Khalid W Freij, Fiona B A T Agbor, Vinodh Srinivasasainagendra, Tammie L Quinn, Hemant K Tiwari, Robert E Sorge, Burel R Goodin, Edwin N Aroke
{"title":"Serial Mediation: How Optimism Reduces and Pessimism Intensifies Chronic Low Back Pain Through Depression and Biological Aging.","authors":"Khalid W Freij, Fiona B A T Agbor, Vinodh Srinivasasainagendra, Tammie L Quinn, Hemant K Tiwari, Robert E Sorge, Burel R Goodin, Edwin N Aroke","doi":"10.1177/10998004251348910","DOIUrl":"10.1177/10998004251348910","url":null,"abstract":"<p><p>There is growing evidence that psychological (e.g., optimism, pessimism, depressive symptoms) and biological factors play an essential role in the experience of chronic low back pain (CLBP). This study aimed to examine the nature of the relationship between optimism or pessimism, depressive symptoms, the pace of biological aging, CLBP severity, and interference. Using mediation analysis, we tested the hypothesis that depressive symptoms and pace of biological aging measured using the Dunedin Pace of Aging from the Epigenome (DunedinPACE) serially mediate the relationship between optimism or pessimism and CLBP severity and interference. Our sample included non-Hispanic Black and non-Hispanic White adults aged 18-82 years: 74 without pain, 56 with low-impact pain, and 77 with high-impact pain. On average, individuals with high-impact pain reported lower levels of optimism, greater pessimism, and faster DunedinPACE than those in the low-impact or no-pain group (<i>p</i> < .05). Mediation analyses revealed indirect associations between both optimism and pessimism with pain severity and interference serially via depressive symptoms and the pace of biological aging (<i>p</i> < .05). These indirect effects were not statistically significant after controlling for chronological age, sex, race, and BMI. The results suggest that psychological interventions that increase optimism and reduce pessimism may slow the biological aging process, which may improve nonspecific CLBP outcomes in non-Hispanic Black and non-Hispanic White adults.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"5-15"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12877770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Aerobic, Resistance, and Combined Exercise Training on Cardiorespiratory Fitness in Healthy People Aged 60 years and Over: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Amin Azimkhani, Rasoul Kasraei, Hamidreza Sabeti, Ameer Almasoodi","doi":"10.1177/10998004251348605","DOIUrl":"10.1177/10998004251348605","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the effects of aerobic, resistance, and combined training on cardiorespiratory fitness in healthy older adults, with a focus on improvements in maximal/peak oxygen uptake (VO<sub>2</sub>max/peak) and the 6-min walk distance (6-MWD).<b>Methods:</b> A systematic review and meta-analysis were conducted through July 2024, searching six databases: PubMed, CINAHL, Medline, Embase, Web of Science, and Scopus. Analyses were performed using Review Manager 5.3. <b>Results:</b> Fifty-one studies involving 3152 participants met the inclusion criteria. Exercise interventions significantly improved VO<sub>2</sub>max/peak (standardized mean difference (SMD): 0.51; 95% confidence interval (CI), 0.38 to 0.65; <i>p</i> < .001) and 6-MWD (MD: 36.18 m; 95% CI, 26.52 to 45.84; <i>p</i> < .001) compared to control groups. Subgroup analyses showed consistent benefits across aerobic, resistance, and combined training modalities. Significant improvements were also observed across both medium-term (≤24 weeks) and long-term (>24 weeks) interventions, and in both male and female participants. <b>Conclusion:</b> Structured exercise interventions, regardless of type, are effective for improving cardiorespiratory fitness in older adults. The consistency of these effects across modalities, durations, and sexes underscores the adaptability and value of exercise as a central component of healthy aging strategies. Future research should aim to standardize intervention protocols and extend follow-up periods to clarify long-term outcomes and inform clinical guidelines.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"72-90"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexis Jimenez, Karla Lindquist, Kayla D Longoria, Benjamin M Stroebel, Bradley E Aouizerat, Elena Flowers
{"title":"Defining Genetic Ancestry: Implications for Nurses.","authors":"Alexis Jimenez, Karla Lindquist, Kayla D Longoria, Benjamin M Stroebel, Bradley E Aouizerat, Elena Flowers","doi":"10.1177/10998004251374146","DOIUrl":"10.1177/10998004251374146","url":null,"abstract":"<p><p><b>Introduction:</b> This paper provides an overview of methods for measuring genetic ancestry, specifically focusing on applications for nurses engaged in research. We describe methods and current tools widely implemented by the research community to introduce nurses who conduct research in the landscape of measuring genetic admixture for individuals and genetic substructure for populations. The intended impact of this paper is to enhance awareness and understanding of the importance of measuring genetic ancestry to control for latent confounding in genetic association studies. <b>Summary of best practices:</b> Measurement of genetic ancestry can prevent confounding in genetic association studies. <b>Conclusions:</b> Nurses approach health from a holistic perspective that includes information about individual, environmental, and social factors. This framework necessitates consideration of individual genetic characteristics and social identity and position. This paper serves as a primer on concepts related to genetic ancestry, including ancestry informative markers, reference populations, and statistical approaches, that nurses engaged in research may incorporate into their study design and implementation.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"149-157"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xin Zhang, Yining Wang, Jingjing He, Hui Li, Yanbin Wang
{"title":"Systematic Review and Meta-Analysis of Aromatherapy in Alleviating Post-Chemotherapy Nausea and Vomiting Among Cancer Patients.","authors":"Xin Zhang, Yining Wang, Jingjing He, Hui Li, Yanbin Wang","doi":"10.1177/10998004251356515","DOIUrl":"10.1177/10998004251356515","url":null,"abstract":"<p><p><b>Background</b>: Chemotherapy-induced nausea and vomiting (CINV) represent prevalent and distressing adverse effects among cancer patients, substantially compromising treatment compliance and quality of life. This systematic review and meta-analysis evaluate the therapeutic efficacy of aromatherapy in managing CINV, with the objective of informing evidence-based clinical decision-making in supportive cancer care. <b>Methods</b>: We systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials (RCTs) assessing aromatherapy's effects on CINV. Two reviewers independently screened studies, extracted data, and evaluated bias risk. Meta-analysis was performed using RevMan 5.4, with outcomes expressed as odds ratios (ORs) or mean differences (MDs) with 95% confidence intervals (CIs). <b>Results</b>: Twelve RCTs (n = 1,572) were included. Aromatherapy significantly reduced acute nausea (OR = 0.46, 95% CI 0.29-0.73), acute vomiting (OR = 0.56, 95% CI 0.40-0.79), and delayed nausea (OR = 0.64, 95% CI 0.47-0.88). However, no significant effects were observed for delayed vomiting (OR = 0.72, 95% CI 0.39-1.34), VAS scores (MD = -1.30, 95% CI -2.76-0.16), or INVR scores (MD = -1.67, 95% CI -3.67-0.32). No publication bias was detected (<i>p</i> > 0.05). <b>Conclusion</b>: The existing body of evidence suggests that aromatherapy may function as a valuable adjunctive therapy in mitigating chemotherapy-induced nausea, especially during the acute phase. Nevertheless, its efficacy in managing vomiting and symptoms in the delayed phase remains uncertain. Future research efforts should focus on conducting large-scale, methodologically robust RCTs that employ standardized aromatherapy protocols and incorporate longitudinal assessments of outcomes and understanding the biological mechanisms associated with aromatherapy therapeutic effects.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"16-29"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dahee Wi, Diane M Flynn, Nathan Tintle, Jeffrey C Ransom, Honor M McQuinn, Tyler J Snow, Sotaro Shimada, Nicholas Ieronimakis, Ardith Z Doorenbos
{"title":"Post-Treatment Urine Metabolites as Indicators of Chronic Pain: A Secondary Data Analysis of a Pragmatic Clinical Trial.","authors":"Dahee Wi, Diane M Flynn, Nathan Tintle, Jeffrey C Ransom, Honor M McQuinn, Tyler J Snow, Sotaro Shimada, Nicholas Ieronimakis, Ardith Z Doorenbos","doi":"10.1177/10998004251362369","DOIUrl":"10.1177/10998004251362369","url":null,"abstract":"<p><p>Biomarkers may complement patient-reported outcomes by providing objective insight into the multidimensional nature of chronic pain. The urine metabolite pain indicator (UMPI), a composite of four urine metabolites, has previously demonstrated cross-sectional associations with pain-related symptoms; however, it is unclear whether these associations are consistent over time. This study evaluated whether the UMPI and its individual metabolites remain associated with chronic pain outcomes following intervention, which would support its potential as a monitoring biomarker. A secondary analysis of a pragmatic clinical trial, where 148 active-duty service members with chronic pain provided urine samples and completed 11 self-reported outcome measures at baseline and 6-week follow-up after either a complementary and integrative health or a standard rehabilitative care pain intervention. Associations were examined using linear regression and mixed models. The UMPI remained significantly associated with physical function and overall pain impact post-intervention. Ethylmalonic acid showed associations with fatigue, anger, and physical function. Notably, methylmalonate, while not significant at baseline, had the most robust association with pain post-intervention, including significant correlations with both physical function and pain impact. Kynurenic acid was associated with sleep-related impairment. Pyroglutamic acid showed no significant adjusted associations. No statistically significant differences in metabolite and symptom correlations were found between time points, suggesting that these associations remained consistent over the short term. The UMPI may serve as a reliable, noninvasive index biomarker for tracking chronic pain burden, particularly physical outcomes. Findings support integrating the UMPI into biologically informed chronic pain assessment.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"40-49"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Significant Impacts of the Body-Mass Index, Blood Pressure, Blood Glucose, and Ankle-Brachial Index on Peripheral Neuropathy Risk in Indonesian With Type 2 Diabetes: A Cross-Sectional Study.","authors":"Siti Fadlilah, Vivi Leona Amelia, Cyruz P Tuppal, Hui-Chen Rita Chang, Ching Wen Chang, Chia Ling Lin, Hsiu Ting Tsai","doi":"10.1177/10998004251336795","DOIUrl":"10.1177/10998004251336795","url":null,"abstract":"<p><p><b>Background:</b> Diabetic peripheral neuropathy is associated with morbidity and mortality in people with diabetes mellitus. <b>Aims:</b> In this study, we determined relationships of the body-mass index (BMI), systolic blood pressure, diastolic blood pressure, fasting blood glucose, HbA1c, and ankle-brachial index (ABI) with diabetic peripheral neuropathy risk. <b>Methods:</b> A cross-sectional study was conducted with 1088 Indonesians and data collected using self-reported questionnaires, laboratory examinations, and physical examinations. Instruments included a digital scale, height measurement device, digital sphygmomanometer, Doppler ultrasound, 10-g monofilament, and a 128-Hz tuning fork. Data analysis used the Chi-square test, Fisher Exact, and multiple logistic regression test with significance <i>p <</i> .05. <b>Results:</b> The BMI (<i>p <</i> .001), blood pressure (<i>p <</i> .001), ABI (<i>p <</i> .001), fasting blood glucose (<i>p =</i> .016), and HbA1c (<i>p <</i> .001) were significantly related to peripheral neuropathy risk. The conditions of obesity, hypertension, high ABI, high fasting blood glucose, and high HbA1c significantly increased the risk of peripheral neuropathy. Moreover, participants with ≥4 co-occurring abnormal levels of the BMI, systolic blood pressure, diastolic blood pressure, fasting blood glucose, HbA1c, and ABI had significantly synergistically increased risks of peripheral neuropathy, and the more abnormal conditions there were, the higher the risk of peripheral neuropathy. <b>Conclusions:</b> Abnormalities of the BMI, blood pressure, fasting blood glucose, HbA1c, and ABI significantly and synergistically increased the risk of peripheral neuropathy and can be considered predictors of peripheral neuropathy. Nurses are expected to be aware of these predictors so that they can immediately take appropriate steps if they encounter abnormal conditions by optimizing their role as educators.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"558-569"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jose Carlos de Andrade Vieira Junior, Murilo Rossi Lima Sander, José Airton de Oliveira Matos, André de Macêdo Medeiros, Flávio Santos da Silva, Caio Augusto Martins Aires
{"title":"Neurological Post-Acute Sequelae of COVID-19 in Non-Hospitalized Patients: An Integrative Review.","authors":"Jose Carlos de Andrade Vieira Junior, Murilo Rossi Lima Sander, José Airton de Oliveira Matos, André de Macêdo Medeiros, Flávio Santos da Silva, Caio Augusto Martins Aires","doi":"10.1177/10998004251335968","DOIUrl":"10.1177/10998004251335968","url":null,"abstract":"<p><p>The COVID-19 pandemic has had a significant impact on the global population. The infection, caused by SARS-CoV-2, presents with a variety of clinical manifestations, from asymptomatic cases to more severe forms, including a variety of neurological symptoms, such as fatigue, weakness, brain fog, paresthesias, dysautonomia, anosmia, and dysgeusia. Additionally, the disease is associated with the long COVID syndrome, in which there is persistence of the effects and symptoms of the acute phase. In recent years the literature has shown relevant data on long COVID, but there is still a need to deepen the knowledge about these long term manifestations. Thus, the present study aimed to describe the main neurological sequelae resulting from SARS-CoV-2 infection in non-hospitalized population during the long phase of the disease, gathering scientific evidence through an integrative review of the prevalence of symptoms, patient profile, duration and severity of sequelae, risk factors, comorbidities, and possible nervous system structural damage. The PubMed/Medline database was used with descriptors and, at the end of the screening process with predefined inclusion and exclusion criteria, 22 studies were included. A group of neurological symptoms associated with long COVID was identified: myalgia, dysgeusia, memory alterations, olfactory dysfunction, dizziness, and pain. Most patients presented multiple symptoms that lasted for more than one year with a significant impact on quality of life. The main risk factors were dyslipidemia, age, ethnicity, muscle/ joint pain, and sex. This review highlights the importance of further studies on the syndrome, its etiology, diagnosis, follow-up, and treatments.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"652-665"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mackenzie Morrison, Jemima Adisa, Olivia Trimiar, John Norfleet, Mathias Basner, Makayla L Cordoza
{"title":"Considerations for the Use of Commercial Wearables to Assess Sleep and Rest-Activity Rhythms.","authors":"Mackenzie Morrison, Jemima Adisa, Olivia Trimiar, John Norfleet, Mathias Basner, Makayla L Cordoza","doi":"10.1177/10998004251337065","DOIUrl":"10.1177/10998004251337065","url":null,"abstract":"<p><p>Use of wearables, which can be considered as devices worn on the body that capture dimensions of health, are common in research. Wearables are useful as they can be employed in a number of environments for a variety of populations and can record over short or long time periods. Recent advancements in technology have significantly improved the accuracy of sensors and the algorithms used to interpret their data. Commercial wearables, such as fitness trackers, smartwatches, and smart rings have seen parallel advancements. Perhaps the most common application of wearables in research is for the assessment of sleep and rest-activity rhythms as most wearables include accelerometers, a sensor commonly used to infer sleep and activity from movement patterns. Commercial wearables are appealing for use in research due to their widespread use in the general population, real-time data syncing capabilities, affordability, and their user-friendly, consumer-oriented design and interfaces. There are, however, several important factors to consider when selecting a commercial wearable for use in research. These include device specifications (durability, price, unique features, etc.), data accessibility, and participant factors. Keeping these considerations in mind can assist in the collection of high-quality data that can ultimately be used to improve population outcomes. The purpose of this methodological review is to describe considerations for the use of commercially available wearables in research for the purposes of assessing sleep and rest-activity patterns.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"640-651"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuo Wang, Jing Han, Qingyan Wang, Qing Li, Yanze Cui
{"title":"The Causal Relationship Between Chronic Pain and Frailty: A Two-Sample Mendelian Randomization Study.","authors":"Shuo Wang, Jing Han, Qingyan Wang, Qing Li, Yanze Cui","doi":"10.1177/10998004251361789","DOIUrl":"10.1177/10998004251361789","url":null,"abstract":"<p><p><b>Objective:</b> Frailty and chronic pain are closely related, but the causal relationship between them needs to be further explored with high-level evidence. Mendelian randomization (MR) was used to analyse the bidirectional causal relationship between nine chronic pain disorders and two frailty indicators in this study. <b>Methods:</b> We used Causal Analysis Using Summary Effect Estimates (CAUSE) as the primary method of analysis. The inverse-variance-weighted, simple model, weighted model, penalized weighted median and MR‒Egger regression methods were used to evaluate the robustness of the results. <b>Results:</b> The frailty index (FI) was significantly associated with the number of chronic pain sites (multisite chronic pain, MCP, <i>p</i><sub>adjust</sub> < .001) and the risk of chronic widespread pain (CWP, <i>p</i><sub>adjust</sub> < .001). The Fried frailty score (FFS) was significantly associated with MCP (<i>p</i><sub>adjust</sub> < .001), the risk of CWP (<i>p</i><sub>adjust</sub> < .001) and chronic back pain (<i>p</i><sub>adjust</sub> = .031). In the reverse analysis, both MCP and CWP were significantly positively associated with the FI (<i>p</i><sub>adjust</sub> < .001; <i>p</i><sub>adjust</sub> = .003) and FFS (<i>p</i><sub>adjust</sub> < .001; <i>p</i><sub>adjust</sub> = .009). <b>Conclusions:</b> This study revealed a bidirectional causal relationship between frailty and chronic pain, with the number of pain sites playing a key role. This finding has significant implications for effectively managing frailty and chronic pain in older adults.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"630-639"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shao-Yu Tsai, Yi-Ching Tung, Chuen-Min Huang, Shu-Yu Kuo, Chien-Chang Lee
{"title":"Sleep and Adiposity Outcomes in School-Age Children with Overweight and Obesity.","authors":"Shao-Yu Tsai, Yi-Ching Tung, Chuen-Min Huang, Shu-Yu Kuo, Chien-Chang Lee","doi":"10.1177/10998004251339743","DOIUrl":"10.1177/10998004251339743","url":null,"abstract":"<p><p><b>Purpose:</b> To examine four dimensions of sleep (timing, quality, quantity, and variability) and their association with adiposity outcomes in a community sample of school-age children with overweight and obesity. <b>Design</b>: A cross-sectional actigraphic study. <b>Methods:</b> 246 school-age children aged 6-9 years with overweight or obesity were recruited from 10 public elementary schools in Taipei, Taiwan. Children's sleep was objectively assessed over a 7-day period using a wrist actigraph. Adiposity outcomes, including BMI, BMI-for-age z-score, and percent body fat, were computed based on measured weight, height, and skinfold thickness following standardized procedures. Associations between sleep and child adiposity outcomes were examined using bivariate and multiple linear regression analyses. <b>Results:</b> In the bivariate analyses, later sleep onset time was correlated with greater percent body fat (<i>p =</i> .01); shorter daily sleep duration was correlated with higher BMI and percent body fat (both <i>p <</i> .05); greater variability in daily sleep duration was correlated with higher BMI, BMI-for-age z-score, and percent body fat (all <i>p <</i> .05). In multiple linear regression analyses, variability in daily sleep duration was the only sleep characteristic that showed a statistically significant association with percent body fat in children (b = 2.36; 95% CI: 0.28 to 4.43; <i>p =</i> .02). <b>Conclusions:</b> Overweight and obesity treatment interventions targeting child weight management should prioritize the assessment and promotion of children's sleep regularity. Future randomized controlled trials are needed to investigate the impact of maintaining a more consistent sleep pattern on measures of adiposity in school-age children with overweight and obesity.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"592-600"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}