Central nervous system agents in medicinal chemistry最新文献

{"title":"Study of the Antidepressant Effects of the Combination of Agmatine and Melatonin Following Restraint Stress in Mice: the Role of Oxidative Factors.","authors":"Saeed Mehrzadi, Ali Jamshidi Naeini, Fahime Azimirad, Azam Hosseinzadeh","doi":"10.2174/0118715249347833250307041355","DOIUrl":"10.2174/0118715249347833250307041355","url":null,"abstract":"<p><strong>Objective: </strong>Major Depressive Disorder (MDD) is a psychiatric disorder that has a tight connection to stressful experiences, decreased levels of endogenous antioxidants and enhanced levels of oxidative stress. We drafted this research to define the results of combining agmatine and melatonin on stress-induced depression in mice.</p><p><strong>Methods: </strong>Experimental groups included the non-stressed group treated with vehicle (ethanol at a concentration of 0.0005%), stressed vehicle (ethanol at a concentration of 0.0005%)-treated group, group treated with fluoxetine (10 mg/kg/day), group treated with melatonin (10 mg/kg/day), group treated with agmatine (1 mg/kg/day), group receiving a combination of melatonin (10 mg/kg/day) and agmatine (1 mg/kg/day). The animals were subjected to restraint stress for two hours daily for a duration of one week, concurrently with the daily oral administration of agents through drinking water. Open field test and forced swimming test were operated on the 8th day. The oxidative stress markers were measured in the mice hippocampus.</p><p><strong>Results: </strong>Stress led to the elevation of immobility time. The combination group showed a significant effect in comparison to the agmatine and melatonin groups. The combination of melatonin and agmatine was successful in the elevation of hippocampus catalase activity; and this effect was comparable in the fluoxetine group. We observed enhancement of superoxide dismutase activity in treatment groups and reduction in <i>malondialdehyde</i> levels in melatonin, agmatine and combination groups.</p><p><strong>Conclusion: </strong>A combination of agmatine and melatonin improves stress-induced depression more effectively than each alone, which may result from suppressing oxidative stress.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":"95-102"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phthalates Induced Neurotoxicity: A Mechanistic Approach.","authors":"Kajal Gaur, Yasir Hasan Siddique","doi":"10.2174/0118715249332874241113030902","DOIUrl":"10.2174/0118715249332874241113030902","url":null,"abstract":"<p><p>Phthalates play a significant role as plastic modifying additives in everyday items like plastics, pesticides, paints, and cosmetics. This review explores the relationship between phthalates and neurotoxicity and sheds light on the potential risks these ubiquitous chemicals pose to neurological health. The review elucidates the diverse neurotoxic effects of phthalates exposure, spanning developmental neurotoxicity, neuropathy, neurodegenerative diseases, and neurobehavioral toxicity. Mechanistic insights reveal the pathways through which phthalates induce cellular damage, including oxidative stress, disruption of calcium signalling, alteration in lipid metabolism, and interference with thyroid hormone homeostasis. Moreover, the review discusses regulatory measures aimed at restricting phthalate usage and highlights the imperative for further research and awareness to safeguard public health against the neurotoxic effects of phthalates.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":"28-45"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Pharmacophore Responsible for the JNK3 Enzyme Inhibition using KPLS-based QSAR Analysis.","authors":"Ravi Kumar Rajan, Maida Engels, Umaa Kuppuswamy","doi":"10.2174/0118715249345667250216034023","DOIUrl":"10.2174/0118715249345667250216034023","url":null,"abstract":"<p><strong>Background: </strong>The pharmacophoric approach relies on the theory of possessing ubiquitous chemical functionalities, and carrying a uniform spatial conformation that provides a route to enhanced potency on the same target receptor. JNK3, also known as c-Jun N-terminal kinase 3, is a protein kinase that plays a crucial role in various cellular processes, particularly in the central nervous system (CNS). In this study, a kernel-based partial least square (KPLS)- based Two-dimensional Quantitative structural activity relationship (2D QSAR) model to predict pharmacophores responsible for c-Jun-N-terminal kinase 3 (JNK3) inhibition.</p><p><strong>Methods: </strong>A library of small molecule JNK3 inhibitors was created from the literature, and a predictive model was built using Canvas 2.6.</p><p><strong>Results: </strong>The analysis revealed key structural determinants of activity. Compounds with high pIC₅₀ values (>6) showed numerous favorable contributions, particularly secondary benzamide nitrogen and methylene groups. Steric effects were more influential than inductive effects, with bulkier groups like t-butyl reducing activity. Positive contributions were observed with OH, OCH3, and -F substituents, while unfavorable effects were linked to tertiary nitrogen, methyl, and primary amino groups. Substituted sulphonamides and benzotriazole moieties enhanced activity unless modified with amino or carbonyl groups. Favorable contributions were noted for terminal heterocyclic rings like pyrimidinyl acetonitrile, whereas phenyl substitutions and certain piperazine configurations were detrimental. Hydrogen in the urea moiety and avoiding bulky substitutions were crucial for activity. These insights guide the design of potent JNK3 inhibitors.</p><p><strong>Conclusion: </strong>The present study highlights the significant impact of substituents on molecular activity, with steric effects, particularly on the phenyl ring, playing a dominant role. Favorable contributions are linked to substitutions like hydroxyl, methoxy, and fluorine, while bulky and meta substitutions reduce activity. Functional groups like unsubstituted sulfonamide or free hydrogen in urea are crucial for activity. Insights into steric, electronic, and positional factors, combined with analysis of JNK3 inhibitors, will guide the design of more selective molecules.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":"63-78"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Review of Potential Drug Targets for Japanese Encephalitis.","authors":"Roshini Singh, Sayak Sanyal, Nikita Basant, Somali Sanyal","doi":"10.2174/0118715249353956250326164211","DOIUrl":"10.2174/0118715249353956250326164211","url":null,"abstract":"<p><p>Japanese encephalitis virus (JEV), first identified in 1935, continues to be a major threat to human health, especially in the Asia-Pacific region, where it remains prevalent. JEV, a neurotropic flavivirus, spreads through Culex tritaeniorhynchus mosquito bites and causes severe brain infections with high morbidity and mortality rates. Despite the availability of vaccines, no licensed anti-JEV drugs exist. This review provides a comprehensive overview of the epidemiology, structural and nonstructural proteins, and pathogenesis of JEV and explores potential drug targets. This study highlights both conventional and nonconventional drug targets, with a focus on nonstructural JEV proteins, which may hold promise for therapeutic development. This review also discusses drug targets shared by JEV and other flaviviruses, such as dengue, Zika, and West Nile virus, which reveal common pathways for viral entry and replication, along with distinct mechanisms specific to JEV. Key receptor interactions, including DC-SIGN, TAM receptor, sialic acid, LDLR, and CLEC5A interactions, are involved in JEV transmission and immune evasion. Additionally, the NMDA receptor has been identified as a critical player in JEV pathogenesis, suggesting new opportunities for neuroprotective therapies. A major obstacle in JEV drug development is the blood-brain barrier (BBB), which hinders the delivery of therapeutic agents to the central nervous system (CNS). Recent research has emphasized the need for innovative drug delivery systems that can cross the BBB, reducing viral replication and neural damage. While clinical trials with traditional antivirals have yielded mixed results, live attenuated and inactivated vaccines have shown promise in preventing JEV infection. Additionally, nucleic acid-based therapies, including microRNAs and short hairpin RNAs (shRNAs), are emerging as potential treatments, with nanoparticle-based delivery systems offering solutions to overcome BBB challenges. This review underscores the need for an integrated approach, including improved vaccines, targeted drug delivery strategies, and novel therapeutics, to effectively combat JEV infections on a global scale.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":"46-62"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Novel Biomarkers in the Early Management of Peripheral Diabetic Neuropathy.","authors":"Jyoshna Rani Dash, Gurudutta Pattnaik, Gangadhar Pradhan, Choudhury Pratyush Kumar Baral, Biswajit Behera, Goutam Ghosh, Goutam Rath, Biswakanth Kar","doi":"10.2174/0118715249358465250522173332","DOIUrl":"10.2174/0118715249358465250522173332","url":null,"abstract":"<p><p>Diabetes can frequently result in peripheral diabetic neuropathy (PDN), a lifethreatening illness that impairs the motor and sensory abilities of peripheral nerves. Prompt identification and management of peripheral neuropathy are essential to avert permanent nerve impairment and enhance the well-being of affected individuals. In addition, axonal degeneration is usually detected at a late stage of the disease and serves as a basis for developing modern diagnostic techniques. Novel biomarkers that can detect PDN early and track its development are thus required. In this review, we highlight the most recent developments in identifying and verifying putative biomarkers for PDN, emphasizing their connections to the pathophysiology and clinical presentations of the illness. The challenges and opportunities for developing biomarker-based diagnostic and therapeutic strategies for PDN are also discussed. It is suggested that biomarkers help predict the response and outcome of PDN treatments, such as poly (ADP-ribose) polymerase inhibitors and regenerative medicine.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":"150-166"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Computational Analysis, and Pharmacological Evaluation of Novel Schiff Base Hybrids for Anxiolytic and Skeletal Muscle-relaxant Activities.","authors":"Amit Kumar, Sushil Kumar, Shivam, Archana Gautam, Afreen Usmani, Sneha Rawat","doi":"10.2174/0118715249355436250806100850","DOIUrl":"10.2174/0118715249355436250806100850","url":null,"abstract":"<p><strong>Introduction: </strong>Schiff bases are a well-known class of substances with a variety of pharmacological properties, including skeletal muscle relaxant and anxiolytic effects. They are ideal candidates for the development of CNS-active drugs due to their structural adaptability and ability to interact with a range of biological targets. The purpose of this study was to create, synthesize, and describe new Schiff base hybrids and assess their possible skeletal muscle relaxant and anxiolytic effects using pharmacological and computational techniques.</p><p><strong>Methods: </strong>By using condensation reactions between primary amines and substituted aromatic aldehydes, several new Schiff base hybrids were created. FT-IR, ¹H NMR, ¹³C NMR, and mass spectrometry were used for structural elucidation. To evaluate binding affinity with GABA-A and NMDA receptor sites, computational investigations involving molecular docking and ADME profiling were carried out. Validated rodent models were utilized for pharmacological evaluations, including the rotarod and traction tests to assess skeletal muscle relaxation, as well as the elevated plus maze and open-field tests to evaluate anxiolytic activity.</p><p><strong>Results: </strong>The synthesized Schiff base derivatives demonstrated high purity and stability. In accordance with the observed <i>in vivo</i> anxiolytic activity, docking studies demonstrated advantageous binding interactions with the GABA-A receptor.</p><p><strong>Discussion: </strong>Certain compounds exhibited moderate skeletal muscle relaxant activity, without producing noticeable sedation or motor impairment, as well as significant anxiolytic effects comparable to those of diazepam (p < 0.05). Good drug-likeness and CNS permeability were predicted for the lead compounds by ADME analysis.</p><p><strong>Conclusion: </strong>Both in silico and <i>in vivo</i> tests support the encouraging skeletal muscle relaxant and anxiolytic properties of the synthesized Schiff base hybrids. These results suggest their potential as top contenders for the development of innovative CNS-active medications.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":"201-211"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Neuroprotective Role of Nutritional Supplements in Neurodegenerative Diseases.","authors":"Sonia Singh","doi":"10.2174/0118715249389608251108031453","DOIUrl":"https://doi.org/10.2174/0118715249389608251108031453","url":null,"abstract":"<p><p>Nutraceuticals obtained from natural sources have been explored as well as studied for significant applications to treat several diseases like diabetes, cardiovascular diseases, and neurodegenerative diseases. The manuscript explores the mode of actions and different nutraceuticals used to treat various neurodegenerative disorders (NDs). The data have been extensively collected from various sources such as Scopus, Science Direct, Web of Science, and PubMed, respectively. Progressive malfunction and loss of neuronal structure as well as function, leading to neuronal cell death, are characteristic of ND conditions. Targeting various neuroprotection strategie avoiding cell death and restoring the function of damaged neurons, may be potential treatments for ND disorders. The application of nutraceuticals as neuroprotective agents in the treatment of ND disorders is a growing field of research. This article summarises the current knowledge regarding the neuroprotective effects of nutraceuticals against the pathologies of ND conditions. There is no way to recommend nutraceuticals in dementia-related therapy guidelines because of the severe scarcity of high-level evidence studies. However, more research is needed because of their promising neuroprotective action potential.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Strategies for Schizophrenia Management: Bridging Traditional Remedies with Modern Psychiatry.","authors":"Harsh Pratap Singh, Avijit Mazumder, Bhavani Pentela","doi":"10.2174/0118715249389638251022054305","DOIUrl":"https://doi.org/10.2174/0118715249389638251022054305","url":null,"abstract":"<p><p>Schizophrenia (SZ), a chronic psychiatric disorder, presents significant challenges in its management, primarily due to its complex etiology and the limitations of current antipsychotic therapies. Traditional antipsychotics often alleviate positive symptoms but exhibit limited efficacy for negative and cognitive symptoms, alongside notable adverse effects. This has led to an increasing exploration of herbal remedies as complementary or alternative approaches. The review highlights the function of medicinal plants and phytochemicals in SZ management. The highlighted neuroprotective, antioxidant, anti-inflammatory, and receptor-modulating characteristics of plant-based compounds, such as alkaloids, glycosides, terpenes, and polyphenols, target critical neurotransmitter systems, including dopaminergic, serotonergic, and GABAergic pathways. Key examples, such as Mitragyna speciosa, Withania somnifera, and Ginkgo biloba, demonstrate the potential to mitigate SZ symptoms through mechanisms like oxidative stress reduction and receptor modulation. Furthermore, the synergistic effects of these herbs, when used as polyherbal formulations, as exemplified by traditional remedies like Yokukansan and Suoquan pill, underscore the therapeutic potential of combining multiple herbs. While promising, challenges remain in standardizing herbal preparations and validating their efficacy through rigorous clinical trials. The review consolidates the current understanding of phytoconstituents and herbal formulations, advocating for their potential integration into mainstream psychiatric care.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Maternal Road Traffic Noise Exposure on Hippocampal Spatial Memory and Neurogenesis of Sprague Dawley Offspring: Therapeutic Effects of Edaravone, Melatonin, and Enriched Environments.","authors":"Vishal Kumar Biswkarma, Anurag Chaudhary, Mandeep Kumar Arora","doi":"10.2174/0118715249381371251019170111","DOIUrl":"https://doi.org/10.2174/0118715249381371251019170111","url":null,"abstract":"<p><p><p> Introduction: Mental problems are associated with early neonatal and in utero exposure to maternal stress. With established negative impacts on mental health and cognitive function, road traffic noise (RTN) has emerged as a ubiquitous environmental stressor. In this work, we have examined the effects of maternal exposure to RTN on the development of neurogenesis and spatial memory in the hippocampus (HC) of offspring and investigated possible strategies for mitigating these effects. </p><p> Method: During the prenatal maturation stage, female Sprague Dawley (SD) rats that were determined to be pregnant were exposed chronically to 100 dB SPL (sound pressure level) RTN for six hours per day. The Morris water maze and elevated plus maze tests were used to evaluate the neurobehavioral performances of the offspring. The oxidative stress and neurogenesis in the HC were evaluated using 2% 2,3,5-triphenyl tetrazolium chloride staining, HC histopathology, and biochemical methods (SOD: superoxide dismutase, GSH: glutathione, CAT: catalase, as well as TBARS: thiobarbituric acid reactive substance, MPO: myeloperoxidase, and AChE: acetylcholinesterase), respectively. Additionally, we looked at the potential therapeutic benefits of melatonin, edaravone, and an enriched environment. </p><p> Result: The results of our investigation showed that maternal exposure to 100 dB SPL RTN considerably reduced the offspring's spatial memory and caused distress. The biochemical estimation of HC tissue supernatant revealed a considerable increase in MPO, AChE, and TBARS levels and a marked reduction in SOD, CAT, and GSH levels. However, there were notable protective effects against these unfavorable outcomes due to the administration of melatonin and edaravone, as well as from being exposed to an enriched environment. </p><p> Discussion: In our study, prenatal exposure to 100 dB SPL RTN caused oxidative stress, which caused neurodegeneration, as well as decreased spatial memory and induced anxiety, being consistent with previous findings. In particular, compared to offspring of the 100 dB SPL RTNexposed group, offspring of the maternally treated EDV and MLT combination groups showed superior spatial memory function, reduced anxiety, and increased neurogenesis. </p><p> Conclusion: The findings of our study have offered promising pathways for public health policies and urban planning concerns, as well as useful insights into the development of tailored therapies to safeguard against the cognitive and neurological repercussions of maternal RTN exposure.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Nature to Neuroscience: Exploring Carvacrol's Therapeutic Potential in Brain Health.","authors":"Ahsas Goyal, Anshika Kumari, Aanchal Verma, Raj Kumar, Mayashankar Thakur, S Gopika","doi":"10.2174/0118715249387846251006093402","DOIUrl":"https://doi.org/10.2174/0118715249387846251006093402","url":null,"abstract":"<p><p>Carvacrol is a major active compound present in the essential oils of various aromatic plants. Research strongly indicates that carvacrol holds considerable promise for use in the development of new pharmaceutical drugs and dietary supplements. Due to its broad spectrum of bioactive properties, carvacrol shows potential therapeutic applications for several complex and challenging brain-related disorders. Its actions are multifaceted; it mitigates neuroinflammation and exerts antioxidant properties as well as other neuroprotective effects that shield neural structures from degeneration. Additionally, carvacrol influences important neural systems, including the cholinergic and dopaminergic pathways, helping to regulate neurotransmitter levels and activity in ways that could mitigate neurological symptoms. Furthermore, its anti-apoptotic effects suggest that it can help prevent programmed cell death, a common factor in neurodegenerative diseases. Collectively, these biological properties make carvacrol an attractive option for use as an adjunctive or supportive therapy in managing a range of brain illnesses, including epilepsy, anxiety, depression, stroke, Parkinson's disease, and Alzheimer's disease. This study presents an extensive review of in vitro as well as in vivo research studies on carvacrol's protective effects across different brain disorders. By examining these studies, this review offers a comprehensive and up-to-date assessment of the biological activities and molecular mechanisms of carvacrol, emphasizing its potential role in therapeutic strategies aimed at supporting brain health and treating complex neurological conditions.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}