Cardiology最新文献

{"title":"Impact of Subclinical Hypothyroidism on Coagulation Parameters and Coronary Artery Disease Severity in Patients with Coronary Heart Disease.","authors":"Wei Guo, Li-Yuan Hou, Xin Yi","doi":"10.1159/000545904","DOIUrl":"10.1159/000545904","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the effect of subclinical hypothyroidism (SCH) on coagulation parameters and the progression of coronary artery disease in patients with coronary heart disease (CHD).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 452 patients who were diagnosed with CHD through coronary angiography between January 2020 and December 2021 at the Department of Cardiology, Jining First People's Hospital. The patients were divided into three groups based on thyroid-stimulating hormone (TSH) levels: a normal thyroid function group (244 cases), a mild SCH group (162 cases), and a severe SCH group (46 cases). General demographic data, coagulation parameters, number of affected coronary vessels, stenosis location, and stenosis severity were compared across the groups.</p><p><strong>Results: </strong>(1) Significant differences were observed among the three groups in terms of sex, age, TSH, free tri-iodothyronine (FT3), free thyroxine (FT4), triglycerides, total cholesterol, low-density lipoprotein cholesterol, fibrinogen, prothrombin time, activated partial thromboplastin time, D-dimer, mean platelet volume, and platelet distribution width (p < 0.05). (2) The Gensini scores were 27 (17, 43.88) for the normal thyroid function group, 37.5 (25, 52.25) for the mild SCH group, and 48 (32.88, 73.75) for the severe SCH group, showing statistically significant differences (p < 0.05). (3) There was a positive correlation between Gensini score and TSH (r = 0.243, p < 0.05) and negative correlations between Gensini score and both FT3 (r = -0.139, p < 0.05) and FT4 (r = -0.12, p < 0.05). (4) TSH level, hypertension history, and lipoprotein(a) were identified as risk factors for Gensini score (p < 0.05).</p><p><strong>Conclusion: </strong>Patients with CHD and SCH present a hypercoagulable state and an elevated risk of thrombosis. TSH levels are linked to the severity of coronary artery stenosis, underscoring the importance of early thyroid function testing in patients with CHD to inform treatment decisions.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic yield of updated indications for endomyocardial biopsy and its clinical predictors in a Chinese cohort.","authors":"Xuejing Duan, Yang Sun, Li Li, Lingmin Wu, Zhongkai Liao, Yuhui Zhang, Litian Yu, Yan Yao, Lei Song, Hongyue Wang","doi":"10.1159/000545748","DOIUrl":"10.1159/000545748","url":null,"abstract":"<p><strong>Introduction: </strong>The challenging and restrictive settings have been proposed in the updated indications for endomyocardial biopsy (EMB), but no data shows its performance. This study aimed to evaluate the diagnostic yield and find its clinical predictors.</p><p><strong>Methods: </strong>All EMB performed between 2018 and 2022 were reviewed. Their clinical scenario and diagnostic yield were categorized retrospectively. Repeated and inadequate biopsies were excluded. Multivariate analysis was used to find the predictors.</p><p><strong>Results: </strong>A total of 681 cases were collected (median age 44.0 years, 65.5% male) and 230 cases (33.8%) yielded specific diagnosis. The higher yield (52.8%) was found in clinically suspected myocarditis while no significant difference between cases with and without acute unstable hemodynamics (66.7% vs 47.1%; P=0.130). There was a much higher yield in unexplained restrictive or hypertrophic cardiomyopathy (RCM/HCM) with suspected infiltrative or storage disorder compared to those without (86.2% vs 10.3%; P<0.001). Dilated cardiomyopathy showed a lower yield, with or without recent-onset moderate-to-severe cardiac dysfunction (13.6% vs 16.3%; P=1.000). The same was true for unexplained atrioventricular block and ventricular arrhythmias (AVB/VA), with or without obvious structural abnormalities (8.2% vs 10.3%; P=0.675). On multivariate analysis, diffuse late gadolinium enhancement (odds ratio [OR] 4.14, 95% confidence interval [CI] 1.86-9.25; P=0.001), time course of disease ≤12 months (OR 3.31, 95% CI 1.75-5.57; P<0.001), elevated（≥1250 pg/ml）NT-proBNP (OR 2.91, 95% CI 1.67-5.06; P<0.001), and elevated (>0.068 ng/ml) hs-cTnI (OR 2.37, 95% CI 1.33-4.22; P=0.004) were independently associated with diagnostic yield.</p><p><strong>Conclusion: </strong>Our results partially support the restrictive settings. EMB can achieve higher yield for unexplained RCM/HCM with suspected infiltrative or storage disorder, as well as strictly defined clinically suspected myocarditis, even in hemodynamically stable patients. However, the restrictive settings of unexplained AVB/VA and dilated cardiomyopathy did not show a clear advantage in diagnostic yield. The predictors this study found may help clinicians in selecting adequate candidates.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-16"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome composition and one-year survival outcomes among patients with reduced ejection fraction heart failure.","authors":"Seyed Mohsen Mirhosseini, Mahdi Rezaei, Masood Soltanipur, Hossein Yarmohammadi, Erfan Soroush, Amirmahdi Taromiha, Nayere Ebrahimzadeh, Ali Nour Neamatollahi, Abolfazl Fateh, Fatemeh Hatefi, Delaram Douroud, Jafar Panahi, Sepideh Jafari Naeini, Seyed Davar Siadat","doi":"10.1159/000545877","DOIUrl":"https://doi.org/10.1159/000545877","url":null,"abstract":"<p><strong>Background: </strong>Imbalances in gut microbiota are linked to chronic diseases, including heart failure, where shifts in microbial composition are evident in patients with reduced ejection fraction (HFrEF). This study compared gut microbiome profiles between HFrEF patients and healthy controls and explored potential links between microbiome composition and patient survival over 6 and 12 months.</p><p><strong>Methods: </strong>In this longitudinal case-control study, 20 HFrEF patients and 40 healthy controls were recruited, with stool samples collected for gut microbiome analysis. Patients were followed for six and twelve months to assess survival. Gut microbiome composition was analyzed using real-time PCR for specific bacterial taxa. Statistical analyses were performed using R to compare HFrEF and control groups and draw the ROC curve to predict survival at six and twelve months.</p><p><strong>Results: </strong>HFrEF patients showed a significantly lower abundance of all bacterial taxa, except for A. muciniphila. Decreased levels of Prevotella, F. prausnitzii, Firmicutes, and Bacteroides, as well as a lower Firmicutes/Bacteroidetes (F/B) ratio, were notable in HFrEF patients, with specific taxa correlating with clinical features like ascites and vitamin D levels. Most bacterial taxa and the F/B ratio could distinguish HFrEF patients from controls, though none effectively predicted survival outcomes at six or twelve months.</p><p><strong>Conclusion: </strong>The study demonstrates that patients with HFrEF exhibit a distinct gut microbiome profile compared to healthy individuals. While specific gut bacteria were effective in distinguishing HFrEF patients from healthy controls, their ability to predict survival outcomes was limited, highlighting the need for further research into the role of the gut microbiome in the progression and prognosis of heart failure.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-20"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Levels of Transient Receptor Potential Vanilloid 1 as a Novel Biomarker for Acute Myocardial Infarction.","authors":"Yong Wu, Yahao Zhang","doi":"10.1159/000545901","DOIUrl":"10.1159/000545901","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the diagnostic significance of plasma transient receptor potential vanilloid 1 (TRPV1) levels in patients with acute myocardial infarction (AMI) and to evaluate its prognostic value.</p><p><strong>Methods: </strong>A total of 152 patients diagnosed with AMI at Zhongda Hospital between May 2023 and March 2024, forming the AMI group, along with 62 non-AMI patients as the control group. Plasma TRPV1 levels were measured using enzyme-linked immunosorbent assay (ELISA) upon admission. All patients with AMI were followed up for 6 months.</p><p><strong>Results: </strong>Plasma TRPV1 levels were significantly higher in the AMI group compared to the control group (p < 0.05). Pearson correlation analysis demonstrated that TRPV1 levels positively correlated with diabetes, lactate dehydrogenase (LDH), white blood cell count, creatine kinase, blood urea nitrogen, serum creatinine (sCr), glycated hemoglobin (HbA1c), brain natriuretic peptide (BNP), cardiac troponin I (cTnI), Gensini scores, and the number of affected vessels, while showing a negative correlation with hemoglobin and left ventricular ejection fraction. Multiple linear regression analysis identified LDH, sCr, and HbA1c as independent factors influencing TRPV1 levels. Receiver operating characteristic curve analysis demonstrated a significant diagnostic value of TRPV1 for AMI (p < 0.001). Furthermore, Cox regression analysis revealed that elevated TRPV1 levels were significantly associated with the occurrence of major adverse cardiac events (MACEs) within 6 months (p < 0.001).</p><p><strong>Conclusion: </strong>Plasma TRPV1 is a promising biomarker for the diagnosis of AMI, with potential links to renal function and glycemic control. Additionally, TRPV1 holds prognostic value for predicting MACE within 6 months following AMI.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Patients with Heart Failure with Reduced Ejection Fraction Treated with Bumetanide versus Torsemide.","authors":"Kazuhiko Kido, Mohammad Al-Mamun","doi":"10.1159/000545876","DOIUrl":"https://doi.org/10.1159/000545876","url":null,"abstract":"<p><p>Introduction Limited evidence guides clinicians regarding the agent selection between bumetanide and torsemide in patients with heart failure (HF). The present study aimed to compare the efficacy and safety profile of bumetanide and torsemide in patients with HF. Methods Patients aged > 18 years with HF with reduced ejection fraction (HFrEF) receiving either bumetanide or torsemide were included from the TriNetX research network. Patients with end-stage renal disease were excluded from this study. The primary outcome was all-cause mortality, and secondary outcomes included all-cause hospitalization or emergency department visits, acute kidney injury, or hypokalemia over one- year follow-up period. Results After propensity score matching, 16,277 patients in each group were included. The use of bumetanide was significantly associated with a higher risk of all-cause mortality (19.7 vs. 16.0 %; OR 1.28; 95% CI [1,21, 1.36]) compared to the torsemide group. The use of bumetanide was also significantly associated with higher risks of all-cause hospitalization or emergency department visits (53.3 vs. 48.3%; OR 1.22 95% CI [1.17, 1.28]), acute kidney injury (33.4 vs. 27.1 %; OR 1.35; 95% CI [1.29, 1.42]), and hypokalemia (16.6 vs. 13.7%; OR 1.21, 95% CI [1.17, 1.33]) compared to the torsemide group. Conclusion The use of torsemide in patients with HFrEF is associated with lower risks of clinical outcomes than bumetanide. Further investigation of this association is warranted in clinical trials.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Correct Diagnosis of Transthyretin Amyloid Cardiomyopathy.","authors":"Carlos Scherr","doi":"10.1159/000544942","DOIUrl":"https://doi.org/10.1159/000544942","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-2"},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Risk Assessment in Prostate Cancer: The Role of Coronary Artery Calcium Scoring.","authors":"Kasper Emil Rosenbech, Alaa Saeid, Manyoo Agarwal, Stephan Peronard Mayntz","doi":"10.1159/000544911","DOIUrl":"https://doi.org/10.1159/000544911","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Never-Ending Challenge of Anti-Inflammatory Therapy after Acute Myocardial Infarction.","authors":"Francesco Angeli, Luca Bergamaschi, Matteo Armillotta, Carmine Pizzi","doi":"10.1159/000545603","DOIUrl":"10.1159/000545603","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Mendelian Randomization in Cardiovascular Disease: Bibliometric Analysis and Visualization from 2003 to 2024.","authors":"Sitong Guo, Dandan Xu, Shiran Qin, Chunxia Chen, Xiaoyu Chen","doi":"10.1159/000545277","DOIUrl":"10.1159/000545277","url":null,"abstract":"<p><strong>Introduction: </strong>Mendelian randomization (MR) is an innovative epidemiological research method. In order to summarize and clarify the research status of MR related to cardiovascular disease (CVD) and point out the possible future development direction, we conducted a comprehensive and multidimensional bibliometric analysis of the literature published in this field from 2003 to 2024.</p><p><strong>Methods: </strong>We analyzed 1,870 articles published between 2003 and 2024 from the Web of Science Core Collection (WoSCC) using VOSviewer, R software, bibliometric online analysis tool, and CiteSpace software.</p><p><strong>Results: </strong>CVD-related MR research demonstrated an overall upward trend, with the USA leading in terms of publication output, followed by the UK and China. The most prolific institution in this field was the University of Bristol, and Smith GD, who had the highest number of publications (n = 103), was also affiliated with this institution. The European Heart Journal (36 publications, 5,023 citations) was the most cited journal. Related topics of frontiers will still focus on MR, coronary heart disease, heart failure, C-reactive protein, cholesterol, and body mass index.</p><p><strong>Conclusions: </strong>As the scope of MR studies continues to expand, especially the number of measurable features continues to increase, the need for rigorous methods and critical interpretation of MR findings becomes increasingly apparent. However, this ease of use can compromise the reliability of study results due to methodological flaws and publication bias, thereby affecting the perceived significance of the results. Nonetheless, with the emergence of large genetic datasets supporting two-sample MR, resources such as MR-Base and PhenoScanner, MR remains a powerful method for identifying potential pathogenic features in cardiometabolic and other diseases. In addition, it plays a crucial role in prioritizing drug targets for entry into clinical trials.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-16"},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in Long-Term Mortality after Takotsubo Syndrome: The Role of Gender, Disease Burden, Socio-Economic Profile, and Psychological Distress.","authors":"Pernille Palm, Helle Wallach-Kildemoes, Lia Evi Bang, Selina Kikkenborg Berg","doi":"10.1159/000543668","DOIUrl":"10.1159/000543668","url":null,"abstract":"<p><strong>Introduction: </strong>While Takotsubo syndrome (TTS) is less common in men, their mortality rates surpass those of women. The influence of socioeconomic factors and psychological distress remains unexplored. This study aimed to investigate gender differences in socioeconomic profiles and psychological distress among patients with incident TTS and to examine gender differences in survival after discharge, accounting for socioeconomic and psychological factors.</p><p><strong>Methods: </strong>A nationwide cohort study using national registers included all patients discharged from Danish hospitals with an incident TTS diagnosis were eligible. Socioeconomic factors, including marital status, cohabitation status, labour market attachment, highest formal education, family income, and psychological distress, were assessed and compared. Cox regression models were applied to analyse the data.</p><p><strong>Results: </strong>Of 662 patients with TTS discharged alive 79 (11.9%) were men with a median age of 67 years (interquartile range: 62-77). Men with TTS were socioeconomically disadvantaged compared to women. Unadjusted analyses indicated that male gender was associated with increased mortality (hazard ratio [HR]: 2.61, 95% confidence interval [CI]: 1.18-3.25, p = 0.009). Low income, living alone, being widowed, and receiving a retirement pension were all significantly associated with 3-year mortality risk. However, in the main adjusted model, aside from the gender difference, only the Charlson comorbidity index was significantly associated with a higher mortality risk (HR: 1.26, 95% CI: 1.15-1.39, p < 0.001). No significant interactions between gender and socioeconomic variables were observed.</p><p><strong>Conclusion: </strong>Men with TTS experienced greater socioeconomic disadvantages and higher 3-year mortality than women, with comorbidity scores significantly influencing outcomes in both genders.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}