WITHDRAWN: Exploring The Diverse Therapeutic Potentials of Synthetic Analogues of Keto-terpenoids (+) Carvone: A Future Scaffold

Central nervous system agents in medicinal chemistry Pub Date : 2024-03-27 DOI:10.2174/0118715249278766240322054108

Snigdha Srivastava, Reema Sinha, Rahul Kaushik, Rajan Kumar Kurmi

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Abstract

The article has been withdrawn at the request of the authors of the journal "Central Nervous System Agents in Medicinal Chemistry" as a conflict has arisen among the authors in adding another author at the later stage of publication

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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探索酮三萜类合成类似物 (+) 香芹酮的多种治疗潜力：未来的支架。

背景：香芹酮是薄荷植物和一些地中海香料中的一种单萜酮。香芹酮化合物有两种对映体，即 S (+) 香芹酮和 R (-) 香芹酮。这两种对映体形式的香芹酮在物理和化学特性上完全相同，只是在气味的旋转能力上有所不同。香芹酮还被用来治疗新生儿胀气绞痛，以及成人的心急胃痛症状、痉挛性胃肠道不适、胀气、胃部不适、消化不良、食欲不振和消化不良。它还被用作利尿剂、镇静剂、镇痛剂和壮阳药，治疗头痛和晨起呕吐，增强肝功能，治疗支气管肺病，治疗咳嗽，还被用作收敛剂。腰痛和风湿病都可以用胡芹籽的蒸汽来治疗。胡芦巴种子含有 1-9% 的成分，其中精油中含有 30 多种不同的化学物质。其中有两种主要成分：香芹酮和柠檬烯。利用 7,12-二甲基苯并蒽 DMBA 诱导的皮肤癌来评估 D-香芹酮（10、20 和 30 毫克/千克体重）在体内的化学预防效果。研究了香芹酮减少黑色素数量的能力及其通过 cAMP 途径对黑色素瘤细胞产生的有益影响：方法：通过 AutoDock4.0 进行硅对接，并使用 SwissADME 进行 ADMET 研究，作为上述事实的一部分，发现 S(+)carvone 是一种前景看好的分子，没有毒性，而且还能穿透血脑屏障。血脑屏障添加剂的渗透性是通过煮鸡蛋预测的，这种预测遵循 Lipinski RO5.Result：所获得的强结合得分结果表明，S(+)香芹酮与相应的抗癫痫、抗癌和抗氧化受体对接后，其结合能分别为-7.05kcal/mol、-4.62kcal/mol和-4.13kcal/mol，是一种很有前途的分子。所提出的香芹酮对映体作为其抗癫痫活性的支架将有利于未来的研究：S（+）香芹酮具有中枢神经系统抑制作用和抗惊厥活性。根据两种对映体的研究参数，R&S 可阻断 GABA 结合位点。因此，这表明 S(+) 香芹酮可能是具有抗惊厥活性的新分子。多项研究表明，S（+）香芹酮比 R（-）香芹酮具有更强的抗惊厥活性。因此，可以认为 S（+）香芹酮可以作为抗惊厥活性的支架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Central nervous system agents in medicinal chemistry

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