Clinical hemorheology and microcirculation最新文献_第3页

Asymptomatic carotid atherosclerosis: Oxidative stress, clinical and inflammation parameters and blood viscosity according to the hemoglobin level. 无症状颈动脉粥样硬化：根据血红蛋白水平检测氧化应激、临床及炎症参数及血液粘度。

Clinical hemorheology and microcirculation Pub Date : 2026-01-01 Epub Date: 2026-04-10 DOI: 10.1177/13860291261433162

Gregorio Caimi, Rosalia Lo Presti, Caterina Urso, Salvatore Brucculeri, Corrado Amato, Melania Carlisi

{"title":"Asymptomatic carotid atherosclerosis: Oxidative stress, clinical and inflammation parameters and blood viscosity according to the hemoglobin level.","authors":"Gregorio Caimi, Rosalia Lo Presti, Caterina Urso, Salvatore Brucculeri, Corrado Amato, Melania Carlisi","doi":"10.1177/13860291261433162","DOIUrl":"10.1177/13860291261433162","url":null,"abstract":"Background and objectiveIn this different revision of our cohort of asymptomatic subjects with carotid atherosclerosis, particularly, we examined the behaviour of oxidative stress, some inflammation parameters, and blood viscosity in relation to the hemoglobin concentration.Patients and methodsOur study population includes 100 subjects (43 men and 57 women) with asymptomatic carotid atherosclerosis (SCA). Specifically, we evaluated the following variables: NOx (metabolites of NO, nitrate and nitrite), lipid peroxidation, high sensitivity C-reactive protein, neutrophil and lymphocyte counts, whole-blood viscosity and plasma viscosity, mean erythrocyte aggregation, hematocrit, fibrinogen, and Yield shear stress (YSS).ResultsFrom the obtained data, we observed an increase in diastolic pressure and uricemia in the subgroup above the median values oh hemoglobin level. In the same subgroup, we observed a reduction in NOx, not associated with an increase in lipid peroxidation, an increase in blood viscosity, at high and low shear rate, as well as an increase in plasma viscosity and erythrocyte aggregation and YSS.ConclusionsIn subjects with subclinical carotid atherosclerosis the subdivision according to the hemoglobin level underlines the role of this parameter in the pathogenesis and progression of the atherosclerosis.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"17-24"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in the red blood cell rheology in pancreatic cancer. 胰腺癌中红细胞流变学的改变。

Clinical hemorheology and microcirculation Pub Date : 2026-01-01 Epub Date: 2026-04-10 DOI: 10.1177/13860291261432433

Maciej Wiewiora, Konrad Karcz, Dorian Andrade, Christian Heiliger, Denis Ehrl

{"title":"Alterations in the red blood cell rheology in pancreatic cancer.","authors":"Maciej Wiewiora, Konrad Karcz, Dorian Andrade, Christian Heiliger, Denis Ehrl","doi":"10.1177/13860291261432433","DOIUrl":"10.1177/13860291261432433","url":null,"abstract":"AimThis study aimed to investigate the effect of pancreatic ductal adenocarcinoma (PDAC) on the RBCs rheological properties at the time of diagnosis and to examine their potential relationship with tumor stage.Material and MethodsWe studied 32 patients with confirmed PDAC.The aggregation and deformability of RBCs were evaluated using a LORCA.The following parameters specific to the aggregation process were estimated: the aggregation index (AI), the aggregation half-time (t1/2), and the threshold shear rate (γthr).RBC deformability expressed as erythrocyte elongation (EI), was measured from 0.3 Pa to 60 Pa shear stresses.ResultsAll measured RBC aggregation parameters among PDAC subjects differed from those in controls. The AI (P < 0.03) was significantly higher in the PDAC group, whereas t1/2 (P < 0.001) and AMP (P < 0.001) were significantly lower compared to the control group. No significant differences in RBC deformability were observed between the PDAC and control groups.There were significant correlations between some RBC aggregation parameters and PDAC tumor staging (T).There was that T correlated positively with t1/2, and negatively with AI and γthr.ConclusionPDAC is associated with alterations in RBC rheology behavior. Results indicated a higher tendency for RBC aggregation and aggregate stability associated with the rigidity of RBC at lower shear stress.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy and influencing factors of hepatic venous pressure gradient, spleen stiffness and liver stiffness in the detection of portal hypertension with liver cirrhosis. 肝静脉压梯度、脾僵硬度、肝僵硬度检测肝硬化门静脉高压的准确性及影响因素

Clinical hemorheology and microcirculation Pub Date : 2026-01-01 Epub Date: 2026-04-10 DOI: 10.1177/13860291261432456

Baohua Li, Fangyu Xu, Dongjun Su, Hui Zhu, Shuangxi Li

{"title":"Accuracy and influencing factors of hepatic venous pressure gradient, spleen stiffness and liver stiffness in the detection of portal hypertension with liver cirrhosis.","authors":"Baohua Li, Fangyu Xu, Dongjun Su, Hui Zhu, Shuangxi Li","doi":"10.1177/13860291261432456","DOIUrl":"10.1177/13860291261432456","url":null,"abstract":"PurposeTo assess the accuracy of hepatic venous pressure gradient (HVPG), spleen stiffness (SS) and liver stiffness (LS) for detecting portal hypertension (PH).MethodsWe measured HVPG, SS, LS and portal pressure gradient (PPG) in 104 patients with liver cirrhosis from April 2019 to April 2024. Correlations between these parameters and PH were analyzed using Pearson correlation or Spearman's rank correlation test appropriate. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis. Multiple linear regression analysis was to identify factors independently associated with HVPG, SS and LS.ResultsHVPG and SS were significantly correlated with PPG (p < 0.005), whereas LS showed no significant correlation with PPG (p = 0.532). For prediction of PH defined by PPG≥12, 20 and 25 mmHg, areas under the ROC curve (AUC) of HVPG were 0.983, 0.875 and 0.680, and the AUC of SS were 0.764, 0.922 and 0.700, respectively. Multiple linear regression analysis showed that factors independently associated with HVPG included aspartate aminotransferase (AST), total bilirubin (TBIL) and previous bleeding, while those associated with SS were white blood cell count (WBC) and Model for End-Stage Liver Disease-Sodium (MELD-Na) score.ConclusionHVPG and SS had favorable diagnostic performance for identifying PH in patients with liver cirrhosis.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"43-52"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood viscosity in clinical practice: A critical review of diagnostic utility, therapeutic implications, and evidence gaps. 临床实践中的血液粘度：对诊断效用、治疗意义和证据差距的重要回顾。

Clinical hemorheology and microcirculation Pub Date : 2026-01-01 Epub Date: 2026-05-06 DOI: 10.1177/13860291261446634

Hassan A Almarshad

{"title":"Blood viscosity in clinical practice: A critical review of diagnostic utility, therapeutic implications, and evidence gaps.","authors":"Hassan A Almarshad","doi":"10.1177/13860291261446634","DOIUrl":"10.1177/13860291261446634","url":null,"abstract":"Blood viscosity is a key rheological measure that is a biomarker of hematological, cardiovascular, and inflammatory conditions. This systematic review analyzed the changing role of blood viscosity and its potential significance in clinical practice. We provide a comprehensive examination of diagnostic methods, ranging from gold-standard rotatory viscometers to novel point-of-care and microfluidic technologies, emphasizing the practical features for precise data interpretation. This comprehensive clinical study revealed unique hemorheological profiles of different clinical conditions and diseases, particularly emphasizing the genetic constitution of sickle cell disease, diabetes mellitus with vascular consequences, and other diseases and syndromes associated with hyperviscosity. We provide a new approach for assessing the clinical value of viscosity as a pathophysiological description, prognostic biomarker, and decision-making measure. The review emphasizes that although substantial evidence supports its prognostic significance, many deficiencies remain in the research results relating to viscosity-guided therapies to improve patient care outcomes. The integration of artificial intelligence, wearable monitoring, and customized hemorheology was analyzed with caution. This synthesis emphasizes the need for established methods, interdisciplinary cooperation, and focused clinical trials to convert blood rheological knowledge into clinical applications for precise blood and cardiovascular therapies.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"3-16"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of microvascular flow imaging and contrast-enhanced ultrasound for the assessment of early chronic kidney disease. 微血管血流显像与超声造影在早期慢性肾病诊断中的比较

Clinical hemorheology and microcirculation Pub Date : 2026-01-01 Epub Date: 2026-04-10 DOI: 10.1177/13860291261432389

Yuping Guo, Mingru Gao, Meijuan Gao, Xin He, Tao Liu, Xiaoqiu Dong

{"title":"A comparison of microvascular flow imaging and contrast-enhanced ultrasound for the assessment of early chronic kidney disease.","authors":"Yuping Guo, Mingru Gao, Meijuan Gao, Xin He, Tao Liu, Xiaoqiu Dong","doi":"10.1177/13860291261432389","DOIUrl":"10.1177/13860291261432389","url":null,"abstract":"ObjectiveTo investigate the value of microvascular flow imaging (MVFI) and contrast-enhanced ultrasound (CEUS) in the assessment of early chronic kidney disease (CKD).Material and methodsA total of 143 patients with CKD were included in this study.We used conventional ultrasound, MVFI, and CEUS parameters to compare patients at different stages of CKD, correlated key parameters with clinical data and histological grading, and evaluated their value for early CKD diagnosis.ResultsParenchymal thickness and echogenicity were significantly different between groups (P < 0.001). Vascular impression, shape, and vascular index (VI) and mean intensity, mean transit time, time to peak, fall time, area under the curve (AUCCEUS), and wash-in rate were significantly different between groups (P < 0.05). VI and AUCCEUS were negatively correlated with blood creatinine, blood urea and histological grading, and positively correlated with estimated glomerular filtration rate, which are more effective than other positive parameters in diagnosing early CKD. The optimal diagnostic cut-off values were 55.75 for VI (AUCROC = 0.844; sensitivity, 75.0%; specificity, 78.8%) and 2100 for AUCCEUS (AUCROC = 0.759; sensitivity, 84.1%; specificity, 71.7%), the combined use of both parameters outperforms either alone.ConclusionMVFI is less invasive and simpler than CEUS and is more suitable for auxiliary examination in early CKD.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of artificial intelligence on magnetocardiology. 人工智能在心脏磁学研究中的应用。

Clinical hemorheology and microcirculation Pub Date : 2025-12-01 Epub Date: 2026-04-15 DOI: 10.1177/13860291251378923

J F Mockler, S H Yang, L Schmid, S Bannasch, A Maier, J W Park

引用次数: 0

A comprehensive review of GLP-1 and aerobic training in cardiovascular disease management. 心血管疾病管理中GLP-1和有氧训练的综合综述

Clinical hemorheology and microcirculation Pub Date : 2025-12-01 Epub Date: 2026-04-10 DOI: 10.1177/13860291251414840

Negin Kordi, Rezvan KheirAndish, Peyman Akraminia, Friedrich Jung, Sajad Karami

{"title":"A comprehensive review of GLP-1 and aerobic training in cardiovascular disease management.","authors":"Negin Kordi, Rezvan KheirAndish, Peyman Akraminia, Friedrich Jung, Sajad Karami","doi":"10.1177/13860291251414840","DOIUrl":"10.1177/13860291251414840","url":null,"abstract":"Secreted by enteroendocrine cells in the gastrointestinal tract, glucagon-like peptide-1 (GLP-1) is pivotal in the management of glycemic variability, as it promotes insulin secretion while concurrently suppressing glucagon release. This review investigates the neural circuits activated by both endogenous and pharmacological forms of GLP-1, with particular attention to the important cell types that express GLP-1 receptors (GLP-1R) and the pathways that relay both metabolic and non-glycemic signals linked to GLP-1. The examination includes the effects of GLP-1 on the benefits and adverse outcomes related to bariatric surgery, as well as its influence on islet function, appetite regulation, inflammation, and cardiovascular health. This review introduces both established and new concepts, identifies outstanding questions, and outlines future challenges in the development and optimization of GLP-1R agonists for the management of cardiovascular disease. The role of GLP-1 in enhancing endurance, muscle recovery, fiber type distribution, muscle mass, and energy efficiency is well-documented. Furthermore, GLP-1 influences various physiological components, including bile acids, short-chain fatty acids, L cells, and G-protein-coupled receptors. Increased levels of GLP-1 due to overexpression lead to higher glycogen concentrations, the development of endurance-oriented muscle fibers, augmented mitochondrial content, and improved glucose uptake in skeletal muscle. Exercise training has been shown to elevate GLP-1 levels, which may be beneficial for those suffering from metabolic syndrome. Nonetheless, additional research is necessary to clarify how exercise promotes GLP-1 secretion in individuals with cardiovascular diseases.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the concordance in the diagnostic efficacy between CEUS LI-RADS and CT/MR LI-RADS for HCC. 超声造影LI-RADS与CT/MR LI-RADS诊断HCC疗效一致性研究。

Clinical hemorheology and microcirculation Pub Date : 2025-12-01 Epub Date: 2026-04-10 DOI: 10.1177/13860291251382301

Peihua Wang, Yanqing Wang, Guojuan Wang, Qi Li, Dan Yang, Fang Nie

{"title":"Study on the concordance in the diagnostic efficacy between CEUS LI-RADS and CT/MR LI-RADS for HCC.","authors":"Peihua Wang, Yanqing Wang, Guojuan Wang, Qi Li, Dan Yang, Fang Nie","doi":"10.1177/13860291251382301","DOIUrl":"10.1177/13860291251382301","url":null,"abstract":"ObjectiveTo investigate the diagnostic concordance between CEUS LI-RADS and CT/MR LI-RADS for focal intrahepatic lesions in patients at high risk of hepatocellular carcinoma.MethodsRetrospective analysis of imaging data of patients at high risk of HCC attending our hospital from January 2018 to January 2021, 165 lesions were classified according to CEUS LI-RADS and CT/MR LI-RADS, respectively, using puncture biopsy or surgical pathology as the criteria. The kappa concordance test was used to evaluate the classification results of intrahepatic focal lesions in high-risk groups.ResultsThe concordance between CEUS and CT/MRI LI-RADS for the classification of intrahepatic focal lesions in the high-risk group of HCC was statistically different (P < 0.001), and the agreement between the two imaging methods was general (kappa = 0.345，P < 0.001). The positive predictive value of CEUS LR-5 for HCC was 95.4%, and the positive predictive value of CT/MRI LR-5 had a positive predictive value of 94.6% for HCC, and the difference between CEUS and CT/MRI LR-5 for HCC was not statistically significant. The positive predictive value of CEUS LR-M for non-HCC malignancies was 34.1%, and the positive predictive value of CT/MRI LR-M for non-HCC malignancies was 76.5%, and the difference between CEUS and CT/MRI LR-M had a statistically significant difference in the positive predictive value for non-HCC malignancies (P < 0.05).ConclusionsThe classification results of CEUS and CT/MRI LI-RADS for focal intrahepatic lesions in a high-risk group of HCC were in general agreement, but both had high diagnostic performance, and both had high specificity and positive predictive value using LR-5 as the diagnostic imaging standard for HCC, while the differential diagnostic value of LR-M for non-HCC malignant tumors and HCC still needs to be further investigated.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"68-76"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observational study of nailfold capillaroscopy features in hypertension, diabetes Mellitus, stroke, and chronic kidney disease: Associations and potential for early detection in cardiovascular and metabolic disorders. 甲襞毛细血管镜检查在高血压、糖尿病、中风和慢性肾脏疾病中的观察性研究：心血管和代谢疾病早期检测的相关性和潜力

Clinical hemorheology and microcirculation Pub Date : 2025-12-01 Epub Date: 2026-04-20 DOI: 10.1177/13860291251414609

Hongxu Li, Fengming Jie, Yutong Zou, Yifan Wu, Mei Feng, Tao Chen, Xiuming Li, Guangyao Zhu, Yin Chen, Yanxiong Wu, Zhimin Yang, Wei Bin

{"title":"Observational study of nailfold capillaroscopy features in hypertension, diabetes Mellitus, stroke, and chronic kidney disease: Associations and potential for early detection in cardiovascular and metabolic disorders.","authors":"Hongxu Li, Fengming Jie, Yutong Zou, Yifan Wu, Mei Feng, Tao Chen, Xiuming Li, Guangyao Zhu, Yin Chen, Yanxiong Wu, Zhimin Yang, Wei Bin","doi":"10.1177/13860291251414609","DOIUrl":"10.1177/13860291251414609","url":null,"abstract":"ObjectivesTo assess nailfold capillary (NFC) features in hypertension, diabetes mellitus (DM), stroke, and chronic kidney disease (CKD) versus healthy controls, and explore relationships between abnormalities.MethodsObservational study of 162 participants (69 M/93F, mean age 39.7 ± 13.16y). NFC evaluated vessel clarity, tubular collateral number/length, input/output tab diameters, apex diameter/width, granular flow rate, blood color ratio, perfused capillary density (PCD) in five groups.ResultsSignificant differences found vs. controls: DM group had reduced tubular collateral length and input tab diameter; Stroke group had reduced tubular collateral length and apex width, plus altered blood color distribution; CKD group had reduced vessel clarity; The PCD was significantly reduced in the hypertension, diabetes mellitus, and stroke groups(P < 0.01). Well-point sites had fewer tubular collaterals than non-well-point sites.ConclusionsSpecific NFC parameters (capillary length, width, blood color, clarity) provide reference values for assessing these cardiovascular/metabolic disorders. Well-point NFC may aid early detection/prevention.","PeriodicalId":93943,"journal":{"name":"Clinical hemorheology and microcirculation","volume":" ","pages":"77-89"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in renal perfusion with brainstem death - revisiting the hypothesis of sympathetically mediated organ hypoperfusion. 脑干死亡时肾灌注的变化——重新审视交感介导的器官灌注不足假说。

Clinical hemorheology and microcirculation Pub Date : 2025-12-01 Epub Date: 2026-04-10 DOI: 10.1177/13860291261421283

Rory McDonald, Adrian Wong, Richard Cashmore, Marlies Ostermann, Sam Hutchings

引用次数: 0