve area was negatively correlated with HSR (r = -0.340, p < 0.01) and LSR (r = -0.358, p < 0.01). At 3 months, HSR decreased by 0.95 ± 0.31 cP and LSR by 18.92 ± 6.32 cP (both p < 0.001). Reductions were significant in both groups without between-group differences and were mainly related to decreases in non-albumin protein fractions.ConclusionBoth TAVI and bAVR markedly reduced WBV, independent of the intervention type. WBV may be a useful biomarker for monitoring hemorheological and protein-based changes following valve intervention.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic analysis of contrast-enhanced ultrasound features in malignant partially cystic thyroid nodules. 甲状腺部分囊性恶性结节的超声造影诊断分析。

Clinical hemorheology and microcirculation Pub Date : 2026-03-01 Epub Date: 2026-04-16 DOI: 10.1177/13860291261430999

Guo Chen, Yanfang Wang, Guojuan Wang, Rong Yang, Ran Zheng, Yuanqing Zhang, Xiaorong Lv, Fang Nie

{"title":"Diagnostic analysis of contrast-enhanced ultrasound features in malignant partially cystic thyroid nodules.","authors":"Guo Chen, Yanfang Wang, Guojuan Wang, Rong Yang, Ran Zheng, Yuanqing Zhang, Xiaorong Lv, Fang Nie","doi":"10.1177/13860291261430999","DOIUrl":"10.1177/13860291261430999","url":null,"abstract":"ObjectivePartially cystic thyroid nodules (PCTNs) are frequently underestimated in clinical practice and managed conservatively, potentially increasing the risk of cervical lymph node metastasis. This study aims to explore the contrast-enhanced ultrasound features associated with malignancy in PCTNs.MethodsThis retrospective study included 94 PCTNs from 87 patients in the Second Hospital of Lanzhou University between January 2019 and December 2024. Conventional ultrasound, contrast-enhanced ultrasound (CEUS) features, and clinical data of the nodules were analyzed. Using pathological diagnosis as the gold standard, univariate and multivariate logistic regression analyses were conducted to identify independent predictors of malignancy in PCTNs. A predictive model was subsequently developed, and its diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis.ResultsCentrifugal perfusion, an ill-defined enhancement boundary, faster washout, and the absence of a peripheral high-enhancement ring are independent predictors of malignant PCTNs. The resulting predictive model exhibited excellent diagnostic performance for PCTNs, with a sensitivity of 92.7%, a specificity of 92.5%, a Youden index of 0.852, and an AUC of 0.968.ConclusionsCEUS features are valuable in differentiating malignant nodules from benign PCTNs, improving physicians' diagnostic confidence in distinguishing benign and malignant PCTNs, and assisting clinicians in clinical decision-making.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"55-64"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptations of blood fluidity markers to progressive resistance training in men. 血液流动性指标对男性进行性阻力训练的适应性

Clinical hemorheology and microcirculation Pub Date : 2026-03-01 Epub Date: 2026-05-30 DOI: 10.1177/13860291261443191

Mahnaz Hassani Valashjerdi, Ali Akbar Hajmohammadi, Ali Nazari, Sajad Ahmadizad

{"title":"Adaptations of blood fluidity markers to progressive resistance training in men.","authors":"Mahnaz Hassani Valashjerdi, Ali Akbar Hajmohammadi, Ali Nazari, Sajad Ahmadizad","doi":"10.1177/13860291261443191","DOIUrl":"10.1177/13860291261443191","url":null,"abstract":"BackgroundEpidemiological evidence suggests that endurance training improves musculoskeletal health and influence blood parameters, but the effects of RT were less clear.ObjectiveThe present study investigated the effect of 12-weeks of RT on resting (pre-exercise) values and responses of blood fluidity parameters to a resistance exercise trial (RET).MethodsEighteen untrained males (Mean ± SD; age, 24.8 ± 1.2 years) were randomly assigned to training (n = 10) or control (n = 8) groups. Subjects in the training group performed a 12-week progressive RT program with 4 sessions per week. The training program consisted of three distinct phases: adaptation, hypertrophy, and strength, increasing intensity from 40-50% to 80-85% of their one-repetition maximum (1RM). Prior and after the 12-week program, both groups underwent a RET. Blood samples were taken before and after each RET.ResultsSignificant (p < 0.05) increases in blood viscosity, plasma viscosity, plasma fibrinogen, and hematocrit were found following the acute RET. However, neither the resting values nor responses to RET were affected by RT. Interestingly, 12 weeks of progressive RT attenuated responses of RBC indexes significantly (p < 0.05).ConclusionsThe study concluded that although 12 weeks of RT does not alter resting blood fluidity, it reduces the acute changes in RBC indexes during high-intensity resistance exercise.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"87-95"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic analysis of epigallocatechin gallate selectively inhibiting shear-induced platelet aggregation under pathological high shear stress. 病理性高剪切应力下表没食子儿茶素没食子酸酯选择性抑制剪切诱导血小板聚集的微流控分析。

Clinical hemorheology and microcirculation Pub Date : 2026-03-01 Epub Date: 2026-04-16 DOI: 10.1177/13860291261441035

Xuanrong Huan, Xuemei Gao, Yongbin Hou, Anya Dai, Fangyu Zhou, Jie Chen, Jiyu Ran, Jia Tang, Zhongyan Gao, Suting Zhang, Qirui Cai, Huijian Liu, Yuan Li

{"title":"Microfluidic analysis of epigallocatechin gallate selectively inhibiting shear-induced platelet aggregation under pathological high shear stress.","authors":"Xuanrong Huan, Xuemei Gao, Yongbin Hou, Anya Dai, Fangyu Zhou, Jie Chen, Jiyu Ran, Jia Tang, Zhongyan Gao, Suting Zhang, Qirui Cai, Huijian Liu, Yuan Li","doi":"10.1177/13860291261441035","DOIUrl":"10.1177/13860291261441035","url":null,"abstract":"ObjectivesTo investigate the mechanism underlying the inhibitory effect of epigallocatechin gallate (EGCG) on shear-induced platelet aggregation(SIPA) and activation.MethodsUsing an 80% eccentric stenotic microfluidic chip, we simulated physiological (1500 s-1) and pathological high shear rates (4500 s-1 and 9000 s-1). Whole blood samples preincubated with EGCG (25-200 μM) were perfused through the chips. SIPA was quantified by real-time image analysis, and platelet activation was measured by flow cytometry for CD62P (P-selectin) and PAC-1 expression. The potential mechanism was probed using Ristocetin-induced activation.ResultsEGCG demonstrated a potent, concentration-dependent inhibition of SIPA and platelet activation at both 4500 s-1 and 9000 s-1, evidenced by reduced platelet aggregate coverage and lower CD62P/PAC-1 expression. The inhibitory effect was confirmed to be mediated through the von Willebrand factor (vWF)-GPIbα pathway, as EGCG also suppressed Ristocetin-induced platelet activation.ConclusionThis study offers systematic microfluidic evidence that EGCG exerts a concentration-dependent, selective inhibition of pathological SIPA and activation at 4500 s-1 and 9000 s-1, while exerting no significant effect on platelet aggregation function under physiological shear rate (1500 s-1). By targeting the vWF-GPIbα axis without affecting coagulation, EGCG emerges as a promising prototype for developing novel, bleeding-risk-free antiplatelet therapies.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"96-108"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of an oral Beta-caryophyllene Indena Phytosome^® for the treatment of pain and inflammation in interstitial cystitis. 口服β -石竹烯Indena Phytosome®治疗间质性膀胱炎疼痛和炎症的评价。

Clinical hemorheology and microcirculation Pub Date : 2026-03-01 Epub Date: 2026-04-24 DOI: 10.1177/13860291261442989

Hannah White, Kayle Dickson, Cassidy Scott, Daniel Neira Agonh, Ashley Cox, Melanie Kelly, Juan Zhou, Christian Lehmann

{"title":"Evaluation of an oral Beta-caryophyllene Indena Phytosome® for the treatment of pain and inflammation in interstitial cystitis.","authors":"Hannah White, Kayle Dickson, Cassidy Scott, Daniel Neira Agonh, Ashley Cox, Melanie Kelly, Juan Zhou, Christian Lehmann","doi":"10.1177/13860291261442989","DOIUrl":"10.1177/13860291261442989","url":null,"abstract":"BackgroundInterstitial cystitis (IC), a chronic inflammatory condition of the urinary bladder characterized by pain and difficulties with urination, has limited treatment options. Beta-caryophyllene (BCP) is a sesquiterpene with anti-inflammatory and analgesic properties, but has poor water solubility and limited intestinal absorption which may limit oral bioavailability. Indena Phytosome® is a proprietary food-grade lecithin-based delivery system that optimizes the bioavailability and pharmacokinetic profile of natural phytochemicals like BCP by producing a stable solid dispersion suitable for oral delivery.ObjectiveTo examine the therapeutic potential of an oral BCP Indena Phytosome® formulation (BCP Indena Phytosome®) for the treatment of IC.MethodsFemale BALB/c mice were pre-treated with BCP Indena Phytosome® or empty Indena Phytosome® vehicle, then IC was induced using lipopolysaccharide. 24 h later, inflammation was evaluated using intravital microscopy and histology. Pain was evaluated using behavior scoring and von Frey asethesiometry.ResultsPre-treatment with BCP Indena Phytosome® reduced leukocyte adhesion, histology scores, and behavior scores in IC mice, indicating a reduction in inflammation and pain. Lipopolysaccharide administration did not alter leukocyte rolling, capillary perfusion, or von Frey scores.ConclusionsOral BCP Indena Phytosome® effectively reduces pain and inflammation in experimental IC by decreasing leukocyte adhesion and extravasation in the bladder.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"65-76"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0