Cardiology最新文献

{"title":"A Risk Score without a Window: The Clinical Timing Problem of Observatoire Régional Breton sur l'Infarctus Risk Score.","authors":"Sarah Louise Duus Holle, Helle Søholm, Martin Frydland, Mikkel Bjerg Andersen, Yusuf Abdi Isse, Joakim Bo Kunkel, Anika Klein, Lene Holmvang, Jacob Eifer Møller, Christian Hassager, Rasmus Paulin Beske","doi":"10.1159/000552034","DOIUrl":"10.1159/000552034","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiogenic shock (CS) is a main cause of mortality in ST-elevation myocardial infarction (STEMI). The ORBI risk score estimates in-hospital CS risk using pre- and post-procedural angiographic variables. The study aimed to prospectively validate the ORBI risk score for predicting in-hospital CS and to assess its ability to identify post-procedural CS, when all score components are available.</p><p><strong>Methods: </strong>Consecutive adult STEMI patients without CS at admission were prospectively registered at a tertiary hospital during 2022-2025. Discrimination and calibration were evaluated in all patients and among patients with post-procedural CS after leaving the catheterization laboratory.</p><p><strong>Results: </strong>Among 2,713 adult patients (median age 64 years; 24% female), the median ORBI score was 4 (IQR 2-7), and 103 patients (3.8%) developed in-hospital CS. Among all patients, 80% were low risk (ORBI ≤7) with 1.0% developing in-hospital CS; 13% were low-to-intermediate risk (ORBI 8-10) with 5.6% developing CS; 3.1% were intermediate-to-high risk (ORBI 11-12) with 23% developing CS; and 3.9% were high risk (ORBI ≥13), of whom 40% developed in-hospital CS. The score demonstrated strong discrimination (area under the receiver operating characteristic curve [AUC] 0.89; 95% CI: 0.87-0.94) for in-hospital CS and for post-procedural CS (AUC 0.87; 95% CI: 0.83-0.95). In patients with in-hospital CS, 68% developed peri-procedural CS. Among patients with post-procedural, CS the score substantially overestimated CS risk.</p><p><strong>Conclusions: </strong>The ORBI risk score performed well at predicting in-hospital CS but markedly overestimated post-procedural CS risk. As post-procedural CS is the clinically relevant endpoint for a model incorporating post-procedural variables, the ORBI score requires recalibration before it can be used to guide post-PCI decisions.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxorubicin-Induced Myocardial Cytotoxicity Is Associated with the Downregulation of the Klotho-Nuclear Factor Erythroid 2-Related Factor 2 Signaling Pathway.","authors":"Yiqin Wu, Xianqu Ye, Pingfang Liu, Dandan Hu, Bo Xie, Zhuofan Xu","doi":"10.1159/000552438","DOIUrl":"https://doi.org/10.1159/000552438","url":null,"abstract":"<p><strong>Introduction: </strong>Doxorubicin (DOX), a widely used chemotherapeutic agent, induces dose-dependent cardiotoxicity through mechanisms involving oxidative stress and inflammatory cell death. This study investigates the role of the Klotho-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling axis in mitigating DOX-induced pyroptosis in cardiomyocytes.</p><p><strong>Methods: </strong>AC16 cells were treated with DOX to induce pyroptosis. Klotho was overexpressed or knocked down via plasmids and small interfering RNA (siRNA). Cell viability, lactate dehydrogenase release, reactive oxygen species (ROS)/malondialdehyde/glutathione (GSH) levels, and pyroptosis markers were measured. Methylation-specific polymerase chain reaction (PCR) and methylation-sensitive high-resolution melting analyzed Klotho promoter methylation and DNA methyltransferase (DNMT) binding, while quantitative real-time polymerase chain reaction and luciferase assays assessed gene expression and Nrf2 activity. DNA methyltransferase 3a (DNMT3a) and DNMT3b were silenced with specific siRNAs to explore their epigenetic roles.</p><p><strong>Results: </strong>We demonstrate that DOX triggers pyroptosis via caspase-1 activation, gasdermin D N-terminal fragment, and interleukin-1β and interleukin-18 secretion, accompanied by an increase in ROS and depletion of GSH and antioxidant enzymes. Pyroptosis was ROS-dependent, as pretreatment with N-acetyl-L-cysteine restored redox balance and suppressed cell death. Mechanistically, DOX downregulated Klotho expression via promoter cytosine-phosphate-guanine hypermethylation mediated by DNMTs DNMT3a and DNMT3b, with DNMT3b playing a dominant role. Klotho suppression exacerbated pyroptosis, while its overexpression reducing apoptosis-associated speck-like protein containing a CARD speck formation. Furthermore, Klotho activated the Nrf2 pathway, restoring Nrf2 levels and upregulating antioxidant genes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1). Critically, the Nrf2 inhibitor ML385 reversed Klotho's protective effects, confirming Nrf2's necessity. Silencing of DNMT3a/3b attenuated DOX-induced Klotho promoter hypermethylation, restored Klotho expression, and inhibited pyroptosis, with DNMT3b siRNA exerting a more pronounced protective effect.</p><p><strong>Conclusion: </strong>These findings reveal that DOX induces myocardial cytotoxicity by epigenetically silencing Klotho via DNMT3a/3b-mediated promoter hypermethylation, thereby disrupting the Klotho-Nrf2 antioxidant axis and unleashing inflammasome-driven pyroptosis, with DNMT3b serving as the key epigenetic regulator in this process.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-14"},"PeriodicalIF":1.9,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble ST2 as an Independent Predictor of Post-Discharge New-Onset Atrial Fibrillation in Patients with ST-Elevation Myocardial Infarction.","authors":"Wen Li, Menghua Xu, Yicheng Shi, Debin Cao, Xiaofu Zhang, Siwen Wu, Ruijie Bao, Jinxiu Yang, Yong Li","doi":"10.1159/000552461","DOIUrl":"10.1159/000552461","url":null,"abstract":"<p><strong>Introduction: </strong>New-onset atrial fibrillation (NOAF) represents a significant complication following ST-elevation myocardial infarction (STEMI). Soluble suppression of tumorigenicity 2 (sST2) is a biomarker reflecting myocardial stress and fibrosis. However, its predictive value for post-discharge NOAF in STEMI patients remains inadequately characterized. This study was to investigate whether elevated sST2 levels during hospitalization independently predict post-discharge NOAF in STEMI patients.</p><p><strong>Methods: </strong>This multicenter, prospective cohort study enrolled 648 consecutive STEMI patients. Serum sST2 concentrations were measured within 24 h of admission using ELISA. Multivariable logistic regression, receiver operating characteristic (ROC) curve analysis, and risk reclassification metrics were employed to assess sST2's predictive performance.</p><p><strong>Results: </strong>NOAF occurred in 56 patients (8.64%) during follow-up. Patients developing NOAF exhibited significantly higher sST2 levels compared to those without NOAF (62.84 ± 54.62 vs. 30.37 ± 34.71 ng/mL, p < 0.001). After adjusting for confounders, sST2 remained an independent predictor of NOAF (OR = 1.02, 95% CI: 1.01-1.02, p < 0.001). The area under the ROC curve for sST2 was 0.785 (95% CI: 0.723-0.848). Incorporating sST2 into the clinical model significantly improved discrimination (AUC from 0.718 to 0.810, p < 0.001) and risk reclassification (NRI = 0.084, p = 0.033; IDI = 0.047, p = 0.003). Restricted cubic spline analysis revealed a nonlinear dose-response relationship between sST2 and NOAF risk.</p><p><strong>Conclusion: </strong>Elevated sST2 levels during hospitalization independently predict post-discharge NOAF in STEMI patients, offering incremental prognostic value beyond traditional risk factors.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13345607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Socioeconomic Status on 1-Year Morbidity and Readmission in Patients with Takotsubo Syndrome: A Danish Cohort Study.","authors":"Pernille Palm, Line Ryberg Rasmussen, Anne Vinggaard Christensen, Lia E Bang, Helle Wallach-Kildemoes, Selina Kikkenborg Berg","doi":"10.1159/000551671","DOIUrl":"10.1159/000551671","url":null,"abstract":"<p><strong>Introduction: </strong>Takotsubo syndrome (TS) is a cardiac condition that mimics myocardial infarction (MI). Long-term readmission data remain limited. Previous studies in other conditions suggest that socioeconomic factors, such as low income and unemployment, may influence readmission rates, but this has not been explored in TS. This study aims to investigate the risk factors of 1-year readmissions in TS patients and the impact of socioeconomic factors, comparing results with matched individuals from the general population and those with MI.</p><p><strong>Methods: </strong>A nationwide cohort study was conducted using national registers. Patients discharged alive from Danish hospitals with an incident TS diagnosis between 2008 and 2018 were identified through the Danish National Patient Registry. Each TS patient was matched with four individuals from the general population and patients with MI by sex and age. In the analyses of 1-year readmission of TS, we included socioeconomic factors such as cohabitation, labor market attachment, education, family income psychological distress, and comorbidities.</p><p><strong>Results: </strong>A total of 1,022 individuals with TS were identified, with a median age of 70 years (IQR 61-77), and 89% were women. Compared to the general population, TS patients had higher rates of cardiovascular comorbidities, respiratory diseases, and psychotropic medication use but fewer cardiac conditions except for heart failure in the MI population. TS patients were more likely to receive incapacity pensions, have basic education, and belong to the lowest income percentile compared to the general population. In the first year, 36% of TS patients were readmitted, compared to 4% in the general population and 44% in the MI group. The most common causes of readmission in the TS cohort were cardiac (27%), \"other\" conditions (22%), respiratory (20%). Readmission rates were higher among TS patients in vulnerable socioeconomic groups compared to the general population: 37% vs. 6% for those in the lowest income percentile, 42% vs. 6% for those with basic education, and 37% vs. 4% for those on incapacity pension but overall lower compared to the MI population. Most readmissions occurred within the first 2 months. The two lowest income quintiles, vocational/high school and below, and living alone all predicted readmission. The lowest income had a hazard ratio of 1.64 and 95% confidence intervals of 1.01-2.69.</p><p><strong>Conclusion: </strong>Although TS patients exhibit a disadvantaged socioeconomic profile and a substantial comorbidity burden, our analyses suggest that socioeconomic factors are associated with readmission risk, with part of this association potentially mediated through comorbidity burden. These findings indicate that, even in healthcare systems with free access such as Denmark's, socioeconomic inequalities may remain relevant for readmission risk in TS patients.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the Disease Burden of Endocarditis across Asia.","authors":"Huange Cai, Kaibin Fang, Yingbin Lin","doi":"10.1159/000552117","DOIUrl":"10.1159/000552117","url":null,"abstract":"<p><strong>Introduction: </strong>This study provides the first comprehensive assessment of the disease burden of endocarditis in Asia, presenting epidemiological trends from 1990 to 2023.</p><p><strong>Methods: </strong>Data on endocarditis for Asian countries and territories were obtained from the Global Burden of Disease Study 2023, covering incidence, prevalence, YLDs (years lived with disability), YLLs (years of life lost), DALYs (disability-adjusted life years), and deaths from 1990 to 2023. A secondary analysis of these data yielded the overall disease burden of endocarditis in Asia. Building on this information, we report the epidemiological trends of endocarditis across Asian countries and territories and project the disease burden for the next 17 years.</p><p><strong>Result: </strong>In 2023, the total number of incident endocarditis cases in Asia was 675,481, with an ASIR of 14.57 per 100,000 population. The overall prevalence was 150,339, yielding an ASPR of 3.28 per 100,000. A total of 30,594 deaths occurred, corresponding to an ASDR of 0.67 per 100,000. DALYs amounted to 887,280, giving an age-standardized DALY rate of 18.96 per 100,000. YLLs totaled 875,657, resulting in an age-standardized YLL rate of 18.71 per 100,000. YLDs summed to 11,623, equivalent to an age-standardized YLD rate of 0.25 per 100,000. Joinpoint regression analysis revealed that from 1990 to 2023, the AAPC values for ASIR, ASPR, ASDR, and the age-standardized YLDs rate of endocarditis in Asia were positive, whereas the AAPC values for the age-standardized DALYs rate and the age-standardized YLLs rate were negative. It is projected that by 2040, endocarditis will continue to impose a substantial disease burden in Asia.</p><p><strong>Conclusion: </strong>In Asia, endocarditis imposes a substantial disease burden and its epidemiological trend is on the rise.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-21"},"PeriodicalIF":1.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between P-Wave Parameters and Atrioventricular Synchrony in Patients with Leadless Pacemakers.","authors":"Zhongxin Qin, Qiao Yu, Yutong Liu, Haiwei Li, Zefeng Wang, Fei Hang, Weiping Sun, Yongquan Wu","doi":"10.1159/000551832","DOIUrl":"10.1159/000551832","url":null,"abstract":"<p><strong>Introduction: </strong>Correlation between P-wave parameters and atrioventricular synchrony (AVS) in patients with leadless pacemakers (LPs) remains controversial. The purpose of this study was to identify the correlation between P-wave parameters and AVS in patients with LPs.</p><p><strong>Methods: </strong>Patients undergoing VDD LP implantation at Beijing Anzhen Hospital between August 2022 and August 2024 were followed up at 1 month and 3 months after implantation, respectively. Demographic data, comorbidities, electrocardiogram parameters, echocardiography parameters, and programmable parameters were compared to those with atrial-synchronized ventricular pacing (AsVP) ≥80% and those with AsVP <80%. Logistic regression models were used to investigate the correlation between P-wave characteristics and AsVP. The AsVP and programmable parameters at 1 and 3 months were compared.</p><p><strong>Results: </strong>A total of 85 patients (average age 69.1 ± 14.1 years; 68.2% male) undergoing VDD LP implantation were divided into two groups based on AsVP (high AsVP ≥80% and low AsVP <80%). The high AsVP group exhibited significantly greater P-wave area as well as smaller P-wave dispersion (PD) on preoperative electrocardiogram (all p < 0.05). Multivariate logistic analysis demonstrated that higher P-wave area and lower PD and E/A were independent predictor of high AsVP. Additionally, a greater AsVP was observed at 3 months compared to 1 month (80.9 ± 13.9% vs. 74.6 ± 23.6%, p = 0.035) after implantation.</p><p><strong>Conclusion: </strong>Preoperative electrocardiogram P-wave parameters may predict AVS after LP implantation. This finding helps us identify more suitable patients for receiving VDD LP.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-14"},"PeriodicalIF":1.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Janus Kinase Inhibitors and Cardiovascular Safety: Interpreting Signals from the Korea Adverse Event Reporting System.","authors":"Bahar Mikaeili, Ana L Hincapie","doi":"10.1159/000551318","DOIUrl":"https://doi.org/10.1159/000551318","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Significance of Right Ventricular Myocardial Features Derived from Echocardiography Using a Deep Learning Framework in Pulmonary Arterial Hypertension.","authors":"Dongwei Xie, Jie Hu, Guizi Liang, Rentao Zhi, Yan Deng","doi":"10.1159/000552266","DOIUrl":"10.1159/000552266","url":null,"abstract":"<p><strong>Introduction: </strong>The function and myocardial characteristics of the right ventricle (RV) are linked to RV dysfunction and prognosis in pulmonary arterial hypertension (PAH). The prognostic value of RV myocardial features derived from echocardiography remains unclear.</p><p><strong>Methods: </strong>A total of 166 patients (mean age, 35.6 ± 11.7 years; 133 females) were included. The primary endpoint was a composite of cardiovascular hospitalization and all-cause mortality. RV myocardium was manually segmented using ITK-SNAP. DenseNet161 was employed to build the deep transfer learning model. Seven machine learning algorithms were used to construct radiomics and deep learning-based radiomics (DLR) models. A combined nomogram was developed, with its predictive performance assessed using time-dependent ROC analysis and Kaplan-Meier estimates.</p><p><strong>Results: </strong>The three myocardial models were constructed, and their performance was evaluated using ROC, calibration curves, decision curve analysis, and other relevant metrics. The DLR model outperformed the others, demonstrating superior AUCs in both the training and test cohorts (AUC = 0.977, 0.875). The combined nomogram demonstrated excellent performance in survival ROC analysis, with AUCs of 0.763, 0.824, and 0.935 for 1-, 3-, and 5-year predictions, respectively. Furthermore, the DLR score added prognostic value to the COMPERA 2.0, as demonstrated by a global chi-square and C-statistic comparison (p < 0.001 for both).</p><p><strong>Conclusion: </strong>Echocardiographic RV myocardial features, analyzed using DLR model, were strongly correlated with RV dysfunction and prognosis in PAH. The combined nomogram demonstrated superior predictive value. These results highlight the potential of myocardial features for improved risk stratification and prognosis in PAH.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Ductus Arteriosus Stenting in Infants with Duct-Dependent Pulmonary Circulation: An Indian Experience.","authors":"Deepali Bangalia, Hemanta Kumar Nayak, Sudipta Bhattacharjya, Somrita Laha, Siddhartha Joshi, Santanu Roy","doi":"10.1159/000552118","DOIUrl":"10.1159/000552118","url":null,"abstract":"<p><strong>Introduction: </strong>The study aimed to evaluate outcomes of patent ductus arteriosus (PDA) stenting using the latest generation drug-eluting coronary stents in neonates with duct-dependent pulmonary circulation.</p><p><strong>Methods: </strong>This was a retrospective, observational study which included infants who were diagnosed with duct-dependent pulmonary circulation and underwent PDA stenting at a tertiary care center in India. All pre- and post-procedural details of each patient were retrospectively collected from the medical records of the hospital. All the patients were regularly followed up for up to 12 months in the outpatient clinic until the subsequent surgical procedure following the PDA stenting.</p><p><strong>Results: </strong>A total of 58 patients who underwent PDA stenting were included in the study. The mean age was 50.22 ± 67.69 days, and mean weight was 3.18 ± 1.15 kg. Among all, 24 (41.4%) patients were prematurely born (<37 gestational weeks). A total of 35 (60.3%) patients required prostaglandins before PDA stenting to maintain patency of the duct until the procedure. The mean PDA diameter at pulmonary artery end was 2.75 ± 0.63 mm, and the mean PDA length was 17.19 ± 4.68 mm. A total of 60 drug-eluting coronary stents were implanted across 58 PDAs with Tetrilimus everolimus-eluting stents being the most implanted (35%). The mean implanted stent length and diameter were 19.50 ± 5.61 mm and 4.06 ± 2.39 mm, respectively. Successful stent deployment at the intended position across the PDA was achieved in all 58 (100%) patients. During hospital stay, four (6.9%) cases of in-hospital mortality were reported. Post-discharge, three deaths were reported up to 12-month follow-up. During 12-month follow-up, 19 (32.8%) patients underwent univentricular surgical repair, while four (6.9%) underwent biventricular surgical pair. Two (3.4%) patients required stent retrieval and subsequently underwent palliative shunting.</p><p><strong>Conclusion: </strong>The PDA stenting with the latest generation drug-eluting coronary stents is found safe and clinically better palliative care strategy for patients with duct-dependent pulmonary circulation, resulting in improved procedural and follow-up outcomes.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Episodic Testing: Toward Ambient Monitoring in Heart Failure.","authors":"Hiroaki Hiraiwa, Takahiro Okumura, Toyoaki Murohara","doi":"10.1159/000551719","DOIUrl":"10.1159/000551719","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}