Clinical hemorheology and microcirculation最新文献

{"title":"First evaluation of microvascular damage through nailfold capillaroscopy of an uncommon case of Raynaud's phenomenon in multiple sclerosis: Case report and literature review.","authors":"Lucrezia Mondini, Gianluca Screm, Francesco Salton, Paola Confalonieri, Maria Chernovsky, Liliana Trotta, Mariangela Barbieri, Anna De Nes, Marta Maggisano, Mario D'Oria, Michael Hughes, Marco Confalonieri, Barbara Ruaro","doi":"10.1177/13860291251361329","DOIUrl":"https://doi.org/10.1177/13860291251361329","url":null,"abstract":"<p><p>IntroductionThe occurrence of Raynaud's phenomenon in patients with multiple sclerosis (MS) is infrequently documented in the literature. Some cases have been attributed to interferon-β therapy, while others have emerged in MS patients who sub-sequently developed Raynaud's phenomenon and/or systemic sclerosis. The association between microangiopathic damage and both Raynaud's phenomenon and systemic sclerosis is well-established, leading to the adoption of nailfold video-capillaroscopy (NVC) as a non invasive diagnostic tool for the initial clinical assessment of these conditions.Case PresentationWe present a case study of a 42-year-old female patient with Raynaud's phenomenon in MS. The patient underwent NVC in 2023 showing microvascular impairment and after one year and Natalizumab treatment she repeated NVC evaluation with significant improvement in previous microangiopathic changes. A comprehensive literature review regarding the relationship between MS and Raynaud's phenomenon was conducted using electronic databases (PUBMED, UpToDate, Google Scholar, ResearchGate), along with manual searches for relevant articles published up to December 2024.DiscussionThis case highlights the potential utility of NVC in the ongoing evaluation of microangiopathic damage in MS patients exhibiting Raynaud's phenomenon. By elucidating the overlap between these conditions, NVC may serve as a valuable tool in the clinical management of affected individuals.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251361329"},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using dynamic nomogram to modify TI-RADS and reduce the unnecessary FNA of thyroid nodules.","authors":"Jiahui Ni, Yunyun Liu, Xiaolong Li, Beibei Ye, Hui Shi, Ying Zhang, Yifeng Zhang","doi":"10.1177/13860291251357792","DOIUrl":"https://doi.org/10.1177/13860291251357792","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend Fine Needle Aspiration (FNA) based on nodule size and ultrasound characteristics; however, these guidelines still lead to a certain amount of unnecessary FNAs.</p><p><strong>Objective: </strong>To develop a dynamic nomogram prediction model based on the ACR Thyroid Imaging, Reporting, and Data System (TI-RADS) to reduce unnecessary FNAs.</p><p><strong>Methods: </strong>This multicenter study analyzed 3313 thyroid nodules undergoing FNA. Univariate and multivariate logistic regression models were constructed. Patients were divided into a training cohort and two validation cohorts to compare diagnostic performance and unnecessary FNAs.</p><p><strong>Results: </strong>This nomogram achieved performance of Area Under the Curve (AUC) 0.914 (95%CI: 0.894-0.934), 0.923 (95%CI: 0.900-0.946), 0.948 (95%CI: 0.918-0.978) in the training, internal and external validation cohort. Using this model, the unnecessary FNA rates for nodules in ACR TI-RADS category 3 (TR3) have decreased from 99.4% to 0%, in TR4 from 77.6% to 47.1%, and in TR5 from 25.4% to 18.9% in Center1, in TR3 have decreased from 91.9% to 0%, in TR4 from 60.0% to 21.1%, and in TR5 from 11.5% to 4.5% in Center 2 (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>This dynamic nomogram achieved better prediction of malignant thyroid nodules compared with the mentioned risk stratification system, leading to a more rational FNA strategy.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251357792"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative prediction of the histological features and lymph nodes status of borderline ovarian tumors: The role of conventional ultrasound and contrast-enhanced ultrasound.","authors":"Luping Liu, Xiao Huang, Ju Zhu, Nan Wang, Fang Nie","doi":"10.1177/13860291251359096","DOIUrl":"https://doi.org/10.1177/13860291251359096","url":null,"abstract":"<p><p>BackgroundBorderline ovarian tumors (BOTs) represent a rare group of neoplasms exhibiting abnormal epithelial proliferation with cellular atypia while lacking stromal invasion or infiltrative destructive growth. And postoperative recurrence may be associated with histological features and lymph node status. Therefore, preoperative prediction of BOTs' histological characteristics and lymph node status is of paramount importance for formulating surgical plans and follow-up treatments.ObjectiveTo investigate the value of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) characteristics for preoperative identification of histological features and lymph node status in BOTs.MethodsPatients with pathologically confirmed primary BOTs were enrolled, which classified into high-risk and low-risk groups based on whether the presence of at least one of microinvasion, micropapillary pattern, extraovarian implantation, or lymph node invasion. CEUS was performed at the maximal solid tumor component identified on gray-scale imaging, with bolus injection of contrast agent and dynamic recording of the wash-in to wash-out phases for quantitative contrast kinetics analysis. A comparative analysis of US and CEUS characteristics was conducted between the groups, with subsequent longitudinal assessment of recurrence-free survival (RFS) curves employing Kaplan-Meier methodology.ResultsThe study comprised 58 patients with BOTs, stratified into low-risk (n = 37) and high-risk (n = 21) groups, with mean patient ages of 42.8 ± 11.8 years. No statistically significant differences were observed in tumor size (maximum diameter, <i>p</i> = 0.840) or location (unilateral versus bilateral, <i>p</i> = 0.077) between the two groups on US. The type of tumor, proportion of solid components, and color score were observed to statistically significantly differ between the two groups (all <i>p</i> < 0.05). Iso- or hyper-enhancement, early or synchronously wash-in, and early wash-out were more likely to occur in the high-risk group (16/21, 76.2%; 11/21, 52.4%; 11/21, 52.4%) than in the low-risk group (15/37, 40.5%; 5/37, 13.5%; 9/37, 24.3%). In quantitative parameters, there were significant differences in MeanLin, PE, RT, TTP, WiR, WiPI, WoAUC, WiWoAUC, FT, and WoR between the two groups (all <i>p</i> < 0.05). During the follow-up, there were 3 cases recurrence in the high-risk group, while no recurrence was observed in the low-risk group.ConclusionThe combination of US and CEUS is capable of facilitating preoperative prediction of the histological features and lymph node status of BOTs, and holds potential value for identifying the recurrence risk.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251359096"},"PeriodicalIF":0.0,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive sleep apnea increases high-shear whole blood viscosity and Plasma Viscosity in adults.","authors":"Chengyu Zhang, Jingjing Huang, Xi Jin, Zhujian Wang, Peixia Wu","doi":"10.1177/13860291251359097","DOIUrl":"https://doi.org/10.1177/13860291251359097","url":null,"abstract":"<p><p>ObjectiveThis study aims to explore the effects of obstructive sleep apnea (OSA) on hemorheological parameters.MethodsBetween February 2023 and March 2024, 882 patients were screened, and 787 were included in the study. The participants were divided into a non-OSA group (72 individuals) and an OSA group (715 individuals). Propensity score overlap weighting was used to balance the clinical variables, red blood cell count, and blood biochemistry results between the two groups, and regression analysis was conducted to assess the relationship between OSA and hemorheological parameters. Sensitivity analysis was conducted using propensity score covariate adjustment to ensure the robustness of the results.ResultsCompared to non-OSA patients, OSA patients exhibited a significant increase in whole blood viscosity at high shear rates by 0.18 mPa.s (95% CI: [0.03, 0.32]) and in plasma viscosity by 0.05 mPa.s (95% CI: [0.01, 0.10]). However, there was no significant difference in whole blood viscosity at low shear rates between the two groups (95%CI: [-0.01, 0.56]).ConclusionAfter adjusting the effects of comorbidities such as hypertension, diabetes, and cardiovascular diseases, OSA still had a significant impact on high-shear whole blood viscosity and plasma viscosity.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251359097"},"PeriodicalIF":0.0,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of cardiopulmonary bypass on hemorheology: Evaluation of clinical outcomes.","authors":"Süleyman Aycan, Nazlı Helvacı, Alev Kural, Gözde Tekin, Mehmet Kızılay","doi":"10.1177/13860291251352316","DOIUrl":"https://doi.org/10.1177/13860291251352316","url":null,"abstract":"<p><p>BackgroundDuring cardiopulmonary bypass (CPB), which is frequently utilized in open-heart surgery, the maintenance of circulation in a non-physiological environment may lead to alterations in the properties of circulating blood components. In our study, we aimed to evaluate these changes using contemporary methodologies.MethodsThe study included 48 patients who underwent cardiac surgery with CPB. CPB duration and hypothermia degree were recorded and analyzed. Erythrocyte deformability (ED), erythrocyte aggregation (EA), whole blood viscosity (WBV), total oxidant status (TOS), and total antioxidant status (TAS) were measured; ED and EA were measured using LORRCA (RR Mechatronics, Hoorn, Netherlands).ResultsCompared to the preoperative period, a decrease in postoperative ED, EA, and WBV was observed. No significant change was detected in TAS levels; however, TOS levels were found to be elevated. No statistically significant correlation was observed between perioperative patient temperature, CPB duration, and ED, EA, or WBV values.ConclusionsIn patients undergoing surgery with CPB, a postoperative decrease in ED, EA, and WBV was demonstrated. Previous studies have suggested that the decline in ED is associated with blood transfusion. However, the significant reduction in ED observed in our study, even in patients who did not receive blood transfusions, is noteworthy.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251352316"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The m6A methyltransferase METTL14 governs NLRP3 and facilitates myocardial infarction via pyroptosis.","authors":"Xiaoling Li, Longwei Zhou, Chengyan Yang, Keqin Wang, Yangjie Li, Sha Han, Xuan Gong, Ke Qin, Zengxue Lu","doi":"10.1177/13860291251352301","DOIUrl":"https://doi.org/10.1177/13860291251352301","url":null,"abstract":"<p><p>BackgroundN6-methyladenosine (m6A) methylation plays an important role in myocardial infarction, which is related to cardiomyocyte pyroptosis. This study aimed to explore the effects of the m6A methyltransferase, METTL14, on pyroptosis and the underlying mechanisms.Materials and methodsThe role of METTL14 <i>in vivo</i> was assessed by TTC staining, biochemical indicators, and H&E assays. Cell pyroptosis was evaluated by PI staining, IF, and western blot assay. The m6A methylation of NLRP3 was evaluated by RIP, dual-luciferase reporter assay, Me-RIP, and stability test.ResultsThe results indicated that METTL14 was highly expressed in LAD-ligated mice and OGD-induced cardiomyocytes. Depletion of METTL14 inhibited OGD-induced pyroptosis of cardiomyocytes and suppressed myocardial injury. Mechanically, METTL14 promoted m6A methylation of NLRP3 to enhance mRNA stability. Overexpression of NLRP3 reversed the effects of METTL14 knockdown on pyroptosis.ConclusionsMETTL14 knockdown attenuated cardiomyocyte pyroptosis and myocardial infarction by suppressing NLRP3 m6A methylation. The findings suggested that METTL14 has the potential to be the therapeutic target of myocardial infarction.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251352301"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in oxygen-gradient ektacytometry parameters and blood viscosity between patients with sickle cell anemia and patients with sickle cell-hemoglobin C disorder.","authors":"Philippe Connes, Marie Martin, Camille Boisson, Emeric Stauffer, Céline Renoux, Philippe Joly, Solene Poutrel, Carine Halfon-Domenech, Alexandra Gauthier, Elie Nader","doi":"10.1177/13860291251357796","DOIUrl":"https://doi.org/10.1177/13860291251357796","url":null,"abstract":"<p><p>Oxygen-gradient ektacytometry (oxygenscan) has been recently used in the context of sickle cell disease (SCD) to determine the ability of red blood cells (RBCs) to deform in normoxia and during deoxygenation. While several studies focused on the determinants of oxygenscan parameters in the homozygous form of SCD (i.e., HbSS), very few studies focused on hemoglobin SC disease (HbSC). Oxygenscan parameters were compared between HbSS (N = 304) and HbSC (N = 58) patients, with or without hydroxyurea (HU). RBC deformability measured in normoxia or at low oxygen level was lower in HbSS patients without HU compared to HbSS patients with HU and HbSC patients with or without HU. The propensity of RBCs to sickle during deoxygenation was greater in HbSS than in HbSC patients. Although no significant impact of HU was observed on RBC deformability/sickling in HbSC patients, those with HU had lower blood viscosity. The ability of RBC to recover their maximum deformability after a deoxygenation/reoxygenation cycle was lower in HbSC compared to HbSS patients. Finally, oxygenscan parameters and routine hematological parameters correlated differently in HbSS and HbSC patients. Our study showed difference in oxygenscan parameters between HbSS and HbSC individuals that could partly explain the difference in the clinical expression of SCD.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251357796"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental investigation of proangiogenic properties of sacubitril on a chorio allantoic membrane model.","authors":"Mustafa Ozgul, Eyup Aydogan","doi":"10.1177/13860291251352350","DOIUrl":"https://doi.org/10.1177/13860291251352350","url":null,"abstract":"<p><p>BackgroundSacubitril is an important and effective agent for cardiovascular remodeling. This study aims to evaluate its proangiogenic effects in an experimental model.MethodsThe chorioallantoic membrane (CAM) model was created for the investigation of the proangiogenic potential of sacubitril with different therapeutic doses (10^-7 M, 10^-6 M, 10^-5 M) and compared with drug-free pellet group (sham) and normal morphology (control) of chick embryo development in drug-free chick embryos. The developing embryo's vascularity and the pellets' effect were evaluated under a stereoscopic microscope. The density of vascular shoots and newly formed vascular nodules were not recorded.ResultsThere was no significant difference between the control and drug-free pellet groups (12.4 ± 2.8 vs. 14.1 ± 1.3 junctions per ROI, p = 0.48). The incremental angiogenic properties were detected in drug groups as follows: 15.3 ± 3.8 per ROI in Group I (10^-7 M concentration); 21.6 ± 5.4 per ROI in Group II (10^-6 M concentration); 22.9 ± 8.1 per ROI in Group III (10^-5 M concentration) (p < 0.001).ConclusionOur findings support that sacubitril provokes angiogenesis in a dose-dependent manner. Investigating these properties can be useful for understanding further effects of this agent in other cardiovascular diseases. Therapeutic angiogenesis is important for ameliorating the results.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251352350"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of ultrasound in the evaluation of the type 2 diabetes mellitus related plantar fascia changes.","authors":"Shengqiao Wang, Xiuyun Lu, Juan Chen, Xinliang Xu, Jun Jiang, Yi Dong","doi":"10.1177/13860291251356171","DOIUrl":"https://doi.org/10.1177/13860291251356171","url":null,"abstract":"<p><p>BackgroundPlantar fasciopathy is a common complication in diabetes patients.ObjectiveTo evaluate the effectiveness of ultrasound in detecting diabetic tendinopathy in type 2 diabetes mellitus (T2DM) patients by assessing plantar fascia (PF) thickness and stiffness.MethodsThis study included 70 T2DM patients with heel pain, diagnosed by American Diabetes Association (ADA). B mode ultrasound was used to evaluate PF thickness. Shear wave elastography (SWE) was used to assess PF stiffness.ResultsIn T2DM patients, the PF thickness (PFT) was significantly thicker (4.40 ± 0.79 mm vs. 2.87 ± 0.26 mm, P < 0.05) and the shear wave velocity (SWV) of PF was significantly lower (3.09 ± 0.57 m/s vs. 4.00 ± 1.01 m/s, P < 0.05) than the control group. PFT and SWV values were strongly correlated with age (r = 0.880, -0.888) and BMI (r = 0.814, -0.853). ROC analysis showed that PFT > 4.33 mm had a sensitivity of 98.0% and specificity of 77.2% for diabetic tendinopathy, with an area under the ROC curve (AUROC) of 0.956, SWV < 3.22 m/s had a sensitivity of 86.3% and specificity of 60.5% (AUROC = 0.789).ConclusionUltrasound is a non-invasive and efficient diagnostic tool for PF in T2DM patients.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"13860291251356171"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ assessment of renal cortical microcirculation in septic acute kidney injury rats using contrast-enhanced ultrasound and sidestream dark-field imaging.","authors":"Wei Su, Tian Li, Jin Lin, Xinjie Guo, Ran Pang, Meili Duan, Jingfeng Liu","doi":"10.1177/13860291251347870","DOIUrl":"10.1177/13860291251347870","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate in situ assessment of renal cortical microcirculation (RCM) in S-AKI rats using CEUS and SDF imaging.</p><p><strong>Methods: </strong>CLP was performed to induce S-AKI in Sprague-Dawley rats; Sham rats served as control. CEUS and SDF imaging were sequentially applied at postoperative 24 h and 48 h to investigate the RCM.</p><p><strong>Results: </strong>At postoperative 24 h and 48 h, CLP rats exhibited hemodynamic deterioration and AKI. Renal injury score and positive staining for pimonidazole were significantly increased (<i>p</i> < 0.05). In CLP rats, parameters of RCM, including peak enhancement (PE), rise time (RT), PE/RT, time to peak (TTP), total small vessel density (TVD), perfused small vessel density (PVD), microvascular flow index (MFI), and proportion of perfused vessels (PPV) were significantly deteriorated compared to Sham rats (<i>p</i> < 0.05). In CLP rats, Lac was significantly negatively correlated with PE, PE/RT, TVD, PVD, PPV and MFI, and significantly positively correlated with RT and TTP. TVD, PVD, PPV and MFI were significantly positively correlated with PE and PE/RT and negatively correlated with RT and TTP.</p><p><strong>Conclusion: </strong>The RCM of S-AKI rats exhibited decreased blood perfusion and heterogeneity in early sepsis. CEUS and SDF imaging are effective methods for detecting the RCM.</p>","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"60-72"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}