Bulletin du cancerPub Date : 2025-09-05DOI: 10.1016/j.bulcan.2025.05.014
Tereza Coman, Fabio Andreozzi, Jaques-Olivier Bay, Jérôme Cornillon, Thierry Guillaume, Fati Hamzy, Laetitia Souchet, Pascal Turlure, Ambroise Marçais, François Dachy, Yves Beguin, Claude Eric Bulabois, Sanae Daghri, Anne Huynh, Leonardo Magro, Yves Chalandon
{"title":"[Acute graft-versus-host disease therapy: Which third line treatment after steroids and ruxolitinib? (SFGM-TC)].","authors":"Tereza Coman, Fabio Andreozzi, Jaques-Olivier Bay, Jérôme Cornillon, Thierry Guillaume, Fati Hamzy, Laetitia Souchet, Pascal Turlure, Ambroise Marçais, François Dachy, Yves Beguin, Claude Eric Bulabois, Sanae Daghri, Anne Huynh, Leonardo Magro, Yves Chalandon","doi":"10.1016/j.bulcan.2025.05.014","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.05.014","url":null,"abstract":"<p><p>Acute graft-versus-host disease (GVHDa) is one of the leading causes of morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT) patients. While the first-line consensus treatment has been based on systemic corticosteroid therapy for many years, ruxolitinib has recently been approved and has become the standard second-line treatment. Nevertheless, the effectiveness of ruxolitinib remains limited to 40 % of cortico-resistant patients, raising the crucial question of selecting a third-line treatment. Among the therapeutic modalities described, this workshop selected fecal microbiota transplantation (FMT), mesenchymal stromal cells (MSC) injection, and extracorporeal photopheresis (ECP) as the most promising or with a benefit/risk balance that favors their prescription at this stage. The workshop also highlighted the importance of research aimed at identifying markers or score calculations that guide toward a risk-adapted approach as early as possible. To date, aside from calprotectin, no marker or score is routinely used, but all are the subject of intense research. Finally, measures associated with specific treatment remain crucial, and new developments in dietary contributions, infection prophylaxis, and tissue regeneration are also addressed.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-09-05DOI: 10.1016/j.bulcan.2025.06.013
Rayan Kabirian, Christine Rousset-Jablonski, Martin Duval, Yazid Belkacemi, Laurent Zelek, Rosine Guimbaud, Charlotte Sonigo, Sophie Catteau-Jonard, Fabien Reyal, Florence Coussy, Anne-Sophie Hamy
{"title":"[The transversal specialized formation in oncology for medical gynecology residents: A five-year review].","authors":"Rayan Kabirian, Christine Rousset-Jablonski, Martin Duval, Yazid Belkacemi, Laurent Zelek, Rosine Guimbaud, Charlotte Sonigo, Sophie Catteau-Jonard, Fabien Reyal, Florence Coussy, Anne-Sophie Hamy","doi":"10.1016/j.bulcan.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.06.013","url":null,"abstract":"<p><strong>Introduction: </strong>The transversal specialized formation (TSF) in oncology has been enabling non-oncologist physicians to acquire oncology skills for five years. This study aims to assess the TSF for medical gynecology residents.</p><p><strong>Materials and methods: </strong>A 23-item questionnaire was sent to physicians from the specialized medical degree (SMD) in medical gynecology who completed the TSF between 2020 and 2023. The data were analyzed using Student's t-tests, Fischer tests, and Chi<sup>2</sup> tests.</p><p><strong>Results: </strong>Of the 22 residents identified, 20 (90.9%) responded to the questionnaire. Nine residents (40.9%) were from the Paris region. The reasons for undertaking the TSF included interest in gynecological and breast cancers (81.8%), clinical richness (50.0%), and scientific dynamism (50.0%). Of the 11 respondents who had completed the SMD or had a defined post-residency project, all reported working in a hospital setting. The main activity was gyneco-oncology (n=6, 55.0%), including sexology, monitoring at-risk women, post-cancer care, and medical oncology (n=5, 45.0%). The average satisfaction with the TSF was 7.2/10, with no significant regional difference (P=0.62). Suggested areas for improvement included harmonizing theoretical courses, offering specialized internships in gynecological oncology, and providing mentorship.</p><p><strong>Discussion: </strong>Five years after its implementation, medical gynecologists are satisfied with the TSF in oncology. The main requests are for strengthening national courses and expanding the range of internships, all focused on the original specialty.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-09-05DOI: 10.1016/j.bulcan.2025.05.018
Vinh-Hoang-Lan Julie Tran, Angelo Paci, Tiphaine Adam de Beaumais, Etienne Rouleau
{"title":"Pharmacogenetics in oncology: Unveiling its potential in treatment personalization and beyond.","authors":"Vinh-Hoang-Lan Julie Tran, Angelo Paci, Tiphaine Adam de Beaumais, Etienne Rouleau","doi":"10.1016/j.bulcan.2025.05.018","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.05.018","url":null,"abstract":"<p><p>The effectiveness and tolerability of medicines can vary considerably from person to person, even at the same dose. This variation is influenced by many factors, including constitutional genetic characteristics. In fact, some people have genetic variations that are common and neutral in the population, known as polymorphisms, which can affect drug metabolism or make them more susceptible to certain adverse effects. These variations can lead to dose-dependent toxicity in the case of genetic polymorphisms of metabolic enzymes or hypersensitivity to drugs. Pharmacogenetics therefore examines the specific genetic factors of each patient to understand their sensitivity to treatment and their risk of developing side effects. By enabling proactive adjustment of dosage and/or treatment, pharmacogenetics minimizes the risk of adverse effects and offers promising prospects for a more personalized approach to tumour management. This review will focus on the potential of pharmacogenetics in cancer care, from cancer treatment to supportive care. It will provide an overview of pharmacogenetic recommendations from national and international scientific and professional societies that are currently used in clinical practice. In addition, we will discuss the challenges and perspectives associated with integrating pharmacogenetics into clinical practice for more personalized management of cancer patients.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-09-04DOI: 10.1016/j.bulcan.2025.06.008
Ludivine Besse, Stéphane Moreau, Michelle Delpy
{"title":"[Representation of infectious risk in patients with multiple myeloma: A multicentric prospective study aimed at adapting the role of advanced practice nurses].","authors":"Ludivine Besse, Stéphane Moreau, Michelle Delpy","doi":"10.1016/j.bulcan.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.06.008","url":null,"abstract":"<p><p>Multiple myeloma is a haematologic malignancy of the bone marrow with an increasing incidence, primarily affecting an elderly and frail population. It benefits from innovative treatments that have been shown to extend patient survival. However, 2% of patients die from infections during the first year of treatment, despite the availability of prophylactic treatments. Thanks to their new skills, advanced practice nurses could play a new role in this care. We conducted a prospective quantitative multicenter study in three French hospitals. Over a two-month period, questionnaires were administered to patients with multiple myeloma in the first year of treatment, followed up in three hospitals. The questionnaire consisted of open and closed questions on the themes of infectious risk, antibiotic prophylaxis and vaccination. A total of 60 participants completed the questionnaire. The results show a lack of knowledge on the part of patients of the risk of infection, the symptoms that need to be reported, and the absence of a specific pathway for effective management. There was also a lack of awareness of the names of recommended prophylactic treatments and their usefulness. Finally, the vaccination strategy is generally appropriate, except for pneumococcal vaccination, which is less systematically applied. This study provides valuable insights into the role that APN could play in therapeutic education, in particular by improving patients' knowledge of therapies, monitoring vaccinations, coordinating care pathways and acting as a resource for patients and the healthcare team.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-09-03DOI: 10.1016/j.bulcan.2025.05.017
Jean-Michel Cayuela, Stéphanie Dulucq, Sandrine Hayette, Frédéric Millot, Olivier Nibourel, Franck-Emmanuel Nicolini, Anna Raimbault, Ivan Sloma, Delphine Réa
{"title":"[Recommendations from the GBMHM and the Fi-LMC for the diagnosis and management of chronic myeloid leukemia].","authors":"Jean-Michel Cayuela, Stéphanie Dulucq, Sandrine Hayette, Frédéric Millot, Olivier Nibourel, Franck-Emmanuel Nicolini, Anna Raimbault, Ivan Sloma, Delphine Réa","doi":"10.1016/j.bulcan.2025.05.017","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.05.017","url":null,"abstract":"<p><p>Molecular biologists play an important role in therapeutic decisions in the context of Chronic Myelogenous Leukemia (CML). Before treatment, it is mandatory to identify the BCR::ABL1 fusion and any prognostic cytogenetic abnormalities that may be present. During treatment, regular assessment of measurable residual disease (MRD) is essential to objectively evaluate the optimal response and identify situations of resistance to treatment. Monitoring of MRD is also required when considering treatment discontinuations. In cases of resistance, identifying mutations that confer resistance to tyrosine kinase inhibitors is essential for adapting the treatment. The Group of Molecular Biologists of Hematologic Malignancies (GBMHM) and the France Intergroup of Chronic Myeloid Leukemia (Fi-LMC) convened a panel of experts to critically review methods used for molecular diagnostics and follow-up of patients with CML, define best practices applicable in this context and formulate recommendations.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-09-02DOI: 10.1016/j.bulcan.2025.07.006
Sophie Lantheaume, Ladislav Moták, Jean-Baptiste Guy, Marine Paucsik, Louis Doublet, Marie Préau, Ilios Kotsou, Eric Huyghe
{"title":"Sexual quality of life, self-compassion and desire to use onco-sexology support by cancer patients.","authors":"Sophie Lantheaume, Ladislav Moták, Jean-Baptiste Guy, Marine Paucsik, Louis Doublet, Marie Préau, Ilios Kotsou, Eric Huyghe","doi":"10.1016/j.bulcan.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.07.006","url":null,"abstract":"<p><strong>Background: </strong>Cancer and its treatments can affect patients' sexual quality of life, yet the use of onco-sexology support remains uncommon. Understanding psychological factors such as self-compassion may help explain patients' desire to seek such support (DUOSS).</p><p><strong>Aim: </strong>To evaluate the role of self-compassion in DUOSS, depending on patients' sexual quality of life.</p><p><strong>Methods: </strong>Five hundred cancer patients were contacted by mail; 96 (19.2%) completed online questionnaires assessing sexual quality of life, self-compassion, and DUOSS. Participants were divided into two groups based on sexual quality of life: group 1 (satisfactory sexual quality of life, n=41) and group 2 (unsatisfactory sexual quality of life, n=55).</p><p><strong>Results: </strong>Group 2 showed lower self-compassion and a greater desire to use onco-sexology support. Significant differences were also observed in marital status and treatment types. Self-compassion was positively associated with sexual quality of life, and sexual quality of life was inversely related to DUOSS. Mediation analysis suggested an indirect relationship between self-compassion, sexual quality of life, and DUOSS.</p><p><strong>Clinical implications: </strong>Self-compassion plays a key role in sexual quality of life and may influence the likelihood of seeking onco-sexology support. Interventions that foster self-compassion could improve patients' sexual well-being and support care engagement.</p><p><strong>Conclusion: </strong>self-compassion contributes to DUOSS in patients with poor sexual quality of life and should be considered early in cancer care pathways.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-08-19DOI: 10.1016/j.bulcan.2025.06.012
Geoffrey Coisnon, Céline Truong, Nicolas Pinsault, Richard Monvoisin, Pauline Girard, Léo Druart
{"title":"[\"Settling down, sorting, and keeping your compass\". Experience of a health education consultation on complementary therapies].","authors":"Geoffrey Coisnon, Céline Truong, Nicolas Pinsault, Richard Monvoisin, Pauline Girard, Léo Druart","doi":"10.1016/j.bulcan.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.06.012","url":null,"abstract":"<p><strong>Introduction: </strong>Use of complementary and alternative medicine (CAMs) by breast cancer patients is frequent but not without risks. An open and patient-centered discussion on the subject is essential. The objective of this study was to explore the experiences of breast cancer patients during a health education consultation about complementary and alternative medicine (CAMs) using a serious game.</p><p><strong>Methods: </strong>This qualitative study was inspired by interpretative phenomenology. Individual semi-structured interviews were conducted with nine breast cancer patients who participated in a health education consultation on CAMs as part of a larger quantitative trial.</p><p><strong>Results: </strong>The participants' use of CAMs assimilated to a form of compensatory medicine in response to their perceived gaps in the conventional healthcare system. The conversation based on the serious game and the caregiver's open, non-judgmental approach fostered horizontal dialogue and critical reflection about the patients' health choices. Although participants expressed a desire for autonomy through this use, they expressed a need for support to avoid bearing the responsibility of decision-making alone. Despite these positive feedbacks, the perceived impact of the serious game intervention on their practice and decision-making was limited.</p><p><strong>Discussion: </strong>The health education consultation provided patients with a space for communication and reflection, serving as support for decision-making and enhancing their experiential knowledge.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-08-14DOI: 10.1016/j.bulcan.2025.06.010
Goran Vujić, Pavao Planinić, Ivan Babić, Marko Škvorc, Marijan Erceg, Ana-Meyra Potkonjak
{"title":"Impact of preoperative conization on treatment outcomes in cervical cancer patients undergoing abdominal radical hysterectomy.","authors":"Goran Vujić, Pavao Planinić, Ivan Babić, Marko Škvorc, Marijan Erceg, Ana-Meyra Potkonjak","doi":"10.1016/j.bulcan.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.06.010","url":null,"abstract":"<p><strong>Purpose: </strong>The optimal surgical treatment for early-stage cervical cancer has been reevaluated in the light of the LACC trial, revealing poorer outcomes with minimally invasive surgery due to inevitable tumor spillage. Preoperative conization contributed to longer disease-free survival, improved overall survival, and reduced recurrence rates in patients undergoing minimally invasive radical hysterectomy (RH). This research evaluated the impact of preoperative conization on recurrence and survival in cervical cancer patients undergoing abdominal RH.</p><p><strong>Methods: </strong>A study retrospectively analyzed 274 patients with cervical cancer who underwent abdominal RH. Treatment outcomes were compared based on whether preoperative conization was performed.</p><p><strong>Results: </strong>While no difference in recurrence was evident, a slight, albeit nonsignificant difference in mortality rates indicated that conization neither improves nor worsens survival. In cases with equal depth of invasion, conization did not affect survival.</p><p><strong>Conclusion: </strong>In comparison to other studies, this research offers insights into conization's role in the treatment of a wider range of tumor stages, affirming its diagnostic significance without adverse effects on survival, particularly in cases of equal invasion depth during abdominal RH.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-08-12DOI: 10.1016/j.bulcan.2025.05.013
Florence Labrell, Fabienne Lemétayer, Laura Lepage, Christine Hassler, Claude Julie Bourque, Jacques Grill
{"title":"[The experience of fathers with a child hospitalized for brain tumor: Exploratory study of French fathers and caregivers].","authors":"Florence Labrell, Fabienne Lemétayer, Laura Lepage, Christine Hassler, Claude Julie Bourque, Jacques Grill","doi":"10.1016/j.bulcan.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.05.013","url":null,"abstract":"<p><strong>Introduction: </strong>The general aim of the study was to explore the fathers' experiences during the hospitalization of a child with a brain tumor, an area that has been little studied. The opinions of the healthcare providers were also examined in order to crosscheck the views of each partner, particularly with regard to fathers' inclusion.</p><p><strong>Methods: </strong>Individual interviews with 14 fathers and focus group interviews with 22 healthcare providers were conducted in 3 hospitals in the Île-de-France and Grand Est regions. The corpus of all the interviews was analyzed qualitatively using thematic analysis, carried out by 4 coders from the two research teams and supported by N'Vivo software (version 11).</p><p><strong>Results: </strong>Four themes emerged from the fathers' statements and the focus groups with the healthcare providers: the experience of the father and his sick child in the hospital; the time spent in the hospital; the involvement of the father in the hospital by the healthcare providers; and the needs and recommendations of each partner.</p><p><strong>Discussion: </strong>Like mothers, fathers report a painful experience of hospitalization and care. Some fathers express their emotions very strongly, which can destabilize the healthcare providers. Healthcare providers point out that the presence of fathers in the hospital is a factor that promotes their inclusion, especially when they can participate in care. The fathers expressed their need to be recognized as parents in their own right and recommended that they be better supported when they leave the hospital, which was confirmed by the healthcare providers.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bulletin du cancerPub Date : 2025-08-11DOI: 10.1016/j.bulcan.2025.04.014
Nicolas Simon, Agnès Bonnin, Alexia Jouvance, Stavroula Masouridi-Levrat, Edouard Forcade, Isabelle Roch-Torreilles, Valérie Coiteux, Léonardo Magro, Amandine Le Bourgeois
{"title":"[Anticipation of pharmacotherapeutic problems prior to allo stem cell transplantation in patients with co-morbidities (SFGM-TC)].","authors":"Nicolas Simon, Agnès Bonnin, Alexia Jouvance, Stavroula Masouridi-Levrat, Edouard Forcade, Isabelle Roch-Torreilles, Valérie Coiteux, Léonardo Magro, Amandine Le Bourgeois","doi":"10.1016/j.bulcan.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.bulcan.2025.04.014","url":null,"abstract":"<p><p>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) frequently involves patients with multiple co-morbidities. The drugs prescribed for these conditions may lead to complications during the transplant procedure, either through their mechanism of action, their adverse reaction profile or the risk of pharmacological interactions with the drugs prescribed for the allo-HSCT procedure and its complications. Therefore, each patient's drug-related risks must be assessed prior to allo-HSCT. Various therapeutic decisions may be considered to limit the occurrence of complications. The aim of this study is to propose a methodology for anticipating these issues prior to allo-HSCT and to propose a consensual therapeutic approach for therapeutic situations commonly encountered in the context of hematopoietic stem cell allogeneic transplantation. We specifically address cardiovascular, psychotropic drugs, and anti-infectives medications, antidiabetics and anticoagulants.</p>","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}