Central nervous system agents in medicinal chemistry最新文献_第6页

To Explore Nasal-Brain Lymphatic System for Brain-Targeted Drug Delivery and to Treat Neurodegenerative Diseases. 探索鼻-脑淋巴系统用于脑靶向给药和治疗神经退行性疾病。

Central nervous system agents in medicinal chemistry Pub Date : 2024-10-15 DOI: 10.2174/0118715249329586240924105624

Rohit Sharma, Monika, Bobby Tyagi, Disha Gupta, Rupa Mazumder, Avijit Mazumder

引用次数: 0

Nattokinase Attenuated Excitatory Amino Acids and Cytokines Release and Restored Cerebral Blood Flow in a Thrombolytic Focal Cerebral Ischemic Rat Model. 纳豆激酶可减轻溶栓性局灶性脑缺血大鼠模型中兴奋性氨基酸和细胞因子的释放并恢复脑血流量

Central nervous system agents in medicinal chemistry Pub Date : 2024-10-09 DOI: 10.2174/0118715249314623240923092315

M Ramanathan, Mohammed Jamshir Km, Jerin M Jose, Nidhya Ganesan

{"title":"Nattokinase Attenuated Excitatory Amino Acids and Cytokines Release and Restored Cerebral Blood Flow in a Thrombolytic Focal Cerebral Ischemic Rat Model.","authors":"M Ramanathan, Mohammed Jamshir Km, Jerin M Jose, Nidhya Ganesan","doi":"10.2174/0118715249314623240923092315","DOIUrl":"https://doi.org/10.2174/0118715249314623240923092315","url":null,"abstract":"Objective: Nattokinase (NK), a protease enzyme present in traditional fermented Japanese food, has shown fibrinolytic properties in vitro as well as in cardiac ischemia. In the present study, the Neuroprotective effect of standardized NK was evaluated in the thrombolytic focal cerebral ischemic model.Methodology: The parameters of behavioural assessment, cerebral blood flow, inflammatory mediators, excitatory amino acids, and immunohistochemistry were measured to support the NK effect. NK was administered at 150 and 300 mg/kg, and its effects were compared with streptokinase (STK) (100μl/rat). Each mg of NK contains 5.5 Units of the enzyme, which can cause lysis of the fibrin.Results: The results indicate that 7 days of treatment of 300 mg NK restored the cerebral blood flow and prevented the release of cytokine and excitatory amino acids. Similarly, neurological scores were reduced, and grip strength increased significantly with NK treatment. The GFAP and synaptophysin staining of the hippocampus (CA1) and cerebrum have shown recovery of neurons from ischemic damage in comparison to vehicle-treated ischemic-reperfused rats. The NK (300 mg/kg) fibrinolytic effect is comparable to STK treatment.Conclusion: To conclude, NK, a serine protease, protects the brain from ischemic degeneration in thrombolytic cerebral ischemia. Consumption of this Japanese food might exhibit prophylactic activity.","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Phytocompounds for Effective Management of Migraine: Current and Future Prospectives. 植物化合物在有效治疗偏头痛方面的作用：当前和未来展望。

Central nervous system agents in medicinal chemistry Pub Date : 2024-09-10 DOI: 10.2174/0118715249308649240730093046

Swapnil Randive, Sanjeev Kumar Sahu, Manish Vyas

引用次数: 0

Multiple Sclerosis: Pathogenesis Mechanism and Biomarkers. 多发性硬化症：发病机制和生物标志物。

Central nervous system agents in medicinal chemistry Pub Date : 2024-09-04 DOI: 10.2174/0118715249307633240817160735

Ashwani Arya, Manish Dhall, Vineet Mittal, Deepak Kaushik, Priya Mudgal, Tarun Kumar, Manisha Pandey, Renu Kadian, Prerna Sharma, Nidhi Rani, Thakur Gurjeet Singh

{"title":"Multiple Sclerosis: Pathogenesis Mechanism and Biomarkers.","authors":"Ashwani Arya, Manish Dhall, Vineet Mittal, Deepak Kaushik, Priya Mudgal, Tarun Kumar, Manisha Pandey, Renu Kadian, Prerna Sharma, Nidhi Rani, Thakur Gurjeet Singh","doi":"10.2174/0118715249307633240817160735","DOIUrl":"https://doi.org/10.2174/0118715249307633240817160735","url":null,"abstract":"Multiple sclerosis (MS) is an unceasing, demyelinating, idiopathic inflammatory, and neurodegenerative disease of the Central Nervous System (CNS.) The disease is characterized by the occurrence of neurological symptoms over a period of days to weeks, abide by partial or absolute diminutions of various durations. In this review, a concise outline on disease activity and progression of MS, pathogenesis with the special prominence on the biomarkers for the MS as therapeutic targets has been discussed by carrying out a comprehensive literature survey employing chief websites and search engines for investigation. Cortical inflammation, neurodegeneration, demyelination, axonal injury, axonal loss, oligodendrocytes, mitochondrial dysfunction, microglia activation, oxidative and nitrosative stress are the pathological hallmarks of the MS. CNS neurofilaments, chitinase and chitinase 3-like proteins, soluble circulating form (sCD163), Chemokine ligand 13 (CXCL13), immunoglobulin M, MicroRNA (miRNA) and messenger Ribonucleic Acid (mRNA), Glial fibrillary acidic protein (GFAP), serum osteopontin, 8-iso-prostaglandin F2α (8-iso-PGF2 α), apo-Lipoprotein E and myelinreactive T cells are some of the therapeutically valuable biomarkers for such multifarious disorder. MS is one of the chronic neurodegenerative diseases with undefined etiology. The study of the pathophysiology of the disease and the involvement of certain biomarkers can help identify new targets for therapeutic intercession, identify individuals at risk of developing the disease later in life, and allow more effective treatment of progressive diseases such as MS.","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of Neurotransmitters in Cerebral Ischemia: Understanding the Role of Serotonin, Dopamine, Glutamate, and GABA in Stroke Recovery and Treatment. 神经递质在脑缺血中的意义：了解羟色胺、多巴胺、谷氨酸和 GABA 在中风恢复和治疗中的作用。

Central nervous system agents in medicinal chemistry Pub Date : 2024-08-19 DOI: 10.2174/0118715249302594240801171612

Marjan Nikbakhtzadeh, Sanaz Bordbar, Samaneh Seyedi, Mina Ranjbaran, Ghorbangol Ashabi, Afshin Kheradmand

{"title":"Significance of Neurotransmitters in Cerebral Ischemia: Understanding the Role of Serotonin, Dopamine, Glutamate, and GABA in Stroke Recovery and Treatment.","authors":"Marjan Nikbakhtzadeh, Sanaz Bordbar, Samaneh Seyedi, Mina Ranjbaran, Ghorbangol Ashabi, Afshin Kheradmand","doi":"10.2174/0118715249302594240801171612","DOIUrl":"https://doi.org/10.2174/0118715249302594240801171612","url":null,"abstract":"Brain ischemia occurs following heart failure, thromboembolism, and atherosclerosis, and it is characterized by the disturbance of blood flow resulting from the blockage of blood vessels. After a series of studies, it is deduced that various changes occur following stroke, including neural death and changes in plasticity. Studies have reported that neurotransmitters tend to change following a stroke. These changes that occur surrounding the infarct area following a stroke can be considered new therapeutic targets for stroke rehabilitation. Although various studies have reported that different neurotransmitters have a promising role in either the progression or the rehabilitation following stroke, they have not found any pharmacological interventions to help the previous rehabilitation therapeutics. Phytocompounds also offer potential therapeutic benefits in stroke management due to their antioxidative and anti-inflammatory properties. This article aimed to compile recent advancements in neurotransmitter research related to ischemia and explore the potential use of neurotransmitter agonists/antagonists in ischemic conditions to identify potential drug candidates for treating the severe and prolonged stages of stroke in the future.","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Applications of Phytoconstituents in Neuropathic Pain. 揭示植物成分在神经病理性疼痛中的应用。

Central nervous system agents in medicinal chemistry Pub Date : 2024-08-13 DOI: 10.2174/0118715249312031240803190651

Rimjhim Priyanshi, Anjana Sharma, Shobhit Kumar, Arpana Gupta, Bhupesh Sharma, Nitin Sharma

{"title":"Unveiling the Applications of Phytoconstituents in Neuropathic Pain.","authors":"Rimjhim Priyanshi, Anjana Sharma, Shobhit Kumar, Arpana Gupta, Bhupesh Sharma, Nitin Sharma","doi":"10.2174/0118715249312031240803190651","DOIUrl":"https://doi.org/10.2174/0118715249312031240803190651","url":null,"abstract":"Background: Neuropathic pain is a complex chronic condition resulting from the damage or dysfunction of the nervous system. Conventional therapies offer limited success and often come with various adverse effects. Therefore, the exploration of alternative therapies, such as phytoconstituents, may be of substantial interest for their potential to alleviate neuropathic pain.Objectives: This review systematically examines the diverse roles and mechanisms of various phytoconstituents in modulating neuropathic pain. In this study, a comprehensive analysis of phytoconstituents in neuropathic pain is carried out to understand their mechanism in preventing the disease.Method: The current search is done in the databases of Google Scholar, PubMed Central, ScienceDirect, and Scopus using the keywords: neuropathic pain, phytoconstituents as analgesics, physiological effects of medicinal plants, and natural products, to find the most relevant articles of the last 10 years.Result: Out of 125 articles, 112 were included in this study, which revealed that several phytoconstituents inhibit several biomarkers responsible for neuropathic pain. Moreover, this review highlights the underlying molecular pathways and targets through which these bioactive compounds exert their therapeutic effects, emphasizing their potential as novel pharmacological agents.Conclusion: This study concludes that phytoconstituents may possess potential applications in managing neuropathic pain and could be effectively used as an alternative approach to mitigate the condition with enhanced risk of safety and tolerability.","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Carvacrol against Oxidative Damage in Aged Rats. 香芹酚对老年大鼠氧化损伤的保护作用

Central nervous system agents in medicinal chemistry Pub Date : 2024-08-13 DOI: 10.2174/0118715249303906240729074821

Mohammad Amin Forqani, Mahsan Akbarian, Sabiheh Amirahmadi, Mohammad Bagher Khorrami, Mahmoud Hosseini, Fatemeh Forouzanfar

{"title":"Protective Effect of Carvacrol against Oxidative Damage in Aged Rats.","authors":"Mohammad Amin Forqani, Mahsan Akbarian, Sabiheh Amirahmadi, Mohammad Bagher Khorrami, Mahmoud Hosseini, Fatemeh Forouzanfar","doi":"10.2174/0118715249303906240729074821","DOIUrl":"https://doi.org/10.2174/0118715249303906240729074821","url":null,"abstract":"Background: Aging affects cellular functions and impairs tissue homeostasis. Carvacrol, a polyphenolic compound, has been shown to exert a wide range of pharmacological effects, such as antioxidant, anti-inflammatory, and anticancer characteristics.Methods: This investigation aimed to evaluate the effect of carvacrol in elderly male rats. Carvacrol at a dose of 15 or 30 mg/kg was administrated daily per os for 60 days to aged rats. The liver, heart, and kidney samples were taken for the analysis of oxidative stress markers. Serum samples were used to evaluate liver enzymes (alanine transaminase (ALT) and aspartate aminotransferase (AST)).Results: The levels of malondialdehyde (MDA) in the liver, heart, and kidney tissues of aged rats were higher. Conversely, the level of thiol was lower in the mentioned tissues than in the young control group. The levels of MDA in the liver, heart, and kidney tissues of aged rats were significantly reduced by carvacrol, which was accompanied by increased levels of total thiol. ALT and AST levels were higher in the serum of aged rats than in the young control ones. Carvacrol decreased ALT and AST levels in the serum of aged rats versus aged control rats.Conclusion: Carvacrol can be effective in protecting susceptible aged tissues and organs by increasing antioxidant defenses and decreasing liver enzymes.","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting-edge Approach of Carbon Nanostructures: Targeted Drug Delivery to Central Nervous System. 碳纳米结构的前沿方法：中枢神经系统靶向给药。

Central nervous system agents in medicinal chemistry Pub Date : 2024-07-12 DOI: 10.2174/0118715249305383240705045921

Venishaa S, Mridul Guleria, Prashant Kumar, Mithun Bhowmick, Pratibha Bhowmick, Sumel Ashique, Iqbal Husain, Radheshyam Pal

{"title":"Cutting-edge Approach of Carbon Nanostructures: Targeted Drug Delivery to Central Nervous System.","authors":"Venishaa S, Mridul Guleria, Prashant Kumar, Mithun Bhowmick, Pratibha Bhowmick, Sumel Ashique, Iqbal Husain, Radheshyam Pal","doi":"10.2174/0118715249305383240705045921","DOIUrl":"https://doi.org/10.2174/0118715249305383240705045921","url":null,"abstract":"Drug delivery through the blood-brain barrier (BBB) is one of the key challenges in the modern era of medicine due to the highly semipermeable characteristics of BBB that restrict the entry of various drugs into the central nervous system (CNS) for the management of brain disorders. Drugs can be easily incorporated into carbon nanocarriers that can cross the bloodbrain barrier. Numerous nanocarriers have been developed, including polymeric nanoparticles, carbon nanoparticles, lipid-based nanoparticles, etc. Among these, carbon nanostructures could be superior due to their easier BBB penetration and strong biocompatibility. Several CDs (Carbon dots) and CD-ligand conjugates have explored effectively penetrating the BBB, which enables significant progress in using CD-based drug delivery systems (DDS) to manage CNS diseases. Despite the drug delivery applications, they might also be used as a central nervous system (CNS) drug; few of the carbon nanostructures show profound neurodegenerative activity. Further, their impact on neuronal growth and anti- amyloid action is quite interesting. The present study covers diverse carbon nanostructures for brain-targeted drug delivery, exploring a variety of CNS activities. Moreover, it emphasizes recent patents on carbon nanostructures for CNS disorders.","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Review on Alzheimer's Disease: Natural Therapeutics, Gaps and Challenges. 阿尔茨海默病综合综述：自然疗法、差距与挑战。

Central nervous system agents in medicinal chemistry Pub Date : 2024-06-27 DOI: 10.2174/0118715249307525240614073143

Prem Shankar Mishra, Rakhi Mishra, Anuj Kumar

{"title":"Comprehensive Review on Alzheimer's Disease: Natural Therapeutics, Gaps and Challenges.","authors":"Prem Shankar Mishra, Rakhi Mishra, Anuj Kumar","doi":"10.2174/0118715249307525240614073143","DOIUrl":"https://doi.org/10.2174/0118715249307525240614073143","url":null,"abstract":"More than 20 million people worldwide have Alzheimer's disease (AD), making it the most prevalent disease. Patients with AD may live for at least a decade after diagnosis, making it the most common cause of disability in the elderly. Each year, 1% to 4% of the population is affected by AD, with prevalence peaking between ages 65 and 70 and declining to 6% among those over 85. Researchers have accumulated evidence on medicinal herbs that may reverse the pathogenesis of Alzheimer's disease. Alzheimer's disease (AD) is associated with severe memory loss, which can negatively impact social and professional life. The first neurotransmitter linked to Alzheimer's was acetylcholine (ACh). There is no known cure, and the available treatments are ineffective. Multiple studies indicate that Ayurvedic restorative herbs and their constituents may be effective in treating Alzheimer's disease. This technique emphasizes the fact that delaying or preventing Alzheimer's disease with the help of natural bio-actives could reduce the number of cases over the next half-century. To provide detailed information, the pathology and pathophysiology of Alzheimer's Disease are discussed in the text of this review, along with an overview of the neurotransmitters involved in the progression of the disease. The importance of different natural bioactives for the treatment of Alzheimer's disease is also outlined in the paper. The information contained in this paper can serve as a template for future research expressing the more beneficial role of other bioactive in acting as an adjuvant in the prevention and treatment of this disease, facing certain challenges and gaps with conventional drugs used to treat Alzheimer's disease.","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Smart Drug Delivery of Rotigotine Using Transdermal Patch for the Successful Management of Parkinson's Disease. 利用透皮贴剂智能给药罗替戈汀，成功治疗帕金森病。

Central nervous system agents in medicinal chemistry Pub Date : 2024-06-21 DOI: 10.2174/0118715249289689240607064642

Jose Prakash Dharmian, Angelin Claret Seraphim PushpaNathan, Prakash Ramakrishnan, Raja Navamani Subramanian, Jayachandran David Levy, Pavazhaviji Palani, Venkateshwaran Krishnaswami

{"title":"The Smart Drug Delivery of Rotigotine Using Transdermal Patch for the Successful Management of Parkinson's Disease.","authors":"Jose Prakash Dharmian, Angelin Claret Seraphim PushpaNathan, Prakash Ramakrishnan, Raja Navamani Subramanian, Jayachandran David Levy, Pavazhaviji Palani, Venkateshwaran Krishnaswami","doi":"10.2174/0118715249289689240607064642","DOIUrl":"https://doi.org/10.2174/0118715249289689240607064642","url":null,"abstract":"Background: A Non-Ergot Dopamine Agonist (NEDA) rotigotine has been designed as a new transdermal drug delivery system.Aim: To maintain optimum homogeneity in drug content, the rotigotine transdermal patch was developed utilizing a solvent casting technique.Methods: The characteristics of a transdermal patch, including patch weight, folding endurance, patch thickness, surface morphology, tensile strength, swelling rate, surface pH, in vitro release studies, water retention rate, uniformity of drug content, and ex-vivo permeation studies, were determined.Results: In vitro drug release studies unequivocally demonstrated that drug release controlled polymer interactions. There was no apparent lag period before the drug release rate started to decline. The developed patch showed 70 ± 1.18 % of prolongation of drug release within 24 hours. The result of the penetration studies demonstrated that 61 ± 2.52% of rotigotine permeated through the epidermal barrier within 24 h.Conclusion: The developed transdermal patch comprising rotigotine was evidently placed on the dermis layer, and an appropriate dose was delivered into circulation for a longer time based on the aforementioned factors. The findings of this study illustrate the effective approach of transdermal patches to treat Parkinson's disease.","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0