Biological research for nursing最新文献_第6页

DNA Methylation of SLC6A4 and NR3C1 in Term and Preterm Infants: A Pilot Study of NICU-Associated Stress. 足月和早产儿SLC6A4和NR3C1的DNA甲基化：新生儿重症监护病房相关压力的初步研究

IF 2.1

Biological research for nursing Pub Date : 2026-04-01 Epub Date: 2025-10-14 DOI: 10.1177/10998004251387628

Kathryn J Malin, Yvette Conley, Aleigha Barry, Rosemary White-Traut

{"title":"DNA Methylation of SLC6A4 and NR3C1 in Term and Preterm Infants: A Pilot Study of NICU-Associated Stress.","authors":"Kathryn J Malin, Yvette Conley, Aleigha Barry, Rosemary White-Traut","doi":"10.1177/10998004251387628","DOIUrl":"10.1177/10998004251387628","url":null,"abstract":"Background: Preterm infants requiring prolonged hospitalization in the neonatal intensive care unit (NICU) are often exposed to early-life stress, which may contribute to long-term health consequences. Epigenetic markers, particularly DNA methylation (DNAm) of stress-related genes such as SLC6A4 and NR3C1, have been identified as potential biomarkers of early-life stress. Limited research has compared DNAm patterns between term and preterm infants or examined associations between NICU-related stress and DNAm in preterm populations. Objectives: This pilot study aimed to (1) compare DNAm patterns between preterm and term infants, (2) examine relationships between NICU-related stress and DNAm alterations in preterm infants, and (3) explore DNAm changes over time in preterm infants. Methods: Buccal swabs were collected from 10 term and 23 preterm infants within the first week of life. Eleven preterm infants returned for a repeat sampling three months post discharge. The Neonatal Infant Stressor Scale (NISS) was used to calculate early-life stress. DNAm at specific CpG sites were analyzed using Mann-Whitney U tests and Spearman's rho correlations. Results: Preterm infants exhibited significantly different DNAm patterns at select CpG sites compared to term infants. Among preterm infants, higher NISS scores during hospitalization correlated with altered DNAm patterns in both genes. At three months post-discharge, new and persistent DNAm alterations were identified; although, total average DNAm did not significantly differ over time. Conclusion: These findings suggest that NICU-related stress is associated with DNAm alterations in preterm infants, supporting the need for further investigation of DNAm as a biomarker of early-life stress.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":"28 2","pages":"187-194"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discrimination Against Immigrant Latina Mothers Associated With Pro-Inflammatory Gene Expression in Their Preschool-Aged Children. 对移民拉丁裔母亲的歧视与其学龄前儿童的促炎基因表达有关。

IF 2.1

Biological research for nursing Pub Date : 2026-04-01 Epub Date: 2025-12-22 DOI: 10.1177/10998004251410515

Rebeca Alvarado-Harris, Krista M Perreira, Hudson P Santos

{"title":"Discrimination Against Immigrant Latina Mothers Associated With Pro-Inflammatory Gene Expression in Their Preschool-Aged Children.","authors":"Rebeca Alvarado-Harris, Krista M Perreira, Hudson P Santos","doi":"10.1177/10998004251410515","DOIUrl":"10.1177/10998004251410515","url":null,"abstract":"Background: For immigrant mothers navigating the challenges of an unfamiliar sociopolitical landscape, the burden of discrimination extends beyond their personal experiences. Over time, cumulative exposure to discrimination may shape the environments in which young children grow and develop, with potential biological effects across the lifespan. Objectives: This cross-sectional observational study examined (1) whether maternal experiences of post-migration discrimination in the past year are associated with pro-inflammatory gene expression in their preschool-aged children, and (2) the potential contributing roles of maternal depressive symptoms and child body mass index (BMI). Methods: Immigrant Latina mothers completed sociodemographic and psychosocial measures (acculturation, discrimination, depressive symptoms). Buccal swabs were collected from children to assess mRNA expression of pro-inflammatory genes (IL-8, IL-1β), and child BMI was measured. Analyses included 70 mother-child dyads with ≥1 valid biomarker. We fit a multivariate model with correlated residuals across biomarkers to test associations between experiences of maternal discrimination and child gene expression. Results: Most mothers (69%) reported experiencing discrimination in the past year, primarily due to race or ancestry. Children whose mothers reported more frequent experiences of discrimination had higher IL-8 (B = .05, SE = .01, p < .001) and IL-1β (Β = .03, SE = .01, p = .03) mRNA expression. Associations persisted after adjusting for maternal depressive symptoms and child BMI. Conclusions: Early life experiences that devalue immigrants and their children may be critical predictors of health disparities that develop after migration. Cultivating welcoming environments for immigrant families may help support children's potential and broader community resilience.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"254-263"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Sex-Based Mechanisms of Inflammation and Neurodegeneration in Multiple Sclerosis. 探讨多发性硬化症炎症和神经变性的性别机制。

IF 2.1

Biological research for nursing Pub Date : 2026-04-01 Epub Date: 2025-10-14 DOI: 10.1177/10998004251387318

Stephanie Buxhoeveden, Theresa Swift-Scanlan, Myla D Goldman, Ryan Canissario, Unsong Oh

{"title":"Exploring Sex-Based Mechanisms of Inflammation and Neurodegeneration in Multiple Sclerosis.","authors":"Stephanie Buxhoeveden, Theresa Swift-Scanlan, Myla D Goldman, Ryan Canissario, Unsong Oh","doi":"10.1177/10998004251387318","DOIUrl":"10.1177/10998004251387318","url":null,"abstract":"Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by both immune-mediated inflammation and progressive neurodegeneration. While both processes occur in all individuals with MS, females more often present with heightened inflammatory activity, whereas males tend toward accelerated neurodegeneration and disability progression. This review synthesizes current evidence on biological, hormonal, genetic, epigenetic, and environmental mechanisms underlying sex-based differences in relapsing-remitting MS (RRMS), the most common MS subtype. We integrate findings from human studies, animal models, and molecular research to examine the contribution of genetics and epigenetic regulation including sex chromosomes, single nucleotide polymorphisms (SNPs), and microRNAs (miRNAs) to MS pathophysiology. We discuss the influence of sex hormones, including estrogen, progesterone, and testosterone, and environmental risk factors such as Epstein-Barr virus infection and vitamin D3 deficiency. Evidence suggests that X-linked immune-related genes, hormone - immune interactions, and sex-specific epigenetic regulation shape differential immune responses and neuronal vulnerability in males and females with MS. miRNAs emerge as critical molecular bridges linking genetic susceptibility, hormonal milieu, and environmental exposures to downstream inflammatory and neurodegenerative pathways. Understanding the mechanisms driving sex differences in MS may enable the development of targeted interventions addressing both neuroinflammation and neurodegeneration. Integrated miRNA - mRNA analyses, explicitly powered to assess sex as a biological variable, hold promise for identifying novel biomarkers and therapeutic targets. Such approaches could inform more personalized treatment strategies and improve long-term outcomes for all people with MS.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":"28 2","pages":"283-295"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Alcohol Consumption and Angiopoietin Serum Levels in Persons with HIV. 艾滋病毒感染者饮酒与血管生成素血清水平之间的关系

IF 2.1

Biological research for nursing Pub Date : 2026-01-01 Epub Date: 2025-10-24 DOI: 10.1177/10998004251381343

Joseph A Belloir, Thomas Myers, Rebecca Schnall

{"title":"Associations Between Alcohol Consumption and Angiopoietin Serum Levels in Persons with HIV.","authors":"Joseph A Belloir, Thomas Myers, Rebecca Schnall","doi":"10.1177/10998004251381343","DOIUrl":"10.1177/10998004251381343","url":null,"abstract":"Background: People with HIV (PWH) are at risk of developing HIV-related comorbidities, such as cardiovascular disease (CVD), which appears independent of combination antiretroviral therapy (cART). Angiopoietin (ANG) has been associated with vascular augmentation (i.e., arterial stiffness) in response to both human immunodeficiency virus (HIV) and alcohol use, but their combined health effects are not well understood. Methods: This study assessed data from the WiseApp study, examining ANG-1/ANG-2 blood serum levels and alcohol consumption in 109 adults with HIV at baseline. Alcohol consumption was measured using the Alcohol Use Disorders Identification Test - Concise (AUDIT-C) measure, and ANG-1 and ANG-2 levels were measured using high sensitivity Enzyme-Linked Immunoassay (ELISA) kits. Generalized linear mixed model analysis was used to explore the effect of alcohol consumption on angiopoietin levels in PWH, adjusting for demographic variables. Results: Alcohol consumption was not significantly associated with either ANG-1 or ANG-2 serum levels in our sample. However, CD4 serum levels were significantly correlated with both ANG-1 and 2, with a positive association for ANG-1 and negative associations for ANG-2. Additionally, demographic factors, including gender identity, sexual identity, and race, were significantly associated with ANG-2 levels but not ANG-1 levels. Conclusion: These findings underscore the complex interplay between immune function, vascular regulation, and demographic characteristics in persons with HIV. Future research should explore these relationships in larger and more diverse cohorts, incorporating longitudinal analyses to better understand the temporal dynamics of alcohol use, immune status, and endothelial function.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"64-71"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Traditional Chinese Exercise on Menopausal Symptoms, Bone Health and Mental Health in Perimenopausal and Postmenopausal Women: A Systematic Review and Meta-Analysis. 中国传统运动对围绝经期和绝经后妇女更年期症状、骨骼健康和心理健康的影响：系统综述和荟萃分析

IF 2.1

Biological research for nursing Pub Date : 2026-01-01 Epub Date: 2025-09-19 DOI: 10.1177/10998004251377748

Yuanxia Liu, Yapeng He, Qi Zhang, Qunfeng Lu

{"title":"Effects of Traditional Chinese Exercise on Menopausal Symptoms, Bone Health and Mental Health in Perimenopausal and Postmenopausal Women: A Systematic Review and Meta-Analysis.","authors":"Yuanxia Liu, Yapeng He, Qi Zhang, Qunfeng Lu","doi":"10.1177/10998004251377748","DOIUrl":"10.1177/10998004251377748","url":null,"abstract":"Background: Perimenopausal and postmenopausal women commonly experience vasomotor symptoms, bone loss, and mental health challenges that diminish quality of life (QoL). Although Traditional Chinese Exercise (TCE) has shown benefits in alleviating certain menopausal symptoms, its overall effects on health-related outcomes remain controversial. Objectives: This study aimed to systematically analyze the effects of TCE on menopausal symptoms, bone health, and mental health in perimenopausal and postmenopausal women. Methods: A systematic search was conducted across 7 databases through April 2025 for randomized controlled trials (RCTs) investigating the effects of TCE in perimenopausal and postmenopausal women. Risk of bias was assessed using the Cochrane Risk of Bias Tool 2 (RoB 2). Stata 17.0 was used for meta-analysis, with pooled outcomes reported as standardized or mean differences (SMD/MD) with 95% confidence intervals (CIs). Results: Twelve RCTs involving 1,023 participants were included. Meta-analysis showed that TCE significantly reduced menopausal symptoms (SMD = -0.82, 95% CI: -1.41 to -0.22), and depression (SMD = -1.73, 95% CI: -2.49 to -0.98). TCE also improved spine BMD (MD = 0.05, 95% CI: 0.02 to 0.08). For upper limb, thigh, pelvis, trunk, and whole-body BMD, effects remained uncertain due to the limited number of studies. Three studies assessed QoL, and pooled results showed no significant improvement in physical (MD = 4.52, 95% CI: -2.93 to 11.97) or mental component scores (MD = 3.28, 95% CI: -3.67 to 10.23). Conclusions: TCE appears to be an effective intervention for menopausal symptoms, spine BMD, and depression. However, its effects on QoL and other skeletal sites remain inconclusive. Larger, high-quality RCTs are warranted to clarify optimal protocols and long-term benefits.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"158-170"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Determinants of Health and Epigenetic Age Acceleration in Type 2 Diabetes: A Systematic Review. 2型糖尿病健康和表观遗传年龄加速的社会决定因素：一项系统综述。

IF 2.1

Biological research for nursing Pub Date : 2026-01-01 Epub Date: 2025-07-26 DOI: 10.1177/10998004251357537

Chelsea Howland, Stephanie Gilbertson-White, Shaoshuai Chen, Young-Eun Cho

{"title":"Social Determinants of Health and Epigenetic Age Acceleration in Type 2 Diabetes: A Systematic Review.","authors":"Chelsea Howland, Stephanie Gilbertson-White, Shaoshuai Chen, Young-Eun Cho","doi":"10.1177/10998004251357537","DOIUrl":"10.1177/10998004251357537","url":null,"abstract":"BackgroundIndividuals with type 2 diabetes (T2D) experience epigenetic age acceleration (EAA), as described by DNA methylation based epigenetic clocks. It is critical to examine relationships between social determinants of health (SDOH) and EAA in people living with T2D to understand mechanisms interconnecting social and biologic drivers of health disparities. The purpose of this systematic review was to describe the role of SDOH as factors influencing EAA in T2D.MethodsPubMed, CINAHL, and Embase were comprehensively searched. Research reports were independently screened and abstracted; quality was assessed using JBI checklists. The Healthy People 2030 SDOH Framework guided this study. Domains of SDOH were benchmarked against the framework to identify roles and gaps.ResultsOf 25 included research reports which evaluated epigenetic aging in T2D, 64% describe at least one SDOH. SDOHs within education access and quality (44%), neighborhood and built environment (40%), and economic stability (36%) domains are the most well represented; however, the depth and breadth of conceptual understanding were limited. Concepts representative of SDOH including childhood low socioeconomic status and victimization, trauma, and lower education and income were positively associated with EAA in T2D.DiscussionWhile SDOH are increasingly included in studies of EAA in people with T2D, critical gaps in understanding the roles and relationships between SDOH and EAA were revealed. Findings support the need to move further than socioeconomic status to comprehensively explore SDOH domains influencing EAA in individuals living with T2D, which will provide a framework for identifying health inequities.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":"28 1","pages":"91-109"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Specific Factors Influencing GrimAge Acceleration in Middle-Aged Korean Adults. 影响韩国中年人面部表情加速的性别因素。

IF 2.1

Biological research for nursing Pub Date : 2026-01-01 Epub Date: 2025-08-25 DOI: 10.1177/10998004251370671

Seungkyu Kim, Jongmin Park

{"title":"Sex-Specific Factors Influencing GrimAge Acceleration in Middle-Aged Korean Adults.","authors":"Seungkyu Kim, Jongmin Park","doi":"10.1177/10998004251370671","DOIUrl":"10.1177/10998004251370671","url":null,"abstract":"Background: Middle-aged adults experience degenerative aging-related changes, often differing by sex. Research identifying sex-specific factors contributing to biological aging among middle-aged adults remains limited. This study aimed to identify sex-specific factors influencing GrimAge acceleration (GrimAA), a DNA methylation-based estimator of biological aging, among middle-aged Korean adults. Methods: Data were derived from the Korean Genome and Epidemiology Study (KoGES) cohort involving 686 middle-aged adults (422 men and 264 women). GrimAA was calculated from DNA methylation data using the GrimAge epigenetic clock. Demographic, lifestyle, clinical, and psychosocial stress variables were assessed, and sex-specific factors influencing GrimAA were identified through hierarchical multiple regression models. Results: In men, higher GrimAA was significantly associated with current smoking, current drinking, physical inactivity, and elevated Hs-CRP or HbA1C levels, whereas among women, early menopause (<50 years) emerged as a notable factor related to increased GrimAA. Hierarchical regression analyses revealed that chronological age, current smoking, and Hs-CRP were robust predictors of GrimAA in men, whereas GrimAA in women was significantly predicted by current smoking and Hs-CRP. Conclusion: Sex differences in GrimAA may result from the interplay of lifestyle behaviors, inflammatory biomarkers, and hormonal factors. Targeted interventions addressing these sex-specific determinants could be effective strategies to mitigate biological aging acceleration among middle-aged adults.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"50-63"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying the Ongoing Risk and the Critical Time Point of Cardiovascular Diseases in Women With Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies. 确定妊娠期糖尿病妇女心血管疾病的持续风险和关键时间点：队列研究的系统回顾和荟萃分析

IF 2.1

Biological research for nursing Pub Date : 2026-01-01 Epub Date: 2025-08-08 DOI: 10.1177/10998004251366590

Zixuan Wei, Tingting Yan, Yi Wu, Linping Shang, Shifan Han, Mingzi Li

{"title":"Identifying the Ongoing Risk and the Critical Time Point of Cardiovascular Diseases in Women With Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies.","authors":"Zixuan Wei, Tingting Yan, Yi Wu, Linping Shang, Shifan Han, Mingzi Li","doi":"10.1177/10998004251366590","DOIUrl":"10.1177/10998004251366590","url":null,"abstract":"This study assessed the risk of cardiovascular diseases (CVD) at various stages in women with gestational diabetes mellitus (GDM) and aimed to identify critical time points when the risk increases. Fifteen cohort studies including a total of 7,515,168 pregnant women were analyzed, among whom 429,564 had GDM and 13,773 developed CVD. Participants were grouped based on follow-up periods of approximately 5, 10, 15, and 25 years. Using random effects models, pooled hazard ratios (HR) with 95% confidence intervals (CI) were calculated. Within five years of diagnosis, women with GDM had a 19% higher risk of CVD (HR 1.19, 95% CI 1.11-1.27) compared to those without GDM, rising to 78% by the tenth year (HR 1.78, 95% CI 1.67-1.89). Long-term follow-up showed risk increases of 31% at 15 years (HR 1.31, 95% CI 1.28-1.35) and 26% at 25 years (HR 1.26, 95% CI 1.16-1.38). Overall, women with GDM had a 35% higher risk of developing CVD than those without (HR 1.35, 95% CI 1.32-1.38). These findings highlight that GDM significantly elevates the risk of cardiovascular diseases, particularly within ten years after diagnosis, emphasizing the need for timely intervention and ongoing monitoring to reduce cardiovascular risk in affected women.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"131-148"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Passive Electronic Cigarette Vapor Exposure in Children: A Systematic Review. 儿童被动电子烟蒸汽暴露：一项系统综述。

IF 2.1

Biological research for nursing Pub Date : 2026-01-01 Epub Date: 2025-07-09 DOI: 10.1177/10998004251357832

Jeannie Rodriguez, Deborah Silverstein, Abby Mutic, Donghai Liang, Shenita Peterson, Irene Yang

{"title":"Passive Electronic Cigarette Vapor Exposure in Children: A Systematic Review.","authors":"Jeannie Rodriguez, Deborah Silverstein, Abby Mutic, Donghai Liang, Shenita Peterson, Irene Yang","doi":"10.1177/10998004251357832","DOIUrl":"10.1177/10998004251357832","url":null,"abstract":"Adults of childbearing age have the highest rate of electronic cigarette (e-cigarette) use in the United States. Users perceive passive e-cigarette vapor exposure to be less harmful than passive conventional cigarette smoke exposure. We conducted a systematic review to understand the risks of passive e-cigarette vapor exposure in children. Data sources included PubMed, CINAHL, Web of Science, and Scopus. Eligibility criteria included studies published between 2010 and 2024 with (1) children ages 0-18 or animal models representing children and in vitro studies, (2) descriptive, experimental, and qualitative designs, and (3) a focus on passive e-cigarette vapor exposure. Two independent reviewers screened studies, with a third for arbitration. Thirty-three studies were included in this review. Emerging evidence, primarily from animal studies, suggests that passive e-cigarette vapor exposure is associated with poor respiratory, immunological, physical growth, and neurological effects. Air assessments noted increased particulate matter and concentrations of nicotine, metals, and volatile organic compounds. Parents were more likely to use e-cigarettes than non-parents, and a majority reported use in the home and car. Risk of bias assessment indicated that 23 of the 33 studies were rated as weak, highlighting methodological limitations in the current evidence base. More rigorously designed studies are needed to strengthen the evidence base. Passive e-cigarette vapor exposure may be harmful to children, and many parents seem unaware of this potential threat. Parents should be cautioned to minimize exposure until more is known.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"110-130"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle and Genetic Factors Associated With Cardiovascular Disease: A Genome-wide Association Study. 与心血管疾病相关的生活方式和遗传因素：一项全基因组关联研究

IF 2.1

Biological research for nursing Pub Date : 2026-01-01 Epub Date: 2025-07-29 DOI: 10.1177/10998004251361807

Haejung Lee, DaeEun Lee, Sukhyun Jun

{"title":"Lifestyle and Genetic Factors Associated With Cardiovascular Disease: A Genome-wide Association Study.","authors":"Haejung Lee, DaeEun Lee, Sukhyun Jun","doi":"10.1177/10998004251361807","DOIUrl":"10.1177/10998004251361807","url":null,"abstract":"Objective: To identify single nucleotide polymorphisms (SNPs) associated with cardiovascular disease (CVD) and examine the association of genetic and lifestyle factors using data from the Korean Genome and Epidemiology Study (KoGES). Methods: A secondary analysis was conducted using Phase 1 data from the Health Examinee (HEXA) cohort, including 26,546 participants (1,919 with CVD and 24,627 controls). Sex-stratified analyses were performed on 17,390 females and 9,156 males. SNPs associated with CVD were identified using PLINK 1.9, and logistic regression models were used to assess associations between CVD and genetic, demographic, and lifestyle factors in IBM SPSS Statistics 27.0. Results: Three SNPs (rs8086325, rs34233878, rs218463) were significantly associated with CVD in the overall sample. In males, rs79682491, rs2540719, and rs2576541 showed significant associations, while in females, rs76830381, rs6496602, rs8086325, and rs34233878 were identified. In multivariate analyses, age ≥60 (OR = 15.56), BMI ≥30 (OR = 4.74), male sex, smoking, low protein intake, low income, and selected SNPs were significantly associated with CVD risk. Conclusion: This study underscores the multifactorial nature of CVD risk, highlighting the joint association of genetic, behavioral, and demographic factors. The observed sex-specific genetic associations reinforce the need for personalized prevention strategies. Nurses are well-positioned to lead efforts in implementing sex-sensitive, genomics-informed approaches to reduce CVD risk and promote cardiovascular health.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"30-39"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0