Bulletin du cancer最新文献_第5页

[Place of hematopoietic stem cell transplantation for very high risk acute myeloblastic leukemia and myelodysplastic syndromes (SFGM-TC)]. [造血干细胞移植治疗极高风险急性骨髓细胞白血病和骨髓增生异常综合征（SFGM-TC）]。

Bulletin du cancer Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1016/j.bulcan.2024.06.016

Clémence Mediavilla, Maud D'Aveni, Anne Huynh, Magalie Joris, Stravoula Masouridi-Levrat, Stéphanie Nguyen, Pascal Turlure, Leonardo Magro, Thierry Guillaume

引用次数: 0

[The SFC in 2025, almost 120 years old and still full of new projects]. （2025年的证监会，成立近120年，仍有很多新项目）。

Bulletin du cancer Pub Date : 2025-01-01 DOI: 10.1016/j.bulcan.2024.12.008

Manuel Rodrigues, Stanislas Quesada

引用次数: 0

[Impact of artificial intelligence on the evolution of clinical practices in oncology: Focus on language models]. [人工智能对肿瘤学临床实践演变的影响：关注语言模型]。

Bulletin du cancer Pub Date : 2025-01-01 Epub Date: 2024-12-18 DOI: 10.1016/j.bulcan.2024.12.005

Daphné Morel, Loïc Verlingue

{"title":"[Impact of artificial intelligence on the evolution of clinical practices in oncology: Focus on language models].","authors":"Daphné Morel, Loïc Verlingue","doi":"10.1016/j.bulcan.2024.12.005","DOIUrl":"10.1016/j.bulcan.2024.12.005","url":null,"abstract":"Artificial intelligence (AI) is addressing many expectations for healthcare practitioners and patients in oncology. It has the potential to deeply transform medical practices as we know them today: improving early diagnosis by analysing large quantities of medical data, refining personalised treatment plans and optimising patient follow-up. AI also makes it easier to identify new biomarkers and predict responses to therapies, reducing margins of error and speeding up clinical decisions. Among the most popular types of AI to revolutionise clinical practice are language models. In a perfect world, the integration of AI would promote more precise, personalised and efficient care, while relieving healthcare providers of tedious or repetitive tasks, allowing them to concentrate more on providing human support to patients, and all this with a low energy consumption. However, the large-scale deployment of AI currently raises fundamental questions about fairness, safety of use and how to assess the results obtained from AI longitudinally. This article explores how the many applications are evaluated for our practice (spoiler alert: they are currently limited), potential clinical benefits and challenges currently encountered when dealing with the integration of AI into routine oncology care. We will focus on language models whose development has been exploding since 2021.","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Haematopoietic stem cell donation from minor donor: Respecting laws, assessing fitness, delivering information and good care (SFGM-TC)]. [未成年人捐献造血干细胞：尊重法律、评估健康状况、提供信息和良好护理（SFGM-TC）]。

Bulletin du cancer Pub Date : 2025-01-01 Epub Date: 2024-05-16 DOI: 10.1016/j.bulcan.2024.04.002

Marie Lejeune, Bertille Menard, Sophie Servais, Christelle Andrianne, Lucie Capelle, Ségolène De Maistre, Catherine Fabaron, Marie Flata Cornier, Marie-Pierre Goutagny, Maguy Pereira, Clea Tardy, Eric Turquet, Malek Benakli, Etienne Baudoux, Solène Evard, Catherine Faucher, Gwenaelle Herrero, Léonardo Magro, Claire Geurten

{"title":"[Haematopoietic stem cell donation from minor donor: Respecting laws, assessing fitness, delivering information and good care (SFGM-TC)].","authors":"Marie Lejeune, Bertille Menard, Sophie Servais, Christelle Andrianne, Lucie Capelle, Ségolène De Maistre, Catherine Fabaron, Marie Flata Cornier, Marie-Pierre Goutagny, Maguy Pereira, Clea Tardy, Eric Turquet, Malek Benakli, Etienne Baudoux, Solène Evard, Catherine Faucher, Gwenaelle Herrero, Léonardo Magro, Claire Geurten","doi":"10.1016/j.bulcan.2024.04.002","DOIUrl":"10.1016/j.bulcan.2024.04.002","url":null,"abstract":"Haematopoietic stem cell collection from paediatric donors is a common and life-saving practice, as evidenced by the fact that there is a growing annual number of cases of transplants from minor donors among SFGM-TC centers over the last decade. Still, medical use of human tissue from a healthy and underage donor requires proper regulations and medical management. The guidelines below aim at underlining the importance of pondering the legal, medical and ethical aspects of using stem cells from healthy paediatric donors and stress out the importance of obtaining informed consent at the time of assessing HLA compatibility. Combined medical and psychological assessments are required before the donation, as well as one month later and one year later to ensure of the child's physical and mental wellbeing. Bone marrow harvest under general anaesthetics remains the preferred method of collection for children. Peripheral blood stem cell collection should only be considered for children who will not require a central venous access for collection. We aim at offering guidelines centered on the healthy child donating stem cells and his/her wellbeing, and these should be regularly reviewed as medical practices evolve.","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":"S78-S86"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Updates on hairy cell leukemia (HCL) and HCL-like disorders]. [毛细胞白血病（HCL）和HCL样疾病的最新进展]。

Bulletin du cancer Pub Date : 2024-12-21 DOI: 10.1016/j.bulcan.2024.12.004

Xavier Troussard, Elsa Maitre, Urbain Tauveron-Jalenques, Jérôme Paillassa, Luca Inchiappa, Cécile Tomowiak

{"title":"[Updates on hairy cell leukemia (HCL) and HCL-like disorders].","authors":"Xavier Troussard, Elsa Maitre, Urbain Tauveron-Jalenques, Jérôme Paillassa, Luca Inchiappa, Cécile Tomowiak","doi":"10.1016/j.bulcan.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.bulcan.2024.12.004","url":null,"abstract":"Hairy cell proliferations represent very different entities. They include hairy cell leukemia in its classic form (HCL), a well-defined entity, but also the variant form of HCL (LT-V ou HCL-V), whose presentation is far from HCL and whose prognosis is poorer. Other hairy cell proliferations include splenic red pulp lymphoma (SDRPL) and splenic marginal zone lymphomas (SMZL) with circulating villous cells. In this article, we emphasize the novelties concerning the different recent biological aspects of HCL, including the unusual clinical presentations but also the importance for the diagnosis of the detection of the BRAFV600E mutation, a molecular marker of the disease, and the presence of other non-canonical mutations that should be identified because of the contraindication to the use of BRAF inhibitors. Finally, the presence of a non-mutated profile of immunoglobulin heavy chains (IGHV), observed in 20% of cases, is associated with a poor prognosis. We also provide guidance in characterizing other hairy cell proliferations when examining the blood smear. The first-line treatment of HCL has recently changed and immunochemotherapy combining cladribine plus rituximab has become the gold standard. In relapsed or refractory forms, other treatments should be discussed in a multidisciplinary consultation meeting and combine BRAF inhibitors with anti-CD20 antibodies, BTK inhibitors or Bcl-2 inhibitors. The choices should be discussed according to the patient's profile but also their biological profile.","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Implementation of geriatric oncology in a remote hospital in French Guiana]. [在法属圭亚那一家偏远医院实施老年肿瘤学]。

Bulletin du cancer Pub Date : 2024-12-20 DOI: 10.1016/j.bulcan.2024.11.002

Olivier Angénieux, Bill Wankpo, Angélique Ferrand, Xavier Coulaud, Gilles Albrand, Diane Vernon, Mathieu Nacher, Jean-Pierre Droz

{"title":"[Implementation of geriatric oncology in a remote hospital in French Guiana].","authors":"Olivier Angénieux, Bill Wankpo, Angélique Ferrand, Xavier Coulaud, Gilles Albrand, Diane Vernon, Mathieu Nacher, Jean-Pierre Droz","doi":"10.1016/j.bulcan.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.bulcan.2024.11.002","url":null,"abstract":"Introduction: The aim was to analyze the implementation of the Onco-Geriatrics model in a remote ultramarine territory: West-French Guiana. The population is socially precarious in terms of income, social coverage and administrative status, and most often speaks a non-French language and has a non-Western culture.Methods: Narrative description of the implementation and retrospective study of anonymized data from the database of older patients managed for cancer between September 2014 and December 2020.Results: A total of 574 new patients were managed. Of these, 107 were aged 70 and over; 78 (73 %) had a G8 test. Forty-two patients had a multidimensional geriatric assessment (MGA). More than half the patients had dependency criteria, malnutrition and a high number of severe comorbidities. Difficulties encountered were language, level of education, clinical context (in 18 patients), but also insufficient involvement of health professional and the consequences of health organization and gradual implementation.Discussion: Implementation was impacted by the fact that quality criteria for implementation were not sufficient. Studies in high-middle-income countries in South America suggest that initial implementation of the MGA may be preferable, that frailty screening tests and the MGA procedure can be adapted to non-Western populations, and that the use of new technologies can improve the management of older patients in this context.","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Medical simulation training for bone marrow harvesting from a healthy donor for an allogeneic hematopoietic cell transplant (SFGM-TC)]. [为异体造血细胞移植从健康捐献者身上获取骨髓的医学模拟训练（SFGM-TC）]。

Bulletin du cancer Pub Date : 2024-12-12 DOI: 10.1016/j.bulcan.2024.10.010

Tamim Alsuliman, Leonardo Magro, Marie Titecat, Marie Robin, Tarek Kanouni, Edouard Forcade, Charlotte Jubert, Ibrahim Yakoub-Agha, Catherine Faucher

引用次数: 0

Cancer, treatment and religion: What impact? 癌症、治疗和宗教：有什么影响？

Bulletin du cancer Pub Date : 2024-12-09 DOI: 10.1016/j.bulcan.2024.09.005

Cyrine Mokrani, Rim Abidi, Khedija Ben Zid, Alia Mousli, Amani Yousfi, Hadhemi Ayadi, Chiraz Nasr

{"title":"Cancer, treatment and religion: What impact?","authors":"Cyrine Mokrani, Rim Abidi, Khedija Ben Zid, Alia Mousli, Amani Yousfi, Hadhemi Ayadi, Chiraz Nasr","doi":"10.1016/j.bulcan.2024.09.005","DOIUrl":"https://doi.org/10.1016/j.bulcan.2024.09.005","url":null,"abstract":"Introduction: Despite advances in treatment, the diagnosis and management of cancer remains a physical and psychological ordeal for the patient. Many authors have studied the impact of religiosity in cancer patients. The aim of our study was to describe the psychological influence of religious beliefs and practices in these patients.Methods: We conducted a descriptive study of 50 patients undergoing treatment in the Radiation Oncology Department. The Arabic version of the Santa Clara Strength of Religious Faith Questionnaire (SCSORFQ) was used to assess religious faith. The patient's psychological experience was assessed through a questionnaire.Results: The entire population was Muslim. The mean age was 60.5years (34-85years), 60% of whom were women. Breast cancer was predominant (46%). Twenty-six percent of the population was illiterate. The majority of patients (66%) reported an increase in their faith since the announcement of the disease. The religiosity score increased significantly with age (P=0.019). A positive correlation between time since diagnosis and number of prayers per day (P=0.009). The lower the level of education, the higher was the degree of faith (P=0.013). Moreover, low degrees of education were linked to greater acceptance of all therapeutic decisions (P=0.016).Conclusion: This study suggests the value of religious beliefs in helping cancer patients come to terms with their illness.","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Serious adverse effects with immunotherapies for the treatment of melanoma, non-small cell lung cancer, and renal cell carcinoma: Real-world evidence study]. [用于治疗黑色素瘤、非小细胞肺癌和肾细胞癌的免疫疗法的严重不良反应：真实世界证据研究]。

Bulletin du cancer Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI: 10.1016/j.bulcan.2024.08.017

Léa Cuenot, Marie-Blanche Valnet-Rabier, Abdelmalek Bendjama, François Aubin, Sarah Fischer, Julien Viot, Virginie Nerich

{"title":"[Serious adverse effects with immunotherapies for the treatment of melanoma, non-small cell lung cancer, and renal cell carcinoma: Real-world evidence study].","authors":"Léa Cuenot, Marie-Blanche Valnet-Rabier, Abdelmalek Bendjama, François Aubin, Sarah Fischer, Julien Viot, Virginie Nerich","doi":"10.1016/j.bulcan.2024.08.017","DOIUrl":"10.1016/j.bulcan.2024.08.017","url":null,"abstract":"Introduction: Immune checkpoint inhibitors (ICIs) are a key component of standard anticancer systemic therapy. While their immune-related adverse effects (irAEs) have been widely described, there are few data on grade≥3 irAEs. The primary aim of our descriptive study was to evaluate their incidence and characteristics.Methods: An observational, retrospective, monocentric study was conducted. It included patients with locally advanced or metastatic melanoma, non-small cell lung cancer or renal cell carcinoma who initiated ICI therapy between 2016-2021 and experienced at least one grade≥3 irAEs coded according to the MedDRA® system.Results: All cancer types and ICIs combined, the incidence of grade≥3 irAEs was estimated at 11.7% [9.6-13.9]. These were mainly hepatobiliary (22%), gastrointestinal (17%), musculoskeletal (16%) and respiratory (16%) disorders. They occurred on average 6.2±6.2 months after the start of treatment, resulting in hospitalization or prolonged hospitalization in over 40 and 20% of cases, respectively. Resolution without sequelae was observed in 56% of cases, but four patients died.Discussion: This real-world study investigated three cancers and several ICIs, unlike previously published studies that focused on a single cancer and/or one ICI. It provides a better understanding of grade≥3 irAEs, most of which are reversible, which an aim to optimize patient care.","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":"1111-1121"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The announcement in pediatric oncology - Feedback on simulation-based training within the GOCE (Grand Ouest cancer de l'enfant - Grand West Childhood Cancer)]. [儿科肿瘤学公告--GOCE（Grand Ouest cancer de l'enfant - Grand West Childhood Cancer）模拟培训反馈]。

Bulletin du cancer Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1016/j.bulcan.2024.06.011

Tiphaine Courtel, Mathilde Lefresne, Ingrid Cartier, Justine Gerasse, Emilie Gislier, Stéphanie Proust, Camille Flambard, Damien Bodet, Isabelle Pellier

{"title":"[The announcement in pediatric oncology - Feedback on simulation-based training within the GOCE (Grand Ouest cancer de l'enfant - Grand West Childhood Cancer)].","authors":"Tiphaine Courtel, Mathilde Lefresne, Ingrid Cartier, Justine Gerasse, Emilie Gislier, Stéphanie Proust, Camille Flambard, Damien Bodet, Isabelle Pellier","doi":"10.1016/j.bulcan.2024.06.011","DOIUrl":"10.1016/j.bulcan.2024.06.011","url":null,"abstract":"The announcement of a cancer diagnosis is a crucial moment in the management of the disease, as it is the starting point for a relationship of trust between patient and caregiver. In 2005, this issue led to the creation of an announcement system as part of the 2003-2007 cancer plan, but its implementation in practice remains uncertain. Pediatric oncology has its own specificities, with a triangular relationship and the need for doctors to adapt to the child's age. These skills require special training, and training opportunities vary from one area to another. To this end, the Angers and Caen centers have developed simulation exercises for training in pediatric oncology announcement. These consist of a theoretical part, followed by an announcement interview with actors, then a debriefing. Evaluation questionnaires are completed by learners before and after the session, and have highlighted the usefulness of this training, particularly in helping them to feel better prepared to face this stressful moment. As simulation has proved its educational value in the healthcare field, GOCE has developed simulation-based training courses for interns/CCAs/assistants in the territory. These courses are much appreciated and are proving extremely useful in clinical practice. This has led the SFCE to extend these courses to all CCAs and young PHs in pediatric oncology in France.","PeriodicalId":93917,"journal":{"name":"Bulletin du cancer","volume":" ","pages":"1095-1101"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0